+F Repair protein KO
#
DNA Repair and Recombination Proteins - Beta vulgaris (sugar beet)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104900793 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 104907877 DExH-box ATP-dependent RNA helicase DExH14 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 104892426 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104902628 uracil-DNA glycosylase, mitochondrial K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104889174 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 104894489 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104884768 hypothetical protein K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 104906652 N-glycosylase/DNA lyase OGG1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 104888774 endonuclease III homolog 1, chloroplastic K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 104894208 putative DNA glycosylase At3g47830 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 104895192 DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 104890594 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 104889194 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 104891331 hypothetical protein K03504 POLD3; DNA polymerase delta subunit 3
F 104890137 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 104900347 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 104888021 DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 104900308 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 104894393 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 104903846 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104900019 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104895393 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 104902910 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 104904648 DNA-repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E 104882954 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 104892527 transcription factor bHLH140 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 104891387 polynucleotide 3'-phosphatase ZDP K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 104900512 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 104894635 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 104898929 poly [ADP-ribose] polymerase 2-A K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 104900329 poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 104895439 DNA repair protein RAD4 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 104907981 probable ubiquitin receptor RAD23a K10839 RAD23; UV excision repair protein RAD23
F 104905940 ubiquitin receptor RAD23d K10839 RAD23; UV excision repair protein RAD23
F 104896513 ubiquitin receptor RAD23c K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 104883468 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 104899743 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 104883798 cullin-4 K10609 CUL4; cullin 4
F 104901181 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 104902748 protein DAMAGED DNA-BINDING 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
F 104883458 hypothetical protein K15082 RAD7; DNA repair protein RAD7
F 104903338 DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 104897786 DNA-directed RNA polymerase II subunit 1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 104900705 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 104904974 DNA-directed RNA polymerases II, IV and V subunit 3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 104902640 DNA-directed RNA polymerases IV and V subunit 4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 104899323 DNA-directed RNA polymerase II subunit 4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 104904036 DNA-directed RNA polymerases II and IV subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 104889472 DNA-directed RNA polymerase V subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 104899275 DNA-directed RNA polymerases II and IV subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 104887552 DNA-directed RNA polymerase V subunit 5C K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 104905507 DNA-directed RNA polymerases II, IV and V subunit 6A K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 104900045 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 104889864 DNA-directed RNA polymerases II, IV and V subunit 8B K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 104888412 DNA-directed RNA polymerases II, IV and V subunit 9A K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 104908813 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 104889793 DNA-directed RNA polymerases II, IV and V subunit 11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 104893387 DNA-directed RNA polymerases II, IV and V subunit 12 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 104883468 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 104899743 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 104883798 cullin-4 K10609 CUL4; cullin 4
F 104901181 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 104902089 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 104894721 protein CHROMATIN REMODELING 8 K10841 ERCC6; DNA excision repair protein ERCC-6
F 104883064 UV-stimulated scaffold protein A homolog K23720 UVSSA; UV-stimulated scaffold protein A
F 104900611 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 104892522 DNA repair helicase XPB1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 104897080 DNA repair helicase XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 104902675 probable RNA polymerase II transcription factor B subunit 1-1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 104884127 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 104891113 RNA polymerase II transcription factor B subunit 4 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 104900717 RNA polymerase II transcription factor B subunit 2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 104886689 RNA polymerase II transcription factor B subunit 5-like K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 104891402 RNA polymerase II transcription factor B subunit 5-like K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 104898151 hypothetical protein K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 104893694 cyclin-dependent kinase D-1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 104890810 cyclin-H1-1 K06634 CCNH; cyclin H
E 104901737 hypothetical protein K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 104884669 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104893066 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104907896 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 104902405 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 104886674 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 104887682 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
D Other NER factors
E 104907763 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 104892834 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 104889188 DNA repair protein UVH3 K10846 ERCC5; DNA excision repair protein ERCC-5
E 104902910 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 104883138 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 104897936 cullin-3A K03869 CUL3; cullin 3
E 104900041 transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 104906637 hypothetical protein K03873 ELOB; elongin-B
E 104903581 hypothetical protein K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 104908225 DNA mismatch repair protein MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E 104906479 DNA mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E 104902177 DNA mismatch repair protein MSH7 K08737 MSH6; DNA mismatch repair protein MSH6
E 104894756 DNA mismatch repair protein MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 104899413 DNA mismatch repair protein MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E 104899154 DNA mismatch repair protein PMS1 K10858 PMS2; DNA mismatch repair protein PMS2
E 104895732 DNA mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 104890594 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 104889194 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 104891331 hypothetical protein K03504 POLD3; DNA polymerase delta subunit 3
E 104890137 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 104884669 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104893066 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104907896 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 104902405 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 104886674 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 104887682 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 104896137 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 104887304 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 104892328 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 104908347 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 104891078 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 104894393 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 104903846 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104900019 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104882922 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 104893686 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 104902910 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 104889014 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 104907235 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 104889779 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104896702 nijmegen breakage syndrome 1 protein K10867 NBN; nibrin
D BRCA1-core complex
E 104899222 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
E 104901168 protein BREAST CANCER SUSCEPTIBILITY 1 homolog K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 104886487 hypothetical protein K20776 BABAM; BRISC and BRCA1-A complex member 1
E 104905121 BRCA1-A complex subunit BRE K12173 BRE; BRCA1-A complex subunit BRE
E 104904591 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 104901128 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 104893213 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 104894746 BRCT domain-containing protein At4g02110 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 104907235 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 104889779 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104896702 nijmegen breakage syndrome 1 protein K10867 NBN; nibrin
D BRCA complex
E 104892556 protein BREAST CANCER SUSCEPTIBILITY 2 homolog B K08775 BRCA2; breast cancer 2 susceptibility protein
E 104901695 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 104901695 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
E 104905386 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104900458 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 104884415 DNA repair protein XRCC2 homolog K10879 XRCC2; DNA-repair protein XRCC2
E 104907735 DNA repair protein XRCC3 homolog K10880 XRCC3; DNA-repair protein XRCC3
E 104883150 DNA repair protein XRCC3 homolog K10880 XRCC3; DNA-repair protein XRCC3
E 104885524 DNA repair protein XRCC3 homolog K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 104892891 hypothetical protein K26556 RAD52-1; DNA repair RAD52-like protein 1, mitochondrial
E 104897449 hypothetical protein K26558 RAD52-2; DNA repair RAD52-like protein 2, chloroplastic
D Rad54 family proteins
E 104905956 SNF2 domain-containing protein CLASSY 1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104904306 protein CHROMATIN REMODELING 35 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104904480 protein CHROMATIN REMODELING 25 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104903989 protein CHROMATIN REMODELING 35 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104908084 SNF2 domain-containing protein CLASSY 4-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104908089 SNF2 domain-containing protein CLASSY 4-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E 104893131 mediator of RNA polymerase II transcription subunit 34 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 104890390 ATP-dependent DNA helicase Q-like 1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 104890300 ATP-dependent DNA helicase Q-like SIM K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 104904548 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104883967 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104897626 ATP-dependent DNA helicase Q-like 5 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 104904548 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104883967 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104889718 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104890580 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104908057 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 104903603 hypothetical protein K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 104884669 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104893066 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 104907896 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 104902405 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 104886674 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 104887682 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 104891764 serine/threonine-protein phosphatase PP-X isozyme 2 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 104908946 serine/threonine-protein phosphatase 4 regulatory subunit 2-A K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 104888409 serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E 104902615 hypothetical protein K19022 AP5B1; AP-5 complex subunit beta-1
E 104902394 AP-5 complex subunit mu K19023 AP5M1; AP-5 complex subunit mu-1
E 104907057 hypothetical protein K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 104907608 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 104906625 structural maintenance of chromosomes protein 6B K22804 SMC6; structural maintenance of chromosomes protein 6
E 104898510 uncharacterized LOC104898510 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 104899928 hypothetical protein K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 104901801 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 104891470 E3 SUMO-protein ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 104889203 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 104889902 non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 104895492 crossover junction endonuclease EME1B-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 104906325 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 104894253 protein DSS1 HOMOLOG ON CHROMOSOME V K10881 SHFM1; 26 proteasome complex subunit DSS1
E 104907463 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 104900278 hypothetical protein K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 104906477 flap endonuclease GEN-like 2 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 104905482 flap endonuclease GEN-like 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 104895461 hypothetical protein K19026 SPG11; spatacsin
E 104887752 hypothetical protein K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 104894890 protein MRG1 K11339 MORF4L1; mortality factor 4-like protein 1
E 104907653 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 104897395 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 104895347 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 104897797 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 104889780 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
E 104891835 DNA-dependent metalloprotease WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E 104907275 DNA-dependent metalloprotease WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E 104897966 single-stranded DNA-binding protein WHY1, chloroplastic K26559 WHY1; single-stranded DNA-binding protein WHY1
E 104892868 single-stranded DNA-bindig protein WHY2, mitochondrial K26561 WHY2; single-stranded DNA-binding protein WHY2
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 104895758 ATP-dependent DNA helicase 2 subunit KU70 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 104905416 ATP-dependent DNA helicase 2 subunit KU80 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 104907235 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 104889779 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 104890064 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 104888754 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 104900512 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 104892527 transcription factor bHLH140 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 104900976 uncharacterized LOC104900976 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 104888577 uncharacterized LOC104888577 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 109134607 uncharacterized LOC109134607 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 104888575 uncharacterized LOC104888575 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
C FA (Fanconi anemia) pathway
D FA core complex
E 104895878 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 104885108 centromere protein S K11511 APITD1; centromere protein S
E 104908568 centromere protein X K15360 STRA13; centromere protein X
D Bloom's syndrome complex (BTR)
E 104904548 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104883967 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104889718 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104890580 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104908057 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 104903603 hypothetical protein K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
D Downstream FA components
E 104892556 protein BREAST CANCER SUSCEPTIBILITY 2 homolog B K08775 BRCA2; breast cancer 2 susceptibility protein
E 104901128 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 104888519 fanconi-associated nuclease 1 homolog K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 104901695 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
E 104905386 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104908733 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 104890989 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 104902517 phytochrome-associated serine/threonine-protein phosphatase K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 104901230 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 104891722 uncharacterized LOC104891722 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
D Others
E 104900548 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 104899313 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 104889014 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 104898859 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 104904866 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 104904934 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 104890826 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 104897962 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 104895852 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 104903614 putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 2 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D 104889518 putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 104885002 ubiquitin-conjugating enzyme E2 variant 1D K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104899836 ubiquitin-conjugating enzyme E2 variant 1D K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104903539 ubiquitin-conjugating enzyme E2 36 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 104891426 ubiquitin-conjugating enzyme E2 35 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 104894393 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 104903846 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 104900019 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
D 104890310 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 104899203 hypothetical protein K10903 HUS1; HUS1 checkpoint protein
D 104893006 hypothetical protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 104895311 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 104887304 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104892328 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104908347 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 104891078 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 104893006 hypothetical protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 104888327 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 104902688 hypothetical protein isoform B K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 104908733 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 104887100 uncharacterized LOC104887100 K20403 TTI1; TELO2-interacting protein 1
D 104883411 hypothetical protein K23115 TTI2; TELO2-interacting protein 2
D 104903721 hypothetical protein isoform A K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 104901844 hypothetical protein K23390 BAG6; large proline-rich protein BAG6
D 104886850 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 104903878 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 104894278 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 104903545 14-3-3-like protein D K06630 YWHAE; 14-3-3 protein epsilon
D 104891933 14-3-3-like protein K06630 YWHAE; 14-3-3 protein epsilon
D 104905814 14-3-3-like protein K06630 YWHAE; 14-3-3 protein epsilon
D 104908435 14-3-3-like protein K06630 YWHAE; 14-3-3 protein epsilon
D 104891554 14-3-3 protein 1 K06630 YWHAE; 14-3-3 protein epsilon
D 104896024 14-3-3 protein 2 K06630 YWHAE; 14-3-3 protein epsilon
D 104896060 14-3-3-like protein GF14 kappa K06630 YWHAE; 14-3-3 protein epsilon
D 104900484 14-3-3-like protein D K06630 YWHAE; 14-3-3 protein epsilon
D 104895805 14-3-3-like protein GF14 iota K06630 YWHAE; 14-3-3 protein epsilon
D 104898957 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 104899077 hypothetical protein isoform A K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 104884769 hypothetical protein K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 104889959 serine/threonine-protein kinase Nek6 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104889260 serine/threonine-protein kinase Nek6 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104899845 serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104894549 serine/threonine-protein kinase Nek2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104891123 serine/threonine-protein kinase Nek3 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104893205 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 104900334 protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 104884550 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 104887767 protein DECREASED SIZE EXCLUSION LIMIT 1 K24770 DSE1; protein decreased size exclusion limit 1
B Other factors with a suspected DNA repair function
C DNA polymerases
D 104884718 helicase and polymerase-containing protein TEBICHI K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 104904785 DNA polymerase V K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 104888354 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 104888897 DNA cross-link repair protein SNM1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 104897095 DNA cross-link repair protein SNM1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 104895399 5' exonuclease Apollo K15340 DCLRE1A; DNA cross-link repair 1A protein
D 104903041 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 104886733 endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 104893980 DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 104909099 endonuclease 1 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
D 104909100 endonuclease 4 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
D 104902824 switch 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 104887874 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 104890617 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 104893690 pre-mRNA-splicing factor SPF27 homolog K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 104899050 protein pleiotropic regulatory locus 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 104896345 nudix hydrolase 1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 104893124 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 104895476 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 104907976 ribonucleoside-diphosphate reductase small chain A K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 104895358 ribonucleoside-diphosphate reductase small chain K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104892426 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104902628 uracil-DNA glycosylase, mitochondrial K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104882981 DNA-3-methyladenine glycosylase 1-like K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E 104889174 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 104894489 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104904875 hypothetical protein isoform A K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 104887122 hypothetical protein K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 104896146 hypothetical protein K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 104904537 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E 104888774 endonuclease III homolog 1, chloroplastic K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 104894208 putative DNA glycosylase At3g47830 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 104889420 DNA-(apurinic or apyrimidinic site) lyase, chloroplastic K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
D DNA ligase
D DNA polymerase I
E 104889482 DNA polymerase I A, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E 104889482 DNA polymerase I A, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 104900714 endonuclease MutS2 K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 104908216 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E 104907597 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
E 104909036 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
D RecFOR pathway proteins
E 104907597 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
E 104909036 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
E 104903728 hypothetical protein isoform B K04485 radA; DNA repair protein RadA/Sms
E 104896864 ATP-dependent DNA helicase homolog RECG, chloroplastic K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F 104883791 DNA gyrase subunit A, chloroplastic/mitochondrial K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F 104889495 DNA gyrase subunit B, chloroplastic/mitochondrial-like K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
F 104891323 probable ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 104907597 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
D 104909036 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
D 104908216 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 104896345 nudix hydrolase 1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 104893124 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024