ID   A0AAZ3R420_ONCTS        Unreviewed;       564 AA.
AC   A0AAZ3R420;
DT   05-FEB-2025, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2025, sequence version 1.
DT   28-JAN-2026, entry version 5.
DE   RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN   Name=LOC112253130 {ECO:0000313|Ensembl:ENSOTSP00005135135.1};
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940 {ECO:0000313|Ensembl:ENSOTSP00005135135.1, ECO:0000313|Proteomes:UP000694402};
RN   [1] {ECO:0000313|Proteomes:UP000694402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=29621340;
RA   Christensen K.A., Leong J.S., Sakhrani D., Biagi C.A., Minkley D.R.,
RA   Withler R.E., Rondeau E.B., Koop B.F., Devlin R.H.;
RT   "Chinook salmon (Oncorhynchus tshawytscha) genome and transcriptome.";
RL   PLoS ONE 13:e0195461-e0195461(2018).
RN   [2] {ECO:0000313|Ensembl:ENSOTSP00005135135.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSOTSP00005135135.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_042179027.1; XM_042323093.1.
DR   AlphaFoldDB; A0AAZ3R420; -.
DR   Ensembl; ENSOTST00005158332.1; ENSOTSP00005135135.1; ENSOTSG00005073936.1.
DR   GeneID; 112253130; -.
DR   KEGG; otw:112253130; -.
DR   GeneTree; ENSGT00940000164285; -.
DR   Proteomes; UP000694402; Unassembled WGS sequence.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000694402};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          408..503
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          498..547
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          88..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  62554 MW;  6156743E1F548CAA CRC64;
     MEKVGKMWSN LRNRCQTLFH SDGAGPSTEN SVVEEDGMHC VADLGRGETS GEAQASLASS
     LSRSLLPLPG VTGGRRHNCV SDIPQMVERT TDRKDNEEAR VAPWGVPMGR RDSYSRHAPW
     GGKKKHSCST KTQSSMDTDR RSGRARGAAG RRERRYGVNS IQEMDDSGDG GRSLSTRSLR
     QRLSDTVGLC LPLPPRRRSL SSSPQTPTIS KRKIHLTELM LETCPFPQGS DLANKWHLIK
     QHTAPASPHS STALLDAFDP AHPSPEDEEE RLRERRRLSI EEGVDPPPNA QIHTLEALAQ
     CSSLYKLGPK MAPGIAEASG EGKMASCSGG AAGSSVQVLG GATAQLADCD SEEDSTTLCL
     QALRPKLRHT SGDGHLSRNQ SGPWKVHTQI DYIHCLVPDL LQITALPCYW GVMDRYEAEA
     LLDGRPEGTF LLRDSAQEDY LFSVSFRRYN RSLHARIEQW NHNFSFDAHD PCVFHSSTVT
     GLLEHYKDPS ACMFFEPLLT APLHRTFPSG LQHLARAAIC RRTTYDGIGT LPLPPALQDF
     LKEYHYKQKV RVRWLEREPP LKVK
//