ID A0A8B7FWV8_MICMU Unreviewed; 440 AA.
AC A0A8B7FWV8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSMICP00000045118.1, ECO:0000313|RefSeq:XP_012613479.1};
GN Name=SOCS4 {ECO:0000313|Ensembl:ENSMICP00000045118.1,
GN ECO:0000313|RefSeq:XP_012613479.1};
OS Microcebus murinus (Gray mouse lemur) (Lemur murinus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=30608 {ECO:0000313|RefSeq:XP_012613479.1};
RN [1] {ECO:0000313|Ensembl:ENSMICP00000045118.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Genome Sequencing Platform;
RG The Genome Assembly Team;
RA Lindblad-Toh K., DiPalma F., Gnerre S., Clamp M., Lander E.S.;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMICP00000045118.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Harris R., Larsen P., Liu Y., Hughes D.S., Murali S., Raveendran M.,
RA Korchina V., Wang M., Jhangiani S., Bandaranaike D., Bellair M.,
RA Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H., English A.,
RA Firestine M., Gnanaolivu R., Gross S., Hernandez B., Javaid M.,
RA Jayaseelan J., Jones J., Khan Z., Kovar C., Kurapati P., Le B., Lee S.,
RA Li M., Mathew T., Narasimhan A., Ngo D., Nguyen L., Okwuonu G., Ongeri F.,
RA Osuji N., Pu L.-L., Puazo M., Quiroz J., Raj R., Rajbhandari K., Reid J.G.,
RA Santibanez J., Sexton D., Skinner E., Vee V., Weissenberger G., Wu Y.,
RA Xin Y., Han Y., Campbell C., Brown A., Sullivan B., Shelton J., Brown S.,
RA Dudchenko O., Machol I., Durand N., Shamim M., Lieberman A., Muzny D.M.,
RA Richards S., Yoder A., Worley K.C., Rogers J., Gibbs R.A.;
RT "Mouse lemur reference genome and diversity panel.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_012613479.1}
RP IDENTIFICATION.
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_012613479.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSMICP00000045118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; ABDC03004273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012613479.1; XM_012758025.2.
DR RefSeq; XP_012613480.1; XM_012758026.1.
DR AlphaFoldDB; A0A8B7FWV8; -.
DR Ensembl; ENSMICT00000070760.1; ENSMICP00000045118.1; ENSMICG00000047239.1.
DR GeneID; 105867701; -.
DR KEGG; mmur:105867701; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000161456; -.
DR OMA; RINNNPC; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694394; Chromosome 3.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694394};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 286..381
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 376..425
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 50546 MW; 9E554F993C7C72E0 CRC64;
MAENNENNSK NVDVRPKTNR SRSADRRDGY VWSGKKLSWS KKSESCSDAE TVNTIEKTEG
SLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINPKSDE WVSTDLSQSE LRDGQLKQRR
NMEEDINCFS HTSVQPCVIT TNNASCRGPM PGSVMNLVSN NSIEDSDMDS DDEIITLCTS
SRKRNKPKWE LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL
LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK
EYHYKSKVRV LRIDAPEQQC
//
