ID B0EVN6_TAKRU Unreviewed; 537 AA.
AC B0EVN6;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 28-JAN-2026, entry version 95.
DE SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|EMBL:ABM68025.1, ECO:0000313|Ensembl:ENSTRUP00000049237.1};
GN Name=SOCS9 {ECO:0000313|EMBL:ABM68025.1};
GN Synonyms=socs9 {ECO:0000313|Ensembl:ENSTRUP00000049237.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:ABM68025.1};
RN [1] {ECO:0000313|EMBL:ABM68025.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J.;
RT "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000049237.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000049237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; EF195752; ABM68025.1; -; mRNA.
DR RefSeq; NP_001116336.1; NM_001122864.1.
DR AlphaFoldDB; B0EVN6; -.
DR STRING; 31033.ENSTRUP00000049237; -.
DR Ensembl; ENSTRUT00000055861.2; ENSTRUP00000049237.1; ENSTRUG00000019559.2.
DR GeneID; 100144312; -.
DR KEGG; tru:100144312; -.
DR CTD; 100003691; -.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; SYRIHTQ; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 388..483
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 478..527
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..46
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..56
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 59668 MW; B427B7D871105843 CRC64;
MSLPKETGNR DEVPDRGARP KVRQSRSEER RDAGRGRKSS RGKKKGSASN AAAAERPVSD
GFEYGELLGD LHTRDQSSSS PLKENWRGFD AATSLPGPEQ VTSRLGLGPF SSSMEPSAPS
ERESRGSNSN RTLRQKIQDA MGQCFPIKTH AAAAAATPQA LAPSAASASA SSRRKIHLSE
LMLDDCPFPA GSELAQKWYL IKQHTAPITQ PPVLDSPAGP STPVSSLPTA VDDVDDRLRE
RRRISIEQGV EPPPNAEIHT FEVTAQINPL YKHGPKLAHG MNELAGPDAA PLPQQQELLL
QRQQQHQLLL QRCLDTLDEV VASASFHACS ANSDAQPDAE LAASGTPPGV DPLQAEHLKP
QHGYRVHTQI DYIHCLVPDL LQISSLPYYW GVMDRYEAET LLEGKPEGTF LLRDSAQEDY
LFSVSFRRYG RSLHARIEQW NHNFSFDVHD PSVFHAPTVT GLLEHYKDPN SCMFFEPLLS
NPIHRKQPFQ LQHICRAVIS SRTTYDGINV LPIPNVLKKH LKEYHYKQRV RVRRMDA
//
