ID A0A9P4IEP9_9PEZI Unreviewed; 994 AA.
AC A0A9P4IEP9;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
DE Flags: Fragment;
GN ORFNames=NA57DRAFT_41407 {ECO:0000313|EMBL:KAF2097157.1};
OS Rhizodiscina lignyota.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Aulographales; Rhizodiscinaceae; Rhizodiscina.
OX NCBI_TaxID=1504668 {ECO:0000313|EMBL:KAF2097157.1, ECO:0000313|Proteomes:UP000799772};
RN [1] {ECO:0000313|EMBL:KAF2097157.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 133067 {ECO:0000313|EMBL:KAF2097157.1};
RA Haridas S., Albert R., Binder M., Bloem J., Labutti K., Salamov A.,
RA Andreopoulos B., Baker S., Barry K., Bills G., Bluhm B., Cannon C.,
RA Castanera R., Culley D., Daum C., Ezra D., Gonzalez J., Henrissat B.,
RA Kuo A., Liang C., Lipzen A., Lutzoni F., Magnuson J., Mondo S., Nolan M.,
RA Ohm R., Pangilinan J., Park H.-J., Ramirez L., Alfaro M., Sun H., Tritt A.,
RA Yoshinaga Y., Zwiers L.-H., Turgeon B., Goodwin S., Spatafora J., Crous P.,
RA Grigoriev I.;
RT "101 Dothideomycetes genomes: a test case for predicting lifestyles and
RT emergence of pathogens.";
RL Stud. Mycol. 0:0-0(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-
CC oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2
CC formaldehyde + 2 succinate + 2 CO2; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00049349};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF2097157.1}.
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DR EMBL; ML978128; KAF2097157.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A9P4IEP9; -.
DR OrthoDB; 9547406at2759; -.
DR Proteomes; UP000799772; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:TreeGrafter.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd15571; ePHD; 1.
DR FunFam; 2.60.120.650:FF:000024; Putative jumonji family transcription factor; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR055500; DUF7072.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF23258; DUF7072; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000799772};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 77..118
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 362..525
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 610..733
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..216
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..266
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..290
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..560
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..585
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 994
FT /evidence="ECO:0000313|EMBL:KAF2097157.1"
SQ SEQUENCE 994 AA; 113319 MW; A1B3D71D9641EFC6 CRC64;
MAAIPSVELE MHHDELPTEP AHKPSALTPP TSEDLDKRDD ASSELSELEL EEDRNLDEED
DDIGDIEPGY YYEDGKIPVF TPTMEQFKDF KKFVEKIDKY GMKSGIVKVI PPKEWRDSLP
TLEEAVKTIK VKNPIMQEFV GTHGTYTQQN IEKQRSYNLP QWRALTNESN HQPPAKRGER
RRNVDPPKPK APRSQNSTPI LDGEKRRPGR PRKHPLRKQD PTDHTAAESS KDPQVPPTPT
SPEEKNGDTD KEIKNEDADD AEEEKAEESP VKSRKPGRPR KSSPKPRGRQ PKATTVAERR
KYNQTVAADE IDEESFKDFD YRYPQASEFT QERCHQLEEV YWKTLNYGTP MYGADMPGSL
FGDSTNSWHV GRLENLLDVL GTKIPGVNTT YLYLGMWKAT FAWHLEDVDL YSINYIHFGA
PKQWYSISQE DARRFEAAMK SIWPTDAKHC DQFLRHKTYL ISPEKLKSQF NIKVNKLVHH
EGEFVITYPY GYHSGFNLGY NCAESVNFAT EAWLNYGRIA KKCNCEADSV WVDVAEIERK
LRGEPTPEYY EETDDEEDET SLLMDRLPSP PASVAGKKKA GRKRKRDVDA KEAGRKKTKR
IKILVKAPNK MPCVLCPNDV VFDKLLPTDT GAKAHRLCAL YTPETYVSEV NGQEIVRNVA
GIDKSRLDLK CIFCRSKRGA CFQCAERKCT RAFHATCATA AGVLVDTGPV PTWDEDGTEF
YCEGFDFRCR FHRPRRPKIA DGEYLEKLKL VKEFAKGLKK NDTIQAQYFG ADAFGGVVIE
NRPEEQTVLV EVLPDGDQVE VEWKYILVLD PAESKRPKPS PDAKPLPEVL HHNASVNVNN
RKDGVPDMGD IFHTNEAQKW AEWNALSNRE VRNTFQEKID ISKPERLWYY LGKASTEAKA
KYTHDPEKSF HNPNSVFLDT VKPPPKSTVI PDRRSFPASY PSGVNFHALN GAMVSQRQQI
HPQQIKMDRP YMYKPKSAIS SILNPQSPVS PQTP
//
