+D Messenger RNA Biogenesis KO
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Prokaryotic Defense System - Escherichia coli O157:H7 TW14359 (EHEC)
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ACRISPR-Cas system
B Universal Cas proteins
C ECSP_3703 ygbT; conserved protein K15342 cas1; CRISP-associated protein Cas1
C ECSP_3702 ygbF; predicted protein K09951 cas2; CRISPR-associated protein Cas2
B Type I CRISPR-Cas system
C Type I signiture cas proteins
D ECSP_3709 ygcB; predicted helicase K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
C Subtype I-A factors
C Subtype I-B factors
C Subtype I-C factors
C Subtype I-D factors
C Subtype I-E factors
D ECSP_3708 hypothetical protein K19123 casA; CRISPR system Cascade subunit CasA
D ECSP_3707 predicted protein K19046 casB; CRISPR system Cascade subunit CasB
D ECSP_3706 predicted protein K19124 casC; CRISPR system Cascade subunit CasC
D ECSP_3705 hypothetical protein K19125 casD; CRISPR system Cascade subunit CasD
D ECSP_3704 hypothetical protein K19126 casE; CRISPR system Cascade subunit CasE
C Subtype I-F factors
C Subtype I-U factors
B Type II CRISPR-Cas system
C Type II signiture cas proteins
C Subtype II-A factors
C Subtype II-B factors
B Type III CRISPR-Cas system
C Type III signiture cas proteins
C Subtype III-A factors
C Subtype III-B factors
C Subtype III-U factors
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ARestriction and modification system (R-M system)
B Type I R-M system
C ECSP_5432 putative restriction modification enzyme R subunit (endonuclease) K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C ECSP_5430 putative restriction modification enzyme S subunit K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C ECSP_5431 putative restriction modification enzyme M subunit (methylase) K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
B Type II R-M system
C Restriction endonucleases
C DNA methyltransferases
D ECSP_4336 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D ECSP_4231 yhdJ; predicted methyltransferase K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D ECSP_1671 putative DNA adenine methyltransferase encoded by prophage CP-933O K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D ECSP_1742 DNA methylase K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D ECSP_6044 hypothetical protein K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D ECSP_2565 dcm; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
B Type III R-M system
B Type IV R-M system
C ECSP_1458 HNH endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
C ECSP_2108 HNH endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
C ECSP_2712 restriction endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
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AToxin-antitoxin system (TA system)
B Type I TA system
C Hok-Sok
D ECSP_1260 predicted protein K18920 hokA; protein HokA
D ECSP_4553 hokA; toxic polypeptide, small K18920 hokA; protein HokA
D ECSP_6064 flmA; small toxic polypeptide K18921 hokB; protein HokB
D ECSP_0016 mokC; regulatory peptide K18919 hokC_D; protein HokC/D
D ECSP_1097 putative cell killing protein encoded within cryptic prophage CP-933M K18919 hokC_D; protein HokC/D
D ECSP_1442 putative Gef-like protein encoded by prophage CP-933N K18919 hokC_D; protein HokC/D
D ECSP_1664 putative killer protein encoded by prophage CP-933O K18919 hokC_D; protein HokC/D
D ECSP_2125 mokP; putative cell killing protein encoded within cryptic prophage CP-933P K18919 hokC_D; protein HokC/D
D ECSP_0635 hokE; toxic polypeptide, small K18922 hokE; protein HokE
D ECSP_0634 predicted protein K18922 hokE; protein HokE
D ECSP_3710 predicted protein K18922 hokE; protein HokE
C SymE-SymR
D ECSP_5429 yjiW; conserved protein K19048 symE; toxic protein SymE
C Ldr-Rdl
D ECSP_1606 ldrA; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D ECSP_1607 ldrB; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D ECSP_4529 ldrD; toxic polypeptide, small K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
C TisB-IstR
C Ibs-Sib
C ShoB-OhsC
C RalR-RalA
D ECSP_2735 hypothetical protein K19779 ralR; endodeoxyribonuclease RalR [EC:3.1.-.-]
B Type II TA system
C MazF-MazE
D ECSP_3734 chpA; toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D ECSP_3735 chpR; antitoxin of the ChpA-ChpR toxin-antitoxin system K07172 mazE; antitoxin MazE
C ChpB-ChpS
D ECSP_5326 chpB; toxin of the ChpB-ChpS toxin-antitoxin system K18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]
D ECSP_5325 chpS; antitoxin of the ChpB-ChpS toxin-antitoxin system K18842 chpS; antitoxin ChpS
C YhaV-PrlF
D ECSP_4101 yhaV; conserved protein K19155 yhaV; toxin YhaV [EC:3.1.-.-]
D ECSP_4100 sohA; predicted regulator K19156 prlF; antitoxin PrlF
C RelE/StbE-RelB/StbD
C YafQ-dinJ
D ECSP_0257 hypothetical protein K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D ECSP_0258 dinJ; predicted antitoxin of YafQ-DinJ toxin-antitoxin system K07473 dinJ; DNA-damage-inducible protein J
C YoeB-YefM
C HipA-HipB
D ECSP_1994 hipA; regulator with hipB K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]
C HicA-HicB
D ECSP_1917 yncN; predicted protein K07339 hicA; mRNA interferase HicA [EC:3.1.-.-]
D ECSP_1918 ydcQ; predicted DNA-binding transcriptional regulator K18843 hicB; antitoxin HicB
C YafO-YafN
D ECSP_0267 yafO; predicted toxin of the YafO-YafN toxin-antitoxin system K19160 yafO; mRNA interferase YafO [EC:3.1.-.-]
D ECSP_0266 yafN; predicted antitoxin of the YafO-YafN toxin-antitoxin system K19161 yafN; antitoxin YafN
C Hha-TomB
D ECSP_0527 hha; hemolysin expression modulating protein K05839 hha; haemolysin expression modulating protein
D ECSP_6079 hemolysin expression-modulating protein K05839 hha; haemolysin expression modulating protein
D ECSP_0528 ybaJ; predicted protein K19162 tomB; hha toxicity modulator TomB
C PspC-PspB
D ECSP_1831 pspC; psp operon regulatory protein K03973 pspC; phage shock protein C
D ECSP_1830 pspB; psp operon regulatory protein K03970 pspB; phage shock protein B
C CcdB-CcdA
D ECSP_6035 ccdB; plasmid maintenance protein K19163 ccdB; toxin CcdB
D ECSP_0053 putative toxin of gyrase inhibiting toxin-antitoxin system K19163 ccdB; toxin CcdB
D ECSP_6032 ccdA; plasmid maintenance protein K19164 ccdA; antitoxin CcdA
D ECSP_0052 putative antitoxin of gyrase inhibiting toxin-antitoxin system K19164 ccdA; antitoxin CcdA
C ParE-ParD
D ECSP_0476 hypothetical protein K19092 parE1_3_4; toxin ParE1/3/4
D ECSP_1086 hypothetical protein K19092 parE1_3_4; toxin ParE1/3/4
D ECSP_2135 plasmid stabilization system protein K19092 parE1_3_4; toxin ParE1/3/4
D ECSP_0475 hypothetical protein K07746 parD1_3_4; antitoxin ParD1/3/4
C Doc-Phd
C HigB-HigA
D ECSP_4057 ygjN; conserved protein K19166 higB; mRNA interferase HigB [EC:3.1.-.-]
D ECSP_4056 ygjM; predicted DNA-binding transcriptional regulator K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D ECSP_0550 ybaQ; predicted DNA-binding transcriptional regulator K21498 higA-1; antitoxin HigA-1
D ECSP_1961 yddM; predicted DNA-binding transcriptional regulator K21498 higA-1; antitoxin HigA-1
C MqsR-MqsA
C VapC-VapB
C PezT-PezA
C YobL-YobK
C YokI-YokJ
C YqcG-YqcF
C YxiD-YxxD
C FitB-FitA
D ECSP_1473 hypothetical protein K21495 fitA; antitoxin FitA
C BC_0920-BC_0921
C Type II TA system related factors
D ECSP_5353 yjgK; conserved protein K19334 tabA; biofilm protein TabA
D ECSP_0903 ybiM; predicted protein K13650 mcbA; MqsR-controlled colanic acid and biofilm protein A
D ECSP_1361 bssS; regulator of biofilm formation K12148 bssS; biofilm regulator BssS
D ECSP_0936 putative receptor K19688 bssR; biofilm regulator BssR
D ECSP_1414 ycfR; predicted protein K12151 bhsA; multiple stress resistance protein BhsA
D ECSP_0098 ftsZ; GTP-binding tubulin-like cell division protein K03531 ftsZ; cell division protein FtsZ
D ECSP_4219 mreB; cell wall structural complex MreBCD, actin-like component MreB K03569 mreB; rod shape-determining protein MreB and related proteins
D ECSP_3995 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D ECSP_4009 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D ECSP_3350 gltX; glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
B Type III TA system
C AbiQ system
B Type IV TA system
C YeeV-YeeU
D ECSP_4656 hypothetical protein K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D ECSP_2676 yeeV; CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D ECSP_1329 hypothetical protein K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D ECSP_2675 yeeU; CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
D ECSP_1328 putative structural protein K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
C CptA-CptB
D ECSP_3864 ygfX; predicted protein K19168 cptA; toxin CptA
D ECSP_3865 ygfY; conserved protein K09159 cptB; antitoxin CptB
B Type V TA system
C GhoT-GhoS
D ECSP_5228 yjdO; predicted protein K18839 ghoT; toxin GhoT
D ECSP_5227 yjdK; predicted protein K18840 ghoS; antitoxin GhoS
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ADNA phosphothiolation system
B Sulfur modification proteins
C ECSP_3474 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
B DNA phosphorothioation-dependent restriction proteins
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 7, 2023