ID A0A7U2N1A1_ASPFN Unreviewed; 1395 AA.
AC A0A7U2N1A1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 7.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=F9C07_2167825 {ECO:0000313|EMBL:QRD93679.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:QRD93679.1, ECO:0000313|Proteomes:UP000596276};
RN [1] {ECO:0000313|Proteomes:UP000596276}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000596276};
RX PubMed=34849826; DOI=10.1093/g3journal/jkab213;
RA Skerker J.M., Pianalto K.M., Mondo S.J., Yang K., Arkin A.P., Keller N.P.,
RA Grigoriev I.V., Louise Glass N.L.;
RT "Chromosome assembled and annotated genome sequence of Aspergillus flavus
RT NRRL 3357.";
RL G3 (Bethesda) 11:jkab213-jkab213(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-
CC oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2
CC formaldehyde + 2 succinate + 2 CO2; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00049349};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
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DR EMBL; CP044623; QRD93679.1; -; Genomic_DNA.
DR Proteomes; UP000596276; Chromosome 6.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:TreeGrafter.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd15571; ePHD; 1.
DR FunFam; 2.60.120.650:FF:000024; Putative jumonji family transcription factor; 1.
DR FunFam; 2.60.120.650:FF:000047; Putative jumonji family transcription factor; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR055500; DUF7072.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF23258; DUF7072; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000596276};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 80..121
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 346..509
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 588..713
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 18..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..218
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..944
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..975
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1018
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1395 AA; 156211 MW; 4BDEEDEE6EEDDC81 CRC64;
MMATALDQPL FESVAGPATA AASITPPHSA NGKKEVPDGV PSELSDLELD PNAVGVPEAA
SVEEEEEDIE PDHYYGGGKI PVFKPTMDQF RDFQSFINKV EKYGMRSGIL KVIPPKEWTD
SLPALDEAVK KIRVKNPIMQ EFHGSHGTYT QANIERQRSY NLPQWKGLCE ESSHQPPARR
GERRRNQERI TRAPPSSRAQ TARPDSQKRR PGPGRPPKRS NQVKVKEEPA EDTLDKIKPE
GPPTPVSPES NPVEAKTEEL SDGESLPAPK PKGRQPKSVT SRRKHNKGDA IDYVDEEAFK
DFDYRIHDNE EYTQERCEEL ETAYWKSLMF NNPLYGADMP GSLFDENITT SWNVARLPNL
LDVLGQKVPG VNTAYLYLGM WKATFAWHLE DVDLYSINYI HFGAPKQWYS ISQEDAPKFE
QAMKSIWPSD AKNCDQFLRH KTYLVSPSLL KSQYGITVNR LVHYEGEFVI TYPYGYHSGY
NLGYNCAESV NFATEKWLDY GRVAKKCHCE SDSVWIDVDE IERKLRGEAT PEYYPEFESD
LDEFEGASDL LTPPRSVPEK SNRGRKRKHD GDTTKAKRMR VNVHVPRKIP CVLCPNDLDY
EDLLPTEDGK NHAHRRCALY TEETSILRDE TGKEVVCDID KIPKARMGLK CLFCREVRGA
CFQCNFGKCT RSYHATCALL AGVQVEQGEI AVIADDGIHY SIPSVDLKCK YHRQKKPSWM
TGGDSPDFDR KLIESAQRMV AGDLVQFQAD KEINGAVVLE NRPAERTLLV KVLPRGDVIE
LPYRWMLVVR RSNFSPLAPG TKPLPAHLAR KPEARKELES ALPVVGNPFG DGRSPYQWAE
FETVDTTNHR FAPPPVQVNL DKGDQIWYYL GQSSTECRAQ YTHNPSVPVH NPRSNFLDSV
KSLGAVMARI PSYPHRHLPQ YATAPPHHLS PAAAAAATAA AAASRPSLLQ RPTLAPPPRT
PSSAAPPAST AMPSAYRSLP TQSARHAPYP QIAKTHQSHH LSQQQHSPQQ SQQQQQQQHS
HHLPANTFAN VRELIARRRL AQITDHANVF AGYTIVSPEL VVETLLGPMG SVPPPTGLEK
LELAMAQQRV QPRAADGTLL PLQPLNMRSE EVTRLLQMLR FSLVSHRDRL DVLQKKETEN
NKQESAHKGS VAAVKLPRKF AYLEQQQEQS PTVYQSPYNM PSGFSEYAQK TFGLTPSEPE
LPKPSLANDY FASLSPEDQE KILKTCGSFV QRAIERSASH SRQSSASNLR LASALAQQTE
NPTIDITTVE DMPLSGLDFP LHADSPCSSF SRPHLRFQSP NDYNAHGPET HHDHHDLFGD
QQANTRFWQH GPWAAGDGNT PNEETRPFFG PHERLKHDYA SSDISLGRGP GSLHSVDMAG
FGMDATDDLC NVLSP
//
