ID A0A9W9XJ66_9EURO Unreviewed; 1379 AA.
AC A0A9W9XJ66;
DT 08-NOV-2023, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 1.
DT 28-JAN-2026, entry version 11.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=N7463_009885 {ECO:0000313|EMBL:KAJ5493798.1};
OS Penicillium fimorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1882269 {ECO:0000313|EMBL:KAJ5493798.1, ECO:0000313|Proteomes:UP001149954};
RN [1] {ECO:0000313|EMBL:KAJ5493798.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 29495 {ECO:0000313|EMBL:KAJ5493798.1};
RA Petersen C.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAJ5493798.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBT 29495 {ECO:0000313|EMBL:KAJ5493798.1};
RX PubMed=36726175;
RA Petersen C., Sorensen T., Nielsen M.R., Sondergaard T.E., Sorensen J.L.,
RA Fitzpatrick D.A., Frisvad J.C., Nielsen K.L.;
RT "Comparative genomic study of the Penicillium genus elucidates a diverse
RT pangenome and 15 lateral gene transfer events.";
RL IMA Fungus 14:0-0(2023).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-
CC oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2
CC formaldehyde + 2 succinate + 2 CO2; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00049349};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ5493798.1}.
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DR EMBL; JAPWDS010000006; KAJ5493798.1; -; Genomic_DNA.
DR OrthoDB; 9547406at2759; -.
DR Proteomes; UP001149954; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:TreeGrafter.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd15571; ePHD; 1.
DR FunFam; 2.60.120.650:FF:000024; Putative jumonji family transcription factor; 1.
DR FunFam; 2.60.120.650:FF:000047; Putative jumonji family transcription factor; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR055500; DUF7072.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694:SF7; [HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE; 1.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF23258; DUF7072; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP001149954};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 88..129
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 349..512
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 592..717
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..227
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 154057 MW; 9524616817CAB805 CRC64;
MATVLDQSQC ESLGGNPVVQ SVSITPPQSA NGKKEAPEGV PSELSDLELD HQSAPAPDTT
KIKQEEMEEK VEEIEEIEPD HYYGGGKVPV FKPTMDQFRD FQSFINKINK YGMQAGIVKV
IPPKEWSESL PPLDEAVKKI RVKNPIMQEF HGSHGTYTQA NIERQRSYNL PQWKGLCEES
SHQPPARRGE RRRNQERVNR AAPTPRPPSA RPEGQKRRPG RPPKRTNKVK EEPPADDAEK
SRLEGPPTPV SPETNPVQPK TEDLSDGESL PTTKPKGRQP KSVTSRRKNN RGDAMDQFDE
EAYTGFDYRI HDHEEYTAER CEELETNYWK SLMYNNPMYG ADMPGSLFED STETWNVAKL
PNLLDVLGQK VPGVNTAYLY MGMWKATFAW HLEDVDLYSI NYIHFGAPKQ WYSISQEDAP
RFEQVMRSIW SSDAKNCDQF LRHKTYLVSP SLLKSQYGIT VNRLVHYEGE FVITFPYGYH
SGYNVGYNCA ESVNFATEQW LDYARIAKKC HCEADSVWID VDEIERKLRG ESTPEYYGEF
ESEFDGFEGA SDLLTPPRSV PGKTSTRGRK RKNPGDGPNS KRPKLHPEGP RKLPCLLCPN
NLDYEDLLPT EDGKGHAHRR CAAFIEETTI LRDASGTEVV CDIDKIPKAR LGLKCLFCRE
VRGACFQCNF GKCTRAYHAT CALLAGVQIE HGAIAVIADD GTQYSIPSVD LKCKFHRQKR
PNGVLGESSD VDRRVIESAR RLVQGNLIQF QADKEINGAI VLENRPSERS LLLKVLPRGD
VIEMPYRWML VVRKSNFTPL ALGIQPLPAH LARKPERKEL ESAVPAAGSA FGDSRSPYQW
AEFETVDGTR NQFAPLRTVN LEGEQIWYYL GMQSTESRAQ YTHNPSVSIH NPRANFLDSV
KSLGMDVSAR ASKISPHHFH YAATASAPPY RNLNQQNIYS NVNALQSRPP SSALQNAPPP
PFIPATGAAA GTAMPSAFRT LPQSARYAPY PSAKHAQQQH HLQSTNTFAN VRELIARRRL
AQITDHANVF AGYTIVSPEL VVETLLGPMG SIPPANGLEK LELAMAQQRV QPRAADGTLL
PPQTLNMRSE EVTRLLQMLR FSLVSHRERL DVIQKKESEG IKQETVDRGS VAAAKMPGKY
AYLDQQRSLA PNVYQSPYNM PSGLSEYAKT AYGLVPAADD PPKPSLSNDY FNNLPQEHQE
KILKACGSFV QRAIERSASH SRQSSSSNLR LSAALAQQTD NPTIDITPVE DPPLLSGLDM
PLHADSPCSS FGRSHLRYQS PNEFPIHGPD PHPDHHDLFG DQQANTRFWQ NGPWVGGDGN
TPNDETRPFF GPHIFGPHER LKHDYASSDI SLGKGPGSLH SVDMAGFGPD LNDDLGLSP
//
