+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Encephalitozoon hellem
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E EHEL_100390 mRNA capping enzyme K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E EHEL_021380 serine/threonine kinase K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E EHEL_090390 mRNA capping enzyme subunit alpha K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
D Cap binding complex
E EHEL_030660 RNA-binding protein K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
D Pre-mRNA cleavage factor IIm (CFIIm)
E EHEL_051230 pre-mRNA cleavage GTPase subunit K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
D Cleavage and polyadenylation specificity factor (CPSF) complex
E EHEL_110480 pre-mRNA cleavage and polyadenylation specificity factor K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1
E EHEL_050430 beta-CASP domain-containing protein K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E EHEL_100910 putative RNA-processing beta-lactamase-fold exonuclease K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E EHEL_010290 cleavage and polyadenylation specificity factor subunit Clipper K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E EHEL_101530 putative zinc finger protein K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E EHEL_111280 polyadenylation factor I complex subunit FIP1-like protein K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E EHEL_090320 DWNN ubiquitin-like domain-containing protein K15541 MPE1; protein MPE1
E EHEL_021330 hypothetical protein K15542 PFS2; polyadenylation factor subunit 2
E EHEL_041550 hypothetical protein K14962 WDR82; COMPASS component SWD2
E EHEL_110540 PP1 serine/threonine phosphatase K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E EHEL_060780 Ssu72-like RNA polymerase II-interacting protein K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E EHEL_080300 RNA binding protein K14407 CSTF2; cleavage stimulation factor subunit 2
E EHEL_020850 Suf domain-containing protein K14408 CSTF3; cleavage stimulation factor subunit 3
E EHEL_060720 symplekin domain-containing protein K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E EHEL_080470 Sm-like protein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E EHEL_030740 small nuclear ribonucleoprotein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E EHEL_020940 LSM domain-containing protein K11097 SNRPE; small nuclear ribonucleoprotein E
E EHEL_040700 Sm-like ribonucleoprotein K11098 SNRPF; small nuclear ribonucleoprotein F
E EHEL_051010 small nuclear ribonucleoprotein K11099 SNRPG; small nuclear ribonucleoprotein G
E EHEL_050430 beta-CASP domain-containing protein K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E EHEL_100910 putative RNA-processing beta-lactamase-fold exonuclease K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E EHEL_080300 RNA binding protein K14407 CSTF2; cleavage stimulation factor subunit 2
E EHEL_060720 symplekin domain-containing protein K06100 SYMPK; symplekin
D DRB sensitivity inducing factor (DSIF) complex
E EHEL_081630 transcription elongation factor SPT4 K15171 SUPT4H1; transcription elongation factor SPT4
E EHEL_111820 SPT5-like transcription initiation protein K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
D Poly(A) addition factors
E EHEL_020650 poly(A) polymerase K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
D TREX complex
D TREX-2 complex
D Nuclear pore complex
E EHEL_061540 hypothetical protein K14298 RAE1; mRNA export factor
E EHEL_111340 hypothetical protein K14004 SEC13; protein transport protein SEC13
E EHEL_111710 hypothetical protein K14306 NUP62; nuclear pore complex protein Nup62
E EHEL_020380 nucleoporin autopeptidase domain-containing protein K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E EHEL_060420 nuclear pore complex subunit Nup170 K14312 NUP155; nuclear pore complex protein Nup155
D Ran-mediated transport factors
E EHEL_041530 GTP-binding nuclear protein K07936 RAN; GTP-binding nuclear protein Ran
E EHEL_011130 AAA+ ATPase K13525 VCP; transitional endoplasmic reticulum ATPase
E EHEL_110120 putative exportin 1 K14290 XPO1; exportin-1
E EHEL_050700 Ran GTPase-activating protein K14319 RANGAP1; Ran GTPase-activating protein 1
D eIF4F and regulatory proteins
E EHEL_111240 translation initiation factor K03259 EIF4E; translation initiation factor 4E
E EHEL_080860 translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E EHEL_091490 ATP-dependent RNA helicase K03257 EIF4A; translation initiation factor 4A
E EHEL_041580 hypothetical protein K03260 EIF4G; translation initiation factor 4G
E EHEL_101120 polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E EHEL_070300 U2 snRNP/pre-mRNA association factor K13126 PABPC; polyadenylate-binding protein
D APOBEC1-ACF complex
D Other transport factors
E EHEL_031300 PelA-like RNA-binding protein K06965 PELO; protein pelota
E EHEL_010400 putative RNA-binding protein K14396 PABPN1; polyadenylate-binding protein 2
E EHEL_021460 putative DEAD-box helicase K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E EHEL_041470 regulator of chromosome condensation domain-containing protein K11493 RCC1; regulator of chromosome condensation
E EHEL_060210 hypothetical protein K22415 ZC3H11; zinc finger CCCH domain-containing protein 11
C Surveillance factors
D Surveillance complex
E EHEL_050400 eukaryotic peptide chain release factor subunit 1 K03265 ETF1; peptide chain release factor subunit 1
E EHEL_061420 translation elongation factor EF-1 alpha K03267 ERF3; peptide chain release factor subunit 3
D Protein phosphatase 2A
E EHEL_040600 PP2A-like phosphoprotein phosphatase K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E EHEL_091170 hypothetical protein K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E EHEL_050890 serine/threonine protein phosphatase 2A-like protein K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E EHEL_040140 protein phosphatase 2A K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
C Factors involved in mRNA localization
D Cargo complex
E EHEL_092020 myosin heavy chain K10357 MYO5; myosin V
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E EHEL_041030 translation elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
D Other mRNA localization factors
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E EHEL_111240 translation initiation factor K03259 EIF4E; translation initiation factor 4E
E EHEL_080860 translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E EHEL_091650 ATP-dependent RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
D P-body specific factors
E EHEL_071610 mRNA decapping enzyme 2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E EHEL_051430 LSM domain-containing protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E EHEL_091840 small nuclear ribonucleoprotein K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E EHEL_030270 U6 snRNA associated Sm-like protein K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E EHEL_080050 putative small nuclear ribonucleoprotein K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E EHEL_061080 small nuclear ribonucleoprotein K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E EHEL_110510 hypothetical protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E EHEL_092020 myosin heavy chain K10357 MYO5; myosin V
E EHEL_071170 alpha tubulin K07374 TUBA; tubulin alpha
E EHEL_111260 negative regulator of transcription cell division control protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E EHEL_010920 general negative regulator of transcription K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E EHEL_110650 putative mRNA deadenylase K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E EHEL_080810 mRNA deadenylase subunit K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E EHEL_071730 RNA polymerase II subunit 7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
D Stress granule specific factors
E EHEL_101120 polyadenylate-binding protein K13126 PABPC; polyadenylate-binding protein
E EHEL_070300 U2 snRNP/pre-mRNA association factor K13126 PABPC; polyadenylate-binding protein
E EHEL_110550 eukaryotic translation initiation factor eIF2A K15026 EIF2A; translation initiation factor 2A
E EHEL_091490 ATP-dependent RNA helicase K03257 EIF4A; translation initiation factor 4A
E EHEL_041580 hypothetical protein K03260 EIF4G; translation initiation factor 4G
E EHEL_081100 WD40 domain-containing protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E EHEL_071610 mRNA decapping enzyme 2 K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E EHEL_091650 ATP-dependent RNA helicase K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
D Lsm complex
E EHEL_051430 LSM domain-containing protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E EHEL_091840 small nuclear ribonucleoprotein K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E EHEL_030270 U6 snRNA associated Sm-like protein K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E EHEL_080050 putative small nuclear ribonucleoprotein K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E EHEL_061080 small nuclear ribonucleoprotein K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E EHEL_110510 hypothetical protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
D 5' exonucleases
D Other 5'-3' decay factors
E EHEL_101750 hypothetical protein K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C 3'-5' decay
D Core exosome factors
E EHEL_101360 Rrp4-like RNA-binding protein K03679 RRP4; exosome complex component RRP4
E EHEL_091450 RNA-binding protein K03681 RRP40; exosome complex component RRP40
E EHEL_090800 ribonuclease K11600 RRP41; exosome complex component RRP41
E EHEL_100260 RNase PH-like protein K12590 RRP46; exosome complex component RRP46
E EHEL_111950 hypothetical protein K12586 RRP43; exosome complex component RRP43
E EHEL_060320 RNase PH-like exoribonuclease K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E EHEL_111020 hypothetical protein K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E EHEL_051040 putative superfamily II RNA helicase K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E EHEL_061510 DNA polymerase sigma K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E EHEL_110530 zinc knuckle domain-containing protein K12597 AIR1_2; protein AIR1/2
E EHEL_040820 superfamily II RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
D Ccr4-NOT complex
E EHEL_110650 putative mRNA deadenylase K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E EHEL_111260 negative regulator of transcription cell division control protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E EHEL_010920 general negative regulator of transcription K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E EHEL_080810 mRNA deadenylase subunit K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E EHEL_010230 cell differentiation protein Rcd1 K12606 RCD1; CCR4-NOT transcription complex subunit 9
D Pan complex
D Other 3'-5' decay factors
E EHEL_101750 hypothetical protein K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C Other degradation factors
D RNases
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AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
D Helicases
D Other RNA degradosome components
E EHEL_101720 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E EHEL_030590 ATP-dependent 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E EHEL_110410 HSP70-like protein K04043 dnaK; molecular chaperone DnaK
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E EHEL_101360 Rrp4-like RNA-binding protein K03679 RRP4; exosome complex component RRP4
D Cofactors
E EHEL_090800 ribonuclease K11600 RRP41; exosome complex component RRP41
D Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024