+F Repair protein KO
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DNA Repair and Recombination Proteins - Ruminiclostridium cellulolyticum
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Ccel_1140 methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Ccel_3329 8-oxoguanine DNA glycosylase domain protein K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E Ccel_1887 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E Ccel_0660 DEAD_2 domain protein K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D Ccel_0230 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D Ccel_0177 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Ccel_1140 methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Ccel_2870 Uracil-DNA glycosylase superfamily K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E Ccel_2416 phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E Ccel_2415 Uracil-DNA glycosylase superfamily K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E Ccel_3230 Uracil-DNA glycosylase superfamily K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E Ccel_1094 methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E Ccel_1887 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E Ccel_3322 exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E Ccel_1925 Xylose isomerase domain protein TIM barrel K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E Ccel_1953 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E Ccel_1976 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E Ccel_2075 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E Ccel_2119 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E Ccel_3265 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E Ccel_2342 ABC transporter related K03701 uvrA; excinuclease ABC subunit A
E Ccel_1413 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E Ccel_0807 excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E Ccel_0661 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_0373 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_1050 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_3423 superfamily I DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_2075 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E Ccel_1976 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F Ccel_0312 DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F Ccel_0313 DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F Ccel_0787 DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F Ccel_1790 DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F Ccel_3090 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E Ccel_1697 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E Ccel_1470 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
E Ccel_1433 DNA mismatch repair protein MutS domain protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E Ccel_1696 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E Ccel_1904 exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E Ccel_1903 exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E Ccel_1459 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E Ccel_0452 DNA polymerase III, alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E Ccel_0002 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E Ccel_1954 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E Ccel_0159 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E Ccel_0242 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E Ccel_1976 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E Ccel_0661 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_0373 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_1050 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_3423 superfamily I DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Ccel_0056 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
E Ccel_3087 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
E Ccel_0834 DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E Ccel_2787 D12 class N6 adenine-specific DNA methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E Ccel_0089 exonuclease V subunit alpha K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E Ccel_0676 recA protein K03553 recA; recombination protein RecA
E Ccel_1347 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Ccel_1348 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Ccel_1346 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E Ccel_1527 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E Ccel_0052 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_2709 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_0065 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_0051 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
E Ccel_0031 metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E Ccel_0676 recA protein K03553 recA; recombination protein RecA
E Ccel_0336 AAA ATPase K04485 radA; DNA repair protein RadA/Sms
E Ccel_0004 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E Ccel_1882 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E Ccel_1953 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E Ccel_0581 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E Ccel_0244 recombination protein RecR K06187 recR; recombination protein RecR
E Ccel_1896 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E Ccel_1347 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Ccel_1348 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Ccel_1346 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E Ccel_1774 recombination helicase AddA K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E Ccel_1775 ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E Ccel_1482 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E Ccel_3119 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E Ccel_0052 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_2709 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_0065 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E Ccel_0051 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
E Ccel_0031 metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E Ccel_0364 Ku protein K10979 ku; DNA end-binding protein Ku
E Ccel_0366 DNA polymerase LigD, polymerase domain protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E Ccel_0365 ATP dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F Ccel_3482 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F Ccel_1399 DNA gyrase/topoisomerase IV subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F Ccel_0006 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F Ccel_1398 DNA gyrase subunit B domain protein K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F Ccel_2056 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F Ccel_3085 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
F Ccel_2424 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F Ccel_1953 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F Ccel_0581 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F Ccel_0244 recombination protein RecR K06187 recR; recombination protein RecR
F Ccel_1976 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F Ccel_2119 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F Ccel_3265 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F Ccel_2342 ABC transporter related K03701 uvrA; excinuclease ABC subunit A
F Ccel_1413 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D Ccel_2007 UMUC domain protein DNA-repair protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D Ccel_1314 UMUC domain protein DNA-repair protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D Ccel_0676 recA protein K03553 recA; recombination protein RecA
D Ccel_1693 SOS-response transcriptional repressor, LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D Ccel_3317 transcriptional regulator, XRE family K01356 lexA; repressor LexA [EC:3.4.21.88]
D Ccel_1896 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D Ccel_0056 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D Ccel_3087 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D Ccel_0677 regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D Ccel_0964 DEAD/DEAH box helicase domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D Ccel_0230 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D Ccel_0177 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D Ccel_2401 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
D Ccel_0459 phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024