ID A0A9N9Q141_9HELO Unreviewed; 1604 AA.
AC A0A9N9Q141;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=HYALB_00008790 {ECO:0000313|EMBL:CAG8982063.1};
OS Hymenoscyphus albidus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Hymenoscyphus.
OX NCBI_TaxID=595503 {ECO:0000313|EMBL:CAG8982063.1, ECO:0000313|Proteomes:UP000701801};
RN [1] {ECO:0000313|EMBL:CAG8982063.1}
RP NUCLEOTIDE SEQUENCE.
RA Durling M.;
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-
CC oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2
CC formaldehyde + 2 succinate + 2 CO2; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00049349};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG8982063.1}.
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DR EMBL; CAJVRM010000562; CAG8982063.1; -; Genomic_DNA.
DR OrthoDB; 9547406at2759; -.
DR Proteomes; UP000701801; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:TreeGrafter.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd15571; ePHD; 1.
DR FunFam; 2.60.120.650:FF:000024; Putative jumonji family transcription factor; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR055500; DUF7072.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF23258; DUF7072; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000701801};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 70..111
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 342..505
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 595..714
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..45
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1002
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1229
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1401..1414
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 178176 MW; ED444ABE893D241A CRC64;
MSAETMVAGP APGPAVEVNG LHSPPDSNTK DASDSELSDL EEEQPEQPAQ PTDEDDIGEI
VPAYYSNDGV PVFEPTMHQF KDFTIYMNKV NPYGMRSGIV KVIPPAEWKA AQPRLDEAVR
TIKVKEPIKQ DIMGTGGTYR QANMIHQRSY NLPQWRQLCE QSDHQPPAKR GERRANQDKP
VTRSTPRTKP SSNGNGSAPA GKRGRGRPSK SAAARAVTVE TDDAGQSTPD RLPTPVSPSA
KPDDNTEAVK LEPDDDIETP EKPRLGSRQA KPTTVSVSSR RKNNRREREG KIDEAAFKDF
KYELEGNEFT PERCEELERA YWKTLTYAPP LYGADMPGTL FDDKTTSWNL GKLDNILDVM
GSKIPGVNTA YLYLGMWKAT FAWHLEDVDL YSINYVHFGA PKQWYAIAQG DARRFEAAMK
TIWPTDAKAC DQFLRHKTFL ISPSALLQNY NIKVNKIVAY PGEFVITFPY GYHSGYNLGY
NCAEAVNFGL ESWLEYGRVA KKCDCDQAQD SVWINVHELE RKLRGEETEY EETDEEEEDE
EEENENDNST LATPPLSTGG LKTKSEKKKR KRATNEKGGD SNIKRVKIRI KATTHEPCVL
CPNDIPSEAL LPTEDGQHAH QICAQYIPET SIDEGKAMDI KYIAKGRLEL KCNYCRSKKG
ACFQCSRKKC TRAYHATCAA AAGVLVEQGE IPVFGEDGTE YKEWGIEFSC RFHRVKREKK
LDSDTLSDCE RLRKAGTEIK VGEVCQAQYL KGDIFAGVVV ENCKDEEVIL LDILPRGDRV
EVEYKWLLIP DPADYHLPKP SPNALPMPKS RKDKASLNTS KRQADDIPRA EDPFVEGHTW
AEFNHEKINL NPYQVKIDFT KETQIWFYLG KTSTEARAQY TEDPRIPRHN TKGNFLDTIP
KPVIAAPRQS YAASYPSNAK NSTPTPIRPP AKVLPAKTDR LEKPYVYKPR EQPRHETYGV
DAQAYRAQKD FLQRSVPQYS FGTDPRWASS TQPSKQSSSP TPFKANANST GHLPQISQVS
VAPPQYRNTQ SSMTPNLYSS TAQYATAASY NSAQATSAVQ HRPDSQHGAA VQYSPTPKQS
PVVQQQASKV HSTAPTQYRS TPPMATSKPN NPFGNRPQPQ RPSNVFQKYY YLQKEHNRSP
SDYKSPYRPG GGFMNGYQGD LMEYTKATLF TGNRPGVSTS QSNATPSYNM SSSYNGTSHK
PSPSLNSSQS PSLDSYGASP ATPYSASPSV KPPMDNSGAS VIPPKTWEKK KDSSQLHPAI
RREFLHTILN KQTNPLPQPS PTQSRSSVLQ PPPLYERPPY PSTSYASQTY TAPHNGYAAP
STPQNQVVPQ PTYNKPVSLS ASHPQQYSRP VAEASQNHQS PQVSYAPSFD YSGKAQGVTS
TAAVPVAEHP RQQSSAGYHN PSTSYQTSSQ PQASFSMHQS ATAKPQATQS PSAYTTAPAS
NPPYGHAQHT TGISTNHPQP SYSQANYAAT SSNYERNTTS QMQASPVIPP LLSNFRQSLP
NTNSSLFQPA MKNTQAGSFH PPAPSHTTPI LPPPRQYQIQ RQSEVQKSTY QHQQSFQRPD
TQMTSSEQHL NAQPACEPAD VPPDSCSIVE KMLRDLKKAR ADSS
//
