ID A0AA97KLA1_EUBMA Unreviewed; 432 AA.
AC A0AA97KLA1;
DT 27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT 27-MAR-2024, sequence version 1.
DT 28-JAN-2026, entry version 10.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_054826130.1};
GN Name=SOCS4 {ECO:0000313|RefSeq:XP_054826130.1};
OS Eublepharis macularius (Leopard gecko) (Cyrtodactylus macularius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Eublepharidae; Eublepharinae;
OC Eublepharis.
OX NCBI_TaxID=481883 {ECO:0000313|Proteomes:UP001190640, ECO:0000313|RefSeq:XP_054826130.1};
RN [1] {ECO:0000313|RefSeq:XP_054826130.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_054826130.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_054826130.1; XM_054970155.1.
DR AlphaFoldDB; A0AA97KLA1; -.
DR GeneID; 129323632; -.
DR KEGG; emc:129323632; -.
DR CTD; 122809; -.
DR Proteomes; UP001190640; Chromosome 2.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001190640};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 278..373
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 368..417
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..55
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 49298 MW; 572E62C1E0FDCA9A CRC64;
MAENKERDNK NTDVRPKTSR SRSADRKDGY VWSRKKLSWS KRSDSSSDAE TASTSGKSTF
GLRNQERKHS CSSTELDLER SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSALPSKR
KIHISELMLD TCPFPPRSEL AFRWHLIKRH TAPIQQKSES WLSVESCHSE GKDGDVESAD
GGGPVVLQAC DFSSGASCRC SPRDESAASR PMKNREESDM DSDDEVVTLC TSSRKRNKPR
WDPDDELLQL ESPPKYHTQI DYVHCLVPDL LQINNNPCYW GVMDKYAAEA LLDGKPEGTF
LLRDSAQEDY LFSVSFRRYS RSLHARIEQW NHNFSFDAHD PCVFHSPDIT GLLEHYKDPS
SCMFFEPLLS TPLNRTFPFS LQHICRTVIC NYTTYDGIDA LPVPPSVKLY LKEYHYKSKV
RVLRIDAPEQ QT
//
