+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Delphinapterus leucas (beluga whale)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      111172187 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      111162703 ALKBH2; DNA oxidative demethylase ALKBH2	K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33] 
D      111184013 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1	K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54] 
D      111164024 ASCC3; activating signal cointegrator 1 complex subunit 3	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
C    BER (base exicision repair)
D      DNA glycosylases
E        111162817 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        111163072 CCNO; cyclin-O	K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-] 
E        111187909 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1	K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] 
E        111185085 MPG; DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        111173925 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        111175742 MUTYH; adenine DNA glycosylase isoform X1	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        111168971 MBD4; methyl-CpG-binding domain protein 4	K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] 
E        111169955 OGG1; N-glycosylase/DNA lyase isoform X1	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        111177837 NEIL1; endonuclease 8-like 1 isoform X1	K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] 
E        111185364 NEIL2; endonuclease 8-like 2	K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18] 
E        111173341 NEIL3; endonuclease 8-like 3 isoform X1	K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18] 
E        111185174 NTHL1; endonuclease III-like protein 1 isoform X1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        111181806 APEX1; DNA-(apurinic or apyrimidinic site) lyase	K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] 
E        111169409 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1	K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2] 
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          111181058 POLD1; DNA polymerase delta catalytic subunit	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
F          111184511 POLD2; DNA polymerase delta subunit 2 isoform X1	K02328 POLD2; DNA polymerase delta subunit 2 
F          111184858 POLD3; DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
F          111183680 DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
F          111183682 POLD4; DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
E        DNA polymerase epsilon complex
F          111186982 POLE; DNA polymerase epsilon catalytic subunit A isoform X1	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          111173187 POLE2; DNA polymerase epsilon subunit 2	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          111177300 POLE3; DNA polymerase epsilon subunit 3	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          111169119 POLE4; DNA polymerase epsilon subunit 4 isoform X1	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        111165627 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        111183886 FEN1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        111180676 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      Short Patch-BER factors
E        111173554 POLB; DNA polymerase beta isoform X1	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
E        111180788 XRCC1; DNA repair protein XRCC1 isoform X1	K10803 XRCC1; DNA-repair protein XRCC1 
E        111170821 LIG3; DNA ligase 3 isoform X1	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        111176168 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        111163193 APTX; aprataxin isoform X2	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        111186508 APLF; aprataxin and PNK-like factor isoform X1	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        111180589 PNKP; bifunctional polynucleotide phosphatase/kinase isoform X1	K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 
E        111175202 HMGB1; high mobility group protein B1	K10802 HMGB1; high mobility group protein B1 
E        111172374 POLL; DNA polymerase lambda	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        111177530 PARP1; poly [ADP-ribose] polymerase 1 isoform X2	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
E        111174336 PARP3; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
E        111181802 PARP2; poly [ADP-ribose] polymerase 2 isoform X1	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          111168852 XPC; DNA repair protein complementing XP-C cells isoform X1	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          111177357 RAD23B; UV excision repair protein RAD23 homolog B	K10839 RAD23; UV excision repair protein RAD23 
F          111166666 RAD23A; UV excision repair protein RAD23 homolog A isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          111170611 CETN2; centrin-2	K10840 CETN2; centrin-2 
E        Cul4-DDB2 complex
F          111186303 RBX1; E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          111168233 CUL4B; cullin-4B isoform X1	K10609 CUL4; cullin 4 
F          111176363 CUL4A; cullin-4A	K10609 CUL4; cullin 4 
F          111175787 LOW QUALITY PROTEIN: cullin-4B-like	K10609 CUL4; cullin 4 
F          111183892 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          111183968 DDB2; DNA damage-binding protein 2 isoform X1	K10140 DDB2; DNA damage-binding protein 2 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          111185756 POLR2A; DNA-directed RNA polymerase II subunit RPB1 isoform X1	K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] 
F          111169199 DNA-directed RNA polymerase II subunit RPB2 isoform X1	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          111165370 POLR2C; DNA-directed RNA polymerase II subunit RPB3	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          111183343 POLR2D; DNA-directed RNA polymerase II subunit RPB4	K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 
F          111170494 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          111186412 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          111183849 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X1	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
F          111173227 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          111181213 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
F          111170304 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5	K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 
F          111182011 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a	K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 
F          111180384 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
E        Cul4-CSA complex
F          111186303 RBX1; E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          111168233 CUL4B; cullin-4B isoform X1	K10609 CUL4; cullin 4 
F          111176363 CUL4A; cullin-4A	K10609 CUL4; cullin 4 
F          111175787 LOW QUALITY PROTEIN: cullin-4B-like	K10609 CUL4; cullin 4 
F          111183892 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          111186400 ERCC8; DNA excision repair protein ERCC-8 isoform X1	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          111169887 ERCC6; DNA excision repair protein ERCC-6	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          111164850 UVSSA; UV-stimulated scaffold protein A	K23720 UVSSA; UV-stimulated scaffold protein A 
F          111166059 ELOF1; transcription elongation factor 1 homolog	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        111183353 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        111180742 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        111179861 GTF2H1; general transcription factor IIH subunit 1	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        111186920 GTF2H3; general transcription factor IIH subunit 3 isoform X1	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        111170695 GTF2H4; general transcription factor IIH subunit 4 isoform X1	K03144 TFIIH4; transcription initiation factor TFIIH subunit 4 
E        111167438 GTF2H5; general transcription factor IIH subunit 5	K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit 
E        111185937 CDK7; cyclin-dependent kinase 7 isoform X1	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        111184613 CCNH; cyclin-H isoform X2	K06634 CCNH; cyclin H 
E        111173094 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        111185703 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        111163345 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        111181480 RPA3; replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
E        111178250 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit	K10741 RPA4; replication factor A4 
D      Other NER factors
E        111187947 XPA; DNA repair protein complementing XP-A cells	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        111180739 ERCC1; DNA excision repair protein ERCC-1 isoform X1	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        111163499 ERCC4; DNA repair endonuclease XPF	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        111176401 ERCC5; DNA repair protein complementing XP-G cells isoform X1	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        111180676 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        111172434 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        111171878 CUL3; cullin-3 isoform X1	K03869 CUL3; cullin 3 
E        111168073 CUL5; cullin-5 isoform X1	K10612 CUL5; cullin 5 
E        111185598 ELOC; elongin-C	K03872 ELOC; elongin-C 
E        111185208 ELOB; elongin-B	K03873 ELOB; elongin-B 
E        111163306 ELOA; elongin-A isoform X1	K15076 ELOA; elongin-A 
E        111163158 UBAP2; ubiquitin-associated protein 2 isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
E        111167192 UBAP2L; ubiquitin-associated protein 2-like isoform X9	K26545 UBAP2; ubiquitin-associated protein 2 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        111174786 MSH2; DNA mismatch repair protein Msh2	K08735 MSH2; DNA mismatch repair protein MSH2 
E        111184789 MSH3; DNA mismatch repair protein Msh3 isoform X2	K08736 MSH3; DNA mismatch repair protein MSH3 
E        111174785 MSH6; DNA mismatch repair protein Msh6 isoform X1	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        111171651 PMS1; PMS1 protein homolog 1 isoform X1	K10864 PMS1; DNA mismatch repair protein PMS1 
E        111164258 MLH1; DNA mismatch repair protein Mlh1 isoform X1	K08734 MLH1; DNA mismatch repair protein MLH1 
E        111181876 PMS2; mismatch repair endonuclease PMS2 isoform X1	K10858 PMS2; DNA mismatch repair protein PMS2 
E        111176244 MLH3; DNA mismatch repair protein Mlh3 isoform X1	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        111181058 POLD1; DNA polymerase delta catalytic subunit	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
E        111184511 POLD2; DNA polymerase delta subunit 2 isoform X1	K02328 POLD2; DNA polymerase delta subunit 2 
E        111184858 POLD3; DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
E        111183680 DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
E        111183682 POLD4; DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
D      RPA (replication factor A)
E        111185703 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        111163345 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        111181480 RPA3; replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
E        111178250 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit	K10741 RPA4; replication factor A4 
D      RFC (replication factor C)
E        111170556 RFC1; replication factor C subunit 1 isoform X1	K10754 RFC1; replication factor C subunit 1 
E        111172856 RFC4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
E        111182052 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
E        111175227 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
E        111186841 RFC5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        111165627 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        111177427 EXO1; exonuclease 1	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        111175202 HMGB1; high mobility group protein B1	K10802 HMGB1; high mobility group protein B1 
E        111180676 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        111181657 WDR76; WD repeat-containing protein 76 isoform X1	K24755 WDR76; WD repeat-containing protein 76 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        111167949 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        111182414 RAD50; DNA repair protein RAD50 isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        111180439 NBN; nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA1-core complex
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111171801 BARD1; BRCA1-associated RING domain protein 1 isoform X1	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111187550 ABRAXAS1; BRCA1-A complex subunit Abraxas 1	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        111169844 UIMC1; BRCA1-A complex subunit RAP80 isoform X1	K20775 UIMC1; BRCA1-A complex subunit RAP80 
E        111166715 BABAM1; BRISC and BRCA1-A complex member 1	K20776 BABAM; BRISC and BRCA1-A complex member 1 
E        111174934 BABAM2; BRISC and BRCA1-A complex member 2 isoform X1	K12173 BRE; BRCA1-A complex subunit BRE 
E        111170735 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111163684 BRIP1; Fanconi anemia group J protein	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        111179195 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111181461 RBBP8; DNA endonuclease RBBP8 isoform X1	K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] 
E        111167949 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        111182414 RAD50; DNA repair protein RAD50 isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        111180439 NBN; nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA complex
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111175212 BRCA2; breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        111182236 PALB2; partner and localizer of BRCA2 isoform X1	K10897 PALB2; partner and localizer of BRCA2 
E        111181740 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        111181740 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        111173034 RAD51B; DNA repair protein RAD51 homolog 2	K10869 RAD51L1; RAD51-like protein 1 
E        111163710 RAD51C; DNA repair protein RAD51 homolog 3 isoform X4	K10870 RAD51L2; RAD51-like protein 2 
E        111170831 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1	K10871 RAD51L3; RAD51-like protein 3 
E        111176543 XRCC2; DNA repair protein XRCC2	K10879 XRCC2; DNA-repair protein XRCC2 
E        111176036 XRCC3; DNA repair protein XRCC3	K10880 XRCC3; DNA-repair protein XRCC3 
D      Rad52 family proteins
E        111176606 RAD52; DNA repair protein RAD52 homolog isoform X1	K10873 RAD52; DNA repair and recombination protein RAD52 
E        115801779 RAD52 motif-containing protein 1-like	K10874 RDM1; RAD52 motif-containing protein 1 
E        111171271 RAD52 motif-containing protein 1-like	K10874 RDM1; RAD52 motif-containing protein 1 
E        111170851 LOW QUALITY PROTEIN: RAD52 motif-containing protein 1-like	K10874 RDM1; RAD52 motif-containing protein 1 
E        111170997 RAD52 motif-containing protein 1-like isoform X1	K10874 RDM1; RAD52 motif-containing protein 1 
D      Rad54 family proteins
E        111175765 RAD54L; DNA repair and recombination protein RAD54-like isoform X1	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        111174339 RAD54L2; helicase ARIP4	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
E        111180422 RAD54B; DNA repair and recombination protein RAD54B isoform X1	K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        111176831 RECQL; ATP-dependent DNA helicase Q1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        111173484 WRN; Werner syndrome ATP-dependent helicase isoform X1	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
E        111169650 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111165072 RECQL4; LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        111182821 RECQL5; ATP-dependent DNA helicase Q5 isoform X1	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        111169650 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111167706 TOP3A; DNA topoisomerase 3-alpha isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111162974 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111166800 RMI1; recQ-mediated genome instability protein 1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        111163485 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      RPA (replication factor A)
E        111185703 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        111163345 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
E        111181480 RPA3; replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
E        111178250 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit	K10741 RPA4; replication factor A4 
D      Protein phosphatase 4
E        111182179 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        111186807 ANKRD60; LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        111163026 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        111174183 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        111186518 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        111176153 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        111176125 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1	K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 
D      AP-5 complex
E        111183741 AP5B1; AP-5 complex subunit beta-1	K19022 AP5B1; AP-5 complex subunit beta-1 
E        111173122 AP5M1; AP-5 complex subunit mu-1 isoform X1	K19023 AP5M1; AP-5 complex subunit mu-1 
E        111184405 AP5S1; AP-5 complex subunit sigma-1	K19024 AP5S1; AP-5 complex subunit sigma-1 
E        111170352 AP5Z1; AP-5 complex subunit zeta-1 isoform X1	K19025 AP5Z1; AP-5 complex subunit zeta-1 
D      SMC5-SMC6 complex
E        111174610 SMC5; structural maintenance of chromosomes protein 5 isoform X1	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        111164440 SMC6; structural maintenance of chromosomes protein 6	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        111164488 LRATD1; protein LRATD1	K22805 FAM84A; protein FAM84A 
E        111182216 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X1	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        111164435 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        111164675 NSMCE3; non-structural maintenance of chromosomes element 3 homolog	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        111172238 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A isoform X1	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
E        111187914 EID3; EP300-interacting inhibitor of differentiation 3	K22826 EID3; EP300-interacting inhibitor of differentiation 3 
E        111184294 SLF1; SMC5-SMC6 complex localization factor protein 1	K26126 SLF1; SMC5-SMC6 complex localization factor protein 1 
E        111172385 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1	K26127 SLF2; SMC5-SMC6 complex localization factor protein 2 
D      Other HR factors
E        111166461 EME1; crossover junction endonuclease EME1 isoform X1	K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] 
E        111185153 EME2; probable crossover junction endonuclease EME2 isoform X3	K10883 EME2; crossover junction endonuclease EME2 
E        111173028 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        111183732 MUS81; crossover junction endonuclease MUS81 isoform X1	K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] 
E        111181329 SEM1; 26S proteasome complex subunit SEM1 isoform X1	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        111177174 SWI5; LOW QUALITY PROTEIN: DNA repair protein SWI5 homolog	K10991 SWI5; DNA repair protein Swi5/Sae3 
E        111172332 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1	K10992 SFR1; Swi5-dependent recombination DNA repair protein 1 
E        111182188 SLX1A; structure-specific endonuclease subunit SLX1	K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] 
E        111185245 SLX4; structure-specific endonuclease subunit SLX4 isoform X1	K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
E        111164441 GEN1; flap endonuclease GEN homolog 1	K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-] 
E        111181649 SPG11; spatacsin isoform X1	K19026 SPG11; spatacsin 
E        111173038 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        111176643 RAD51AP1; RAD51-associated protein 1 isoform X1	K20778 RAD51AP1; RAD51-associated protein 1 
E        111164746 MORF4L1; mortality factor 4-like protein 1 isoform X1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        111184208 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        111184556 FIGNL1; fidgetin-like protein 1	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        111165868 SPIDR; DNA repair-scaffolding protein isoform X1	K22806 SPIDR; DNA repair-scaffolding protein 
E        111164371 LRATD2; protein LRATD2 isoform X1	K22810 FAM84B; protein FAM84B 
E        111169358 BRAT1; BRCA1-associated ATM activator 1 isoform X1	K23112 BRAT1; BRCA1-associated ATM activator 1 
E        111186346 CFAP410; cilia- and flagella-associated protein 410 isoform X1	K23456 CFAP410; cilla- and flagella-associated protein 
E        111166069 HDGFL2; hepatoma-derived growth factor-related protein 2 isoform X1	K25065 HDGFL2; hepatoma-derived growth factor-related protein 2 
E        111167748 ZSWIM7; zinc finger SWIM domain-containing protein 7 isoform X1	K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7 
E        111166024 ATPase SWSAP1-like	K25771 SWSAP1; ATPase SWSAP1 
E        111165946 ATPase SWSAP1-like	K25771 SWSAP1; ATPase SWSAP1 
E        111184889 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X1	K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY 
E        111186321 HSF2BP; heat shock factor 2-binding protein isoform X1	K25791 HSF2BP; heat shock factor 2-binding protein 
E        111163817 MMS22L; protein MMS22-like	K26125 MMS22L; protein MMS22-like 
E        111165068 TONSL; tonsoku-like protein isoform X1	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
E        111171439 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1	K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 
E        111187892 PARPBP; PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        111186331 XRCC6; X-ray repair cross-complementing protein 6	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        111171807 XRCC5; X-ray repair cross-complementing protein 5	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
E        111165833 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      MRX complex
E        111167949 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        111182414 RAD50; DNA repair protein RAD50 isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
E        111176395 LIG4; DNA ligase 4	K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] 
E        111184639 XRCC4; DNA repair protein XRCC4 isoform X1	K10886 XRCC4; DNA-repair protein XRCC4 
E        111171840 NHEJ1; non-homologous end-joining factor 1 isoform X1	K10980 NHEJ1; non-homologous end-joining factor 1 
D      X-family DNA polymerases
E        111172374 POLL; DNA polymerase lambda	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        111184509 POLM; LOW QUALITY PROTEIN: DNA-directed DNA/RNA polymerase mu	K03513 POLM; DNA polymerase mu [EC:2.7.7.7] 
E        111172631 DNTT; DNA nucleotidylexotransferase isoform X1	K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31] 
E        111173554 POLB; DNA polymerase beta isoform X1	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
D      Other NHEJ factors
E        111163193 APTX; aprataxin isoform X2	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        111186508 APLF; aprataxin and PNK-like factor isoform X1	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        111178088 DCLRE1C; protein artemis isoform X1	K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] 
E        111168570 TDP2; tyrosyl-DNA phosphodiesterase 2 isoform X1	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
E        111163067 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1	K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 
E        111169542 PWWP3B; PWWP domain-containing DNA repair factor 3B	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        111170488 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X1	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        111177004 PAXX; protein PAXX isoform X1	K25772 PAXX; protein PAXX 
E        111178086 CYREN; cell cycle regulator of non-homologous end joining isoform X1	K26155 CYREN; cell cycle regulator of non-homologous end joining 
E        111185118 JMJD8; jmjC domain-containing protein 8 isoform X1	K25792 JMJD8; jumonji domain-containing protein 8 
E        111165614 SHLD1; shieldin complex subunit 1 isoform X1	K26128 SHLD1; shieldin complex subunit 1 
E        111168760 SHLD2; shieldin complex subunit 2 isoform X1	K26129 SHLD2; shieldin complex subunit 2 
E        115801637 SHLD3; shieldin complex subunit 3	K26130 SHLD3; shieldin complex subunit 3 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        111179358 FANCA; Fanconi anemia group A protein isoform X1	K10888 FANCA; fanconi anemia group A protein 
E        111168909 FANCB; Fanconi anemia group B protein isoform X1	K10889 FANCB; fanconi anemia group B protein 
E        111166834 FANCC; Fanconi anemia group C protein isoform X1	K10890 FANCC; fanconi anemia group C protein 
E        111178722 RPL10A; 60S ribosomal protein L10a isoform X1	K10892 FANCE; fanconi anemia group E protein 
E        111179831 FANCF; Fanconi anemia group F protein	K10893 FANCF; fanconi anemia group F protein 
E        111188118 FANCG; Fanconi anemia group G protein isoform X1	K10894 FANCG; fanconi anemia group G protein 
E        111186602 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
E        111173198 FANCM; Fanconi anemia group M protein isoform X1	K10896 FANCM; fanconi anemia group M protein 
E        111180939 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1	K10898 FAAP24; fanconi anemia-associated protein 
E        111182707 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1	K10993 FAAP100; fanconi anemia core complex 100 kDa subunit 
D      FA core complex binding factors
E        111172508 HES1; transcription factor HES-1	K06054 HES1; hairy and enhancer of split 1 
E        111187283 centromere protein S isoform X1	K11511 APITD1; centromere protein S 
E        111182683 CENPX; centromere protein X isoform X1	K15360 STRA13; centromere protein X 
E        111168350 UBE2T; ubiquitin-conjugating enzyme E2 T	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        111169650 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111167706 TOP3A; DNA topoisomerase 3-alpha isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111162974 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111166800 RMI1; recQ-mediated genome instability protein 1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        111163485 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      FANCD2-I complex
E        111169956 FANCD2; Fanconi anemia group D2 protein isoform X1	K10891 FANCD2; fanconi anemia group D2 protein 
E        111169689 FANCI; Fanconi anemia group I protein isoform X1	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        111166258 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        111175212 BRCA2; breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        111163684 BRIP1; Fanconi anemia group J protein	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        111182236 PALB2; partner and localizer of BRCA2 isoform X1	K10897 PALB2; partner and localizer of BRCA2 
D      Other FA pathway factors
E        111164758 FAN1; fanconi-associated nuclease 1 isoform X1	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        111181740 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        111163710 RAD51C; DNA repair protein RAD51 homolog 3 isoform X4	K10870 RAD51L2; RAD51-like protein 2 
E        111185144 TELO2; telomere length regulation protein TEL2 homolog	K11137 TELO2; telomere length regulation protein 
E        111178911 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1-like	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        111178475 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        111169461 WDR48; WD repeat-containing protein 48	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        111177219 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        111180972 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1	K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 
E        111186438 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1	K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 
E        111183644 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        111168184 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
E        111171688 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1	K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 
E        111173876 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C	K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 
D      Ubiquitin ligases
E        111178759 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X1	K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
E        111172210 RNF168; E3 ubiquitin-protein ligase RNF168 isoform X1	K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31] 
E        111184861 RNF169; E3 ubiquitin-protein ligase RNF169	K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31] 
E        111183327 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        111185754 WRAP53; telomerase Cajal body protein 1	K23314 WRAP53; telomerase Cajal body protein 1 
E        111176986 TPRN; taperin	K24164 TPRN; taperin 
E        111181947 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X2	K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1 
E        111187379 WDR70; WD repeat-containing protein 70 isoform X1	K24752 WDR70; WD repeat-containing protein 70 
E        111181657 WDR76; WD repeat-containing protein 76 isoform X1	K24755 WDR76; WD repeat-containing protein 76 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      111178859 POLH; DNA polymerase eta isoform X1	K03509 POLH; DNA polymerase eta [EC:2.7.7.7] 
D      111180248 POLI; DNA polymerase iota isoform X1	K03510 POLI; DNA polymerase iota [EC:2.7.7.7] 
D      111185272 POLK; DNA polymerase kappa	K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] 
D      111187524 REV1; DNA repair protein REV1 isoform X1	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
D      111164684 REV3L; DNA polymerase zeta catalytic subunit isoform X1	K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] 
C    A-family DNA polymerase
D      111164819 POLN; DNA polymerase nu	K16618 POLN; DNA polymerase nu [EC:2.7.7.7] 
C    Rad6 epistasis group
D      111169045 UBE2A; ubiquitin-conjugating enzyme E2 A	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      111182450 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1	K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] 
D      111169968 RAD18; E3 ubiquitin-protein ligase RAD18	K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
D      111179293 HLTF; helicase-like transcription factor isoform X1	K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27] 
D      111171742 ubiquitin-conjugating enzyme E2 variant 1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      111186631 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      111165804 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      111177777 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      111180459 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      111176111 ubiquitin-conjugating enzyme E2 N-like	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
D      111163581 UBE2N; ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      111165627 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      111187892 PARPBP; PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
D      111163922 SPRTN; sprT-like domain-containing protein Spartan isoform X1	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      111167801 GCNA; acidic repeat-containing protein	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      111183675 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      111186824 RAD9B; cell cycle checkpoint control protein RAD9B	K10995 RAD9B; cell cycle checkpoint control protein RAD9B 
D      111184564 HUS1; checkpoint protein HUS1	K10903 HUS1; HUS1 checkpoint protein 
D      111187680 RAD1; cell cycle checkpoint protein RAD1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      111185831 RAD17; cell cycle checkpoint protein RAD17 isoform X1	K06662 HRAD17; cell cycle checkpoint protein 
D      111172856 RFC4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
D      111182052 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      111175227 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
D      111186841 RFC5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      111187680 RAD1; cell cycle checkpoint protein RAD1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      111173868 TIMELESS; protein timeless homolog isoform X1	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      111177742 TIPIN; TIMELESS-interacting protein	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      111175571 CLSPN; claspin	K25773 CLSPN; claspin 
C    Triple T complex
D      111185144 TELO2; telomere length regulation protein TEL2 homolog	K11137 TELO2; telomere length regulation protein 
D      111184192 TTI1; TELO2-interacting protein 1 homolog isoform X1	K20403 TTI1; TELO2-interacting protein 1 
D      111173490 TTI2; TELO2-interacting protein 2	K23115 TTI2; TELO2-interacting protein 2 
C    BAG6-UBL4A-GET4 complex
D      111170728 BAG6; large proline-rich protein BAG6 isoform X1	K23390 BAG6; large proline-rich protein BAG6 
D      111170971 UBL4A; ubiquitin-like protein 4A isoform X1	K23388 UBL4; ubiquitin-like protein 4 
D      111179890 UBL4B; LOW QUALITY PROTEIN: ubiquitin-like protein 4B	K23388 UBL4; ubiquitin-like protein 4 
D      111169348 Golgi to ER traffic protein 4 homolog	K23387 GET4; golgi to ER traffic protein 4 
D      111169346 Golgi to ER traffic protein 4 homolog	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      111179265 ATR; serine/threonine-protein kinase ATR isoform X1	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      111174432 ATRIP; ATR-interacting protein isoform X1	K10905 ATRIP; ATR interacting protein 
D      111168050 ATM; serine-protein kinase ATM isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      111185755 TP53; cellular tumor antigen p53	K04451 TP53; tumor protein p53 
D      111167465 CHEK1; serine/threonine-protein kinase Chk1 isoform X1	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      111162720 CHEK2; serine/threonine-protein kinase Chk2	K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] 
D      111174440 CDC25A; M-phase inducer phosphatase 1 isoform X1	K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48] 
D      111184400 CDC25B; M-phase inducer phosphatase 2 isoform X1	K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] 
D      111182493 CDC25C; M-phase inducer phosphatase 3	K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48] 
D      111180376 YWHAZ; 14-3-3 protein zeta/delta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111184144 YWHAB; 14-3-3 protein beta/alpha isoform X1	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111164449 YWHAQ; 14-3-3 protein theta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111175442 14-3-3 protein gamma-like	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      111179149 14-3-3 protein gamma-like	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      111182017 YWHAG; 14-3-3 protein gamma	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      111162810 YWHAH; 14-3-3 protein eta	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      111185838 YWHAE; 14-3-3 protein epsilon	K06630 YWHAE; 14-3-3 protein epsilon 
D      111179843 NAV2; neuron navigator 2 isoform X1	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      111169208 wee1-like protein kinase	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      111177584 WEE2; wee1-like protein kinase 2	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      111165276 wee1-like protein kinase isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      111185783 PER1; period circadian protein homolog 1 isoform X1	K21944 PER1; period circadian protein 1 
D      111171985 PER2; period circadian protein homolog 2	K02633 PER2; period circadian protein 2 
D      111187052 PER3; period circadian protein homolog 3 isoform X1	K21945 PER3; period circadian protein 3 
D      111170665 MDC1; mediator of DNA damage checkpoint protein 1 isoform X1	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      111165749 PLS3; plastin-3 isoform X1	K17336 PLS3; plastin-3 
D      111169334 AEN; apoptosis-enhancing nuclease	K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-] 
D      111175730 PLK3; serine/threonine-protein kinase PLK3	K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21] 
D      111170522 PLK5; inactive serine/threonine-protein kinase PLK5	K19596 PLK5; inactive serine/threonine-protein kinase PLK5 
D      111175280 serine/threonine-protein kinase Nek5	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      111174295 NEK4; serine/threonine-protein kinase Nek4 isoform X1	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      111185341 NEK1; serine/threonine-protein kinase Nek1 isoform X1	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      111170108 NEK10; serine/threonine-protein kinase Nek10	K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1] 
D      111168188 NEK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek11	K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1] 
D      111163841 DONSON; protein downstream neighbor of Son isoform X1	K22422 DONSON; protein downstream neighbor of Son 
D      111166078 KANK2; KN motif and ankyrin repeat domain-containing protein 2 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      111174628 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      111178478 KANK4; KN motif and ankyrin repeat domain-containing protein 4	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      111166122 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      111172531 KLLN; LOW QUALITY PROTEIN: killin	K23389 KLLN; killin 
D      111170827 SLFN11; LOW QUALITY PROTEIN: schlafen family member 11	K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-] 
D      111164932 CHMP4C; charged multivesicular body protein 4c	K24782 CHMP4C; charged multivesicular body protein 4C 
D      111179582 VPS4A; vacuolar protein sorting-associated protein 4A isoform X1	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      111180197 VPS4B; vacuolar protein sorting-associated protein 4B	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      111181733 ZFYVE19; abscission/NoCut checkpoint regulator isoform X1	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      111177524 SDE2; replication stress response regulator SDE2 isoform X1	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      111169860 POLQ; DNA polymerase theta isoform X1	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      111185912 MYBBP1A; myb-binding protein 1A	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      111173399 PRIMPOL; DNA-directed primase/polymerase protein isoform X1	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      111174434 TREX1; three-prime repair exonuclease 1	K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2] 
D      111170595 TREX2; LOW QUALITY PROTEIN: three prime repair exonuclease 2	K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2] 
D      111172289 DCLRE1A; DNA cross-link repair 1A protein	K15340 DCLRE1A; DNA cross-link repair 1A protein 
D      111180007 DCLRE1B; 5' exonuclease Apollo isoform X1	K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-] 
D      111175652 EXO5; exonuclease V	K17815 EXO5; exonuclease V [EC:3.1.-.-] 
D      111182726 ENDOV; endonuclease V isoform X1	K21813 ENDOV; endonuclease V [EC:3.1.26.-] 
D      111172709 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      111166668 ANKLE1; ankyrin repeat and LEM domain-containing protein 1	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      111187549 HELQ; helicase POLQ-like isoform X1	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
D      111166849 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1	K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-] 
C    PSO4 complex
D      111183905 PRPF19; pre-mRNA-processing factor 19	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      111178879 CDC5L; cell division cycle 5-like protein	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      111179997 BCAS2; pre-mRNA-splicing factor SPF27	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      111187728 PLRG1; pleiotropic regulator 1 isoform X1	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      111175324 NUDT15; LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      111169384 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase	K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 
D      111168994 NUDT18; 8-oxo-dGDP phosphatase NUDT18	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      111181622 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      111170548 RRM1; ribonucleoside-diphosphate reductase large subunit	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      111180369 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
D      111164455 RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
D      115803136 LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      111172187 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
C    BER (base exicision repair)
D      DNA glycosylases
E        111162817 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        111173925 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        111185085 MPG; DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        111175742 MUTYH; adenine DNA glycosylase isoform X1	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        111185174 NTHL1; endonuclease III-like protein 1 isoform X1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
E        111177543 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1	K03111 ssb; single-strand DNA-binding protein 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
D      111177543 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1	K03111 ssb; single-strand DNA-binding protein 
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      111175324 NUDT15; LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      111181622 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
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#Last updated: March 29, 2024