ID A0A8H6QTX1_9EURO Unreviewed; 1421 AA.
AC A0A8H6QTX1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=CNMCM7691_007483 {ECO:0000313|EMBL:KAF7178669.1};
OS Aspergillus felis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=1287682 {ECO:0000313|EMBL:KAF7178669.1, ECO:0000313|Proteomes:UP000641853};
RN [1] {ECO:0000313|EMBL:KAF7178669.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNM-CM7691 {ECO:0000313|EMBL:KAF7178669.1};
RA Dos Santos R.A.C., Rivero-Menendez O., Steenwyk J.L., Mead M.E.,
RA Goldman G.H., Alastruey-Izquierdo A., Rokas A.;
RT "Draft genome sequences of strains closely related to Aspergillus parafelis
RT and Aspergillus hiratsukae.";
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-
CC oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2
CC formaldehyde + 2 succinate + 2 CO2; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00049349};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF7178669.1}.
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DR EMBL; JACBAG010001876; KAF7178669.1; -; Genomic_DNA.
DR Proteomes; UP000641853; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:TreeGrafter.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd15571; ePHD; 1.
DR FunFam; 2.60.120.650:FF:000024; Putative jumonji family transcription factor; 1.
DR FunFam; 2.60.120.650:FF:000047; Putative jumonji family transcription factor; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR055500; DUF7072.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF23258; DUF7072; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000641853};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 81..122
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 345..508
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 588..713
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1050
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1421 AA; 157870 MW; 1FC2000413E5D117 CRC64;
MMAAALDQPP FASLAGSRPN DAASITPPHS ANGKKEVPDG VPSELSDLEL DPSASTVKIE
DSVEGEEDVI EPDHYYGGGK IPVFKPTMEQ FRDFQSFISK VDHYGMRSGI VKVIPPKEWL
DAQPPLDEPI KKIRVKNPIM QEFHGSHGTY TQANIERQRT YNLPQWKALC EESSHQPPAR
RGERRRNQER ATRTPAAPKP QTTGSSSQKR GPGRPPKRAN QVKVKEEPPA DDALEKTKPE
GPPTPVSPES NPVETKSEDL SDGESLPEPK PKGRQPKSVT ARRKHNKGDN IDSVDEEAFK
NFDYRIHDQE EYTQERCEEL ETAYWKSLMF NNPLYGADMP GSLFDDSTTS WNVAKLPNLL
DVIGQKVPGV NTAYLYLGMW KATFAWHLED VDLYSINYIH FGAPKQWYSI SQEDAPRFEQ
VMKSIWPSDA KSCDQFLRHK TYLVSPSLLK SQYGITVNKL VHYEGEFVIT YPYGYHSGFN
LGYNCAESVN FATEKWLDYG RVAKKCNCEA DSVWIDVDEI ERKLRGEATP EYYDDFDSDM
DVMEGASDLL TPPRSVPEKT STRGRKRKHP GETTKAKRMR VNVEIPRKAP CMLCPNDLDY
EDLLPTEDGK SHAHRRCALY TEETSILRDE SGKEVVCDID YIPKARMGLK CLFCREVRGA
CFQCNFGKCT RSYHATCALL AGVQVEHGSI AVIADDGNQY SIPSVDLKCK YHRQKRPNWM
TNDAADYDRK VNATAQRLVA GDLVQFQADK EINGAVVLQN RPEERTLLVK ILPRGWLLIV
RKSNFAPLAP GTKPLPAHLA RKPDARKELE SAVPVAGNPF GDGRSPYQWA EFETVDVTKH
VSAPPPLHVD LNKGEQIWYY MGQSSTECRA QYTHNPSLSV HNPRSNFLDS VKSLGGVVTR
LPSYPHHFPQ YASASASAVV APPRQHHHLL SPAAAATAAA ASAAAAAAAN RPSLLQRPPL
APPPAAAPRS SSSTVASAAA ASAMPSAYRT LPTQSARHAP YPQVLKAHNL HQQQQQQQHP
FYHSPQPLQS QQQQQNNNNT NAATTTNGLP ANTFANVREL IARRRLAQIT DHANVFAGYT
IVSPELVVET LLGPMGSVPP PNGLEKLELA MAQQRVQPRA PDGTLLPLQP LNMRSEEVTR
LLQMLRFSLV SHRERLDVLQ KRESENIKQE ATAKGSAASA KLAGKYAYLD QQRAQAPTVY
QSPYDMPSGF TEYAKKTYEL IPCAPELPKH SLANDYFASL STEDQEKILK TCGSYVQRAI
ERSAPHSRQN SASNLRLTSA LAQQTENPTI DITTVEDLPL SGLDLPLHAD SPSSSFSRSH
LRFQSPNDFT SHGPEAHHDH HDLFGDQQAN TRFWQHGPWA AGDGNTPNEE NRPFFGPHER
LKHDYASSDI SLGRGPGSLH SVDMAGFGLD GTDDICAELS P
//
