KEGG   Xenopus laevis (African clawed frog): 108718090
Entry
108718090         CDS       T01010                                 
Symbol
pik3ca.S
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
xla  Xenopus laevis (African clawed frog)
Pathway
xla00562  Inositol phosphate metabolism
xla01100  Metabolic pathways
xla04012  ErbB signaling pathway
xla04068  FoxO signaling pathway
xla04070  Phosphatidylinositol signaling system
xla04081  Hormone signaling
xla04140  Autophagy - animal
xla04145  Phagocytosis
xla04150  mTOR signaling pathway
xla04210  Apoptosis
xla04218  Cellular senescence
xla04370  VEGF signaling pathway
xla04510  Focal adhesion
xla04517  IgSF CAM signaling
xla04518  Integrin signaling
xla04620  Toll-like receptor signaling pathway
xla04625  C-type lectin receptor signaling pathway
xla04810  Regulation of actin cytoskeleton
xla04910  Insulin signaling pathway
xla04914  Progesterone-mediated oocyte maturation
xla05100  Bacterial invasion of epithelial cells
xla05132  Salmonella infection
xla05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:xla00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    108718090 (pik3ca.S)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    108718090 (pik3ca.S)
   04370 VEGF signaling pathway
    108718090 (pik3ca.S)
   04068 FoxO signaling pathway
    108718090 (pik3ca.S)
   04070 Phosphatidylinositol signaling system
    108718090 (pik3ca.S)
   04150 mTOR signaling pathway
    108718090 (pik3ca.S)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    108718090 (pik3ca.S)
   04517 IgSF CAM signaling
    108718090 (pik3ca.S)
   04518 Integrin signaling
    108718090 (pik3ca.S)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    108718090 (pik3ca.S)
   04140 Autophagy - animal
    108718090 (pik3ca.S)
  09143 Cell growth and death
   04210 Apoptosis
    108718090 (pik3ca.S)
   04218 Cellular senescence
    108718090 (pik3ca.S)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108718090 (pik3ca.S)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108718090 (pik3ca.S)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    108718090 (pik3ca.S)
   04625 C-type lectin receptor signaling pathway
    108718090 (pik3ca.S)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108718090 (pik3ca.S)
   04914 Progesterone-mediated oocyte maturation
    108718090 (pik3ca.S)
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    108718090 (pik3ca.S)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108718090 (pik3ca.S)
   05100 Bacterial invasion of epithelial cells
    108718090 (pik3ca.S)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:xla04131]
    108718090 (pik3ca.S)
Enzymes [BR:xla01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     108718090 (pik3ca.S)
Membrane trafficking [BR:xla04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    108718090 (pik3ca.S)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 ABC1 Ribosomal_S15 Retrotran_gag_4
Other DBs
NCBI-GeneID: 108718090
NCBI-ProteinID: XP_018121180
Xenbase: XB-GENE-17344667
UniProt: A0A1L8G3Z7
Position
5S:complement(95655069..95685148)
AA seq 1065 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMVVVLECLREATLVNIKHELFKEARKYPLYH
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVVEPVGNREEKILNREIGFA
IGMPVCEFDMVKDSEVQDFRKNILNVCKDSVELRDANGPISRALYVYPPNVESSSELPKH
IESKLDKGQIIVVIWVIVSPNNEKQKYSLKINHDCVPEHVIAEAIRKKTRSMLLSTEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQLPMD
SFTMPSYSRRISMAAPYMNGEASAKSLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGI
YHGVEPLCDNVNTQRVPCSNPRWNEWLLYDMFIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVSGSNPNKETPCLELEFDCF
SSPVKFPDMTAIEDHANKVLEREMGYNYSHSGLSNRIVRENEVRESDKEQLKAISNRDPL
SEITEQEKEFLWSHRLYCRNVPEILPKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAME
LLDFNYPDRIVRSFAVSCNEKYLTDDKLSQYLIQLVQVMKYEQYLDNHLVRFLLKKALVN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSKQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMKRPDFMDALQGFTSPLNPAHQLGNLRLEECRLMSSAKRPLW
LNWENPDIMSEMLFLNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRCSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEMYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDNGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGMQECTKTRDFERFQEMCYKAYLAIRQHANLFINLFSMMLGCGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKHL
NT seq 3198 nt   +upstreamnt  +downstreamnt
atgccgccaagaccttcctccggggagctatggggcattcatttgatgcccccaagaatt
ctagtggaatgcttattaccaaatggaatggtggtggtgttagaatgtcttcgtgaagcg
acccttgtaaatatcaaacatgagctctttaaagaggcccgaaagtaccctctttaccat
ctactccaggatgagtcctcttatatttttgtgagtgttacacaggaggcggaaagagaa
gaattttttgacgaaactcgccgtctttgtgatcttcgactgttccaacctttcttgaaa
gtagttgagcctgtaggaaacagagaagagaaaattcttaatcgagaaattggcttcgcc
attggaatgccagtgtgtgaatttgatatggttaaggactccgaggttcaggactttaga
aaaaacatccttaatgtttgtaaagattcagttgaacttcgtgatgcgaatgggccgatc
agcagagcattatatgtttacccacccaatgtagaatcctcttcagagcttcccaaacac
atagaaagcaaactagataaagggcaaataattgtggtcatatgggtcattgtatccccc
aacaacgaaaagcagaagtattctttgaagattaaccatgattgtgtgccagaacatgtc
atcgctgaagcaatccggaagaaaacaagaagcatgctgctgtccaccgaacaactaaag
ctttgtgttctagagtaccaaggaaaatacattttgaaagtctgtggatgtgatgagtat
ttgcttgaaaagtatccactgagtcaatataagtatattagaagttgtataatgcttggt
cggatgcctaatttaatgttaatggccaaagacagcctgtacagccaacttcctatggat
agctttacaatgccatcttattcaaggaggatttccatggcagcaccatacatgaatgga
gaagcttcagcaaaatcattgtgggcaatcaacagtactcttagaataaaaatcctttgt
gccacatatgtcaatgtaaacattcgagacattgataagatctatgttcgaactggtatc
tatcatggggttgagccgttgtgtgacaatgttaacactcagagggtgccttgctcaaat
ccaagatggaatgaatggcttttatatgatatgttcattcctgatttaccacgagctgca
cgactttgcctctctatttgctccgtaaagggacggaagggcgccaaagaagaacactgc
cctttagcatggggaaatattaacctgtttgactacacagatacactggtgtctggaaaa
atggctctaaatttgtggcctgtgcctcatgggttagaagacttgctaaatcctattgga
gtcagtggctccaatcctaacaaggaaacaccctgtttggaactagaatttgactgtttc
agtagcccagtcaaatttcctgatatgaccgcaatagaagatcatgcaaataaagttctg
gagcgggaaatgggctataattacagccattctggactaagtaacagaattgttagagaa
aatgaagtaagagaaagtgacaaggagcagctcaaagccatttctaaccgtgaccctctc
tctgaaattactgaacaagaaaaagaattcctttggagccacagactgtattgtcgaaat
gtacctgaaattcttcctaagctgcttctgtctgtgaaatggaattgcagagatgatgtt
tcacagatgtattgtcttctaaaagagtggcctgctatccggcctgaacaagcaatggaa
ctgctggattttaattacccagatcggattgtacgatcatttgcagtttcttgcaatgag
aagtatctgacagatgataagctatctcagtatttgatccaacttgtgcaggttatgaaa
tatgagcagtacttggacaaccatctagtgagatttctgctgaaaaaggccctggtcaat
caaagaataggacatttctttttctggcatttaaagtcagaaatgcacaacaaaactgtc
agccagcggtttggtcttttgctggagtcctattgccgtgcatgtggaatgtatttaaaa
catttaagcaagcaagtggaggctatggaaaaactgatcaacctcacagatattctaaag
caggagaagaaggatgagacacaaaaggtgcaaatgaagttcctggttgaacaaatgaag
cggccagactttatggatgccttacagggatttacatctcctctaaatcctgctcaccaa
ttaggaaacctaaggcttgaagagtgcagactaatgtcatctgcaaaaaggccactctgg
ttaaactgggaaaatccagatataatgtcagagatgctgtttttgaataatgagatcatc
tttaaaaacggagatgatttacggcaagatatgctcacgctccagatcataaggatcatg
gaaaacatttggcaaaatcaaggccttgatttacggatgttgccatatggttgcctgtca
attggagactgtgtcggacttattgaagtagtgagatgttcacataccattatgcagatt
cagtgcaaaggaggtctgaaaggagcattgcaattcaacagtcatacattgcatcaatgg
ctcaaggataaaaacaagggggaaatgtatgatgccgccattgatctgttcactcgatcg
tgtgctggttactgtgttgcaactttcattcttggaataggtgatcggcataacagtaac
attatggttaaagacaatgggcaactgtttcacatagattttggccactttttggatcac
aaaaagaaaaaatttggctataaacgtgaaagggtaccgtttgtcttaactcaagatttt
ctgattgtgatcagcaaggggatgcaagaatgcacaaaaaccagggattttgaaagattt
caagagatgtgttacaaagcgtatttagcaatccgccagcatgccaaccttttcatcaac
ttgttctctatgatgcttggctgtggaatgcctgaactacaatcttttgatgacattgcc
tatattcgaaagacattagctttggataaaactgagcaagaggctttggaatacttcatg
aagcagatgaatgacgcacatcacggtggctggacaacaaaaatggactggatcttccat
acaataaagcatctttaa

  All links  
Gene (44)   
   RefGene (40)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
   XENBASE (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (9)   
   Pfam (9)   
All databases (58)   

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