UniProt: A0A851ZGQ6

Database: UniProt
Entry: A0A851ZGQ6_CALOR

LinkDB:  A0A851ZGQ6_CALOR 
Original site:  A0A851ZGQ6_CALOR

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Ontology (12)   
   GO (12)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (19)   
   InterPro (9)   
   Pfam (5)   
   PROSITE (2)   
   SMART (3)   
All databases (33)   

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ID   A0A851ZGQ6_CALOR        Unreviewed;       996 AA.
AC   A0A851ZGQ6;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   28-JAN-2026, entry version 20.
DE   RecName: Full=Exosome RNA helicase MTR4 {ECO:0000256|ARBA:ARBA00069430};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE   AltName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000256|ARBA:ARBA00082023};
DE   AltName: Full=TRAMP-like complex helicase {ECO:0000256|ARBA:ARBA00077324};
DE   Flags: Fragment;
GN   Name=Mtrex {ECO:0000313|EMBL:NXE59885.1};
GN   ORFNames=CALORN_R10538 {ECO:0000313|EMBL:NXE59885.1};
OS   Calcarius ornatus (Chestnut-collared longspur).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC   Passeriformes; Passeroidea; Fringillidae; Emberizinae; Emberizini;
OC   Calcarius.
OX   NCBI_TaxID=198940 {ECO:0000313|EMBL:NXE59885.1, ECO:0000313|Proteomes:UP000603627};
RN   [1] {ECO:0000313|EMBL:NXE59885.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B10K-DU-015-28 {ECO:0000313|EMBL:NXE59885.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:NXE59885.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00049390};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC         Evidence={ECO:0000256|ARBA:ARBA00049390};
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC       Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus,
CC       nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010140}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXE59885.1}.
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DR   EMBL; WBNL01000032; NXE59885.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A851ZGQ6; -.
DR   Proteomes; UP000603627; Unassembled WGS sequence.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd18024; DEXHc_Mtr4-like; 1.
DR   CDD; cd13154; KOW_Mtr4; 1.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   FunFam; 3.40.50.300:FF:000083; ATP-dependent RNA helicase DOB1; 1.
DR   FunFam; 3.40.50.300:FF:000141; ATP-dependent RNA helicase DOB1; 1.
DR   FunFam; 2.40.30.300:FF:000001; Mtr4 exosome RNA helicase; 1.
DR   FunFam; 1.10.3380.30:FF:000002; superkiller viralicidic activity 2-like 2; 1.
DR   FunFam; 1.10.3380.30:FF:000004; Superkiller viralicidic activity 2-like 2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 2.40.30.300; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR025696; Beta-barrel_MTR4.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C-like.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR050699; RNA-DNA_Helicase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:NXE59885.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000603627};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          102..258
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          359..531
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXE59885.1"
FT   NON_TER         996
FT                   /evidence="ECO:0000313|EMBL:NXE59885.1"
SQ   SEQUENCE   996 AA;  113091 MW;  C8385E1843EA0C7B CRC64;
     KRLEEKPSVP AAIVKPKREA EIDSTENVIL GKKPKLEDIL SDDVNLTDLM PQVKVQSVET
     VEGCTHEVAL PANEEFTGLK PRTGKAAKEY PFILDAFQRE AILCVDNNQS VLVSAHTSAG
     KTVCAEYAIA LALREKQRVI FTSPIKALSN QKYREMYEEF QDVGLMTGDV TINPTASCLV
     MTTEILRSML YRGSEVMREV AWVIFDEIHY MRDTERGVVW EETIILLPDN VHYVFLSATI
     PNARQFAEWI CHLHKQPCHV IYTDYRPTPL QHYIFPAGGD GLHLVVDENG DFREDNFNTA
     MQVLRDAGDL AKGDQKGRKG GTKGPSNVFK IVKMIMERNF QPVIIFSFSK KDCEAYALQM
     TKLDFNTDEE KKMVEEVFNN AIDCLSDEDK KLPQVEHVLP LLKRGIGIHH GGLLPILKET
     IEILFSEGLI KALFATETFA MGINMPARTV LFTSASKFDG KDFRWISSGE YIQMSGRAGR
     RGMDDRGIVI LMVDEKMSPT IGKQLLKGSA DPLNSAFHLT YNMVLNLLRV EEINPEYMLE
     KSFYQFQHYR TIPEIVERVN NLEAQYNKIV IPNEENVVIY YRIRQQLAKL GKDIEEYIHK
     PKYCLPFLQP GRLVKVKNEG DDYGWGVVVN FSKKSNVKPN SGELDPLYVV EVLLHCSKDS
     LKNSATESAK PARPDERGEM QVVPVLVHLV SAISSIRLYI PKDLRPVDNR QSVLKSVLEV
     QRRFPDGVPL LDPIDDMGIK DQGLKKVIQK IEAFEHRMYS HPLHNDPNLE TIYKLCEKKA
     QIAMDIKVAK RELKKARTVL QMDELKCRKR VLRRLGFATS SDVIEMKGRV ACEISSADEL
     LLTEMMFNGL FNDLSAEQAT ALLSCFVFQE NSSEMPKLTE QLAGPLRQMQ ECAKRIAKVS
     AEAKLETDEE NYLNSFRPNL MDVVYTWANG ANFAHICKMT DVFEGSIIRC MRRLEELLRQ
     MCQAAKAIGN TELENKFAEG ITKIKRDIVF AASLYL
//

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