+D Messenger RNA Biogenesis KO
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Prokaryotic Defense System - Escherichia coli K-12 BW2952
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ACRISPR-Cas system
B Universal Cas proteins
C BWG_2491 ygbT; conserved protein K15342 cas1; CRISP-associated protein Cas1
C BWG_2490 ygbF; predicted protein K09951 cas2; CRISPR-associated protein Cas2
B Type I CRISPR-Cas system
C Type I signiture cas proteins
D BWG_2497 ygcB; conserved protein, member of DEAD box family K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
C Subtype I-A factors
C Subtype I-B factors
C Subtype I-C factors
C Subtype I-D factors
C Subtype I-E factors
D BWG_2496 ygcL; predicted protein K19123 casA; CRISPR system Cascade subunit CasA
D BWG_2495 ygcK; predicted protein K19046 casB; CRISPR system Cascade subunit CasB
D BWG_2494 ygcJ; predicted protein K19124 casC; CRISPR system Cascade subunit CasC
D BWG_2493 ygcI; predicted protein K19125 casD; CRISPR system Cascade subunit CasD
D BWG_2492 ygcH; predicted protein K19126 casE; CRISPR system Cascade subunit CasE
C Subtype I-F factors
C Subtype I-U factors
B Type II CRISPR-Cas system
C Type II signiture cas proteins
C Subtype II-A factors
C Subtype II-B factors
B Type III CRISPR-Cas system
C Type III signiture cas proteins
C Subtype III-A factors
C Subtype III-B factors
C Subtype III-U factors
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ARestriction and modification system (R-M system)
B Type I R-M system
C BWG_4043 hsdR; endonuclease R K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C BWG_4041 hsdS; specificity determinant for hsdM and hsdR K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C BWG_4042 hsdM; DNA methylase M K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
B Type II R-M system
C Restriction endonucleases
C DNA methyltransferases
D BWG_3078 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D BWG_2961 yhdJ; predicted methyltransferase K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D BWG_1765 dcm; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
B Type III R-M system
B Type IV R-M system
C BWG_4039 mcrB; 5-methylcytosine-specific restriction enzyme McrBC, subunit McrB K07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]
C BWG_4038 mcrC; 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC K19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC
C BWG_4044 mrr; methylated adenine and cytosine restriction protein K07448 mrr; restriction system protein
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AToxin-antitoxin system (TA system)
B Type I TA system
C Hok-Sok
D BWG_3245 hokA; toxic polypeptide, small K18920 hokA; protein HokA
D BWG_1245 hokB; toxic polypeptide, small K18921 hokB; protein HokB
D BWG_0016 mokC; regulatory protein for HokC, overlaps CDS of hokC K18919 hokC_D; protein HokC/D
D BWG_1381 hokD; Qin prophage; small toxic polypeptide K18919 hokC_D; protein HokC/D
D BWG_4269 hokC; toxic membrane protein, small K18919 hokC_D; protein HokC/D
D BWG_0453 hokE; toxic polypeptide, small K18922 hokE; protein HokE
D BWG_4223 sokB; Antisense sRNA blocking mokB, and hence hokB, translation K18870 sokB; sRNA antisense regulator of MokB and HokB protein
D BWG_4208 sokC; Antisense sRNA blocking mokC, and hence hokC, translation; IS186A interrupts hokC transcript downstream of hokC gene in K-12 K18871 sokC; sRNA antisense regulator of MokC and HokC protein
C SymE-SymR
D BWG_4040 symE; conserved protein K19048 symE; toxic protein SymE
D BWG_4265 symR; sRNA destabilizing divergent and overlapping symE mRNA K18524 symR; sRNA antisense regulator of SymE protein
C Ldr-Rdl
D BWG_1041 ldrA; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D BWG_1042 ldrB; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D BWG_1043 ldrC; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D BWG_3227 ldrD; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D BWG_4217 rdlB; Antisense sRNA RdlB affects LdrB translation; proposed addiction module in LDR-B repeat, with toxic peptide LdrB K18863 rdlA_B_C_D; sRNA antisense regulator of LdrA/B/C/D protein
D BWG_4218 rdlC; Antisense sRNA RdlC affects LdrC translation; proposed addiction module in LDR-C repeat, with toxic peptide LdrC K18863 rdlA_B_C_D; sRNA antisense regulator of LdrA/B/C/D protein
D BWG_4216 rdlA; Antisense sRNA RdlA affects LdrA translation; proposed addiction module in LDR-A repeat, with toxic peptide LdrA K18863 rdlA_B_C_D; sRNA antisense regulator of LdrA/B/C/D protein
D BWG_4257 rdlD; Antisense sRNA RdlD affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD K18863 rdlA_B_C_D; sRNA antisense regulator of LdrA/B/C/D protein
C TisB-IstR
D BWG_3365 tisB; lexA-regulated toxic peptide K19148 tisB; small toxic protein TisB
D BWG_4258 istR; sRNAs IstR-1 and IstR-2, tisB regulators K18526 istR; sRNA antisense regulator of TisB protein
C Ibs-Sib
D BWG_4233 ryeC; Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown K18864 sibA; sRNA antisense regulator of IbsA protein
D BWG_4234 ryeD; Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes K18865 sibB; sRNA antisense regulator of IbsB protein
D BWG_4248 rygC; Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes K18867 sibC; sRNA antisense regulator of IbsC protein
D BWG_4249 rygD; Putative sRNA, function unknown; paralogous to the other QUAD sRNA genes K18868 sibD; sRNA antisense regulator of IbsD protein
D BWG_4250 rygE; Putative sRNA, function unknown; paralogous to the other QUAD sRNA genes K18869 sibE; sRNA antisense regulator of IbsE protein
C ShoB-OhsC
D BWG_4240 ryfC; Novel sRNA, function unknown K18872 ohsC; sRNA antisense regulator of ShoB protein
C RalR-RalA
D BWG_1182 lar; Rac prophage; restriction alleviation protein K19779 ralR; endodeoxyribonuclease RalR [EC:3.1.-.-]
D BWG_1181 ydaC; Rac prophage; predicted protein K19780 ralA; antisense regulator of RalR protein
B Type II TA system
C MazF-MazE
D BWG_2517 chpA; toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D BWG_2518 chpR; antitoxin of the ChpA-ChpR toxin-antitoxin system K07172 mazE; antitoxin MazE
C ChpB-ChpS
D BWG_3935 chpB; toxin of the ChpB-ChpS toxin-antitoxin system K18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]
D BWG_3934 chpS; antitoxin of the ChpB-ChpS toxin-antitoxin system K18842 chpS; antitoxin ChpS
C YhaV-PrlF
D BWG_2836 yhaV; conserved protein K19155 yhaV; toxin YhaV [EC:3.1.-.-]
D BWG_2835 sohA; predicted regulator K19156 prlF; antitoxin PrlF
C RelE/StbE-RelB/StbD
D BWG_1382 relE; Qin prophage; toxin of the RelE-RelB toxin-antitoxin system K06218 relE; mRNA interferase RelE/StbE
D BWG_1383 relB; Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor K18918 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB
C YafQ-dinJ
D BWG_0211 yafQ; predicted toxin of the YafQ-DinJ toxin-antitoxin system K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D BWG_0212 dinJ; predicted antitoxin of YafQ-DinJ toxin-antitoxin system K07473 dinJ; DNA-damage-inducible protein J
C YoeB-YefM
D BWG_1807 yoeB; toxin of the YoeB-YefM toxin-antitoxin system K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D BWG_1808 yefM; antitoxin of the YoeB-YefM toxin-antitoxin system K19159 yefM; antitoxin YefM
C HipA-HipB
D BWG_1326 hipA; regulator with hipB K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]
D BWG_1327 hipB; DNA-binding transcriptional regulator K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB
C HicA-HicB
D BWG_1262 yncN; predicted protein K07339 hicA; mRNA interferase HicA [EC:3.1.-.-]
D BWG_1263 ydcQ; predicted DNA-binding transcriptional regulator K18843 hicB; antitoxin HicB
C YafO-YafN
D BWG_0217 yafO; predicted toxin of the YafO-YafN toxin-antitoxin system K19160 yafO; mRNA interferase YafO [EC:3.1.-.-]
D BWG_0216 yafN; predicted antitoxin of the YafO-YafN toxin-antitoxin system K19161 yafN; antitoxin YafN
C Hha-TomB
D BWG_0341 hha; modulator of gene expression, with H-NS K05839 hha; haemolysin expression modulating protein
D BWG_0342 ybaJ; predicted protein K19162 tomB; hha toxicity modulator TomB
C PspC-PspB
D BWG_1138 pspC; DNA-binding transcriptional activator K03973 pspC; phage shock protein C
D BWG_1137 pspB; DNA-binding transcriptional regulator of psp operon K03970 pspB; phage shock protein B
C CcdB-CcdA
C ParE-ParD
C Doc-Phd
C HigB-HigA
D BWG_2793 ygjN; conserved protein K19166 higB; mRNA interferase HigB [EC:3.1.-.-]
D BWG_2792 ygjM; predicted DNA-binding transcriptional regulator K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D BWG_0364 ybaQ; predicted DNA-binding transcriptional regulator K21498 higA-1; antitoxin HigA-1
D BWG_1298 yddM; predicted DNA-binding transcriptional regulator K21498 higA-1; antitoxin HigA-1
C MqsR-MqsA
D BWG_2735 mqsR; predicted cyanide hydratase K13651 mqsR; motility quorum-sensing regulator / GCU-specific mRNA interferase toxin
D BWG_2734 ygiT; predicted DNA-binding transcriptional regulator K13655 mqsA; HTH-type transcriptional regulator / antitoxin MqsA
C VapC-VapB
C PezT-PezA
C YobL-YobK
C YokI-YokJ
C YqcG-YqcF
C YxiD-YxxD
C FitB-FitA
C BC_0920-BC_0921
C Type II TA system related factors
D BWG_3958 yjgK; conserved protein K19334 tabA; biofilm protein TabA
D BWG_0659 ybiM; predicted protein K13650 mcbA; MqsR-controlled colanic acid and biofilm protein A
D BWG_0908 bssS; predicted protein K12148 bssS; biofilm regulator BssS
D BWG_0689 bssR; conserved protein K19688 bssR; biofilm regulator BssR
D BWG_0960 bhsA; predicted protein K12151 bhsA; multiple stress resistance protein BhsA
D BWG_0090 ftsZ; GTP-binding tubulin-like cell division protein K03531 ftsZ; cell division protein FtsZ
D BWG_2951 mreB; cell wall structural complex MreBCD, actin-like component MreB K03569 mreB; rod shape-determining protein MreB and related proteins
D BWG_2732 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D BWG_2743 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D BWG_2165 gltX; glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
B Type III TA system
C AbiQ system
B Type IV TA system
C YeeV-YeeU
D BWG_1796 yeeV; CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D BWG_0226 ykfI; CP4-6 prophage; toxin of the YkfI-YafW toxin-antitoxin system K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D BWG_2400 ypjF; CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D BWG_1795 yeeU; CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
D BWG_0227 yafW; CP4-6 prophage; antitoxin of the YkfI-YafW toxin-antitoxin system K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
D BWG_2399 yfjZ; CP4-57 prophage; antitoxin of the YpjF-YfjZ toxin-antitoxin system K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
C CptA-CptB
D BWG_2621 ygfX; predicted protein K19168 cptA; toxin CptA
D BWG_2622 ygfY; conserved protein K09159 cptB; antitoxin CptB
B Type V TA system
C GhoT-GhoS
D BWG_3842 yjdO; predicted protein K18839 ghoT; toxin GhoT
D BWG_3841 yjdK; predicted protein K18840 ghoS; antitoxin GhoS
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ADNA phosphothiolation system
B Sulfur modification proteins
C BWG_2294 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
B DNA phosphorothioation-dependent restriction proteins
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 7, 2023