KEGG   Varanus komodoensis (Komodo dragon): 123025684
Entry
123025684         CDS       T07701                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
vko  Varanus komodoensis (Komodo dragon)
Pathway
vko00562  Inositol phosphate metabolism
vko01100  Metabolic pathways
vko04012  ErbB signaling pathway
vko04068  FoxO signaling pathway
vko04070  Phosphatidylinositol signaling system
vko04081  Hormone signaling
vko04140  Autophagy - animal
vko04145  Phagocytosis
vko04150  mTOR signaling pathway
vko04210  Apoptosis
vko04218  Cellular senescence
vko04370  VEGF signaling pathway
vko04510  Focal adhesion
vko04517  IgSF CAM signaling
vko04518  Integrin signaling
vko04620  Toll-like receptor signaling pathway
vko04625  C-type lectin receptor signaling pathway
vko04810  Regulation of actin cytoskeleton
vko04910  Insulin signaling pathway
vko04914  Progesterone-mediated oocyte maturation
vko05100  Bacterial invasion of epithelial cells
vko05132  Salmonella infection
vko05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:vko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123025684 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123025684 (PIK3CA)
   04370 VEGF signaling pathway
    123025684 (PIK3CA)
   04068 FoxO signaling pathway
    123025684 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    123025684 (PIK3CA)
   04150 mTOR signaling pathway
    123025684 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123025684 (PIK3CA)
   04517 IgSF CAM signaling
    123025684 (PIK3CA)
   04518 Integrin signaling
    123025684 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    123025684 (PIK3CA)
   04140 Autophagy - animal
    123025684 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    123025684 (PIK3CA)
   04218 Cellular senescence
    123025684 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123025684 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123025684 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    123025684 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    123025684 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123025684 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    123025684 (PIK3CA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    123025684 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123025684 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    123025684 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vko04131]
    123025684 (PIK3CA)
Enzymes [BR:vko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     123025684 (PIK3CA)
Membrane trafficking [BR:vko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123025684 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 ABC1 Retrotran_gag_4 Ribosomal_S15 Phage_tail_APC
Other DBs
NCBI-GeneID: 123025684
NCBI-ProteinID: XP_044290589
Ensembl: ENSVKKG00000012369
UniProt: A0A8D2L844
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLLNIKHELFKEARKYPLYQ
LLQDESSYIFVSVTQEAEKEEFFDETRRLCDLRLFQPFLKVIEPEGNRDEKILNREIGFA
IGMPVCEFDLVKDPEVQDFRRNILNVCKEAVELRDVNAPHSRALYVCPPNIESSSELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKHPLSQYKYIRSCIMLGRMPNLMLMAKESLYAQLPKD
TFAMPSYSRRISTATPYMNGEASAKSLWVINSHLRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEQLCDNVNTQRVPCSNPRWNEWLQYEMHVLDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINMFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDCF
SSPVKFPDMSVIEEYANRTTPRDQGFNYSHAGLSNRLTRDNELRESDREQLRAICTRDPL
SEITEQEKDFLWSHRQRCRNIPEILPKLLLAVKWNSRDEVAQMYCLIKEWPYIKHEQAME
LLDCNYPDPMVRAFAIRCLEEDLTDDQLSQYLIQLVQVLKYEQYLDNQLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKNVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFISPLNPAHQLGTLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQIQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEMYDPAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccttcgtccggtgaattgtggggcatccacttgatgccaccaagaatc
ctagtagagtgtcttctacctaatggtatgatagtgactttagaatgcctccgtgaggcc
accctgttaaatatcaaacatgaactctttaaagaagctagaaaataccctctctatcag
ctccttcaagatgagtcatcttacattttcgtaagtgttacacaagaagcagaaaaagaa
gaattttttgatgaaacacggcgactatgtgacttgcgactcttccagccttttttaaaa
gtgattgaaccagaaggaaacagagatgagaaaatcctgaatcgagaaattggttttgct
attggcatgcctgtctgcgaatttgacttggttaaagatccagaagttcaggacttcaga
agaaatatccttaatgtttgtaaagaagcagtagaactgcgagatgttaatgcaccccat
agtagagcattgtatgtgtgtcccccaaacatagaatcttcatctgagttgcccaagcat
atatacaataaacttgacaaaggacaaataatagtggtgatatgggttatagtttcccct
aataatgacaagcagaagtacaccttaaaaatcaatcatgattatgtgccagagcaagta
attgctgaagcaatcaggaaaaaaacacgaagtatgttgctgtcatcagaacaactaaaa
ctctgtgtgttagagtaccaggggaagtatatattaaaagtatgtggttgtgatgaatac
ttgctagaaaaacatcccctgagtcagtataagtacatccggagctgtatcatgcttggt
cgaatgcccaatttgatgctgatggctaaggaaagtctttacgcgcagctgccaaaggat
acctttgcaatgccatcttattctaggcgtatctccacagcaacaccatatatgaatgga
gaggcttctgccaaatccctctgggttattaacagccatctcagaataaagattctctgt
gctacctatgtaaatgtaaatattcgagacattgacaagatctatgtccgaactggtatc
taccatggtggagagcaattgtgtgataatgtgaatactcagagggtgccttgctccaat
ccgagatggaatgaatggctgcagtatgagatgcacgttcttgatcttccacgtgctgct
cgactttgcctctctatttgctccgttaaaggccggaaaggtgcaaaggaggagcactgt
ccattggcgtgggggaatattaatatgtttgattatacagacactcttgtttctggcaaa
atggctctgaatctgtggcctgtacctcatgggttggaagacctcttaaatcccattgga
gtcactggatcaaatccaaataaggaaactccatgtttggagctggaatttgattgcttt
agcagtcctgtgaaatttcctgacatgtcagtaattgaagagtatgccaaccggactacg
cctagagatcagggatttaactacagtcacgcagggctgagtaatagactaactagagat
aatgaattaagagagagtgacagagagcagctccgtgcaatctgcactcgtgatcccctg
tctgaaataactgagcaagaaaaggacttcctttggagccacaggcagcgctgtcgaaat
ataccagaaatcctacctaagctgctattagctgtgaaatggaactctagagatgaagtt
gcccagatgtactgtttgataaaagaatggccttacatcaagcacgaacaggcaatggag
cttttagactgcaactatccagatccaatggtgcgagcatttgcaattaggtgtttggaa
gaagacttgacagatgaccaactgtcccagtatttgattcagctggtacaggttctgaaa
tatgagcagtacttggataatcagttggtgagatttttactcaagaaggcactgaccaat
cagaggataggacacttcttcttttggcatctgaaatctgaaatgcacaataaaaatgtt
agccagagatttggtctgcttttggagtcctattgtcgagcatgtgggatgtacctaaaa
catctgagcaggcaagtggaagctatggaaaaactgattaacctcacagacatccttaag
caggagaaaaaagatgaaacacaaaaggtacagatgaagttcctcgtggagcagatgagg
aggccagacttcatggatgcattgcagggcttcatatctcctctcaatcctgctcatcag
cttggaacccttaggcttgaggagtgcaggattatgtcatcagctaaaaggccattatgg
cttaattgggaaaaccctgatattatgtctgagctgctgttccagaacaatgagatcatc
tttaaaaatggggatgatttgcgccaggatatgctcacacttcaaataattcgaattatg
gagaacatctggcaaattcaaggccttgatcttaggatgttgccttatggctgtttatct
atcggtgactgtgtggggctcattgaggtggtgagaaattcacacacaatcatgcagatc
cagtgcaaaggtggccttaaaggtgcgctgcagttcaacagccatacattacatcagtgg
ctcaaagacaagaacaagggggaaatgtatgatccagctattgatttgtttacacgctct
tgtgctggctattgcgtagcaactttcatattgggaattggagatcgtcataatagcaat
atcatggtgaaagatgatgggcagctgtttcacattgattttgggcacttcttggatcac
aaaaagaagaaatttggctacaaacgagagcgagtgccatttgtcttgacacaagatttc
ttgatagtaattagtaaaggagctcaagaatgtactaaaacgagggaatttgaaaggttc
caagaaatgtgttacaaggcttacctagcaattcgacagcatgccaatcttttcataaac
ctcttctccatgatgcttggttctgggatgccagagctacagtcctttgatgacattgca
tatatccgcaagactcttgcactggacaaaactgagcaggaagcacttgagtatttcatg
aaacagatgaatgatgcgcatcatgggggatggacaacaaaaatggactggatcttccac
acaatcaagcagcatgccttgaactga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (16)   

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