+C Two-component system KO
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Two-Component System - Hahella chejuensis
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C HCH_00770 Signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C HCH_00947 Signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C HCH_00771 phoB; Phosphate regulon transcriptional regulatory protein phoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C HCH_06409 Signal transduction histidine kinase K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C HCH_06410 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C HCH_01436 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C HCH_01758 Signal transduction histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C HCH_04119 Signal transduction histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C HCH_06042 Signal transduction histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C HCH_06918 Signal transduction histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C HCH_01757 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07661 rstA; two-component system, OmpR family, response regulator RstA
C HCH_04118 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07661 rstA; two-component system, OmpR family, response regulator RstA
C HCH_06917 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
C HCH_00065 Signal transduction histidine kinase K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C HCH_00064 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C HCH_03612 Signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C HCH_03613 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C HCH_06619 Signal transduction histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C HCH_06618 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C HCH_02554 Osmosensitive K+ channel histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C HCH_02462 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C HCH_01636 Signal transduction histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C HCH_01637 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
C HCH_04354 Signal transduction histidine kinase K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C HCH_00209 Signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HCH_06043 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
C HCH_06085 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
C HCH_04353 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
C HCH_01849 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
C HCH_00579 Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C HCH_04013 Signal transduction histidine kinase, nitrate/nitrite-specific K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C HCH_00419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C HCH_04021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C HCH_01804 Signal transduction histidine kinase K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C HCH_04041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C HCH_00418 Signal transduction histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C HCH_00293 predicted signal transduction protein with a C-terminal ATPase domain K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C HCH_00292 algR; alginate biosynthesis regulatory protein AlgR-like protein K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C HCH_01034 Signal transduction histidine kinase, nitrogen specific K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C HCH_01033 ntrC; nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
C HCH_04233 sigma 54-dependent transcriptional activator K07714 atoC; two-component system, NtrC family, response regulator AtoC
C HCH_00696 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
C HCH_05924 Signal transduction histidine kinase K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C HCH_05925 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
C HCH_01429 Signal transduction histidine kinase K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C HCH_06659 Signal transduction histidine kinase K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C HCH_01427 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K07715 glrR; two-component system, NtrC family, response regulator GlrR
C HCH_06661 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C HCH_00325 Signal transduction histidine kinase regulating C4-dicarboxylate transport system K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C HCH_00924 Signal transduction histidine kinase regulating C4-dicarboxylate transport system K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C HCH_00326 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C HCH_00925 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C HCH_00674 Signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C HCH_00230 Signal transduction histidine kinase regulating C4-dicarboxylate transport system K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C HCH_04025 Signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C HCH_04028 Signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C HCH_00455 Chemotaxis protein histidine kinase and related kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C HCH_03709 Chemotaxis protein histidine kinase and related kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C HCH_03847 Chemotaxis protein histidine kinase and related kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C HCH_05168 Chemotaxis protein histidine kinase and related kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C HCH_03711 FOG: CheY-like receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HCH_00454 FOG: CheY-like receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HCH_05170 FOG: CheY-like receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HCH_00672 FOG: CheY-like receiver K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HCH_00463 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C HCH_03703 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C HCH_03846 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C HCH_05166 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C HCH_04719 Chemotaxis signal transduction protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C HCH_04764 Chemotaxis signal transduction protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C HCH_00541 Chemotaxis protein histidine kinase and related kinase K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C HCH_00546 FOG: CheY-like receiver K02657 pilG; twitching motility two-component system response regulator PilG
C HCH_00545 FOG: CheY-like receiver K02658 pilH; twitching motility two-component system response regulator PilH
C HCH_05828 Response regulator containing a CheY-like receiver domain and a GGDEF domain K02658 pilH; twitching motility two-component system response regulator PilH
C HCH_00540 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
C HCH_04264 FOG: CheY-like receiver K11443 divK; two-component system, cell cycle response regulator DivK
C HCH_04265 FOG: CheY-like receiver K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C HCH_05218 Signal transduction histidine kinase K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3]
C HCH_05150 Response regulator K14987 fixJ; two-component system, LuxR family, response regulator FixJ
C HCH_05220 Response regulator K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C HCH_05197 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C HCH_05196 sigma 54-dependent transcriptional activator containing CheY-like receiver domain K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C HCH_01390 Signal transduction histidine kinase K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C HCH_01391 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C HCH_02306 Signal transduction histidine kinase K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C HCH_03924 Signal transduction histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C HCH_03646 Signal transduction histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C HCH_00305 Signal transduction histidine kinase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C HCH_05088 Signal transduction histidine kinase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C HCH_05549 Signal transduction histidine kinase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C HCH_05184 FOG: HPt domain K20976 hptB; histidine phosphotransfer protein HptB
C HCH_05185 Response regulator containing a CheY-like receiver domain and a GGDEF domain K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
C HCH_00451 Serine phosphatase RsbU, regulator of sigma subunit K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C HCH_03701 Signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C HCH_00794 FOG: PAS/PAC domain K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C HCH_00809 Signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C HCH_00861 Signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C HCH_04933 Signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023