+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Ceratosolen solmsi marchali (fig wasp)
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E 105361219 mRNA cap guanine-N7 methyltransferase K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E 105362898 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 105368320 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 K14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]
E 105368692 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 K14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]
D Cap binding complex
E 105359735 nuclear cap-binding protein subunit 1 K12882 NCBP1; nuclear cap-binding protein subunit 1
E 105368984 nuclear cap-binding protein subunit 2 K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
E 105363629 cleavage and polyadenylation specificity factor subunit 5 isoform X1 K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5
E 105364547 cleavage and polyadenylation specificity factor subunit CG7185 isoform X1 K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7
D Pre-mRNA cleavage factor IIm (CFIIm)
E 105364680 protein CLP1 homolog K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
E 105360352 uncharacterized protein LOC105360352 K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
E 105359850 uncharacterized protein LOC105359850 K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
D Cleavage and polyadenylation specificity factor (CPSF) complex
E 105361975 cleavage and polyadenylation specificity factor subunit 1 K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1
E 105364686 probable cleavage and polyadenylation specificity factor subunit 2 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E 105364520 cleavage and polyadenylation specificity factor 73 isoform X1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E 105364202 cleavage and polyadenylation specificity factor subunit 4 K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E 105362862 pre-mRNA 3'-end-processing factor FIP1 isoform X1 K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E 105365875 uncharacterized protein LOC105365875 isoform X1 K15542 PFS2; polyadenylation factor subunit 2
E 105365781 WD repeat-containing protein 82 K14962 WDR82; COMPASS component SWD2
E 105363640 serine/threonine-protein phosphatase alpha-2 isoform K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E 105368070 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E 105365871 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E 105360629 cleavage stimulation factor subunit 1 K14406 CSTF1; cleavage stimulation factor subunit 1
E 105360934 cleavage stimulation factor subunit 2 isoform X1 K14407 CSTF2; cleavage stimulation factor subunit 2
E 105360638 protein suppressor of forked K14408 CSTF3; cleavage stimulation factor subunit 3
E 105360992 symplekin K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E 105366164 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 105365579 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 105365861 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 105362472 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 105366400 U7 snRNA-associated Sm-like protein LSm10 K25591 LSM10; U7 snRNA-associated Sm-like protein LSm10
E 105369028 U7 snRNA-associated Sm-like protein LSm11 K25592 LSM11; U7 snRNA-associated Sm-like protein LSm11
E 105364686 probable cleavage and polyadenylation specificity factor subunit 2 K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E 105364520 cleavage and polyadenylation specificity factor 73 isoform X1 K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E 105360934 cleavage stimulation factor subunit 2 isoform X1 K14407 CSTF2; cleavage stimulation factor subunit 2
E 105360992 symplekin K06100 SYMPK; symplekin
E 105368375 histone RNA hairpin-binding protein K18710 SLBP; histone RNA hairpin-binding protein
D DRB sensitivity inducing factor (DSIF) complex
E 105359886 transcription elongation factor SPT4 K15171 SUPT4H1; transcription elongation factor SPT4
E 105367770 transcription elongation factor SPT5 K15172 SUPT5H; transcription elongation factor SPT5
E 105359432 transcription elongation factor SPT5-like K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E 105362090 N6-adenosine-methyltransferase subunit METTL3 K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E 105368592 methyltransferase-like protein 14 homolog K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
E 105364272 methyltransferase-like protein 4 K24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]
E 105368924 methyltransferase-like protein 16 homolog K11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]
E 105368613 pre-mRNA-splicing regulator WTAP K22824 WTAP; pre-mRNA-splicing regulator WTAP
E 105363206 protein virilizer K22910 VIRMA; protein virilizer
E 105361442 putative RNA-binding protein 15 K13190 RBM15; RNA-binding protein 15
E 105368734 zinc finger CCCH domain-containing protein 13-like isoform X1 K22909 ZC3H13; zinc finger CCCH domain-containing protein 13
E 105365332 E3 ubiquitin-protein ligase Hakai K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
D Poly(A) addition factors
E 105359219 poly(A) polymerase type 3-like isoform X1 K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
E 105362483 poly(A) polymerase gamma-like isoform X1 K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
E 105359354 poly(A) RNA polymerase gld-2 homolog A-like isoform X1 K14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]
E 105368512 speckle targeted PIP5K1A-regulated poly(A) polymerase-like K18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]
D Negative regulators of mRNA 3' end processing
E 105367603 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
E 105363650 RNA-binding protein 26 K13192 RBM26; RNA-binding protein 26
E 105365483 uncharacterized protein LOC105365483 isoform X1 K23600 TARDBP; TAR DNA-binding protein 43
C Other processing factors
D 105361501 DNA/RNA-binding protein KIN17 K13102 KIN; DNA/RNA-binding protein KIN17
D 105363101 methyltransferase-like protein 22 K23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]
D 105363002 protein FAM46C K23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]
D 105361109 zinc finger CCCH domain-containing protein 14 isoform X1 K23038 ZC3H14; zinc finger CCCH domain-containing protein 14
D 105367794 serrate RNA effector molecule homolog K27103 SRRT; serrate RNA effector molecule
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E 105368661 RNA-binding protein 8A K12876 RBM8A; RNA-binding protein 8A
E 105359887 protein mago nashi homolog K12877 MAGOH; protein mago nashi
E 105362714 THO complex subunit 4-like K12881 THOC4; THO complex subunit 4
E 105365637 THO complex subunit 4-A-like K12881 THOC4; THO complex subunit 4
E 105365779 ATP-dependent RNA helicase WM6 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E 105366960 eukaryotic initiation factor 4A-III K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E 105362499 coiled-coil domain-containing protein 174 K25178 CCDC174; coiled-coil domain-containing protein 174
E 105364790 protein CASC3 K14323 CASC3; protein CASC3
E 105367787 histone deacetylase complex subunit SAP18 K14324 SAP18; histone deacetylase complex subunit SAP18
E 105366003 pinin K13114 PNN; pinin
E 105368702 apoptotic chromatin condensation inducer in the nucleus K12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus
E 105364054 RNA-binding protein with serine-rich domain 1-A-like K14325 RNPS1; RNA-binding protein with serine-rich domain 1
E 105364699 serine/arginine repetitive matrix protein 1 K13171 SRRM1; serine/arginine repetitive matrix protein 1
D TREX complex
E 105359322 THO complex subunit 1 K12878 THOC1; THO complex subunit 1
E 105363481 THO complex subunit 2 K12879 THOC2; THO complex subunit 2
E 105363413 THO complex subunit 3 K12880 THOC3; THO complex subunit 3
E 105362714 THO complex subunit 4-like K12881 THOC4; THO complex subunit 4
E 105365637 THO complex subunit 4-A-like K12881 THOC4; THO complex subunit 4
E 105368920 THO complex subunit 5 homolog K13174 THOC5; THO complex subunit 5
E 105365582 THO complex subunit 6 isoform X1 K13175 THOC6; THO complex subunit 6
E 105366322 THO complex subunit 7 homolog K13176 THOC7; THO complex subunit 7
D TREX-2 complex
E 105366946 PCI domain-containing protein 2 homolog isoform X1 K23801 PCID2; nuclear mRNA export protein PCID2/THP1
E 105368146 26S proteasome complex subunit DSS1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 105369043 transcription and mRNA export factor ENY2-like K11368 ENY2; enhancer of yellow 2 transcription factor
D Nuclear pore complex
E 105360728 nucleoprotein TPR K09291 TPR; nucleoprotein TPR
E 105363966 mRNA export factor K14298 RAE1; mRNA export factor
E 105364657 protein SEC13 homolog K14004 SEC13; protein transport protein SEC13
E 105363464 nucleoporin Nup37 K14302 NUP37; nuclear pore complex protein Nup37
E 105359163 LOW QUALITY PROTEIN: nuclear pore complex protein Nup85 K14304 NUP85; nuclear pore complex protein Nup85
E 105360463 nucleoporin Nup43 K14305 NUP43; nuclear pore complex protein Nup43
E 105359190 nuclear pore complex protein Nup50 K14295 NUP50; nuclear pore complex protein Nup50
E 105368779 nuclear pore complex protein Nup54 K14308 NUP54; nuclear pore complex protein Nup54
E 105362520 nuclear pore glycoprotein p62 K14306 NUP62; nuclear pore complex protein Nup62
E 105368722 nuclear pore complex protein Nup88 K14318 NUP88; nuclear pore complex protein Nup88
E 105363176 nuclear pore complex protein Nup93-like K14309 NUP93; nuclear pore complex protein Nup93
E 105368456 nuclear pore complex protein Nup98-Nup96 K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E 105361531 nuclear pore complex protein Nup107 K14301 NUP107; nuclear pore complex protein Nup107
E 105365199 nuclear pore complex protein Nup133 K14300 NUP133; nuclear pore complex protein Nup133
E 105361922 LOW QUALITY PROTEIN: nucleoporin NUP188 homolog K14311 NUP188; nuclear pore complex protein Nup188
E 105360411 nuclear pore complex protein Nup153 K14296 NUP153; nuclear pore complex protein Nup153
E 105361306 nuclear pore complex protein Nup155 K14312 NUP155; nuclear pore complex protein Nup155
E 105365866 nuclear pore complex protein Nup160 homolog K14303 NUP160; nuclear pore complex protein Nup160
E 105364952 nucleoporin NUP53-like K14313 NUP35; nuclear pore complex protein Nup53
E 105364953 nucleoporin NUP53-like isoform X1 K14313 NUP35; nuclear pore complex protein Nup53
E 105360673 nuclear pore complex protein Nup205 K14310 NUP205; nuclear pore complex protein Nup205
E 105364045 nuclear pore membrane glycoprotein 210 K14314 NUP210; nuclear pore complex protein Nup210
E 105359064 nuclear pore complex protein Nup214-like K14317 NUP214; nuclear pore complex protein Nup214
E 105361634 putative GPI-anchored protein PB15E9.01c K14316 POM121; nuclear pore complex protein Nup121
E 105366716 nucleoporin p58/p45 K14307 NUPL1; nucleoporin p58/p45
E 105363761 nucleoporin Ndc1 K14315 NDC1; nucleoporin NDC1
E 105366036 nucleoporin seh1-A K14299 SEH1; nucleoporin SEH1
E 105364096 E3 SUMO-protein ligase RanBP2-like K12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
E 105368044 aladin K14320 AAAS; aladin
E 105361920 nuclear pore complex protein Nup98-Nup96-like K18716 NUP42; nucleoporin NUP42
E 105359091 nucleoporin GLE1 K18723 GLE1; nucleoporin GLE1
E 105365887 nuclear RNA export factor 1 K14284 NXF; nuclear RNA export factor
E 105365125 nuclear RNA export factor 1-like K14284 NXF; nuclear RNA export factor
E 105365008 nuclear RNA export factor 1-like isoform X1 K14284 NXF; nuclear RNA export factor
E 105365889 NTF2-related export protein isoform X1 K14285 NXT1_2; NTF2-related export protein 1/2
D Ran-mediated transport factors
E 105365474 GTP-binding nuclear protein Ran K07936 RAN; GTP-binding nuclear protein Ran
E 105361775 acidic leucine-rich nuclear phosphoprotein 32 family member A K18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D
E 105359899 ELAV-like protein 3 isoform X1 K13208 ELAVL2_3_4; ELAV like protein 2/3/4
E 105361921 FAS-associated factor 2 K18726 FAF2; FAS-associated factor 2
E 105363493 transitional endoplasmic reticulum ATPase TER94 K13525 VCP; transitional endoplasmic reticulum ATPase
E 105363762 protein-lysine methyltransferase METTL21D-like K21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]
E 105366028 exportin-1 K14290 XPO1; exportin-1
E 105367305 exportin-7 K18460 XPO7; exportin-7
E 105360163 ran GTPase-activating protein 1 K14319 RANGAP1; Ran GTPase-activating protein 1
D eIF4F and regulatory proteins
E 105363949 eukaryotic translation initiation factor 4E type 2 K03259 EIF4E; translation initiation factor 4E
E 105367572 eukaryotic translation initiation factor 4E-like isoform X1 K03259 EIF4E; translation initiation factor 4E
E 105363494 eukaryotic initiation factor 4A-I isoform X1 K03257 EIF4A; translation initiation factor 4A
E 105364459 eukaryotic translation initiation factor 4 gamma 2 isoform X1 K03260 EIF4G; translation initiation factor 4G
E 105365864 eukaryotic translation initiation factor 4 gamma 3-like K03260 EIF4G; translation initiation factor 4G
E 105362670 eukaryotic translation initiation factor 4B-like K03258 EIF4B; translation initiation factor 4B
E 105364336 eukaryotic translation initiation factor 4E-binding protein 1 K18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2
E 105359283 eukaryotic translation initiation factor 4E transporter-like K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter
E 105368472 protein angel K18729 ANGEL; protein angel
E 105361869 fragile X mental retardation syndrome-related protein 1 K15516 FMR; fragile X mental retardation protein
E 105363416 cytoplasmic FMR1-interacting protein K05749 CYFIP; cytoplasmic FMR1 interacting protein
E 105363547 gem-associated protein 5 K13133 GEMIN5; gem associated protein 5
E 105367827 cytoplasmic polyadenylation element-binding protein 2 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
E 105362778 cytoplasmic polyadenylation element-binding protein 1 isoform X1 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
E 105367442 ATP-dependent RNA helicase bel K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E 105360263 PERQ amino acid-rich with GYF domain-containing protein CG11148-like isoform X1 K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E 105367871 polyadenylate-binding protein 4-like K13126 PABPC; polyadenylate-binding protein
E 105360235 polyadenylate-binding protein-interacting protein 1 K14322 PAIP1; polyadenylate-binding protein-interacting protein 1
E 105365508 polyadenylate-binding protein-interacting protein 2 isoform X1 K27470 PAIP2; polyadenylate-binding protein-interacting protein 2
E 105364656 helicase SKI2W K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E 105368092 deformed epidermal autoregulatory factor 1 K23041 DEAF1; deformed epidermal autoregulatory factor 1
E 105359345 malignant T-cell-amplified sequence 1 K07575 MCTS; malignant T-cell-amplified sequence
E 105368926 density-regulated protein K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E 105365585 partner of Y14 and mago isoform X1 K14294 WIBG; partner of Y14 and mago
E 105363023 heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
E 105364276 RNA-binding protein Musashi homolog Rbp6 K14411 MSI; RNA-binding protein Musashi
E 105367756 RNA-binding protein Musashi homolog 2 isoform X1 K14411 MSI; RNA-binding protein Musashi
E 105365257 heterogeneous nuclear ribonucleoprotein 27C isoform X1 K14411 MSI; RNA-binding protein Musashi
E 105360357 HBS1-like protein K14416 HBS1; elongation factor 1 alpha-like protein
E 105359707 protein pelota K06965 PELO; protein pelota
E 105361871 polyadenylate-binding protein 2-B-like K14396 PABPN1; polyadenylate-binding protein 2
E 105361021 DEAD-box helicase Dbp80 K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E 105365939 pre-mRNA-splicing factor SYF1 K12867 SYF1; pre-mRNA-splicing factor SYF1
E 105359862 SAP domain-containing ribonucleoprotein K18732 SARNP; SAP domain-containing ribonucleoprotein
E 105368653 regulator of chromosome condensation K11493 RCC1; regulator of chromosome condensation
E 105359263 transcriptional activator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
E 105359652 polymerase delta-interacting protein 3-like K22414 POLDIP3; polymerase delta-interacting protein 3
E 105363732 zinc finger CCCH domain-containing protein 11A-like isoform X1 K22415 ZC3H11; zinc finger CCCH domain-containing protein 11
E 105361929 leukocyte receptor cluster member 8 homolog isoform X1 K23802 LENG8; SAC3 family protein LENG8/THP3
C Surveillance factors
D Surveillance complex
E 105364296 eukaryotic peptide chain release factor subunit 1 isoform X1 K03265 ETF1; peptide chain release factor subunit 1
E 105361753 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 K03267 ERF3; peptide chain release factor subunit 3
E 105359351 regulator of nonsense transcripts 1 K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E 105359310 regulator of nonsense transcripts 2 K14327 UPF2; regulator of nonsense transcripts 2
E 105365232 regulator of nonsense transcripts 3A K14328 UPF3; regulator of nonsense transcripts 3
D Protein phosphatase 2A
E 105368684 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E 105364740 serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E 105361565 protein phosphatase PP2A 55 kDa regulatory subunit K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E 105364779 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like isoform X1 K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
E 105359688 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
E 105366756 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
E 105361076 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
E 105365633 serine/threonine-protein kinase SMG1 K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1]
E 105361024 protein SMG5 K11125 SMG5; protein SMG5
E 105360001 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
E 105364371 protein SMG7-like K14409 SMG7; protein SMG7
E 105363267 protein SMG8 K18734 SMG8; protein SMG8
E 105359858 protein SMG9 isoform X1 K18735 SMG9; protein SMG9
E 105360263 PERQ amino acid-rich with GYF domain-containing protein CG11148-like isoform X1 K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E 105364254 probable ATP-dependent RNA helicase DHX34 K20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]
E 105368749 GTP-binding protein 1 K24887 GTPBP1; GTP-binding protein 1
C Factors involved in mRNA localization
D Cargo complex
E 105359600 protein penguin K14844 PUF6; pumilio homology domain family member 6
E 105365325 unconventional myosin-Va K10357 MYO5; myosin V
E 105368037 protein bicaudal D isoform X1 K18739 BICD; protein bicaudal D
E 105363426 uncharacterized protein LOC105363426 K18740 EXD1; exonuclease 3'-5' domain-containing protein 1
D Factors that have mRNA localization signals
E 105359224 actin-5C K05692 ACTB_G1; actin beta/gamma 1
E 105359323 serine/arginine repetitive matrix protein 1 K04377 MYC; Myc proto-oncogene protein
E 105368609 T-box-containing protein TBX6L-like K10180 TBX6; T-box protein 6
E 105365883 nanos homolog 3 K18741 NANOS1; protein nanos 1
E 105364582 protein hairy K09090 HESN; hairy and enhancer of split, invertebrate
E 105364586 transcription factor HES-1-A-like K09090 HESN; hairy and enhancer of split, invertebrate
D Trans-acting binding proteins
E 105364756 far upstream element-binding protein 3 isoform X1 K13210 FUBP; far upstream element-binding protein
E 105366196 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
E 105368029 elongation factor 1-gamma K03233 EEF1G; elongation factor 1-gamma
E 105364766 HCLS1-associated protein X-1-like isoform X1 K16220 HAX1; HCLS1-associated protein X-1
E 105359932 arf-GAP domain and FG repeat-containing protein 1 K15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1
E 105368010 double-stranded RNA-binding protein Staufen homolog 2 K17597 STAU; double-stranded RNA-binding protein Staufen
E 105360618 polypyrimidine tract-binding protein 1 isoform X1 K13218 PTBP1; polypyrimidine tract-binding protein 1
E 105368218 RNA-binding protein squid K03102 SQD; squid
E 105365704 RNA-binding protein squid-like isoform X1 K03102 SQD; squid
E 105367827 cytoplasmic polyadenylation element-binding protein 2 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
E 105362778 cytoplasmic polyadenylation element-binding protein 1 isoform X1 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
D Other mRNA localization factors
E 105361869 fragile X mental retardation syndrome-related protein 1 K15516 FMR; fragile X mental retardation protein
E 105363416 cytoplasmic FMR1-interacting protein K05749 CYFIP; cytoplasmic FMR1 interacting protein
E 105362930 poly(rC)-binding protein 3 isoform X1 K21444 PCBP3_4; poly(rC)-binding protein 3/4
E 105359332 caprin homolog K18743 CAPRIN1; caprin-1
E 105363937 CUGBP Elav-like family member 1 isoform X1 K02177 BRU; bruno
E 105361284 Y-box factor homolog isoform X1 K09276 YBX1; Y-box-binding protein 1
E 105365303 sex-lethal homolog isoform X1 K18747 SXL; protein sex-lethal
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E 105365383 5'-3' exoribonuclease 1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E 105362850 protein argonaute-2-like K11593 ELF2C; eukaryotic translation initiation factor 2C
E 105368168 protein argonaute-2 isoform X1 K11593 ELF2C; eukaryotic translation initiation factor 2C
E 105363949 eukaryotic translation initiation factor 4E type 2 K03259 EIF4E; translation initiation factor 4E
E 105367572 eukaryotic translation initiation factor 4E-like isoform X1 K03259 EIF4E; translation initiation factor 4E
E 105359351 regulator of nonsense transcripts 1 K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E 105367442 ATP-dependent RNA helicase bel K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E 105364750 putative ATP-dependent RNA helicase me31b K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E 105367558 RNA-binding protein MEX3B K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
E 105361421 protein LSM14 homolog B K18749 LSM14; protein LSM14
E 105361284 Y-box factor homolog isoform X1 K09276 YBX1; Y-box-binding protein 1
E 105359874 LIM domain-containing protein jub isoform X1 K16682 AJUBA; LIM domain-containing protein
E 105363271 proline-rich nuclear receptor coactivator 2 K18751 PNRC2; proline-rich nuclear receptor coactivator 2
E 105362914 transportin-1 K18752 TNPO1; transportin-1
E 105365633 serine/threonine-protein kinase SMG1 K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1]
E 105361024 protein SMG5 K11125 SMG5; protein SMG5
E 105360001 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
E 105364371 protein SMG7-like K14409 SMG7; protein SMG7
E 105368497 protein TIS11 K15308 TTP; tristetraprolin
E 105364173 LOW QUALITY PROTEIN: huntingtin K04533 HD; huntingtin
E 105368831 protein bicaudal C K18756 BICC1; protein bicaudal C
E 105363023 heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
E 105359234 cAMP-dependent protein kinase catalytic subunit-like K04345 PKA; protein kinase A [EC:2.7.11.11]
E 105362910 cAMP-dependent protein kinase catalytic subunit K04345 PKA; protein kinase A [EC:2.7.11.11]
E 105362742 la-related protein 1B K18757 LARP1; la-related protein 1
E 105363699 ataxin-2-like protein K23625 ATXN2_2L; ataxin 2/2L
D P-body specific factors
E 105363177 m7GpppN-mRNA hydrolase K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E 105363434 mRNA-decapping enzyme 1A K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]
E 105359574 U6 snRNA-associated Sm-like protein LSm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E 105367514 U6 snRNA-associated Sm-like protein LSm2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E 105368560 U6 snRNA-associated Sm-like protein LSm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E 105365780 U6 snRNA-associated Sm-like protein LSm4 isoform X1 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E 105360592 U6 snRNA-associated Sm-like protein LSm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E 105363914 U6 snRNA-associated Sm-like protein LSm6 isoform X1 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E 105361639 U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E 105361914 LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E 105361372 U6 snRNA-associated Sm-like protein LSm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E 105368133 kinesin light chain isoform X1 K10407 KLC; kinesin light chain
E 105365325 unconventional myosin-Va K10357 MYO5; myosin V
E 105361972 tubulin alpha-1C chain-like K07374 TUBA; tubulin alpha
E 105363153 tubulin alpha-4 chain-like isoform X1 K07374 TUBA; tubulin alpha
E 105361311 tubulin alpha-1 chain K07374 TUBA; tubulin alpha
E 105361636 tubulin alpha-1 chain-like K07374 TUBA; tubulin alpha
E 105367827 cytoplasmic polyadenylation element-binding protein 2 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
E 105362778 cytoplasmic polyadenylation element-binding protein 1 isoform X1 K02602 CPEB; cytoplasmic polyadenylation element-binding protein
E 105363547 gem-associated protein 5 K13133 GEMIN5; gem associated protein 5
E 105363183 protein Gawky isoform X1 K18412 TNRC6; trinucleotide repeat-containing gene 6 protein
E 105359581 CCR4-NOT transcription complex subunit 1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E 105360472 regulator of gene activity K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E 105359921 CCR4-NOT transcription complex subunit 3 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E 105361808 alpha-protein kinase 1 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E 105360738 CCR4-NOT transcription complex subunit 6-like isoform X1 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E 105365078 CCR4-NOT transcription complex subunit 7 isoform X1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E 105362523 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E 105365128 LOW QUALITY PROTEIN: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
E 105362549 protein BTG3-like K14443 TOB; protein Tob/BTG
E 105366168 protein Tob1-like isoform X1 K14443 TOB; protein Tob/BTG
E 105361380 protein BTG2-like K14443 TOB; protein Tob/BTG
E 105359283 eukaryotic translation initiation factor 4E transporter-like K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter
E 105363073 protein PAT1 homolog 1 K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
E 105359205 enhancer of mRNA-decapping protein 3 isoform X1 K12615 EDC3; enhancer of mRNA-decapping protein 3
E 105360077 enhancer of mRNA-decapping protein 4 K12616 EDC4; enhancer of mRNA-decapping protein 4
E 105359310 regulator of nonsense transcripts 2 K14327 UPF2; regulator of nonsense transcripts 2
E 105365232 regulator of nonsense transcripts 3A K14328 UPF3; regulator of nonsense transcripts 3
E 105362169 E3 ubiquitin-protein ligase TRIM71 K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
E 105364558 RING finger protein nhl-1 isoform X1 K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
E 105368322 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
E 105367874 YTH domain-containing family protein 3 isoform X1 K20102 YTHDF; YTH domain-containing family protein
D Stress granule specific factors
E 105366052 nucleolysin TIAR K13201 TIA1; nucleolysin TIA-1/TIAR
E 105367890 nucleolysin TIAR isoform X1 K13201 TIA1; nucleolysin TIA-1/TIAR
E 105367871 polyadenylate-binding protein 4-like K13126 PABPC; polyadenylate-binding protein
E 105368010 double-stranded RNA-binding protein Staufen homolog 2 K17597 STAU; double-stranded RNA-binding protein Staufen
E 105361869 fragile X mental retardation syndrome-related protein 1 K15516 FMR; fragile X mental retardation protein
E 105368219 ras GTPase-activating protein-binding protein 2 isoform X1 K24983 G3BP2; Ras GTPase-activating protein-binding protein 2
E 105368599 eukaryotic translation initiation factor 2A K15026 EIF2A; translation initiation factor 2A
E 105362434 eukaryotic translation initiation factor 3 subunit B K03253 EIF3B; translation initiation factor 3 subunit B
E 105363494 eukaryotic initiation factor 4A-I isoform X1 K03257 EIF4A; translation initiation factor 4A
E 105366960 eukaryotic initiation factor 4A-III K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E 105362670 eukaryotic translation initiation factor 4B-like K03258 EIF4B; translation initiation factor 4B
E 105364459 eukaryotic translation initiation factor 4 gamma 2 isoform X1 K03260 EIF4G; translation initiation factor 4G
E 105365864 eukaryotic translation initiation factor 4 gamma 3-like K03260 EIF4G; translation initiation factor 4G
E 105360921 ribosomal protein S6 kinase 2 beta K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
E 105368686 guanine nucleotide-binding protein subunit beta-like protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
E 105365887 nuclear RNA export factor 1 K14284 NXF; nuclear RNA export factor
E 105365125 nuclear RNA export factor 1-like K14284 NXF; nuclear RNA export factor
E 105365008 nuclear RNA export factor 1-like isoform X1 K14284 NXF; nuclear RNA export factor
E 105365193 histone deacetylase 6 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
E 105363147 tudor domain-containing protein 3 K18404 TDRD3; tudor domain-containing protein 3
E 105365044 la-related protein CG11505 isoform X1 K18763 LARP4; la-related protein 4
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E 105363434 mRNA-decapping enzyme 1A K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]
E 105363177 m7GpppN-mRNA hydrolase K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E 105364750 putative ATP-dependent RNA helicase me31b K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E 105359205 enhancer of mRNA-decapping protein 3 isoform X1 K12615 EDC3; enhancer of mRNA-decapping protein 3
E 105360077 enhancer of mRNA-decapping protein 4 K12616 EDC4; enhancer of mRNA-decapping protein 4
E 105363073 protein PAT1 homolog 1 K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
D Lsm complex
E 105359574 U6 snRNA-associated Sm-like protein LSm1 K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E 105367514 U6 snRNA-associated Sm-like protein LSm2 K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E 105368560 U6 snRNA-associated Sm-like protein LSm3 K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E 105365780 U6 snRNA-associated Sm-like protein LSm4 isoform X1 K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E 105360592 U6 snRNA-associated Sm-like protein LSm5 K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E 105363914 U6 snRNA-associated Sm-like protein LSm6 isoform X1 K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E 105361639 U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E 105361914 LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm7 K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E 105361372 U6 snRNA-associated Sm-like protein LSm8 K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E 105365383 5'-3' exoribonuclease 1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D Other 5'-3' decay factors
E 105364356 m7GpppX diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
E 105363442 probable helicase with zinc finger domain K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]
C 3'-5' decay
D Core exosome factors
E 105368806 exosome complex component CSL4 K07573 CSL4; exosome complex component CSL4
E 105359123 exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E 105364352 exosome complex component RRP40 K03681 RRP40; exosome complex component RRP40
E 105363776 exosome complex component RRP41 K11600 RRP41; exosome complex component RRP41
E 105360958 exosome complex component RRP46 K12590 RRP46; exosome complex component RRP46
E 105363254 exosome complex component MTR3-like K12587 MTR3; exosome complex component MTR3
E 105360888 exosome complex component RRP42 isoform X1 K12589 RRP42; exosome complex component RRP42
E 105365082 exosome complex component RRP43-like isoform X1 K12586 RRP43; exosome complex component RRP43
E 105365429 exosome complex component rrp45 K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E 105360026 exosome component 10 K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E 105367554 nuclear nucleic acid-binding protein C1D-like K12592 C1D; exosome complex protein LRP1
E 105368755 M-phase phosphoprotein 6 K12593 MPHOSPH6; M-phase phosphoprotein 6, animal type
D TRAMP complex
E 105360224 non-canonical poly(A) RNA polymerase PAPD5-like K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E 105366740 LOW QUALITY PROTEIN: superkiller viralicidic activity 2-like 2 K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
E 105364656 helicase SKI2W K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E 105360467 tetratricopeptide repeat protein 37 K12600 SKI3; superkiller protein 3
E 105364471 WD repeat-containing protein 61 K12602 WDR61; WD repeat-containing protein 61
D Ccr4-NOT complex
E 105360738 CCR4-NOT transcription complex subunit 6-like isoform X1 K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E 105359581 CCR4-NOT transcription complex subunit 1 K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E 105360472 regulator of gene activity K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E 105359921 CCR4-NOT transcription complex subunit 3 K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E 105361808 alpha-protein kinase 1 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E 105365078 CCR4-NOT transcription complex subunit 7 isoform X1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E 105365328 cell differentiation protein RCD1 homolog K12606 RCD1; CCR4-NOT transcription complex subunit 9
E 105359417 CCR4-NOT transcription complex subunit 10-B K12607 CNOT10; CCR4-NOT transcription complex subunit 10
D Pan complex
E 105362523 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E 105365128 LOW QUALITY PROTEIN: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E 105362171 poly(A)-specific ribonuclease PARN-like K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]
E 105366238 ATP-dependent RNA helicase DHX36 K14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]
E 105362549 protein BTG3-like K14443 TOB; protein Tob/BTG
E 105366168 protein Tob1-like isoform X1 K14443 TOB; protein Tob/BTG
E 105361380 protein BTG2-like K14443 TOB; protein Tob/BTG
E 105364356 m7GpppX diphosphatase K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
E 105363442 probable helicase with zinc finger domain K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]
E 105364612 protein NRDE2 homolog K26109 NRDE2; nuclear exosome regulator NRDE2
E 105360999 protein Smaug homolog 1 K27396 SMG; protein Smaug
C Other degradation factors
D RNases
E 105359025 NEDD4-binding protein 1 K18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]
E 105362954 uncharacterized protein LOC105362954 K18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
E 105368531 ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3]
E 105366516 oligoribonuclease, mitochondrial-like isoform X1 K13288 orn; oligoribonuclease [EC:3.1.-.-]
E 105364147 LOW QUALITY PROTEIN: oligoribonuclease, mitochondrial-like K13288 orn; oligoribonuclease [EC:3.1.-.-]
D Helicases
D Other RNA degradosome components
E 105365546 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E 105360320 alpha-enolase-like K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E 105367008 enolase-like K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E 105361080 polyribonucleotide nucleotidyltransferase 1, mitochondrial K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
E 105363131 ATP-dependent 6-phosphofructokinase isoform X1 K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E 105359801 heat shock 70 kDa protein cognate 5 K04043 dnaK; molecular chaperone DnaK
E 105365884 60 kDa heat shock protein, mitochondrial K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E 105359123 exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E 105368806 exosome complex component CSL4 K07573 CSL4; exosome complex component CSL4
D Cofactors
E 105363776 exosome complex component RRP41 K11600 RRP41; exosome complex component RRP41
E 105360888 exosome complex component RRP42 isoform X1 K12589 RRP42; exosome complex component RRP42
D Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024