+F Repair protein KO
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DNA Repair and Recombination Proteins - Geobacter sulfurreducens PCA
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D GSU1173 ogt; methylated DNA--protein cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D GSU2829 deoxyribodipyrimidine photolyase, putative K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E GSU1613 endonuclease III family protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E GSU1450 endonuclease III-related DNA glycosidase, HhH-GPD superfamily K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D GSU0870 NUDIX hydrolase, MutT family K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU0154 NUDIX hydrolase, type 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU2015 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU1595 dut; deoxyuridine-5'-triphosphate pyrophosphohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D GSU1173 ogt; methylated DNA--protein cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D GSU2829 deoxyribodipyrimidine photolyase, putative K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E GSU1126 uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E GSU1613 endonuclease III family protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E GSU0567 tag; 3-methyladenine-DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E GSU0997 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E GSU1450 endonuclease III-related DNA glycosidase, HhH-GPD superfamily K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E GSU1539 xth; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E GSU0529 nfo; endodeoxyribonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E GSU2614 recJ; single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E GSU0890 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E GSU0541 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E GSU3325 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E GSU2758 excinuclease ABC family protein K03701 uvrA; excinuclease ABC subunit A
E GSU3262 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E GSU3279 uvrC; excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E GSU3411 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E GSU0541 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E GSU0890 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F GSU2863 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F GSU2862 rpoC; DNA-directed RNA polymerase, beta-prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F GSU2831 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F GSU2237 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F GSU0017 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E GSU1822 mutS-1; DNA mismatch repair ATPase MutS-1 K03555 mutS; DNA mismatch repair protein MutS
E GSU0547 mutS-2; DNA mismatch repair ATPase MutS-2 K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E GSU2001 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E GSU1767 xseA; exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E GSU1766 xseB; exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E GSU1401 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E GSU0001 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E GSU2207 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E GSU2230 holB; DNA polymerase III, delta-prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E GSU1383 3'-to-5' exonuclease, putative K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E GSU0094 dnaX; DNA polymerase III, gamma and tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E GSU0890 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E GSU3411 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E GSU3117 ssb-2; single-strand-binding protein K03111 ssb; single-strand DNA-binding protein
E GSU2151 ssb-1; single-strand-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E GSU1534 recB; exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E GSU1533 recC; exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E GSU1535 recD; exodeoxyribonuclease V, alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E GSU0145 recA; recombinase A K03553 recA; recombination protein RecA
E GSU1076 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E GSU1077 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E GSU1075 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E GSU0128 priA; primosomal protein N', ATP-dependent helicase K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E GSU1724 sbcD-2; DNA repair exonuclease SbcCD, D subunit, putative K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E GSU0145 recA; recombinase A K03553 recA; recombination protein RecA
E GSU0285 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E GSU0002 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E GSU1326 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E GSU2614 recJ; single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E GSU0577 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E GSU0096 recR; recombination protein RecR K06187 recR; recombination protein RecR
E GSU2064 recN; DNA repair ATPase RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E GSU0133 hypothetical protein K03554 rdgC; recombination associated protein RdgC
E GSU1076 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E GSU1077 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E GSU1075 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E GSU0057 cas1-1_cas4; CRISPR-associated exonuclease Cas4 and endodeoxyribonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
E GSU1392 cas1-2; CRISPR-associated endodeoxyribonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E GSU1724 sbcD-2; DNA repair exonuclease SbcCD, D subunit, putative K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F GSU0004 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F GSU0003 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F GSU2549 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F GSU3132 hup; histone-like protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F GSU2614 recJ; single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F GSU0577 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F GSU0096 recR; recombination protein RecR K06187 recR; recombination protein RecR
F GSU0890 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F GSU1521 ihfA-1; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F GSU2120 ihfA-2; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F GSU2602 ihfB-2; integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
F GSU1746 ihfB-1; integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F GSU0898 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F GSU3325 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F GSU2758 excinuclease ABC family protein K03701 uvrA; excinuclease ABC subunit A
F GSU3262 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D GSU1616 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D GSU0043 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D GSU0145 recA; recombinase A K03553 recA; recombination protein RecA
D GSU0041 lexA-1; transcriptional repressor, LexA family K01356 lexA; repressor LexA [EC:3.4.21.88]
D GSU1617 lexA-2; transcriptional repressor, LexA family K01356 lexA; repressor LexA [EC:3.4.21.88]
D GSU2064 recN; DNA repair ATPase RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D GSU3117 ssb-2; single-strand-binding protein K03111 ssb; single-strand DNA-binding protein
D GSU2151 ssb-1; single-strand-binding protein K03111 ssb; single-strand DNA-binding protein
D GSU0147 recX; recombination regulator RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D GSU0363 dinG; ATP-dependent DNA helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D GSU0870 NUDIX hydrolase, MutT family K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU0154 NUDIX hydrolase, type 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU2015 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D GSU1595 dut; deoxyuridine-5'-triphosphate pyrophosphohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D GSU1871 nrdJ; ribonucleoside diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
D GSU1590 phosphoesterase, putative K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024