+D GENES KO
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KEGG Orthology (KO) - Candidatus Hamiltonella defensa (Acyrthosiphon pisum)
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A09100 Metabolism
B
B 09101 Carbohydrate metabolism
C 00010 Glycolysis / Gluconeogenesis [PATH:hde00010]
D HDEF_0049 pgi; glucosephosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_1539 fbaA; fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D HDEF_0053 tpiA; triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D HDEF_0023 gapA; glyceraldehyde-3-phosphate dehydrogenase A K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D HDEF_1540 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D HDEF_0267 gpmA; phosphoglyceromutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D HDEF_0803 pykF; pyruvate kinase I (formerly F), fructose-stimulated K00873 PK; pyruvate kinase [EC:2.7.1.40]
D HDEF_2044 aceE; pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding K00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]
D HDEF_2043 aceF; pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_0382 pckA; phosphoenolpyruvate carboxykinase K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
D HDEF_0322 crr; PTS family enzyme IIA component K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
D HDEF_0454 ptsG; PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal), glucose-specific K02779 ptsG; glucose PTS system EIICB or EIICBA component [EC:2.7.1.199]
C 00020 Citrate cycle (TCA cycle) [PATH:hde00020]
D HDEF_1882 gltA; citrate synthase K01647 CS; citrate synthase [EC:2.3.3.1]
D HDEF_1307 acnA; aconitate hydratase 1 K01681 ACO; aconitate hydratase [EC:4.2.1.3]
D HDEF_2304 icdA; isocitrate dehydrogenase, specific for NADP+ K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]
D HDEF_1887 sucA; 2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex, thiamin-binding K00164 OGDH; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
D HDEF_1888 sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_1890 sucD; succinyl-CoA synthetase, alpha subunit, NAD(P)-binding K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
D HDEF_1889 sucC; succinyl-CoA synthetase, beta subunit K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
D HDEF_1885 sdhA; succinate dehydrogenase, catalytic and NAD/flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
D HDEF_1886 sdhB; succinate dehydrogenase, Fe-S protein K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
D HDEF_1883 sdhC; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhD K00241 sdhC; succinate dehydrogenase cytochrome b subunit
D HDEF_1884 sdhD; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhC K00242 sdhD; succinate dehydrogenase membrane anchor subunit
D HDEF_1745 fumC; fumarase C (fumarate hydratase Class II) K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_0382 pckA; phosphoenolpyruvate carboxykinase K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
D HDEF_2044 aceE; pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding K00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]
D HDEF_2043 aceF; pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
C 00030 Pentose phosphate pathway [PATH:hde00030]
D HDEF_0049 pgi; glucosephosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D HDEF_0646 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D HDEF_1256 pgl; 6-phosphogluconolactonase K07404 pgl; 6-phosphogluconolactonase [EC:3.1.1.31]
D HDEF_0040 gnd; gluconate-6-phosphate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
D HDEF_1637 rpe; D-ribulose-5-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D HDEF_1525 tktB; transketolase 2, thiamin-binding, isozyme K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D HDEF_0722 talB; transaldolase B K00616 TALDO1; transaldolase [EC:2.2.1.2]
D HDEF_2073 rpiA; ribose-5-phosphate isomerase A, constitutive K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]
D HDEF_2083 prsA; phosphoribosylpyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D HDEF_1539 fbaA; fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00040 Pentose and glucuronate interconversions [PATH:hde00040]
D HDEF_0538 ugd; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D HDEF_0041 galU; glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D HDEF_1637 rpe; D-ribulose-5-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
C 00051 Fructose and mannose metabolism [PATH:hde00051]
D HDEF_0487 manA; mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D HDEF_0176 cpsG; phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_1821 fruK; fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
D HDEF_1539 fbaA; fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D HDEF_0053 tpiA; triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D HDEF_1822 fruA; PTS family enzyme IIB'BC, fructose-specific K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D HDEF_0159 manX; PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D HDEF_0158 manY; PTS family enzyme IIC, mannose-specific K02795 manY; mannose PTS system EIIC component
D HDEF_0157 manZ; PTS family enzyme IID, mannose-specific K02796 manZ; mannose PTS system EIID component
C 00052 Galactose metabolism [PATH:hde00052]
D HDEF_0190 galE_2; UDP-galactose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0189 dTDP-glucose 4,6-dehydratase, epimerase domain protein K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0041 galU; glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00053 Ascorbate and aldarate metabolism
D HDEF_0538 ugd; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
C 00500 Starch and sucrose metabolism [PATH:hde00500]
D HDEF_0041 galU; glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D HDEF_0322 crr; PTS family enzyme IIA component K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
D HDEF_0049 pgi; glucosephosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
C 00520 Amino sugar and nucleotide sugar metabolism [PATH:hde00520]
D HDEF_0322 crr; PTS family enzyme IIA component K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
D HDEF_0225 glmS; L-glutamine:D-fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D HDEF_1962 glmM; phosphoglucosamine mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10]
D HDEF_0226 glmU; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D HDEF_1955 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D HDEF_1599 murB; UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D HDEF_0857 arnA; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase K10011 arnA; UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) [EC:2.1.2.13 1.1.1.305]
D HDEF_0856 arnC; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase K10012 arnC; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [EC:2.4.2.53]
D HDEF_0858 arnD; putative polysaccharide deacetylase K13014 arnD; undecaprenyl phosphate-alpha-L-ara4FN deformylase [EC:3.5.1.-]
D HDEF_0454 ptsG; PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal), glucose-specific K02779 ptsG; glucose PTS system EIICB or EIICBA component [EC:2.7.1.199]
D HDEF_0041 galU; glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D HDEF_0538 ugd; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D HDEF_0190 galE_2; UDP-galactose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0189 dTDP-glucose 4,6-dehydratase, epimerase domain protein K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0159 manX; PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D HDEF_0158 manY; PTS family enzyme IIC, mannose-specific K02795 manY; mannose PTS system EIIC component
D HDEF_0157 manZ; PTS family enzyme IID, mannose-specific K02796 manZ; mannose PTS system EIID component
D HDEF_0049 pgi; glucosephosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D HDEF_0487 manA; mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D HDEF_0176 cpsG; phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8]
C 00620 Pyruvate metabolism [PATH:hde00620]
D HDEF_2044 aceE; pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding K00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]
D HDEF_2043 aceF; pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_1644 ackA; acetate kinase A and propionate kinase 2 K00925 ackA; acetate kinase [EC:2.7.2.1]
D HDEF_1643 pta; phosphate acetyltransferase K13788 pta; phosphate acetyltransferase [EC:2.3.1.8]
D HDEF_0803 pykF; pyruvate kinase I (formerly F), fructose-stimulated K00873 PK; pyruvate kinase [EC:2.7.1.40]
D HDEF_0208 accA; acetylCoA carboxylase, carboxytransferase alpha colanic acid synthesis K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D HDEF_0073 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D HDEF_0072 accC; acetyl CoA carboxylase, biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D HDEF_0784 accD; acetylCoA carboxylase, carboxyltransferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D HDEF_1992 ldhA; fermentative D-lactate dehydrogenase, NAD-dependent K03778 ldhA; D-lactate dehydrogenase [EC:1.1.1.28]
D HDEF_2129 gloB; putative hydroxyacylglutathione hydrolase with metallo-hydrolase/oxidoreductase domain K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6]
D HDEF_1806 sfcA; NAD-linked malate dehydrogenase K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_1745 fumC; fumarase C (fumarate hydratase Class II) K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
D HDEF_0382 pckA; phosphoenolpyruvate carboxykinase K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
C 00630 Glyoxylate and dicarboxylate metabolism [PATH:hde00630]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_1882 gltA; citrate synthase K01647 CS; citrate synthase [EC:2.3.3.1]
D HDEF_1307 acnA; aconitate hydratase 1 K01681 ACO; aconitate hydratase [EC:4.2.1.3]
D HDEF_0160 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_2061 purU; formyltetrahydrofolate hydrolase K01433 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10]
C 00640 Propanoate metabolism [PATH:hde00640]
D HDEF_1644 ackA; acetate kinase A and propionate kinase 2 K00925 ackA; acetate kinase [EC:2.7.2.1]
D HDEF_1643 pta; phosphate acetyltransferase K13788 pta; phosphate acetyltransferase [EC:2.3.1.8]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_0208 accA; acetylCoA carboxylase, carboxytransferase alpha colanic acid synthesis K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D HDEF_0073 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D HDEF_0072 accC; acetyl CoA carboxylase, biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D HDEF_0784 accD; acetylCoA carboxylase, carboxyltransferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D HDEF_1889 sucC; succinyl-CoA synthetase, beta subunit K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
D HDEF_1890 sucD; succinyl-CoA synthetase, alpha subunit, NAD(P)-binding K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
C 00650 Butanoate metabolism
D HDEF_1885 sdhA; succinate dehydrogenase, catalytic and NAD/flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
D HDEF_1886 sdhB; succinate dehydrogenase, Fe-S protein K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
D HDEF_1883 sdhC; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhD K00241 sdhC; succinate dehydrogenase cytochrome b subunit
D HDEF_1884 sdhD; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhC K00242 sdhD; succinate dehydrogenase membrane anchor subunit
C 00660 C5-Branched dibasic acid metabolism
D HDEF_1889 sucC; succinyl-CoA synthetase, beta subunit K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
D HDEF_1890 sucD; succinyl-CoA synthetase, alpha subunit, NAD(P)-binding K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
C 00562 Inositol phosphate metabolism [PATH:hde00562]
D HDEF_1744 suhB; inositol monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D HDEF_2244 appA; bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase) K01093 appA; 4-phytase / acid phosphatase [EC:3.1.3.26 3.1.3.2]
D HDEF_0053 tpiA; triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
B
B 09102 Energy metabolism
C 00190 Oxidative phosphorylation [PATH:hde00190]
D HDEF_0271 nuoA; NADH dehydrogenase I chain A K00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2]
D HDEF_0272 nuoB; NADH dehydrogenase I chain B, binds FeS cluster N2 K00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]
D HDEF_0273 nuoC; NADH dehydrogenase I chain C, D K13378 nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:7.1.1.2]
D HDEF_0274 nuoE; NADH dehydrogenase I chain E K00334 nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2]
D HDEF_0275 nuoF; NADH dehydrogenase I chain F K00335 nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2]
D HDEF_1616 nuoG; NADH dehydrogenase I chain G K00336 nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2]
D HDEF_1615 nuoH; NADH dehydrogenase I chain H K00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2]
D HDEF_1614 nuoI; NADH dehydrogenase I chain I, 2Fe-2S ferredoxin-related K00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2]
D HDEF_1613 nuoJ; NADH dehydrogenase I chain J K00339 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2]
D HDEF_1612 nuoK; NADH dehydrogenase I chain K K00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]
D HDEF_1611 nuoL; NADH dehydrogenase I chain L, membrane subunit K00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]
D HDEF_1610 nuoM; NADH dehydrogenase I chain M, membrane subunit K00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2]
D HDEF_0502 nuoN; NADH dehydrogenase I chain N, membrane subunit K00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]
D HDEF_1885 sdhA; succinate dehydrogenase, catalytic and NAD/flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
D HDEF_1886 sdhB; succinate dehydrogenase, Fe-S protein K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
D HDEF_1883 sdhC; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhD K00241 sdhC; succinate dehydrogenase cytochrome b subunit
D HDEF_1884 sdhD; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhC K00242 sdhD; succinate dehydrogenase membrane anchor subunit
D HDEF_0066 cyoE; protoheme IX farnesyltransferase (heme O biosynthesis) K02257 COX10; heme o synthase [EC:2.5.1.141]
D HDEF_0067 cyoD; cytochrome o ubiquinol oxidase, subunit IV K02300 cyoD; cytochrome o ubiquinol oxidase subunit IV
D HDEF_0068 cyoC; cytochrome o ubiquinol oxidase, subunit III K02299 cyoC; cytochrome o ubiquinol oxidase subunit III
D HDEF_0069 cyoB_1; cytochrome o ubiquinol oxidase, subunit I-1 K02298 cyoB; cytochrome o ubiquinol oxidase subunit I [EC:7.1.1.3]
D HDEF_1996 cyoB_2; cytochrome o ubiquinol oxidase, subunit I -2 K02298 cyoB; cytochrome o ubiquinol oxidase subunit I [EC:7.1.1.3]
D HDEF_0070 cyoA_1; cytochrome o ubiquinol oxidase, subunit II-1 K02297 cyoA; cytochrome o ubiquinol oxidase subunit II [EC:7.1.1.3]
D HDEF_2337 atpD; membrane-bound ATP synthase, F1 sector, beta-subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D HDEF_2335 atpA; membrane-bound ATP synthase, F1 sector, alpha-subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D HDEF_2336 atpG; membrane-bound ATP synthase, F1 sector, gamma-subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D HDEF_2338 atpH; membrane-bound ATP synthase, F1 sector, delta-subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D HDEF_2334 atpC; membrane-bound ATP synthase, F1 sector, epsilon-subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D HDEF_2341 atpB; membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D HDEF_2339 atpF; membrane-bound ATP synthase, F0 sector, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D HDEF_2340 atpE; membrane-bound ATP synthase, F0 sector, subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D HDEF_0373 ppa; inorganic pyrophosphatase K01507 ppa; inorganic pyrophosphatase [EC:3.6.1.1]
C 00195 Photosynthesis
C 00196 Photosynthesis - antenna proteins
C 00710 Carbon fixation in photosynthetic organisms [PATH:hde00710]
D HDEF_1540 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D HDEF_0023 gapA; glyceraldehyde-3-phosphate dehydrogenase A K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D HDEF_1539 fbaA; fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D HDEF_1525 tktB; transketolase 2, thiamin-binding, isozyme K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D HDEF_2073 rpiA; ribose-5-phosphate isomerase A, constitutive K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]
D HDEF_0053 tpiA; triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D HDEF_1637 rpe; D-ribulose-5-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D HDEF_0722 talB; transaldolase B K00616 TALDO1; transaldolase [EC:2.2.1.2]
D HDEF_0382 pckA; phosphoenolpyruvate carboxykinase K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
C 00720 Carbon fixation pathways in prokaryotes [PATH:hde00720]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_1745 fumC; fumarase C (fumarate hydratase Class II) K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]
D HDEF_1885 sdhA; succinate dehydrogenase, catalytic and NAD/flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]
D HDEF_1886 sdhB; succinate dehydrogenase, Fe-S protein K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]
D HDEF_1883 sdhC; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhD K00241 sdhC; succinate dehydrogenase cytochrome b subunit
D HDEF_1884 sdhD; succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with SdhC K00242 sdhD; succinate dehydrogenase membrane anchor subunit
D HDEF_1890 sucD; succinyl-CoA synthetase, alpha subunit, NAD(P)-binding K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]
D HDEF_1889 sucC; succinyl-CoA synthetase, beta subunit K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]
D HDEF_2304 icdA; isocitrate dehydrogenase, specific for NADP+ K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]
D HDEF_1307 acnA; aconitate hydratase 1 K01681 ACO; aconitate hydratase [EC:4.2.1.3]
D HDEF_0208 accA; acetylCoA carboxylase, carboxytransferase alpha colanic acid synthesis K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D HDEF_0073 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D HDEF_0072 accC; acetyl CoA carboxylase, biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D HDEF_0784 accD; acetylCoA carboxylase, carboxyltransferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D HDEF_1897 folD; bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D HDEF_1643 pta; phosphate acetyltransferase K13788 pta; phosphate acetyltransferase [EC:2.3.1.8]
D HDEF_1644 ackA; acetate kinase A and propionate kinase 2 K00925 ackA; acetate kinase [EC:2.7.2.1]
C 00680 Methane metabolism [PATH:hde00680]
D HDEF_0160 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_1539 fbaA; fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_1644 ackA; acetate kinase A and propionate kinase 2 K00925 ackA; acetate kinase [EC:2.7.2.1]
D HDEF_1643 pta; phosphate acetyltransferase K13788 pta; phosphate acetyltransferase [EC:2.3.1.8]
D HDEF_0267 gpmA; phosphoglyceromutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HDEF_2074 serA; D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D HDEF_0290 serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]
C 00910 Nitrogen metabolism
D HDEF_1956 can; carbonic anhydrase K01673 cynT; carbonic anhydrase [EC:4.2.1.1]
C 00920 Sulfur metabolism
B
B 09103 Lipid metabolism
C 00061 Fatty acid biosynthesis [PATH:hde00061]
D HDEF_0208 accA; acetylCoA carboxylase, carboxytransferase alpha colanic acid synthesis K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D HDEF_0073 accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D HDEF_0072 accC; acetyl CoA carboxylase, biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D HDEF_0784 accD; acetylCoA carboxylase, carboxyltransferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D HDEF_0448 acpP; acyl carrier protein K02078 acpP; acyl carrier protein
D HDEF_1211 hypothetical protein, contains phosphopantetheine attachment site K02078 acpP; acyl carrier protein
D HDEF_0446 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D HDEF_0445 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III; acetylCoA ACP transacylase K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D HDEF_0092 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I K00647 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]
D HDEF_0449 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D HDEF_0447 fabG; 3-oxoacyl-[acyl-carrier-protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D HDEF_2300 fabA; beta-hydroxydecanoyl thioester dehydrase (trans-2-decenoyl-ACP isomerase) K01716 fabA; 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
D HDEF_0589 fabZ; (3R)-hydroxymyristol acyl carrier protein dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D HDEF_2100 fabI; enoyl-[acyl-carrier-protein] reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
C 00062 Fatty acid elongation
C 00071 Fatty acid degradation
C 00073 Cutin, suberine and wax biosynthesis
C 00100 Steroid biosynthesis
C 00120 Primary bile acid biosynthesis
C 00121 Secondary bile acid biosynthesis
C 00140 Steroid hormone biosynthesis
C 00561 Glycerolipid metabolism [PATH:hde00561]
D HDEF_0089 plsB; glycerolphosphate acyltransferase K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
D HDEF_0802 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D HDEF_0227 diacylglycerol kinase K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
C 00564 Glycerophospholipid metabolism [PATH:hde00564]
D HDEF_0792 fusion of serine acetyltransferase; glycerol-3-phosphate dehydrogenase (NAD+) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
D HDEF_0089 plsB; glycerolphosphate acyltransferase K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
D HDEF_0802 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D HDEF_0194 glycerol-3-phosphate cytidylyltransferase K00980 tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]
D HDEF_0227 diacylglycerol kinase K00901 dgkA; diacylglycerol kinase (ATP) [EC:2.7.1.107]
D HDEF_1313 pldA; outer membrane phospholipase A K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
D HDEF_0594 cdsA; CDP-diglyceride synthase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]
D HDEF_0866 pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) K00998 pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
D HDEF_0478 psd; phosphatidylserine decarboxylase K01613 psd; phosphatidylserine decarboxylase [EC:4.1.1.65]
D HDEF_1530 pgsA; phosphatidylglycerophosphate synthetase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
D HDEF_1927 pgpA; phosphatidylglycerophosphatase A K01095 pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]
D HDEF_0117 pgpB; phosphatidylglycerophosphate phosphatase B K01096 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27]
D HDEF_2064 cls; cardiolipin synthase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]
C 00565 Ether lipid metabolism [PATH:hde00565]
D HDEF_1313 pldA; outer membrane phospholipase A K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
C 00600 Sphingolipid metabolism
C 00590 Arachidonic acid metabolism
D HDEF_1313 pldA; outer membrane phospholipase A K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
C 00591 Linoleic acid metabolism
D HDEF_1313 pldA; outer membrane phospholipase A K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
C 00592 alpha-Linolenic acid metabolism [PATH:hde00592]
D HDEF_1313 pldA; outer membrane phospholipase A K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
C 01040 Biosynthesis of unsaturated fatty acids
B
B 09104 Nucleotide metabolism
C 00230 Purine metabolism [PATH:hde00230]
D HDEF_2083 prsA; phosphoribosylpyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D HDEF_0788 purF; amidophosphoribosyltransferase (PRPP amidotransferase) K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D HDEF_2036 purD; phosphoribosylglycinamide synthetase (GAR synthetase) K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13]
D HDEF_0692 purN; phosphoribosylglycinamide formyltransferase 1 K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D HDEF_0875 purL; phosphoribosylformyl-glycineamide synthetase (FGAM synthetase) K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]
D HDEF_0691 purM; phosphoribosylaminoimidazole synthetase (AIR synthetase) K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]
D HDEF_0295 purK; AIR carboxylase converting aminoimidazole ribonucleotide (AIR) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR), ATP and HCO3-requiring K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]
D HDEF_0294 purE; N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]
D HDEF_1837 purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase) K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]
D HDEF_0557 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D HDEF_2035 purH; bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D HDEF_2086 apt; adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D HDEF_1925 guaB; IMP dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D HDEF_0747 ndk; multifunctional: nucleoside diphosphate kinase; apyrimidinic endonuclease; 3'-phosphodiesterase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D HDEF_1922 rdgB; dITP/dXTP pyrophosphatase K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]
D HDEF_1926 guaA; GMP synthetase (glutamine aminotransferase) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D HDEF_0624 gmk; guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8]
D HDEF_0307 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HDEF_0306 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D HDEF_1489 dgt; deoxyguanosine triphosphate triphosphohydrolase K01129 dgt; dGTPase [EC:3.1.5.1]
D HDEF_1196 putative hydrolase, HD superfamily K08722 yfbR; 5'-deoxynucleotidase [EC:3.1.3.89]
D HDEF_0626 spoT; bifunctional: (p)ppGpp synthetase II; guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D HDEF_0393 relA; (p)ppGpp synthetase I (GTP pyrophosphokinase) K00951 relA; GTP pyrophosphokinase [EC:2.7.6.5]
D HDEF_0302 purA; adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D HDEF_0153 lysine decarboxylase family protein K06966 ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]
D HDEF_2095 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D HDEF_0774 apaH; diadenosine tetraphosphatase K01525 apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41]
C 00240 Pyrimidine metabolism [PATH:hde00240]
D HDEF_0108 carB; carbamoyl phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D HDEF_0107 carA; carbamoyl phosphate synthetase, glutamine amidotransferase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D HDEF_1941 pyrB; aspartate carbamoyltransferase, catalytic subunit K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D HDEF_0353 pyrC; dihydroorotase K01465 URA4; dihydroorotase [EC:3.5.2.3]
D HDEF_0655 pyrD; dihydroorotate oxidase, FMN-linked K00254 DHODH; dihydroorotate dehydrogenase [EC:1.3.5.2]
D HDEF_0508 pyrE; orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]
D HDEF_0114 pyrF; orotidine-5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
D HDEF_1310 pyrH; uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22]
D HDEF_0747 ndk; multifunctional: nucleoside diphosphate kinase; apyrimidinic endonuclease; 3'-phosphodiesterase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D HDEF_0765 pyrG; CTP synthetase K01937 pyrG; CTP synthase [EC:6.3.4.2]
D HDEF_0695 cmk; cytidine monophosphate (CMP) kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25]
D HDEF_0153 lysine decarboxylase family protein K06966 ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]
D HDEF_0043 dcd; 2'-deoxycytidine 5'-triphosphate deaminase K01494 dcd; dCTP deaminase [EC:3.5.4.13]
D HDEF_0307 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HDEF_0306 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D HDEF_1196 putative hydrolase, HD superfamily K08722 yfbR; 5'-deoxynucleotidase [EC:3.1.3.89]
D HDEF_0451 tmk; thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9]
D HDEF_2318 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D HDEF_1917 thyA; thymidylate synthetase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
B
B 09105 Amino acid metabolism
C 00250 Alanine, aspartate and glutamate metabolism [PATH:hde00250]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
D HDEF_0526 nadB; quinolinate synthetase, B protein (L-aspartate oxidase) K00278 nadB; L-aspartate oxidase [EC:1.4.3.16]
D HDEF_2098 asnB; asparagine synthetase B K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
D HDEF_1823 aspC_2; aspartate aminotransferase, PLP-dependent - 2 K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D HDEF_2247 aspA; aspartate ammonia-lyase (aspartase) K01744 aspA; aspartate ammonia-lyase [EC:4.3.1.1]
D HDEF_0302 purA; adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D HDEF_0557 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D HDEF_1941 pyrB; aspartate carbamoyltransferase, catalytic subunit K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D HDEF_1208 putA; multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase K13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
D HDEF_0108 carB; carbamoyl phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D HDEF_0107 carA; carbamoyl phosphate synthetase, glutamine amidotransferase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D HDEF_0225 glmS; L-glutamine:D-fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D HDEF_0788 purF; amidophosphoribosyltransferase (PRPP amidotransferase) K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C 00260 Glycine, serine and threonine metabolism [PATH:hde00260]
D HDEF_1900 thrA; bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
D HDEF_2070 asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D HDEF_1899 thrB; homoserine kinase K00872 thrB; homoserine kinase [EC:2.7.1.39]
D HDEF_1898 thrC; threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
D HDEF_0160 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D HDEF_0267 gpmA; phosphoglyceromutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HDEF_2074 serA; D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D HDEF_0290 serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_0866 pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) K00998 pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
D HDEF_1873 cysK; subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme K01697 CBS; cystathionine beta-synthase [EC:4.2.1.22]
C 00270 Cysteine and methionine metabolism [PATH:hde00270]
D HDEF_1873 cysK; subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme K01697 CBS; cystathionine beta-synthase [EC:4.2.1.22]
D HDEF_0506 metK; methionine adenosyltransferase 1 (AdoMet synthetase) K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D HDEF_0511 speD; S-adenosylmethionine decarboxylase, proenzyme K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D HDEF_0512 speE; spermidine synthase (putrescine aminopropyltransferase) K00797 speE; spermidine synthase [EC:2.5.1.16]
D HDEF_0873 expI; autoinducer synthase K22956 expI; acyl homoserine lactone synthase [EC:2.3.1.184]
D HDEF_1490 mtn; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9]
D HDEF_0909 dcm_1; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D HDEF_1900 thrA; bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
D HDEF_2070 asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D HDEF_2331 gshA; gamma-glutamate-cysteine ligase K01919 gshA; glutamate--cysteine ligase [EC:6.3.2.2]
D HDEF_0603 gshB; glutathione synthetase K01920 gshB; glutathione synthase [EC:6.3.2.3]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
D HDEF_0460 mdh; malate dehydrogenase, NAD(P)-binding K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D HDEF_2074 serA; D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D HDEF_0290 serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]
C 00280 Valine, leucine and isoleucine degradation [PATH:hde00280]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
C 00290 Valine, leucine and isoleucine biosynthesis
D HDEF_1823 aspC_2; aspartate aminotransferase, PLP-dependent - 2 K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
C 00300 Lysine biosynthesis [PATH:hde00300]
D HDEF_1900 thrA; bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
D HDEF_2070 asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D HDEF_1839 dapA; dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D HDEF_0637 dapB; dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
D HDEF_0152 dapD; 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase K00674 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]
D HDEF_0094 dapE; N-succinyl-diaminopimelate deacylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
D HDEF_0699 dapF; diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]
D HDEF_1874 putative lysine/ornithine decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
D HDEF_1788 murE; UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D HDEF_1787 murF; D-alanine:D-alanine-adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
C 00310 Lysine degradation [PATH:hde00310]
D HDEF_1888 sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
C 00220 Arginine biosynthesis [PATH:hde00220]
D HDEF_0108 carB; carbamoyl phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D HDEF_0107 carA; carbamoyl phosphate synthetase, glutamine amidotransferase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
D HDEF_1823 aspC_2; aspartate aminotransferase, PLP-dependent - 2 K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
C 00330 Arginine and proline metabolism [PATH:hde00330]
D HDEF_1524 speA; biosynthetic arginine decarboxylase, PLP-binding K01585 speA; arginine decarboxylase [EC:4.1.1.19]
D HDEF_0599 aguA; agmatine deiminase, PAD_porph domain protein K10536 aguA; agmatine deiminase [EC:3.5.3.12]
D HDEF_0600 aguB; N-carbamoylputrescine amidohydrolase K12251 aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]
D HDEF_0512 speE; spermidine synthase (putrescine aminopropyltransferase) K00797 speE; spermidine synthase [EC:2.5.1.16]
D HDEF_0511 speD; S-adenosylmethionine decarboxylase, proenzyme K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D HDEF_0693 speG; spermidine N1-acetyltransferase K00657 speG; diamine N-acetyltransferase [EC:2.3.1.57]
D HDEF_0483 proC; pyrroline-5-carboxylate reductase, NAD(P)-binding K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]
D HDEF_1208 putA; multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase K13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
C 00340 Histidine metabolism
C 00350 Tyrosine metabolism
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
C 00360 Phenylalanine metabolism
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
C 00380 Tryptophan metabolism
D HDEF_1888 sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:hde00400]
D HDEF_0075 aroH; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase), tryptophan-repressible K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D HDEF_1640 aroB; dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4]
D HDEF_0074 aroQ; 3-dehydroquinate dehydratase, class II K03786 aroQ; 3-dehydroquinate dehydratase II [EC:4.2.1.10]
D HDEF_1254 aroE; dehydroshikimate reductase, NAD(P)-binding K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
D HDEF_1641 aroK; shikimate kinase I K00891 aroK; shikimate kinase [EC:2.7.1.71]
D HDEF_0694 aroA; 3-enolpyruvylshikimate-5-phosphate synthetase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
D HDEF_0459 aroC; chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5]
D HDEF_0096 chorismate mutase type II K04093 pheA1; chorismate mutase [EC:5.4.99.5]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
B
B 09106 Metabolism of other amino acids
C 00410 beta-Alanine metabolism
C 00430 Taurine and hypotaurine metabolism [PATH:hde00430]
D HDEF_1643 pta; phosphate acetyltransferase K13788 pta; phosphate acetyltransferase [EC:2.3.1.8]
D HDEF_1644 ackA; acetate kinase A and propionate kinase 2 K00925 ackA; acetate kinase [EC:2.7.2.1]
C 00440 Phosphonate and phosphinate metabolism [PATH:hde00440]
D HDEF_0203 phosphoenolpyruvate phosphomutase K01841 pepM; phosphoenolpyruvate phosphomutase [EC:5.4.2.9]
D HDEF_0202 putative thiamine pyrophosphate enzyme K09459 E4.1.1.82; phosphonopyruvate decarboxylase [EC:4.1.1.82]
D HDEF_0201 putative aminotransferase class V K03430 phnW; 2-aminoethylphosphonate-pyruvate transaminase [EC:2.6.1.37]
C 00450 Selenocompound metabolism [PATH:hde00450]
D HDEF_0063 sufS; selenocysteine lyase, PLP-dependent K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]
D HDEF_1807 metG; methionine tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
C 00460 Cyanoamino acid metabolism
D HDEF_0160 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
C 00470 D-Amino acid metabolism [PATH:hde00470]
D HDEF_0679 alr; alanine racemase 1, PLP-binding, biosynthetic K01775 alr; alanine racemase [EC:5.1.1.1]
D HDEF_1781 ddlB; D-alanine-D-alanine ligase B, affects cell division K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D HDEF_0474 murI; glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D HDEF_1785 murD; UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D HDEF_0699 dapF; diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]
D HDEF_1874 putative lysine/ornithine decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
C 00480 Glutathione metabolism [PATH:hde00480]
D HDEF_2331 gshA; gamma-glutamate-cysteine ligase K01919 gshA; glutamate--cysteine ligase [EC:6.3.2.2]
D HDEF_0603 gshB; glutathione synthetase K01920 gshB; glutathione synthase [EC:6.3.2.3]
D HDEF_0221 pepA; aminopeptidase A, a cyteinylglycinase K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
D HDEF_0876 pepN; aminopeptidase N, a cysteinylglycinase K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D HDEF_1909 lpd_1; lipoamide dehydrogenase, E3 component is part of three enzyme complexes K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7]
D HDEF_2304 icdA; isocitrate dehydrogenase, specific for NADP+ K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]
D HDEF_0040 gnd; gluconate-6-phosphate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
D HDEF_0646 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D HDEF_0512 speE; spermidine synthase (putrescine aminopropyltransferase) K00797 speE; spermidine synthase [EC:2.5.1.16]
B
B 09107 Glycan biosynthesis and metabolism
C 00510 N-Glycan biosynthesis
C 00513 Various types of N-glycan biosynthesis
C 00512 Mucin type O-glycan biosynthesis
C 00515 Mannose type O-glycan biosynthesis
C 00514 Other types of O-glycan biosynthesis
C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
C 00533 Glycosaminoglycan biosynthesis - keratan sulfate
C 00531 Glycosaminoglycan degradation
C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series
C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series
C 00604 Glycosphingolipid biosynthesis - ganglio series
C 00511 Other glycan degradation
C 00540 Lipopolysaccharide biosynthesis [PATH:hde00540]
D HDEF_0588 lpxA; UDP-N-acetylglucosamine acetyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
D HDEF_1777 lpxC; UDP-3-O-acyl N-acetylglucosamine deacetylase K02535 lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
D HDEF_0590 lpxD; UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
D HDEF_1543 lpxH; UDP-2,3-diacylglucosamine pyrophosphatase K03269 lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
D HDEF_0587 lpxB; tetraacyldisaccharide-1-P synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]
D HDEF_0231 lpxK; tetraacyldisaccharide 4' kinase (lipid A 4'kinase) K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
D HDEF_1948 kdsD; D-arabinose 5-phosphate isomerase K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13]
D HDEF_0386 kdsA; 3-deoxy-D-manno-octulosonic acid 8-P synthetase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]
D HDEF_1947 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]
D HDEF_0235 kdsB; CTP:CMP-3-deoxy-D-manno-octulosonate transferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]
D HDEF_1810 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]
D HDEF_0823 lpxL; lauroyl transferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-]
D HDEF_0653 lpxM; myristoyl-acyl carrier protein (ACP)-dependent acyltransferase K02560 lpxM; lauroyl-Kdo2-lipid IVA myristoyltransferase [EC:2.3.1.243]
D HDEF_0859 arnT; 4-amino-4-deoxy-L-arabinose transferase K07264 arnT; 4-amino-4-deoxy-L-arabinose transferase [EC:2.4.2.43]
D HDEF_2106 lpcA; D-sedoheptulose 7-phosphate isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D HDEF_0185 fusion of GMHP sugar kinase and isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D HDEF_0794 rfaE; bifunctional ADP-L-glycero-D-manno-heptose synthase: putative kinase (N-terminal); putative sugar nucleotide transferase (C-terminal) K03272 gmhC; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70]
D HDEF_0048 rfaD; ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding K03274 gmhD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
D HDEF_0842 rfaC; ADP-heptose; LPS heptosyl transferase I K02841 waaC; lipopolysaccharide heptosyltransferase I [EC:2.4.99.23]
D HDEF_0841 rfaF; ADP-heptose; LPS heptosyltransferase II K02843 waaF; lipopolysaccharide heptosyltransferase II [EC:2.4.99.24]
D HDEF_0516 rfaQ; lipopolysaccharide core biosynthesis K02849 waaQ; lipopolysaccharide heptosyltransferase III [EC:2.4.99.25]
D HDEF_2072 O-antigen biosynthesis protein, Wzy_C domain protein K02847 waaL; O-antigen ligase [EC:2.4.99.26]
C 00542 O-Antigen repeat unit biosynthesis [PATH:hde00542]
D HDEF_2026 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:hde00541]
D HDEF_0041 galU; glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D HDEF_0190 galE_2; UDP-galactose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0189 dTDP-glucose 4,6-dehydratase, epimerase domain protein K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D HDEF_0538 ugd; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D HDEF_1518 rffA; TDP-4-oxo-6-deoxy-D-glucose transaminase K02805 wecE; dTDP-4-amino-4,6-dideoxygalactose transaminase [EC:2.6.1.59]
D HDEF_0487 manA; mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D HDEF_0176 cpsG; phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8]
D HDEF_0226 glmU; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
C 00550 Peptidoglycan biosynthesis [PATH:hde00550]
D HDEF_1955 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D HDEF_1599 murB; UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D HDEF_1782 murC; UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D HDEF_1785 murD; UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D HDEF_1788 murE; UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D HDEF_1781 ddlB; D-alanine-D-alanine ligase B, affects cell division K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D HDEF_1787 murF; D-alanine:D-alanine-adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D HDEF_0595 ispU; undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D HDEF_1786 mraY; phospho-N-acetylmuramoyl-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D HDEF_1783 murG; UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D HDEF_0862 mrcB; bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal); transpeptidase (C-terminal) K05365 mrcB; penicillin-binding protein 1B [EC:2.4.99.28 3.4.16.4]
D HDEF_0672 mrdA; cell elongation-specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase) K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
D HDEF_1789 ftsI; division-specific transpeptidase, penicillin-binding protein 3 K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]
D HDEF_0674 dacA; D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C 00552 Teichoic acid biosynthesis [PATH:hde00552]
D HDEF_2026 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D HDEF_0197 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase K09809 tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12]
C 00571 Lipoarabinomannan (LAM) biosynthesis
C 00572 Arabinogalactan biosynthesis - Mycobacterium
C 00543 Exopolysaccharide biosynthesis [PATH:hde00543]
D HDEF_2026 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D HDEF_0770 putative acyltransferase K16568 exoZ; exopolysaccharide production protein ExoZ
B
B 09108 Metabolism of cofactors and vitamins
C 00730 Thiamine metabolism [PATH:hde00730]
D HDEF_0542 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D HDEF_1608 dxs; 1-deoxy-D-xylulose 5-phosphate synthase; flavoprotein, thiamin-binding K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]
D HDEF_1928 thiL; thiamin-monophosphate kinase K00946 thiL; thiamine-monophosphate kinase [EC:2.7.4.16]
D HDEF_0477 putative GTP-binding protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D HDEF_2095 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
C 00740 Riboflavin metabolism [PATH:hde00740]
D HDEF_0118 ribA; GTP cyclohydrolase II K01497 ribA; GTP cyclohydrolase II [EC:3.5.4.25]
D HDEF_0030 ribD; bifunctional: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); 5-amino-6-(5-phosphoribosylamino) uracil reductase (C-terminal) K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D HDEF_0105 ribB; 3,4 dihydroxy-2-butanone-4-phosphate synthase K02858 ribB; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]
D HDEF_1930 ribE; riboflavin synthase, alpha chain K00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
D HDEF_0623 ribC; riboflavin synthase, alpha subunit K00793 ribE; riboflavin synthase [EC:2.5.1.9]
D HDEF_0830 ribF; bifunctional: flavokinase; FAD synthetase K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]
D HDEF_2244 appA; bifunctional: phytase; phosphoanhydride phosphorylase (pH 2.5 acid phosphatase) K01093 appA; 4-phytase / acid phosphatase [EC:3.1.3.26 3.1.3.2]
D HDEF_2108 fre; flavin reductase K05368 fre; NAD(P)H-flavin reductase [EC:1.5.1.41]
D HDEF_0789 ubiX; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
C 00750 Vitamin B6 metabolism [PATH:hde00750]
D HDEF_0670 pdxH; pyridoxine 5'-phosphate oxidase K00275 pdxH; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]
D HDEF_0780 pdxB; erythronate-4-phosphate dehydrogenase K03473 pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]
D HDEF_0290 serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]
D HDEF_0776 pdxA; NAD-dependent dehydrogenase/carboxylase, pyridoxine phosphate biosynthetic protein PdxJ-PdxA subunit K00097 pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]
D HDEF_2293 pdxJ; pyridoxine 5'-phosphate synthesizing enzyme K03474 pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2]
D HDEF_1898 thrC; threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
C 00760 Nicotinate and nicotinamide metabolism [PATH:hde00760]
D HDEF_0526 nadB; quinolinate synthetase, B protein (L-aspartate oxidase) K00278 nadB; L-aspartate oxidase [EC:1.4.3.16]
D HDEF_1746 nadA; quinolinate synthetase, A protein K03517 nadA; quinolinate synthase [EC:2.5.1.72]
D HDEF_1274 nadC; quinolinate phosphoribosyltransferase K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
D HDEF_2041 nadD; nicotinic acid mononucleotide adenylyltransferase, NAD(P)-requiring K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]
D HDEF_0212 nadE; NAD synthetase K01950 E6.3.5.1; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]
D HDEF_1755 nadK; NAD kinase K00858 ppnK; NAD+ kinase [EC:2.7.1.23]
D HDEF_0374 sthA; soluble pyridine nucleotide transhydrogenase K00322 sthA; NAD(P) transhydrogenase [EC:1.6.1.1]
C 00770 Pantothenate and CoA biosynthesis [PATH:hde00770]
D HDEF_1738 coaA; pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33]
D HDEF_2317 dfp; bifunctional: 4'-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding K13038 coaBC; phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]
D HDEF_1812 coaD; CMP-deoxy-D-manno-octulosonate-lipid A transferase (phosphopantetheine adenylyltransferase) K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
D HDEF_0296 coaE; dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24]
D HDEF_2292 acpS; holo-[acyl-carrier-protein] synthase (CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase) K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
C 00780 Biotin metabolism [PATH:hde00780]
D HDEF_1201 bioC; biotin biosynthesis; reaction prior to pimeloyl CoA K02169 bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197]
D HDEF_0092 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I K00647 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]
D HDEF_0449 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D HDEF_0447 fabG; 3-oxoacyl-[acyl-carrier-protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D HDEF_0589 fabZ; (3R)-hydroxymyristol acyl carrier protein dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D HDEF_2100 fabI; enoyl-[acyl-carrier-protein] reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
D HDEF_0547 bioH; carboxylesterase in pimeloyl-CoA (biotin precursor) synthesis with alpha/beta-hydrolase domain K02170 bioH; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85]
D HDEF_1202 bioF; 7-keto-8-aminopelargonic acid synthetase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]
D HDEF_0279 bioA; 7,8-diaminopelargonic acid synthetase, PLP-dependent K00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]
D HDEF_1200 bioD; dethiobiotin synthetase K01935 bioD; dethiobiotin synthetase [EC:6.3.3.3]
D HDEF_1203 bioB; biotin synthetase K01012 bioB; biotin synthase [EC:2.8.1.6]
D HDEF_1598 birA; bifunctional: biotin-[acetylCoA carboxylase] holoenzyme synthetase; transcriptional repressor of biotin synthesis (BirA family) K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
C 00785 Lipoic acid metabolism [PATH:hde00785]
D HDEF_0676 lipB; lipoyl(octanyl)-acyl carrier protein: protein transferase K03801 lipB; lipoyl(octanoyl) transferase [EC:2.3.1.181]
D HDEF_0677 lipA; lipoate protein ligase, an iron-sulfur enzyme K03644 lipA; lipoyl synthase [EC:2.8.1.8]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_2044 aceE; pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding K00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]
D HDEF_2043 aceF; pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
D HDEF_1887 sucA; 2-oxoglutarate decarboxylase, component of the 2-oxoglutarate dehydrogenase complex, thiamin-binding K00164 OGDH; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
D HDEF_1888 sucB; dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
C 00790 Folate biosynthesis [PATH:hde00790]
D HDEF_0402 folE; GTP cyclohydrolase I K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16]
D HDEF_0467 folB; dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81]
D HDEF_1622 folK; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
D HDEF_1963 folP; 7,8-dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15]
D HDEF_1626 folA; dihydrofolate reductase type I, trimethoprim resistance K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D HDEF_0785 folC; bifunctional: folylpolyglutamate synthase; dihydrofolate synthase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D HDEF_0118 ribA; GTP cyclohydrolase II K01497 ribA; GTP cyclohydrolase II [EC:3.5.4.25]
D HDEF_0822 pabA; aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex K01664 pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]
D HDEF_0339 pabB; aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex K01665 pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]
D HDEF_1717 sscR; 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D HDEF_0210 conserved hypothetical protein, Radical_SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D HDEF_0767 queC; queuosine biosynthesis protein, ExsB domain protein K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D HDEF_1045 queF_1; GTP cyclohydrolase I, copy 1 K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D HDEF_1522 queF_2; GTP cyclohydrolase I, -2 K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
C 00670 One carbon pool by folate [PATH:hde00670]
D HDEF_1626 folA; dihydrofolate reductase type I, trimethoprim resistance K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D HDEF_1897 folD; bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D HDEF_0160 glyA; serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D HDEF_0692 purN; phosphoribosylglycinamide formyltransferase 1 K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D HDEF_2035 purH; bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D HDEF_1721 fmt; 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D HDEF_1917 thyA; thymidylate synthetase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
D HDEF_2061 purU; formyltetrahydrofolate hydrolase K01433 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10]
D HDEF_2075 5-formyltetrahydrofolate cyclo-ligase K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
C 00830 Retinol metabolism
C 00860 Porphyrin metabolism [PATH:hde00860]
D HDEF_0366 gltX; glutamate tRNA synthetase, catalytic subunit K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D HDEF_1725 hemL; glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]
D HDEF_2111 hemB; 5-aminolevulinate dehydratase (porphobilinogen synthase) K01698 hemB; porphobilinogen synthase [EC:4.2.1.24]
D HDEF_0703 hemC; hydroxymethylbilane synthase (porphobilinogen deaminase) K01749 hemC; hydroxymethylbilane synthase [EC:2.5.1.61]
D HDEF_0704 hemD; uroporphyrinogen III synthase K01719 hemD; uroporphyrinogen-III synthase [EC:4.2.1.75]
D HDEF_2274 hemE; uroporphyrinogen decarboxylase K01599 hemE; uroporphyrinogen decarboxylase [EC:4.1.1.37]
D HDEF_1258 hemF; coproporphyrinogen III oxidase K00228 CPOX; coproporphyrinogen III oxidase [EC:1.3.3.3]
D HDEF_1765 hemG; protoporphyrin flavoprotein oxidase, O2 dependent K00230 hemG; menaquinone-dependent protoporphyrinogen oxidase [EC:1.3.5.3]
D HDEF_0207 hemH; ferrochelatase K01772 hemH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9]
D HDEF_0705 hemX; uroporphyrinogen III methylase K02496 hemX; uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
D HDEF_0066 cyoE; protoheme IX farnesyltransferase (heme O biosynthesis) K02257 COX10; heme o synthase [EC:2.5.1.141]
C 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:hde00130]
D HDEF_1632 ubiC; chorismate pyruvate lyase K03181 ubiC; chorismate lyase [EC:4.1.3.40]
D HDEF_1631 ubiA; p-hydroxybenzoate octaprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]
D HDEF_2109 ubiD; 3-octaprenyl-4-hydroxybenzoate decarboxylase K03182 ubiD; 4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98]
D HDEF_0789 ubiX; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
D HDEF_2080 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family K18800 ubiI; 2-polyprenylphenol 6-hydroxylase [EC:1.14.13.240]
D HDEF_1517 ubiG; bifunctional: 3-demethylubiquinone-9 3-methyltransferase; 2-octaprenyl-6-hydroxy phenol methylase K00568 ubiG; 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.222 2.1.1.64]
D HDEF_0027 ubiH; 2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding K03185 ubiH; 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-]
D HDEF_1732 ubiE; bifunctional: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; S-adenosylmethionine:2-DMK methyltransferase K03183 ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]
D HDEF_0071 ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase K03184 ubiF; 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60]
B
B 09109 Metabolism of terpenoids and polyketides
C 00900 Terpenoid backbone biosynthesis [PATH:hde00900]
D HDEF_1608 dxs; 1-deoxy-D-xylulose 5-phosphate synthase; flavoprotein, thiamin-binding K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]
D HDEF_1308 dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase K00099 dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]
D HDEF_1715 ispD; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase K00991 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]
D HDEF_2120 ispE; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase K00919 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]
D HDEF_1714 ispF; 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase K01770 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]
D HDEF_0752 ispG; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase K03526 gcpE; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]
D HDEF_0834 ispH; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein K03527 ispH; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]
D HDEF_0789 ubiX; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
D HDEF_1607 ispA; geranyltranstransferase (farnesyldiphosphate synthase) K00795 ispA; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
D HDEF_1760 ispB; octaprenyl diphosphate synthase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]
D HDEF_0595 ispU; undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
C 00902 Monoterpenoid biosynthesis
C 00909 Sesquiterpenoid and triterpenoid biosynthesis
C 00904 Diterpenoid biosynthesis
C 00906 Carotenoid biosynthesis
C 00905 Brassinosteroid biosynthesis
C 00981 Insect hormone biosynthesis
C 00908 Zeatin biosynthesis
C 00903 Limonene degradation
C 00907 Pinene, camphor and geraniol degradation
C 01052 Type I polyketide structures
C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides
C 01051 Biosynthesis of ansamycins
D HDEF_1525 tktB; transketolase 2, thiamin-binding, isozyme K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
C 01059 Biosynthesis of enediyne antibiotics
C 01056 Biosynthesis of type II polyketide backbone
C 01057 Biosynthesis of type II polyketide products
C 00253 Tetracycline biosynthesis
C 00523 Polyketide sugar unit biosynthesis
C 01054 Nonribosomal peptide structures
C 01053 Biosynthesis of siderophore group nonribosomal peptides
C 01055 Biosynthesis of vancomycin group antibiotics
B
B 09110 Biosynthesis of other secondary metabolites
C 00940 Phenylpropanoid biosynthesis
C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
C 00941 Flavonoid biosynthesis
C 00944 Flavone and flavonol biosynthesis
C 00942 Anthocyanin biosynthesis
C 00943 Isoflavonoid biosynthesis
C 00946 Degradation of flavonoids
C 00901 Indole alkaloid biosynthesis
C 00403 Indole diterpene alkaloid biosynthesis
C 00950 Isoquinoline alkaloid biosynthesis
C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis
C 00996 Biosynthesis of various alkaloids
C 00232 Caffeine metabolism
C 00965 Betalain biosynthesis
C 00966 Glucosinolate biosynthesis
C 00402 Benzoxazinoid biosynthesis
C 00311 Penicillin and cephalosporin biosynthesis
D HDEF_1020 beta-lactamase K17836 penP; beta-lactamase class A [EC:3.5.2.6]
C 00332 Carbapenem biosynthesis
C 00261 Monobactam biosynthesis [PATH:hde00261]
D HDEF_1900 thrA; bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
D HDEF_2070 asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D HDEF_1839 dapA; dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D HDEF_0637 dapB; dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
C 00331 Clavulanic acid biosynthesis
C 00521 Streptomycin biosynthesis
D HDEF_1744 suhB; inositol monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
C 00524 Neomycin, kanamycin and gentamicin biosynthesis
C 00525 Acarbose and validamycin biosynthesis
C 00401 Novobiocin biosynthesis
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
C 00404 Staurosporine biosynthesis
C 00405 Phenazine biosynthesis
C 00333 Prodigiosin biosynthesis
D HDEF_0446 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D HDEF_0447 fabG; 3-oxoacyl-[acyl-carrier-protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D HDEF_2100 fabI; enoyl-[acyl-carrier-protein] reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
C 00254 Aflatoxin biosynthesis
C 00998 Biosynthesis of various antibiotics [PATH:hde00998]
D HDEF_0448 acpP; acyl carrier protein K02078 acpP; acyl carrier protein
D HDEF_1211 hypothetical protein, contains phosphopantetheine attachment site K02078 acpP; acyl carrier protein
D HDEF_0203 phosphoenolpyruvate phosphomutase K01841 pepM; phosphoenolpyruvate phosphomutase [EC:5.4.2.9]
D HDEF_0202 putative thiamine pyrophosphate enzyme K09459 E4.1.1.82; phosphonopyruvate decarboxylase [EC:4.1.1.82]
C 00999 Biosynthesis of various plant secondary metabolites [PATH:hde00999]
D HDEF_0506 metK; methionine adenosyltransferase 1 (AdoMet synthetase) K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D HDEF_1254 aroE; dehydroshikimate reductase, NAD(P)-binding K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
C 00997 Biosynthesis of various other secondary metabolites
B
B 09111 Xenobiotics biodegradation and metabolism
C 00362 Benzoate degradation
C 00627 Aminobenzoate degradation
D HDEF_0789 ubiX; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
C 00364 Fluorobenzoate degradation
C 00625 Chloroalkane and chloroalkene degradation
C 00361 Chlorocyclohexane and chlorobenzene degradation
C 00623 Toluene degradation
C 00622 Xylene degradation
C 00633 Nitrotoluene degradation
C 00642 Ethylbenzene degradation
C 00643 Styrene degradation
C 00791 Atrazine degradation
C 00930 Caprolactam degradation
C 00363 Bisphenol degradation
C 00621 Dioxin degradation
C 00626 Naphthalene degradation
C 00624 Polycyclic aromatic hydrocarbon degradation
C 00365 Furfural degradation
C 00984 Steroid degradation
C 00980 Metabolism of xenobiotics by cytochrome P450
C 00982 Drug metabolism - cytochrome P450
C 00983 Drug metabolism - other enzymes
B
B 09112 Not included in regular maps
C 09113 Global maps only
#
A09120 Genetic Information Processing
B
B 09121 Transcription
C 03020 RNA polymerase [PATH:hde03020]
D HDEF_0711 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D HDEF_0710 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D HDEF_1841 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D HDEF_0625 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
C 03022 Basal transcription factors
C 03040 Spliceosome
B
B 09122 Translation
C 03010 Ribosome [PATH:hde03010]
D HDEF_0696 rpsA; 30S ribosomal subunit protein S1 K02945 RP-S1; small subunit ribosomal protein S1
D HDEF_1312 rpsB; 30S ribosomal subunit protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D HDEF_1860 rpsC; 30S ribosomal subunit protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D HDEF_1842 rpsD; 30S ribosomal subunit protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D HDEF_1849 rpsE; 30S ribosomal subunit protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D HDEF_0585 rpsF; 30S ribosomal subunit protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D HDEF_0720 rpsG; 30S ribosomal subunit protein S7, initiates assembly K02992 RP-S7; small subunit ribosomal protein S7
D HDEF_1852 rpsH; 30S ribosomal subunit protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D HDEF_1260 rpsI; 30S ribosomal subunit protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D HDEF_1867 rpsJ; 30S ribosomal subunit protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D HDEF_1843 rpsK; 30S ribosomal subunit protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D HDEF_0721 rpsL; 30S ribosomal subunit protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D HDEF_1844 rpsM; 30S ribosomal subunit protein S13 K02952 RP-S13; small subunit ribosomal protein S13
D HDEF_1853 rpsN; 30S ribosomal subunit protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D HDEF_0328 rpsO; 30S ribosomal subunit protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D HDEF_2326 rpsP; 30S ribosomal subunit protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D HDEF_1857 rpsQ; 30S ribosomal subunit protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D HDEF_0583 rpsR; 30S ribosomal subunit protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D HDEF_1862 rpsS; 30S ribosomal subunit protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D HDEF_0369 rpsT; 30S ribosomal subunit protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D HDEF_0643 rpsU; 30S ribosomal subunit protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D HDEF_0714 rplA; 50S ribosomal subunit protein L1, regulates synthesis of L1 and L11 K02863 RP-L1; large subunit ribosomal protein L1
D HDEF_1863 rplB; 50S ribosomal subunit protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D HDEF_1866 rplC; 50S ribosomal subunit protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D HDEF_1865 rplD; 50S ribosomal subunit protein L4, regulates expression of S10 operon K02926 RP-L4; large subunit ribosomal protein L4
D HDEF_1854 rplE; 50S ribosomal subunit protein L5 K02931 RP-L5; large subunit ribosomal protein L5
D HDEF_1851 rplF; 50S ribosomal subunit protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D HDEF_0712 rplL; 50S ribosomal subunit protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D HDEF_0795 rplI; 50S ribosomal subunit protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D HDEF_0713 rplJ; 50S ribosomal subunit protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D HDEF_0715 rplK; 50S ribosomal subunit protein L11, N-terminal believed to regulate RelA K02867 RP-L11; large subunit ribosomal protein L11
D HDEF_1259 rplM; 50S ribosomal subunit protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D HDEF_1856 rplN; 50S ribosomal subunit protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D HDEF_1847 rplO; 50S ribosomal subunit protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D HDEF_1859 rplP; 50S ribosomal subunit protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D HDEF_1840 rplQ; 50S ribosomal subunit protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D HDEF_1850 rplR; 50S ribosomal subunit protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D HDEF_2323 rplS; 50S ribosomal subunit protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D HDEF_1827 rplT; 50S ribosomal subunit protein L20, also posttranslational autoregulator K02887 RP-L20; large subunit ribosomal protein L20
D HDEF_2333 rplU; 50S ribosomal subunit protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D HDEF_1861 rplV; 50S ribosomal subunit protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D HDEF_1864 rplW; 50S ribosomal subunit protein L23 K02892 RP-L23; large subunit ribosomal protein L23
D HDEF_1855 rplX; 50S ribosomal subunit protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D HDEF_0466 rplY; 50S ribosomal subunit protein L25 K02897 RP-L25; large subunit ribosomal protein L25
D HDEF_2332 rpmA; 50S ribosomal subunit protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D HDEF_1914 rpmB; 50S ribosomal subunit protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D HDEF_1858 rpmC; 50S ribosomal subunit protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D HDEF_1848 rpmD; 50S ribosomal subunit protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D HDEF_0384 rpmE; 50S ribosomal subunit protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D HDEF_0444 rpmF; 50S ribosomal subunit protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D HDEF_1915 rpmG; 50S ribosomal subunit protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D HDEF_2012 rpmH; 50S ribosomal subunit protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D HDEF_1826 rpmI; 50S ribosomal subunit protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D HDEF_1845 rpmJ; 50S ribosomal subunit protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D HDEF_1753 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1320 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_2034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1317 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_2032 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_1751 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_1316 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_2031 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_1750 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
C 00970 Aminoacyl-tRNA biosynthesis [PATH:hde00970]
D HDEF_1304 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D HDEF_1318 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D HDEF_1646 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0548 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_1919 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0015 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0360 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D HDEF_0684 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D HDEF_1532 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D HDEF_0812 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D HDEF_0813 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D HDEF_1752 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D HDEF_2033 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D HDEF_0686 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D HDEF_1531 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D HDEF_0549 tRNA-His K14226 tRNA-His; tRNA His
D HDEF_1319 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D HDEF_0336 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_1594 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0814 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0550 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_1533 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0572 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_1527 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_1658 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_2246 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0815 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0335 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0871 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D HDEF_0551 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D HDEF_2112 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D HDEF_0014 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_2069 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_2291 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_0685 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D HDEF_0688 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D HDEF_1315 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_1749 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_2030 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_0687 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D HDEF_0571 tRNA-Val K14237 tRNA-Val; tRNA Val
D HDEF_1515 tRNA-Val K14237 tRNA-Val; tRNA Val
D HDEF_0366 gltX; glutamate tRNA synthetase, catalytic subunit K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D HDEF_0764 glnS; glutamine tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D HDEF_0012 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D HDEF_0868 aspS; aspartate tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D HDEF_0877 asnS; asparagine tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D HDEF_0611 glyQ; glycine tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D HDEF_0612 glyS; glycine tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D HDEF_1824 thrS; threonine tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D HDEF_1279 serS; serine tRNA synthetase; also charges selenocystein tRNA with serine K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D HDEF_1542 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D HDEF_1807 metG; methionine tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D HDEF_1721 fmt; 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D HDEF_0219 valS; valine tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D HDEF_2038 leuS; leucine tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D HDEF_0831 ileS; isoleucine tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D HDEF_0009 lysU; lysine tRNA synthetase, inducible K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D HDEF_0639 argS; arginine tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D HDEF_0391 proS; proline tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D HDEF_0753 hisS; histidine tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D HDEF_1828 pheS; phenylalanine tRNA synthetase, alpha-subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D HDEF_1830 pheT; phenylalanine tRNA synthetase, beta-subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D HDEF_0671 tyrS; tyrosine tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D HDEF_1634 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C 03013 Nucleocytoplasmic transport
C 03015 mRNA surveillance pathway
C 03008 Ribosome biogenesis in eukaryotes
B
B 09123 Folding, sorting and degradation
C 03060 Protein export [PATH:hde03060]
D HDEF_1846 secY; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03076 secY; preprotein translocase subunit SecY
D HDEF_0717 secE; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03073 secE; preprotein translocase subunit SecE
D HDEF_0337 secG; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03075 secG; preprotein translocase subunit SecG
D HDEF_0083 secD; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03072 secD; preprotein translocase subunit SecD
D HDEF_0082 secF; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03074 secF; preprotein translocase subunit SecF
D HDEF_0084 yajC; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03210 yajC; preprotein translocase subunit YajC
D HDEF_2009 yidC; protein involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY K03217 yidC; YidC/Oxa1 family membrane protein insertase
D HDEF_2096 secA; preprotein translocase, ATPase secretion component (General Secretory Pathway) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D HDEF_0791 secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) K03071 secB; preprotein translocase subunit SecB
D HDEF_2327 ffh; 4.5S-RNP protein, GTP-binding export factor, part of signal recognition particle with 4.5 RNA K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D HDEF_2308 ftsY; cell division protein: membrane binding (N-terminal); GTPase domain (C-terminal) K03110 ftsY; fused signal recognition particle receptor
D HDEF_1735 tatA; TatABCE protein translocation system subunit K03116 tatA; sec-independent protein translocase protein TatA
D HDEF_1737 tatC; twin-arginine translocase subunit, sec-independent protein export K03118 tatC; sec-independent protein translocase protein TatC
D HDEF_0531 lepB; leader peptidase (signal peptidase I), serine protease K03100 lepB; signal peptidase I [EC:3.4.21.89]
D HDEF_0743 signal peptidase I, Peptidase_S24 domain protein K03100 lepB; signal peptidase I [EC:3.4.21.89]
D HDEF_0832 lspA; prolipoprotein signal peptidase (SPase II) K03101 lspA; signal peptidase II [EC:3.4.23.36]
C 04141 Protein processing in endoplasmic reticulum
C 04130 SNARE interactions in vesicular transport
C 04120 Ubiquitin mediated proteolysis
C 04122 Sulfur relay system [PATH:hde04122]
D HDEF_0542 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D HDEF_0517 sirA; conserved protein required for cell growth K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D HDEF_0076 tusB; tRNA 2-thiouridine synthesizing protein B K07237 tusB; tRNA 2-thiouridine synthesizing protein B
D HDEF_0077 tusC; tRNA 2-thiouridine synthesizing protein C K07236 tusC; tRNA 2-thiouridine synthesizing protein C
D HDEF_0078 tusD; tRNA 2-thiouridine synthesizing sulfurtransferase D K07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D HDEF_1918 tusE; tRNA 2-thiouridine synthesizing sulfurtransferase E K11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]
D HDEF_0556 mnmA; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
C 03050 Proteasome
C 03018 RNA degradation [PATH:hde03018]
D HDEF_0654 rppH; dinucleoside polyphosphate hydrolase, NUDIX domain protein K08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]
D HDEF_0352 rne; RNase E: endoribonuclease for rRNA processing and mRNA degradation K08300 rne; ribonuclease E [EC:3.1.26.12]
D HDEF_0090 rhlB; ATP-dependent RNA helicase K03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D HDEF_0327 pnp; polynucleotide phosphorylase/polyadenylase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D HDEF_0292 rhlE; putative ATP-dependent RNA helicase with P-loop hydrolase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]
D HDEF_0301 rnr; RNase R, 3'-5' exoribonuclease K12573 rnr; ribonuclease R [EC:3.1.13.1]
D HDEF_0325 deaD; cold-shock DeaD box ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D HDEF_2027 rho; transcription termination factor Rho; polarity suppressor K03628 rho; transcription termination factor Rho
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_0372 dnaK; chaperone Hsp70 in DNA biosynthesis/cell division K04043 dnaK; molecular chaperone DnaK
D HDEF_0629 groEL; chaperone Hsp60 (GroEL) K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D HDEF_0494 hfq; host factor I for bacteriophage Q beta replication K03666 hfq; host factor-I protein
D HDEF_1621 pcnB; poly(A) polymerase I K00970 pcnB; poly(A) polymerase [EC:2.7.7.19]
B
B 09124 Replication and repair
C 03030 DNA replication [PATH:hde03030]
D HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
D HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D HDEF_0678 dnaB; replicative DNA helicase; chromosome replication; chain elongation K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D HDEF_0644 dnaG; DNA biosynthesis; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0682 rnhA; RNase HI, degrades RNA of DNA-RNA hybrids K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D HDEF_0586 rnhB; RNAse HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03410 Base excision repair [PATH:hde03410]
D HDEF_1596 nth; DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D HDEF_0455 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D HDEF_0358 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D HDEF_1122 mpg_1; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D HDEF_1323 mpg_2; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D HDEF_0641 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03420 Nucleotide excision repair [PATH:hde03420]
D HDEF_0121 mfd; transcription-repair ATP-dependent coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D HDEF_1815 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
D HDEF_1619 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
D HDEF_1529 uvrC; excinuclease UvrABC, endonuclease subunit K03703 uvrC; excinuclease ABC subunit C
D HDEF_0700 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03430 Mismatch repair [PATH:hde03430]
D HDEF_1628 mutS; methyl-directed mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D HDEF_0492 mutL_1; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_p0005 mutL; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_1386 mutL_2; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_1904 mutH_1; putative methyl-directed mismatch repair protein with restriction endonuclease-like domain K03573 mutH; DNA mismatch repair protein MutH
D HDEF_0700 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D HDEF_1920 sbcB; exonuclease I, 3' --> 5'-specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
D HDEF_1282 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D HDEF_1606 xseB; exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
D HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D HDEF_1639 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
C 03440 Homologous recombination [PATH:hde03440]
D HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0534 recO; gap repair protein, part of RecFOR complex K03584 recO; DNA repair protein RecO (recombination protein O)
D HDEF_2089 recR; gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction K06187 recR; recombination protein RecR
D HDEF_0025 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_1940 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
D HDEF_1939 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D HDEF_0870 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D HDEF_0627 recG; DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D HDEF_0033 recB; exonuclease V, beta chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
D HDEF_0034 recC; exonuclease V, gamma chain with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
D HDEF_0032 recD; exonuclease V (RecBCD complex), alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
D HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D HDEF_0504 priA; primosomal protein N' (factor Y) directs replication fork assembly at D-loops, ATP-dependent K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D HDEF_0584 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
C 03450 Non-homologous end-joining
C 03460 Fanconi anemia pathway
B
B 09126 Chromosome
C 03082 ATP-dependent chromatin remodeling
C 03083 Polycomb repressive complex
B
B 09125 Information processing in viruses
C 03230 Viral genome structure
C 03240 Viral replication
C 03250 Viral life cycle - HIV-1
C 03260 Virion - Human immunodeficiency virus
C 03271 Virion - Rotavirus
C 03262 Virion - Coronavirus
C 03261 Virion - Influenza virus
C 03263 Virion - Enterovirus
C 03264 Virion - Flavivirus
C 03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
C 03266 Virion - Herpesvirus
C 03268 Virion - Orthopoxvirus
C 03267 Virion - Adenovirus
C 03259 Virion - Bacteriophages T4 and T7
C 03258 Virion - Bacteriophage lambda
#
A09130 Environmental Information Processing
B
B 09131 Membrane transport
C 02010 ABC transporters [PATH:hde02010]
D HDEF_0607 tbpA; thiamin transporter subunit K02064 thiB; thiamine transport system substrate-binding protein
D HDEF_0606 thiP; thiamin transport protein (ABC superfamily, membrane) K02063 thiP; thiamine transport system permease protein
D HDEF_0605 thiQ; thiamin transport protein (ABC superfamily, atp_bind) K02062 thiQ; thiamine transport system ATP-binding protein [EC:7.6.2.15]
D HDEF_1953 putative ABC-type transport system protein K07323 mlaC; phospholipid transport system substrate-binding protein
D HDEF_1952 yrbD; putative organic solvent ABC transporter, cytoplasmic membrane protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein
D HDEF_1951 yrbE; putative ABC transporter, permease protein K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein
D HDEF_1950 yrbF; putative ABC-type transport system, resistance to organic solvents, ATP-binding protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein
D HDEF_2256 pstS; high-affinity phosphate transport protein (ABC superfamily, peri_bind) K02040 pstS; phosphate transport system substrate-binding protein
D HDEF_2255 pstC; high-affinity phosphate transport protein (ABC superfamily, membrane) K02037 pstC; phosphate transport system permease protein
D HDEF_2254 pstA; high-affinity phosphate transport protein (ABC superfamily, membrane) K02038 pstA; phosphate transport system permease protein
D HDEF_2253 ptsB; phosphate transport ATP-binding K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D HDEF_0376 glnH; high-affinity glutamine transport protein (ABC superfamily, peri_bind) K10036 glnH; glutamine transport system substrate-binding protein
D HDEF_0377 glnP; high-affinity glutamine transport protein (ABC superfamily, membrane) K10037 glnP; glutamine transport system permease protein
D HDEF_0378 glnQ; high-affinity glutamine transport protein (ABC superfamily, atp_bind) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_1771 artI; arginine transport protein (ABC superfamily, peri_bind) K09997 artI; arginine transport system substrate-binding protein
D HDEF_1773 artQ; arginine transport protein (ABC superfamily, membrane) K09998 artM; arginine transport system permease protein
D HDEF_1772 artM; arginine transport protein (ABC superfamily, membrane) K09999 artQ; arginine transport system permease protein
D HDEF_1770 artP; arginine transport protein (ABC superfamily, atp_bind) K10000 artP; arginine transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_1618 gltL; glutamate-aspartate ABC transporter ATP-binding component K10004 gltL; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_0389 metQ; D-methionine transport protein (ABC superfamily, peri_bind) K02073 metQ; D-methionine transport system substrate-binding protein
D HDEF_0388 metI; D- and L-methionine transport protein (ABC superfamily, membrane) K02072 metI; D-methionine transport system permease protein
D HDEF_0387 metN; D- and L-methionine transport protein (ABC superfamily, atp_bind) K02071 metN; D-methionine transport system ATP-binding protein
D HDEF_2104 sapB; peptide transport protein (ABC superfamily, membrane) K19227 sapB; cationic peptide transport system permease protein
D HDEF_2103 sapC; peptide transport protein (ABC superfamily, membrane) K19228 sapC; cationic peptide transport system permease protein
D HDEF_2102 sapD; peptide transport protein (ABC superfamily, atp_bind) K19229 sapD; cationic peptide transport system ATP-binding protein
D HDEF_2101 sapF; peptide transport protein (ABC superfamily, atp_bind) K19230 sapF; cationic peptide transport system ATP-binding protein
D HDEF_0651 znuA; high-affinity Zn transport protein (ABC superfamily, peri_bind) K09815 znuA; zinc transport system substrate-binding protein
D HDEF_0649 znuB; high-affinity Zn transport protein (ABC superfamily, membrane) K09816 znuB; zinc transport system permease protein
D HDEF_0650 znuC; high-affinity Zn transport protein (ABC superfamily, atp_bind) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D HDEF_2126 yfeA; chelated iron ABC transporter, periplasmic iron binding protein K11604 sitA; manganese/iron transport system substrate-binding protein
D HDEF_2124 yfeC; chelated iron transport system membrane protein K11605 sitC; manganese/iron transport system permease protein
D HDEF_2123 yfeD; chelated iron ABC transporter, permease protein K11606 sitD; manganese/iron transport system permease protein
D HDEF_2125 yfeB; chelated iron ABC transporter, ATP-binding protein K11607 sitB; manganese/iron transport system ATP-binding protein
D HDEF_0122 lolC; transport protein of outer membrane lipoproteins (ABC superfamily, membrane) K09808 lolC_E; lipoprotein-releasing system permease protein
D HDEF_0124 lolE; transport protein of outer membrane lipoproteins (ABC superfamily, membrane) K09808 lolC_E; lipoprotein-releasing system permease protein
D HDEF_0123 lolD; transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind) K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-]
D HDEF_0222 putative permease K07091 lptF; lipopolysaccharide export system permease protein
D HDEF_0223 putative permease K11720 lptG; lipopolysaccharide export system permease protein
D HDEF_1944 yhbG; putative transport protein (ABC superfamily, atp_bind) K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5]
D HDEF_2306 ftsX; cell division protein for septal ring assimbly and stability K09811 ftsX; cell division transport system permease protein
D HDEF_2307 ftsE; cell division protein for septal ring assimbly and stability K09812 ftsE; cell division transport system ATP-binding protein
D HDEF_1204 msbA; lipid transport protein, flippase (ABC superfamily, membrane (N-terminal), atp_bind (C-terminal)) K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6]
D HDEF_0268 putative ABC-type secretion protein K12541 lapB; ATP-binding cassette, subfamily C, bacterial LapB
D HDEF_0539 ABC-type antimicrobial peptide transport system, permease K05685 macB; macrolide transport system ATP-binding/permease protein [EC:7.6.2.-]
C 02060 Phosphotransferase system (PTS) [PATH:hde02060]
D HDEF_0323 ptsI; PTS family enzyme I and Hpr components, PEP-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D HDEF_0324 ptsH; PTS family Hpr protein, phosphohistidinoprotein-hexose phosphotransferase K02784 ptsH; phosphocarrier protein HPr
D HDEF_0322 crr; PTS family enzyme IIA component K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
D HDEF_0454 ptsG; PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal), glucose-specific K02779 ptsG; glucose PTS system EIICB or EIICBA component [EC:2.7.1.199]
D HDEF_0159 manX; PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D HDEF_0158 manY; PTS family enzyme IIC, mannose-specific K02795 manY; mannose PTS system EIIC component
D HDEF_0157 manZ; PTS family enzyme IID, mannose-specific K02796 manZ; mannose PTS system EIID component
D HDEF_1820 fruB; PTS family enzyme IIA (N-terminal); FPr (C-terminal), fructose-specific K11183 fruB; multiphosphoryl transfer protein [EC:2.7.1.202]
D HDEF_1822 fruA; PTS family enzyme IIB'BC, fructose-specific K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D HDEF_1821 fruK; fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
D HDEF_1943 ptsN; PTS family enzyme IIA, sugar-specific, regulates N metabolism K02806 ptsN; nitrogen PTS system EIIA component [EC:2.7.1.-]
C 03070 Bacterial secretion system [PATH:hde03070]
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_0137 ssaG; type III secretion system apparatus protein K03221 yscF; type III secretion protein F
D HDEF_1218 putative type III secretion needle protein K03221 yscF; type III secretion protein F
D HDEF_0147 ssaC; type III outer membrane secretin precursor K03219 yscC; type III secretion protein C
D HDEF_0134 ssaJ; needle complex inner membrane lipoprotein K03222 yscJ; type III secretion protein J
D HDEF_2251 ssaR; type III secretion system protein K03226 yscR; type III secretion protein R
D HDEF_2250 ssaS; type III secretion system apparatus protein K03227 yscS; type III secretion protein S
D HDEF_2249 ssaT; type III secretion system apparatus protein K03228 yscT; type III secretion protein T
D HDEF_2248 ssaU; type III secretion system apparatus protein K03229 yscU; type III secretion protein U
D HDEF_1499 invA; type III needle complex export protein K03230 yscV; type III secretion protein V
D HDEF_0129 ssaV; type III secretion system apparatus protein K03230 yscV; type III secretion protein V
D HDEF_0128 ssaN; type III secretion system ATPase K03224 yscN; ATP synthase in type III secretion protein N [EC:7.4.2.8]
D HDEF_1505 spaO; type III surface presentation of antigens protein K03225 yscQ; type III secretion protein Q
D HDEF_0125 ssaQ; type III secretion system protein K03225 yscQ; type III secretion protein Q
D HDEF_0241 gspD; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02453 gspD; general secretion pathway protein D
D HDEF_0243 hypothetical protein K02452 gspC; general secretion pathway protein C
D HDEF_0349 gspG; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02456 gspG; general secretion pathway protein G
D HDEF_0348 gspH; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02457 gspH; general secretion pathway protein H
D HDEF_0347 gspI; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02458 gspI; general secretion pathway protein I
D HDEF_0346 gspJ; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02459 gspJ; general secretion pathway protein J
D HDEF_0344 gspK; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02460 gspK; general secretion pathway protein K
D HDEF_0343 gspL; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02461 gspL; general secretion pathway protein L
D HDEF_0342 gspM; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02462 gspM; general secretion pathway protein M
D HDEF_0239 gspE; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02454 gspE; general secretion pathway protein E [EC:7.4.2.8]
D HDEF_0083 secD; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03072 secD; preprotein translocase subunit SecD
D HDEF_0082 secF; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03074 secF; preprotein translocase subunit SecF
D HDEF_0717 secE; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03073 secE; preprotein translocase subunit SecE
D HDEF_0337 secG; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03075 secG; preprotein translocase subunit SecG
D HDEF_1846 secY; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03076 secY; preprotein translocase subunit SecY
D HDEF_0084 yajC; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03210 yajC; preprotein translocase subunit YajC
D HDEF_2009 yidC; protein involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY K03217 yidC; YidC/Oxa1 family membrane protein insertase
D HDEF_2096 secA; preprotein translocase, ATPase secretion component (General Secretory Pathway) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D HDEF_2308 ftsY; cell division protein: membrane binding (N-terminal); GTPase domain (C-terminal) K03110 ftsY; fused signal recognition particle receptor
D HDEF_0791 secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) K03071 secB; preprotein translocase subunit SecB
D HDEF_2327 ffh; 4.5S-RNP protein, GTP-binding export factor, part of signal recognition particle with 4.5 RNA K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D HDEF_1735 tatA; TatABCE protein translocation system subunit K03116 tatA; sec-independent protein translocase protein TatA
D HDEF_1737 tatC; twin-arginine translocase subunit, sec-independent protein export K03118 tatC; sec-independent protein translocase protein TatC
D HDEF_1331 triB; TriB conjugal transfer protein K03197 virB2; type IV secretion system protein VirB2
D HDEF_0432 virB5; VirB5 conjugal transfer protein K03200 virB5; type IV secretion system protein VirB5
D HDEF_1333 triD; TriD conjugal transfer protein K03200 virB5; type IV secretion system protein VirB5
D HDEF_0419 virB9; VirB9 conjugative transfer protein K03204 virB9; type IV secretion system protein VirB9
D HDEF_1339 triH; TriH conjugal transfer protein K03204 virB9; type IV secretion system protein VirB9
D HDEF_0428 virB6; VirB6 conjugal transfer protein K03201 virB6; type IV secretion system protein VirB6
D HDEF_1335 triE; TriE conjugal transfer protein K03201 virB6; type IV secretion system protein VirB6
D HDEF_1338 triG; TriG conjugal transfer protein K03203 virB8; type IV secretion system protein VirB8
D HDEF_1340 triI; TriI conjugal transfer protein K03195 virB10; type IV secretion system protein VirB10
D HDEF_0417 virB10; VirB10 conjugal transfer protein K03195 virB10; type IV secretion system protein VirB10
D HDEF_1341 triJ; TriJ conjugal transfer protein K03196 virB11; type IV secretion system protein VirB11 [EC:7.4.2.8]
D HDEF_0416 virB11; VirB11 conjugative transfer protein K03196 virB11; type IV secretion system protein VirB11 [EC:7.4.2.8]
D HDEF_1342 taxB; TaxB conjugal transfer protein K03205 virD4; type IV secretion system protein VirD4 [EC:7.4.2.8]
B
B 09132 Signal transduction
C 02020 Two-component system [PATH:hde02020]
D HDEF_2256 pstS; high-affinity phosphate transport protein (ABC superfamily, peri_bind) K02040 pstS; phosphate transport system substrate-binding protein
D HDEF_0289 integral membrane protein K07790 pagO; putative membrane protein PagO
D HDEF_2275 ompN; outer membrane pore protein N, non-specific K09476 ompF; outer membrane pore protein F
D HDEF_1803 cpxR; response regulator in two-component regulatory system with CpxA K07662 cpxR; two-component system, OmpR family, response regulator CpxR
D HDEF_1488 degP_2; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1479 degP_1; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1519 arcB; hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
D HDEF_1901 arcA; response regulator in two-component regulatory system with ArcB (or CpxA), regulates respiratory and fermentative metabolism (OmpR family) K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
D HDEF_1739 dnaA; DNA replication initiator protein K02313 dnaA; chromosomal replication initiator protein
D HDEF_1806 sfcA; NAD-linked malate dehydrogenase K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
D HDEF_1801 rcsB; response regulator (positive) in two-component regulatory system with RcsC and YojN K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
D HDEF_1629 barA; hybrid sensory histidine kinase in two-component regulatory system with UvrY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
D HDEF_1528 uvrY; UvrY transcriptional regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
D HDEF_0013 csrA; carbon storage regulator K03563 csrA; carbon storage regulator
D HDEF_0080 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA, regulates multidrug resistance K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
D HDEF_2060 putative transcriptional regulator, response regulator receiver and GerE domains K07690 evgA; two-component system, NarL family, response regulator EvgA
D HDEF_0318 hypothetical protein K02279 cpaB; pilus assembly protein CpaB
D HDEF_0317 rcpA; putative tight adherance operon protein K02280 cpaC; pilus assembly protein CpaC
D HDEF_0315 hypothetical protein K02282 cpaE; pilus assembly protein CpaE
D HDEF_0313 tadB; putative tight adherance operon protein B K12510 tadB; tight adherence protein B
D HDEF_0312 tadC; putative tight adherance operon protein C K12511 tadC; tight adherence protein C
D HDEF_0149 putative two-component sensor/regulator K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA
D HDEF_0150 putative regulator in two-component regulatory system with BarA (LuxR/UhpA familiy) K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB
D HDEF_1618 gltL; glutamate-aspartate ABC transporter ATP-binding component K10004 gltL; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_0827 crp; transcriptional regulator, cyclic AMP receptor protein (CAMP-binding family), interacts with RNAP K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
D HDEF_0278 rtxB_2; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12530 rtxB; ATP-binding cassette, subfamily B, bacterial RtxB
D HDEF_0277 rtxD; putative ABC associated RTX toxin transporter, HlyD/MFP family K12532 rtxD; membrane fusion protein, RTX toxin transport system
D HDEF_0276 rtxB_1; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12531 rtxE; ATP-binding cassette, subfamily B, bacterial RtxE
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
C 04010 MAPK signaling pathway
C 04013 MAPK signaling pathway - fly
C 04016 MAPK signaling pathway - plant
C 04011 MAPK signaling pathway - yeast
C 04012 ErbB signaling pathway
C 04014 Ras signaling pathway
C 04015 Rap1 signaling pathway
C 04310 Wnt signaling pathway
C 04330 Notch signaling pathway
C 04340 Hedgehog signaling pathway
C 04341 Hedgehog signaling pathway - fly
C 04350 TGF-beta signaling pathway
C 04390 Hippo signaling pathway
C 04391 Hippo signaling pathway - fly
C 04392 Hippo signaling pathway - multiple species
C 04370 VEGF signaling pathway
C 04371 Apelin signaling pathway
C 04630 JAK-STAT signaling pathway
C 04064 NF-kappa B signaling pathway
C 04668 TNF signaling pathway
C 04066 HIF-1 signaling pathway
C 04068 FoxO signaling pathway
C 04020 Calcium signaling pathway
C 04070 Phosphatidylinositol signaling system
C 04072 Phospholipase D signaling pathway
C 04071 Sphingolipid signaling pathway
C 04024 cAMP signaling pathway
C 04022 cGMP-PKG signaling pathway
C 04151 PI3K-Akt signaling pathway
C 04152 AMPK signaling pathway
C 04150 mTOR signaling pathway
C 04075 Plant hormone signal transduction
B
B 09133 Signaling molecules and interaction
C 04080 Neuroactive ligand-receptor interaction
C 04060 Cytokine-cytokine receptor interaction
C 04061 Viral protein interaction with cytokine and cytokine receptor
C 04512 ECM-receptor interaction
C 04514 Cell adhesion molecules
#
A09140 Cellular Processes
B
B 09141 Transport and catabolism
C 04144 Endocytosis
C 04145 Phagosome
C 04142 Lysosome
C 04146 Peroxisome
C 04140 Autophagy - animal
C 04138 Autophagy - yeast
C 04136 Autophagy - other
C 04137 Mitophagy - animal
C 04139 Mitophagy - yeast
C 04148 Efferocytosis
B
B 09143 Cell growth and death
C 04110 Cell cycle
C 04111 Cell cycle - yeast
C 04112 Cell cycle - Caulobacter
C 04113 Meiosis - yeast
C 04114 Oocyte meiosis
C 04210 Apoptosis
C 04214 Apoptosis - fly
C 04215 Apoptosis - multiple species
C 04216 Ferroptosis
C 04217 Necroptosis
C 04115 p53 signaling pathway
C 04218 Cellular senescence
B
B 09144 Cellular community - eukaryotes
C 04510 Focal adhesion
C 04520 Adherens junction
C 04530 Tight junction
C 04540 Gap junction
C 04550 Signaling pathways regulating pluripotency of stem cells
B
B 09145 Cellular community - prokaryotes
C 02024 Quorum sensing [PATH:hde02024]
D HDEF_0494 hfq; host factor I for bacteriophage Q beta replication K03666 hfq; host factor-I protein
D HDEF_0075 aroH; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase), tryptophan-repressible K01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D HDEF_0873 expI; autoinducer synthase K22956 expI; acyl homoserine lactone synthase [EC:2.3.1.184]
D HDEF_0874 expR; autoinducer response regulator K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D HDEF_1635 smaR; autoinducer response regulator K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D HDEF_0827 crp; transcriptional regulator, cyclic AMP receptor protein (CAMP-binding family), interacts with RNAP K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
D HDEF_0118 ribA; GTP cyclohydrolase II K01497 ribA; GTP cyclohydrolase II [EC:3.5.4.25]
D HDEF_0030 ribD; bifunctional: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); 5-amino-6-(5-phosphoribosylamino) uracil reductase (C-terminal) K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D HDEF_2009 yidC; protein involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY K03217 yidC; YidC/Oxa1 family membrane protein insertase
D HDEF_0717 secE; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03073 secE; preprotein translocase subunit SecE
D HDEF_0337 secG; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03075 secG; preprotein translocase subunit SecG
D HDEF_1846 secY; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03076 secY; preprotein translocase subunit SecY
D HDEF_0084 yajC; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03210 yajC; preprotein translocase subunit YajC
D HDEF_2096 secA; preprotein translocase, ATPase secretion component (General Secretory Pathway) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D HDEF_2308 ftsY; cell division protein: membrane binding (N-terminal); GTPase domain (C-terminal) K03110 ftsY; fused signal recognition particle receptor
D HDEF_0791 secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) K03071 secB; preprotein translocase subunit SecB
D HDEF_2327 ffh; 4.5S-RNP protein, GTP-binding export factor, part of signal recognition particle with 4.5 RNA K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
C 05111 Biofilm formation - Vibrio cholerae
C 02025 Biofilm formation - Pseudomonas aeruginosa
C 02026 Biofilm formation - Escherichia coli
B
B 09142 Cell motility
C 02030 Bacterial chemotaxis
C 02040 Flagellar assembly
D HDEF_0645 rpoD; RNA polymerase, sigma 70 (sigma D) factor K03086 rpoD; RNA polymerase primary sigma factor
C 04814 Motor proteins
C 04820 Cytoskeleton in muscle cells
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C 04810 Regulation of actin cytoskeleton
#
A09150 Organismal Systems
B
B 09151 Immune system
C 04640 Hematopoietic cell lineage
C 04610 Complement and coagulation cascades
C 04611 Platelet activation
C 04613 Neutrophil extracellular trap formation
C 04620 Toll-like receptor signaling pathway
C 04624 Toll and Imd signaling pathway
C 04621 NOD-like receptor signaling pathway
C 04622 RIG-I-like receptor signaling pathway
C 04623 Cytosolic DNA-sensing pathway
C 04625 C-type lectin receptor signaling pathway
C 04650 Natural killer cell mediated cytotoxicity
C 04612 Antigen processing and presentation
C 04660 T cell receptor signaling pathway
C 04658 Th1 and Th2 cell differentiation
C 04659 Th17 cell differentiation
C 04657 IL-17 signaling pathway
C 04662 B cell receptor signaling pathway
C 04664 Fc epsilon RI signaling pathway
C 04666 Fc gamma R-mediated phagocytosis
C 04670 Leukocyte transendothelial migration
C 04672 Intestinal immune network for IgA production
C 04062 Chemokine signaling pathway
B
B 09152 Endocrine system
C 04911 Insulin secretion
C 04910 Insulin signaling pathway
C 04922 Glucagon signaling pathway
C 04923 Regulation of lipolysis in adipocytes
C 04920 Adipocytokine signaling pathway
C 03320 PPAR signaling pathway
C 04929 GnRH secretion
C 04912 GnRH signaling pathway
C 04913 Ovarian steroidogenesis
C 04915 Estrogen signaling pathway
C 04914 Progesterone-mediated oocyte maturation
C 04917 Prolactin signaling pathway
C 04921 Oxytocin signaling pathway
C 04926 Relaxin signaling pathway
C 04935 Growth hormone synthesis, secretion and action
C 04918 Thyroid hormone synthesis
C 04919 Thyroid hormone signaling pathway
C 04928 Parathyroid hormone synthesis, secretion and action
C 04916 Melanogenesis
C 04924 Renin secretion
C 04614 Renin-angiotensin system
C 04925 Aldosterone synthesis and secretion
C 04927 Cortisol synthesis and secretion
B
B 09153 Circulatory system
C 04260 Cardiac muscle contraction
C 04261 Adrenergic signaling in cardiomyocytes
C 04270 Vascular smooth muscle contraction
B
B 09154 Digestive system
C 04970 Salivary secretion
C 04971 Gastric acid secretion
C 04972 Pancreatic secretion
C 04976 Bile secretion
C 04973 Carbohydrate digestion and absorption
C 04974 Protein digestion and absorption
C 04975 Fat digestion and absorption
C 04979 Cholesterol metabolism
C 04977 Vitamin digestion and absorption
C 04980 Cobalamin transport and metabolism
C 04978 Mineral absorption
B
B 09155 Excretory system
C 04962 Vasopressin-regulated water reabsorption
C 04960 Aldosterone-regulated sodium reabsorption
C 04961 Endocrine and other factor-regulated calcium reabsorption
C 04964 Proximal tubule bicarbonate reclamation
C 04966 Collecting duct acid secretion
B
B 09156 Nervous system
C 04724 Glutamatergic synapse
C 04727 GABAergic synapse
C 04725 Cholinergic synapse
C 04728 Dopaminergic synapse
C 04726 Serotonergic synapse
C 04720 Long-term potentiation
C 04730 Long-term depression
C 04723 Retrograde endocannabinoid signaling
C 04721 Synaptic vesicle cycle
C 04722 Neurotrophin signaling pathway
B
B 09157 Sensory system
C 04744 Phototransduction
C 04745 Phototransduction - fly
C 04740 Olfactory transduction
C 04742 Taste transduction
C 04750 Inflammatory mediator regulation of TRP channels
B
B 09158 Development and regeneration
C 04320 Dorso-ventral axis formation
C 04360 Axon guidance
C 04361 Axon regeneration
C 04380 Osteoclast differentiation
B
B 09149 Aging
C 04211 Longevity regulating pathway
C 04212 Longevity regulating pathway - worm
C 04213 Longevity regulating pathway - multiple species
B
B 09159 Environmental adaptation
C 04710 Circadian rhythm
C 04713 Circadian entrainment
C 04711 Circadian rhythm - fly
C 04712 Circadian rhythm - plant
C 04714 Thermogenesis
C 04626 Plant-pathogen interaction
#
A09160 Human Diseases
B
B 09161 Cancer: overview
C 05200 Pathways in cancer
C 05202 Transcriptional misregulation in cancer
C 05206 MicroRNAs in cancer
C 05205 Proteoglycans in cancer
C 05204 Chemical carcinogenesis - DNA adducts
C 05207 Chemical carcinogenesis - receptor activation
C 05208 Chemical carcinogenesis - reactive oxygen species
C 05203 Viral carcinogenesis
C 05230 Central carbon metabolism in cancer
C 05231 Choline metabolism in cancer
C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
B
B 09162 Cancer: specific types
C 05210 Colorectal cancer
C 05212 Pancreatic cancer
C 05225 Hepatocellular carcinoma
C 05226 Gastric cancer
C 05214 Glioma
C 05216 Thyroid cancer
C 05221 Acute myeloid leukemia
C 05220 Chronic myeloid leukemia
C 05217 Basal cell carcinoma
C 05218 Melanoma
C 05211 Renal cell carcinoma
C 05219 Bladder cancer
C 05215 Prostate cancer
C 05213 Endometrial cancer
C 05224 Breast cancer
C 05222 Small cell lung cancer
C 05223 Non-small cell lung cancer
B
B 09172 Infectious disease: viral
C 05166 Human T-cell leukemia virus 1 infection
C 05170 Human immunodeficiency virus 1 infection
C 05161 Hepatitis B
C 05160 Hepatitis C
C 05171 Coronavirus disease - COVID-19
C 05164 Influenza A
C 05162 Measles
C 05168 Herpes simplex virus 1 infection
C 05163 Human cytomegalovirus infection
C 05167 Kaposi sarcoma-associated herpesvirus infection
C 05169 Epstein-Barr virus infection
C 05165 Human papillomavirus infection
B
B 09171 Infectious disease: bacterial
C 05110 Vibrio cholerae infection
C 05120 Epithelial cell signaling in Helicobacter pylori infection
C 05130 Pathogenic Escherichia coli infection
C 05132 Salmonella infection
C 05131 Shigellosis
C 05135 Yersinia infection
C 05133 Pertussis
C 05134 Legionellosis
C 05150 Staphylococcus aureus infection
C 05152 Tuberculosis
C 05100 Bacterial invasion of epithelial cells
B
B 09174 Infectious disease: parasitic
C 05146 Amoebiasis
C 05144 Malaria
C 05145 Toxoplasmosis
C 05140 Leishmaniasis
C 05142 Chagas disease
C 05143 African trypanosomiasis
B
B 09163 Immune disease
C 05310 Asthma
C 05322 Systemic lupus erythematosus
C 05323 Rheumatoid arthritis
C 05320 Autoimmune thyroid disease
C 05321 Inflammatory bowel disease
C 05330 Allograft rejection
C 05332 Graft-versus-host disease
C 05340 Primary immunodeficiency
B
B 09164 Neurodegenerative disease
C 05010 Alzheimer disease
C 05012 Parkinson disease
C 05014 Amyotrophic lateral sclerosis
C 05016 Huntington disease
C 05017 Spinocerebellar ataxia
C 05020 Prion disease
C 05022 Pathways of neurodegeneration - multiple diseases
B
B 09165 Substance dependence
C 05030 Cocaine addiction
C 05031 Amphetamine addiction
C 05032 Morphine addiction
C 05033 Nicotine addiction
C 05034 Alcoholism
B
B 09166 Cardiovascular disease
C 05417 Lipid and atherosclerosis
C 05418 Fluid shear stress and atherosclerosis
C 05410 Hypertrophic cardiomyopathy
C 05412 Arrhythmogenic right ventricular cardiomyopathy
C 05414 Dilated cardiomyopathy
C 05415 Diabetic cardiomyopathy
C 05416 Viral myocarditis
B
B 09167 Endocrine and metabolic disease
C 04930 Type II diabetes mellitus
C 04940 Type I diabetes mellitus
C 04950 Maturity onset diabetes of the young
C 04936 Alcoholic liver disease
C 04932 Non-alcoholic fatty liver disease
C 04931 Insulin resistance
C 04933 AGE-RAGE signaling pathway in diabetic complications
C 04934 Cushing syndrome
B
B 09175 Drug resistance: antimicrobial
C 01501 beta-Lactam resistance [PATH:hde01501]
D HDEF_2275 ompN; outer membrane pore protein N, non-specific K09476 ompF; outer membrane pore protein F
D HDEF_1020 beta-lactamase K17836 penP; beta-lactamase class A [EC:3.5.2.6]
D HDEF_1623 multidrug efflux pump, membrane fusion (MFP/HlyD) family K03585 acrA; membrane fusion protein, multidrug efflux system
D HDEF_1624 multidrug efflux pump K18138 acrB; multidrug efflux pump
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_0672 mrdA; cell elongation-specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase) K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
D HDEF_1789 ftsI; division-specific transpeptidase, penicillin-binding protein 3 K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]
C 01502 Vancomycin resistance [PATH:hde01502]
D HDEF_1781 ddlB; D-alanine-D-alanine ligase B, affects cell division K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D HDEF_0679 alr; alanine racemase 1, PLP-binding, biosynthetic K01775 alr; alanine racemase [EC:5.1.1.1]
D HDEF_1787 murF; D-alanine:D-alanine-adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D HDEF_1786 mraY; phospho-N-acetylmuramoyl-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D HDEF_1783 murG; UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:hde01503]
D HDEF_0856 arnC; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase K10012 arnC; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [EC:2.4.2.53]
D HDEF_0857 arnA; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase K10011 arnA; UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) [EC:2.1.2.13 1.1.1.305]
D HDEF_0858 arnD; putative polysaccharide deacetylase K13014 arnD; undecaprenyl phosphate-alpha-L-ara4FN deformylase [EC:3.5.1.-]
D HDEF_0859 arnT; 4-amino-4-deoxy-L-arabinose transferase K07264 arnT; 4-amino-4-deoxy-L-arabinose transferase [EC:2.4.2.43]
D HDEF_0860 arnE; subunit of ArnE/ArnF undecaprenyl-phosphate-alpha-L-Ara4N flippase K12962 arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE
D HDEF_0861 arnF; subunit of ArnE/ArnF undecaprenyl-phosphate-alpha-L-Ara4N flippase K12963 arnF; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnF
D HDEF_2104 sapB; peptide transport protein (ABC superfamily, membrane) K19227 sapB; cationic peptide transport system permease protein
D HDEF_2103 sapC; peptide transport protein (ABC superfamily, membrane) K19228 sapC; cationic peptide transport system permease protein
D HDEF_2102 sapD; peptide transport protein (ABC superfamily, atp_bind) K19229 sapD; cationic peptide transport system ATP-binding protein
D HDEF_2101 sapF; peptide transport protein (ABC superfamily, atp_bind) K19230 sapF; cationic peptide transport system ATP-binding protein
D HDEF_0400 putative metalloprotease, Serralysin and RTX domains K01406 prtC; serralysin [EC:3.4.24.40]
D HDEF_1803 cpxR; response regulator in two-component regulatory system with CpxA K07662 cpxR; two-component system, OmpR family, response regulator CpxR
D HDEF_0491 amiB; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D HDEF_1488 degP_2; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1479 degP_1; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1545 dsbA; periplasmic protein disulfide isomerase I K03673 dsbA; protein dithiol oxidoreductase (disulfide-forming) [EC:1.8.4.15]
D HDEF_1623 multidrug efflux pump, membrane fusion (MFP/HlyD) family K03585 acrA; membrane fusion protein, multidrug efflux system
D HDEF_1624 multidrug efflux pump K18138 acrB; multidrug efflux pump
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_0588 lpxA; UDP-N-acetylglucosamine acetyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
B
B 09176 Drug resistance: antineoplastic
C 01521 EGFR tyrosine kinase inhibitor resistance
C 01524 Platinum drug resistance
C 01523 Antifolate resistance
C 01522 Endocrine resistance
#
A09180 Brite Hierarchies
B
B 09181 Protein families: metabolism
C 01000 Enzymes [BR:hde01000]
C 01001 Protein kinases [BR:hde01001]
D HDEF_1642 serine/threonine protein kinase involved in cell cycle control K07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]
D HDEF_1519 arcB; hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
D HDEF_1629 barA; hybrid sensory histidine kinase in two-component regulatory system with UvrY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
D HDEF_0080 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA, regulates multidrug resistance K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
D HDEF_0149 putative two-component sensor/regulator K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA
C 01009 Protein phosphatases and associated proteins [BR:hde01009]
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
C 01002 Peptidases and inhibitors [BR:hde01002]
D HDEF_0832 lspA; prolipoprotein signal peptidase (SPase II) K03101 lspA; signal peptidase II [EC:3.4.23.36]
D HDEF_0340 pilD; PilD type IV pilus leader peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D HDEF_1926 guaA; GMP synthetase (glutamine aminotransferase) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D HDEF_0788 purF; amidophosphoribosyltransferase (PRPP amidotransferase) K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D HDEF_0225 glmS; L-glutamine:D-fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D HDEF_2098 asnB; asparagine synthetase B K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
D HDEF_1835 conserved hypothetical protein, YkuD and peptidoglycan binding domains K21470 ycbB; L,D-transpeptidase YcbB
D HDEF_0876 pepN; aminopeptidase N, a cysteinylglycinase K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D HDEF_1836 prlC; oligopeptidase A K01414 prlC; oligopeptidase A [EC:3.4.24.70]
D HDEF_0400 putative metalloprotease, Serralysin and RTX domains K01406 prtC; serralysin [EC:3.4.24.40]
D HDEF_1700 phage endolysin K17733 cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]
D HDEF_0221 pepA; aminopeptidase A, a cyteinylglycinase K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
D HDEF_0094 dapE; N-succinyl-diaminopimelate deacylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
D HDEF_0652 putative M23 peptidase family protein K19304 mepM; murein DD-endopeptidase [EC:3.4.24.-]
D HDEF_0151 map; methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
D HDEF_1964 hflB; ATP-dependent zinc-metallo protease K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D HDEF_1482 htpX_1; heat shock protein, integral membrane protein K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
D HDEF_1485 htpX_2; heat shock protein, integral membrane protein K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
D HDEF_0525 putative peptidase, M24 family K01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-]
D HDEF_0593 rseP; zinc metallopeptidase K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
D HDEF_1488 degP_2; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1479 degP_1; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1818 degS; periplasmic serine endoprotease K04691 hhoB; serine protease DegS [EC:3.4.21.-]
D HDEF_0674 dacA; D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D HDEF_0809 clpP; proteolytic subunit of clpA-clpP ATP-dependent serine protease K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
D HDEF_0807 lon; DNA-binding ATP-dependent protease La; heat shock K-protein K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
D HDEF_2299 ycbZ; putative ATP-dependent protease K04770 lonH; Lon-like ATP-dependent protease [EC:3.4.21.-]
D HDEF_0531 lepB; leader peptidase (signal peptidase I), serine protease K03100 lepB; signal peptidase I [EC:3.4.21.89]
D HDEF_0743 signal peptidase I, Peptidase_S24 domain protein K03100 lepB; signal peptidase I [EC:3.4.21.89]
D HDEF_1481 prc_1; carboxy-terminal protease for penicillin-binding protein 3 K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
D HDEF_1486 prc_2; carboxy-terminal protease for penicillin-binding protein 3 K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
D HDEF_0642 sppA; protease IV, a signal peptide peptidase K04773 sppA; protease IV [EC:3.4.21.-]
D HDEF_1768 sohB; putative peptidase K04774 sohB; serine protease SohB [EC:3.4.21.-]
D HDEF_0800 LD-carboxypeptidase family protein K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D HDEF_1440 phage capsid protease K06904 GP4; Escherichia/Staphylococcus phage prohead protease
D HDEF_1271 hslV; peptidase component of the HslUV protease K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
D HDEF_1730 tldD; putative enzyme for maturation of Microcin B17 and degradation of CcdA with winged helix domain K03568 tldD; TldD protein
D HDEF_0498 hflC; HflC K04087 hflC; modulator of FtsH protease HflC
D HDEF_0497 hflK; HflK K04088 hflK; modulator of FtsH protease HflK
C 01003 Glycosyltransferases [BR:hde01003]
D HDEF_0862 mrcB; bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal); transpeptidase (C-terminal) K05365 mrcB; penicillin-binding protein 1B [EC:2.4.99.28 3.4.16.4]
D HDEF_2026 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
C 01005 Lipopolysaccharide biosynthesis proteins [BR:hde01005]
D HDEF_0588 lpxA; UDP-N-acetylglucosamine acetyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
D HDEF_0587 lpxB; tetraacyldisaccharide-1-P synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]
D HDEF_1777 lpxC; UDP-3-O-acyl N-acetylglucosamine deacetylase K02535 lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
D HDEF_0590 lpxD; UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
D HDEF_1543 lpxH; UDP-2,3-diacylglucosamine pyrophosphatase K03269 lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
D HDEF_0231 lpxK; tetraacyldisaccharide 4' kinase (lipid A 4'kinase) K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
D HDEF_0823 lpxL; lauroyl transferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-]
D HDEF_0653 lpxM; myristoyl-acyl carrier protein (ACP)-dependent acyltransferase K02560 lpxM; lauroyl-Kdo2-lipid IVA myristoyltransferase [EC:2.3.1.243]
D HDEF_1810 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]
D HDEF_0859 arnT; 4-amino-4-deoxy-L-arabinose transferase K07264 arnT; 4-amino-4-deoxy-L-arabinose transferase [EC:2.4.2.43]
D HDEF_0386 kdsA; 3-deoxy-D-manno-octulosonic acid 8-P synthetase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]
D HDEF_0235 kdsB; CTP:CMP-3-deoxy-D-manno-octulosonate transferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]
D HDEF_1947 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]
D HDEF_1948 kdsD; D-arabinose 5-phosphate isomerase K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13]
D HDEF_0842 rfaC; ADP-heptose; LPS heptosyl transferase I K02841 waaC; lipopolysaccharide heptosyltransferase I [EC:2.4.99.23]
D HDEF_1811 glycosyltransferase group 2 K12984 waaE; (heptosyl)LPS beta-1,4-glucosyltransferase [EC:2.4.1.-]
D HDEF_0841 rfaF; ADP-heptose; LPS heptosyltransferase II K02843 waaF; lipopolysaccharide heptosyltransferase II [EC:2.4.99.24]
D HDEF_2072 O-antigen biosynthesis protein, Wzy_C domain protein K02847 waaL; O-antigen ligase [EC:2.4.99.26]
D HDEF_0516 rfaQ; lipopolysaccharide core biosynthesis K02849 waaQ; lipopolysaccharide heptosyltransferase III [EC:2.4.99.25]
D HDEF_2106 lpcA; D-sedoheptulose 7-phosphate isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D HDEF_0185 fusion of GMHP sugar kinase and isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D HDEF_0794 rfaE; bifunctional ADP-L-glycero-D-manno-heptose synthase: putative kinase (N-terminal); putative sugar nucleotide transferase (C-terminal) K03272 gmhC; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70]
D HDEF_0048 rfaD; ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding K03274 gmhD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
D HDEF_2026 rfe; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D HDEF_0179 galE_1; UDP-glucose 4-epimerase K19997 gnu; GlcNAc-P-P-Und epimerase [EC:5.1.3.26]
C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:hde01011]
D HDEF_1955 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D HDEF_1599 murB; UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D HDEF_1782 murC; UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D HDEF_1785 murD; UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D HDEF_1788 murE; UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D HDEF_1781 ddlB; D-alanine-D-alanine ligase B, affects cell division K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D HDEF_0679 alr; alanine racemase 1, PLP-binding, biosynthetic K01775 alr; alanine racemase [EC:5.1.1.1]
D HDEF_0474 murI; glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D HDEF_0800 LD-carboxypeptidase family protein K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D HDEF_1786 mraY; phospho-N-acetylmuramoyl-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D HDEF_1783 murG; UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D HDEF_0640 mviN; putative virulence factor K03980 murJ; putative peptidoglycan lipid II flippase
D HDEF_0205 virulence factor mviN-like protein K03980 murJ; putative peptidoglycan lipid II flippase
D HDEF_0862 mrcB; bifunctional penicillin-binding protein 1b: glycosyl transferase (N-terminal); transpeptidase (C-terminal) K05365 mrcB; penicillin-binding protein 1B [EC:2.4.99.28 3.4.16.4]
D HDEF_0672 mrdA; cell elongation-specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase) K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
D HDEF_1789 ftsI; division-specific transpeptidase, penicillin-binding protein 3 K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]
D HDEF_0674 dacA; D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5 K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D HDEF_1835 conserved hypothetical protein, YkuD and peptidoglycan binding domains K21470 ycbB; L,D-transpeptidase YcbB
D HDEF_0652 putative M23 peptidase family protein K19304 mepM; murein DD-endopeptidase [EC:3.4.24.-]
D HDEF_1700 phage endolysin K17733 cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]
D HDEF_0356 mltC; lytic murein transglycosylase C, membrane-bound K08306 mltC; peptidoglycan lytic transglycosylase C [EC:4.2.2.29]
D HDEF_2128 membrane-bound lytic murein transglycosylase K08307 mltD; peptidoglycan lytic transglycosylase D [EC:4.2.2.29]
D HDEF_0450 putative aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]
D HDEF_0491 amiB; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D HDEF_1483 amiD_1; putative amidase and lipoprotein K11066 amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D HDEF_1484 amiD_2; putative amidase and lipoprotein K11066 amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
C 01004 Lipid biosynthesis proteins [BR:hde01004]
D HDEF_0446 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D HDEF_0445 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III; acetylCoA ACP transacylase K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D HDEF_0092 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I K00647 fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]
D HDEF_0449 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D HDEF_0447 fabG; 3-oxoacyl-[acyl-carrier-protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D HDEF_2300 fabA; beta-hydroxydecanoyl thioester dehydrase (trans-2-decenoyl-ACP isomerase) K01716 fabA; 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
D HDEF_0589 fabZ; (3R)-hydroxymyristol acyl carrier protein dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D HDEF_2100 fabI; enoyl-[acyl-carrier-protein] reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
D HDEF_0089 plsB; glycerolphosphate acyltransferase K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
D HDEF_0802 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
C 01008 Polyketide biosynthesis proteins
C 01006 Prenyltransferases [BR:hde01006]
D HDEF_1607 ispA; geranyltranstransferase (farnesyldiphosphate synthase) K00795 ispA; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
D HDEF_1760 ispB; octaprenyl diphosphate synthase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]
D HDEF_0595 ispU; undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D HDEF_0493 miaA; delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D HDEF_1631 ubiA; p-hydroxybenzoate octaprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]
D HDEF_0066 cyoE; protoheme IX farnesyltransferase (heme O biosynthesis) K02257 COX10; heme o synthase [EC:2.5.1.141]
C 01007 Amino acid related enzymes [BR:hde01007]
D HDEF_0366 gltX; glutamate tRNA synthetase, catalytic subunit K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D HDEF_0764 glnS; glutamine tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D HDEF_0671 tyrS; tyrosine tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D HDEF_1634 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D HDEF_1542 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D HDEF_0639 argS; arginine tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D HDEF_1807 metG; methionine tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D HDEF_0831 ileS; isoleucine tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D HDEF_0219 valS; valine tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D HDEF_2038 leuS; leucine tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D HDEF_0009 lysU; lysine tRNA synthetase, inducible K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D HDEF_0868 aspS; aspartate tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D HDEF_0877 asnS; asparagine tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D HDEF_0753 hisS; histidine tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D HDEF_0611 glyQ; glycine tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D HDEF_0612 glyS; glycine tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D HDEF_1279 serS; serine tRNA synthetase; also charges selenocystein tRNA with serine K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D HDEF_0391 proS; proline tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D HDEF_1824 thrS; threonine tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D HDEF_0012 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D HDEF_1828 pheS; phenylalanine tRNA synthetase, alpha-subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D HDEF_1830 pheT; phenylalanine tRNA synthetase, beta-subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D HDEF_0100 aspC_1; aspartate aminotransferase, PLP-dependent-1 K00813 aspC; aspartate aminotransferase [EC:2.6.1.1]
D HDEF_1823 aspC_2; aspartate aminotransferase, PLP-dependent - 2 K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D HDEF_1202 bioF; 7-keto-8-aminopelargonic acid synthetase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]
D HDEF_0279 bioA; 7,8-diaminopelargonic acid synthetase, PLP-dependent K00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]
D HDEF_1725 hemL; glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]
D HDEF_0201 putative aminotransferase class V K03430 phnW; 2-aminoethylphosphonate-pyruvate transaminase [EC:2.6.1.37]
D HDEF_0290 serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]
D HDEF_1518 rffA; TDP-4-oxo-6-deoxy-D-glucose transaminase K02805 wecE; dTDP-4-amino-4,6-dideoxygalactose transaminase [EC:2.6.1.59]
C 00199 Cytochrome P450
C 00194 Photosynthesis proteins [BR:hde00194]
D HDEF_2334 atpC; membrane-bound ATP synthase, F1 sector, epsilon-subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D HDEF_2335 atpA; membrane-bound ATP synthase, F1 sector, alpha-subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D HDEF_2336 atpG; membrane-bound ATP synthase, F1 sector, gamma-subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D HDEF_2337 atpD; membrane-bound ATP synthase, F1 sector, beta-subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D HDEF_2338 atpH; membrane-bound ATP synthase, F1 sector, delta-subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D HDEF_2339 atpF; membrane-bound ATP synthase, F0 sector, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D HDEF_2340 atpE; membrane-bound ATP synthase, F0 sector, subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D HDEF_2341 atpB; membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly K02108 ATPF0A; F-type H+-transporting ATPase subunit a
B
B 09182 Protein families: genetic information processing
C 03000 Transcription factors [BR:hde03000]
D HDEF_0909 dcm_1; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D HDEF_1793 leuO; putative transcriptional regulator of leucine biosynthesis with periplasmic binding protein domain (LysR family) K05798 leuO; LysR family transcriptional regulator, transcriptional activator for leuABCD operon
D HDEF_1766 cysB; transcriptional regulator of biosynthesis of L-cysteine and regulator of sulfur assimilation (LysR familiy) K13634 cysB; LysR family transcriptional regulator, cys regulon transcriptional activator
D HDEF_0375 fabR; putative regulator with homeodomain-like DNA binding domain with homeodomain-like DNA binding domain (TetR/AcrR family) K22105 fabR; TetR/AcrR family transcriptional regulator, fatty acid biosynthesis regulator
D HDEF_0874 expR; autoinducer response regulator K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D HDEF_1635 smaR; autoinducer response regulator K19734 expR; LuxR family transcriptional regulator, quorum-sensing system regulator ExpR
D HDEF_0664 slyA; transcriptional activator for hemolysin (MarR family) K06075 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin
D HDEF_2289 fur; transcriptional repressor of iron transport (Fur family) K03711 fur; Fur family transcriptional regulator, ferric uptake regulator
D HDEF_0827 crp; transcriptional regulator, cyclic AMP receptor protein (CAMP-binding family), interacts with RNAP K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
D HDEF_1598 birA; bifunctional: biotin-[acetylCoA carboxylase] holoenzyme synthetase; transcriptional repressor of biotin synthesis (BirA family) K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D HDEF_0367 fis; DNA-binding protein for site-specific recombination and inversion, transcription of rRNA and tRNA operons, and DNA replication K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
D HDEF_1764 nlp; transcriptional activator of maltose metabolism K07724 ner; Ner family transcriptional regulator
D HDEF_1036 putative transcriptional regulator, HTH_3 domain protein K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D HDEF_1137 putative transcriptional regulator, HTH_3 domain protein K07726 K07726; putative transcriptional regulator
D HDEF_1630 metJ; transcriptional repressor for methionine biosynthesis (MetJ family) K03764 metJ; MetJ family transcriptional regulator, methionine regulon repressor
D HDEF_1208 putA; multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase K13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
D HDEF_1076 addiction module antitoxin K18918 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB
D HDEF_0057 bolA; transcriptional activator of morphogenic pathway (BolA family) K05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator
D HDEF_p0055 rfaH; transcriptional activator affecting biosynthesis, assembly and export of lipopolysaccharide core, F pilin, and hemolysin K05785 rfaH; transcriptional antiterminator RfaH
D HDEF_2110 rfaH; transcriptional activator affecting biosynthesis, assembly and export of lipopolysaccharide core, F pilin, and hemolysin K05785 rfaH; transcriptional antiterminator RfaH
D HDEF_1435 putative NusG-type transcription antiterminator K05785 rfaH; transcriptional antiterminator RfaH
D HDEF_1493 hilA; invasion protein transcriptional regulator K22486 hilA; transcriptional regulator HilA, main transcriptional regulator of SPI1
D HDEF_0602 hypothetical protein K07735 algH; putative transcriptional regulator
D HDEF_1620 dksA; DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor
D HDEF_0031 nrdR; transcriptional regulator K07738 nrdR; transcriptional repressor NrdR
D HDEF_0211 crl; transcriptional regulator K11926 crl; sigma factor-binding protein Crl
D HDEF_1792 mraZ; cell division protein K03925 mraZ; transcriptional regulator MraZ
C 03021 Transcription machinery [BR:hde03021]
D HDEF_1841 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D HDEF_0711 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D HDEF_0710 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D HDEF_0625 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D HDEF_0645 rpoD; RNA polymerase, sigma 70 (sigma D) factor K03086 rpoD; RNA polymerase primary sigma factor
D HDEF_1712 rpoS; RNA polymerase, sigma S (sigma 38) factor K03087 rpoS; RNA polymerase nonessential primary-like sigma factor
D HDEF_0527 rpoE; RNA polymerase, sigma 24 (sigma E) factor K03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily
D HDEF_2107 rpoH; sigma H (sigma 32) factor of RNA polymerase; transcription of heat shock and stress proteins K03089 rpoH; RNA polymerase sigma-32 factor
D HDEF_2316 hepA; RNA polymerase-associated helicase protein (ATPase and RNA polymerase recycling factor) K03580 hepA; ATP-dependent helicase HepA [EC:5.6.2.-]
D HDEF_0332 nusA; transcription pausing; L factor K02600 nusA; transcription termination/antitermination protein NusA
D HDEF_1929 nusB; transcription termination; L factor K03625 nusB; transcription antitermination protein NusB
D HDEF_0716 nusG; component in transcription antitermination K02601 nusG; transcription termination/antitermination protein NusG
D HDEF_1261 sspA; stringent starvation protein A K03599 sspA; stringent starvation protein A
D HDEF_1262 sspB; stringent starvation protein B, specificity factor for ClpXP protease K03600 sspB; stringent starvation protein B
D HDEF_0528 rseA; anti sigma E (sigma 24) factor, negative regulator K03597 rseA; sigma-E factor negative regulatory protein RseA
D HDEF_0529 rseB; anti sigma E (sigma 24) factor, negative regulator K03598 rseB; sigma-E factor negative regulatory protein RseB
D HDEF_1620 dksA; DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor
D HDEF_1966 greA; transcription elongation factor, cleaves 3' nucleotide of paused mRNA K03624 greA; transcription elongation factor GreA
D HDEF_2027 rho; transcription termination factor Rho; polarity suppressor K03628 rho; transcription termination factor Rho
C 03019 Messenger RNA biogenesis [BR:hde03019]
D HDEF_0352 rne; RNase E: endoribonuclease for rRNA processing and mRNA degradation K08300 rne; ribonuclease E [EC:3.1.26.12]
D HDEF_1729 rng; RNase G (ribonuclease G) K08301 rng; ribonuclease G [EC:3.1.26.-]
D HDEF_0532 rnc; RNase III, ds RNA K03685 rnc; ribonuclease III [EC:3.1.26.3]
D HDEF_0301 rnr; RNase R, 3'-5' exoribonuclease K12573 rnr; ribonuclease R [EC:3.1.13.1]
D HDEF_0476 orn; oligoribonuclease K13288 orn; oligoribonuclease [EC:3.1.-.-]
D HDEF_0090 rhlB; ATP-dependent RNA helicase K03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]
D HDEF_0292 rhlE; putative ATP-dependent RNA helicase with P-loop hydrolase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]
D HDEF_0325 deaD; cold-shock DeaD box ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D HDEF_0327 pnp; polynucleotide phosphorylase/polyadenylase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D HDEF_2027 rho; transcription termination factor Rho; polarity suppressor K03628 rho; transcription termination factor Rho
D HDEF_1894 pfkA; 6-phosphofructokinase I K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D HDEF_0372 dnaK; chaperone Hsp70 in DNA biosynthesis/cell division K04043 dnaK; molecular chaperone DnaK
D HDEF_0629 groEL; chaperone Hsp60 (GroEL) K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D HDEF_0494 hfq; host factor I for bacteriophage Q beta replication K03666 hfq; host factor-I protein
D HDEF_1621 pcnB; poly(A) polymerase I K00970 pcnB; poly(A) polymerase [EC:2.7.7.19]
D HDEF_0654 rppH; dinucleoside polyphosphate hydrolase, NUDIX domain protein K08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]
D HDEF_0013 csrA; carbon storage regulator K03563 csrA; carbon storage regulator
D HDEF_1942 putative P-loop ATPase K06958 rapZ; RNase adapter protein RapZ
D HDEF_0103 hrpA; helicase, ATP-dependent K03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]
C 03041 Spliceosome
C 03011 Ribosome [BR:hde03011]
D HDEF_0696 rpsA; 30S ribosomal subunit protein S1 K02945 RP-S1; small subunit ribosomal protein S1
D HDEF_1312 rpsB; 30S ribosomal subunit protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D HDEF_1860 rpsC; 30S ribosomal subunit protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D HDEF_1842 rpsD; 30S ribosomal subunit protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D HDEF_1849 rpsE; 30S ribosomal subunit protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D HDEF_0585 rpsF; 30S ribosomal subunit protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D HDEF_0720 rpsG; 30S ribosomal subunit protein S7, initiates assembly K02992 RP-S7; small subunit ribosomal protein S7
D HDEF_1852 rpsH; 30S ribosomal subunit protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D HDEF_1260 rpsI; 30S ribosomal subunit protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D HDEF_1867 rpsJ; 30S ribosomal subunit protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D HDEF_1843 rpsK; 30S ribosomal subunit protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D HDEF_0721 rpsL; 30S ribosomal subunit protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D HDEF_1844 rpsM; 30S ribosomal subunit protein S13 K02952 RP-S13; small subunit ribosomal protein S13
D HDEF_1853 rpsN; 30S ribosomal subunit protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D HDEF_0328 rpsO; 30S ribosomal subunit protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D HDEF_2326 rpsP; 30S ribosomal subunit protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D HDEF_1857 rpsQ; 30S ribosomal subunit protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D HDEF_0583 rpsR; 30S ribosomal subunit protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D HDEF_1862 rpsS; 30S ribosomal subunit protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D HDEF_0369 rpsT; 30S ribosomal subunit protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D HDEF_0643 rpsU; 30S ribosomal subunit protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D HDEF_0714 rplA; 50S ribosomal subunit protein L1, regulates synthesis of L1 and L11 K02863 RP-L1; large subunit ribosomal protein L1
D HDEF_1863 rplB; 50S ribosomal subunit protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D HDEF_1866 rplC; 50S ribosomal subunit protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D HDEF_1865 rplD; 50S ribosomal subunit protein L4, regulates expression of S10 operon K02926 RP-L4; large subunit ribosomal protein L4
D HDEF_1854 rplE; 50S ribosomal subunit protein L5 K02931 RP-L5; large subunit ribosomal protein L5
D HDEF_1851 rplF; 50S ribosomal subunit protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D HDEF_0795 rplI; 50S ribosomal subunit protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D HDEF_0713 rplJ; 50S ribosomal subunit protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D HDEF_0715 rplK; 50S ribosomal subunit protein L11, N-terminal believed to regulate RelA K02867 RP-L11; large subunit ribosomal protein L11
D HDEF_0712 rplL; 50S ribosomal subunit protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D HDEF_1259 rplM; 50S ribosomal subunit protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D HDEF_1856 rplN; 50S ribosomal subunit protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D HDEF_1847 rplO; 50S ribosomal subunit protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D HDEF_1859 rplP; 50S ribosomal subunit protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D HDEF_1840 rplQ; 50S ribosomal subunit protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D HDEF_1850 rplR; 50S ribosomal subunit protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D HDEF_2323 rplS; 50S ribosomal subunit protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D HDEF_1827 rplT; 50S ribosomal subunit protein L20, also posttranslational autoregulator K02887 RP-L20; large subunit ribosomal protein L20
D HDEF_2333 rplU; 50S ribosomal subunit protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D HDEF_1861 rplV; 50S ribosomal subunit protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D HDEF_1864 rplW; 50S ribosomal subunit protein L23 K02892 RP-L23; large subunit ribosomal protein L23
D HDEF_1855 rplX; 50S ribosomal subunit protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D HDEF_2332 rpmA; 50S ribosomal subunit protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D HDEF_1914 rpmB; 50S ribosomal subunit protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D HDEF_1858 rpmC; 50S ribosomal subunit protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D HDEF_1848 rpmD; 50S ribosomal subunit protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D HDEF_0384 rpmE; 50S ribosomal subunit protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D HDEF_0444 rpmF; 50S ribosomal subunit protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D HDEF_1915 rpmG; 50S ribosomal subunit protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D HDEF_2012 rpmH; 50S ribosomal subunit protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D HDEF_1826 rpmI; 50S ribosomal subunit protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D HDEF_1845 rpmJ; 50S ribosomal subunit protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D HDEF_0466 rplY; 50S ribosomal subunit protein L25 K02897 RP-L25; large subunit ribosomal protein L25
D HDEF_1316 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_2031 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_1750 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_1753 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1320 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_2034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1317 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_2032 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_1751 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
C 03009 Ribosome biogenesis [BR:hde03009]
D HDEF_0532 rnc; RNase III, ds RNA K03685 rnc; ribonuclease III [EC:3.1.26.3]
D HDEF_1642 serine/threonine protein kinase involved in cell cycle control K07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]
D HDEF_0476 orn; oligoribonuclease K13288 orn; oligoribonuclease [EC:3.1.-.-]
D HDEF_0533 era; GTPase believed to be involved in coordination of cell cycle, energy metabolism, cell division K03595 era; GTPase
D HDEF_0355 obgE; GTP-binding protein associated with DNA replication of some extrachromosomal elements K03979 obgE; GTPase [EC:3.6.5.-]
D HDEF_1620 dksA; DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor
D HDEF_0332 nusA; transcription pausing; L factor K02600 nusA; transcription termination/antitermination protein NusA
D HDEF_1929 nusB; transcription termination; L factor K03625 nusB; transcription antitermination protein NusB
D HDEF_0716 nusG; component in transcription antitermination K02601 nusG; transcription termination/antitermination protein NusG
D HDEF_1255 rsuA; 16S rRNA pseudouridylate 516 synthase K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D HDEF_0775 ksgA; S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]
D HDEF_1722 sun; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]
D HDEF_2301 rsmC; 16S RNA m2G1207 methylase K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]
D HDEF_2309 16S rRNA m(2)G966-methyltransferase, Cons_hypoth95 domain protein K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]
D HDEF_0604 rsmE; 16S rRNA methyltransferase K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]
D HDEF_2342 gidB; methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D HDEF_1791 mraW; S-adenosyl-dependent methyl transferase K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]
D HDEF_0361 putative tetrapyrrole methylase K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]
D HDEF_0300 rRNA methylase K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]
D HDEF_1965 rrmJ; 23S rRNA methyltransferase K02427 rlmE; 23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166]
D HDEF_0657 23S rRNA m(2)G2445 methyltransferase, UPF0020 domain protein K12297 rlmKL; 23S rRNA (guanine2069-N7)-methyltransferase / 23S rRNA (guanine2445-N2)-methyltransferase [EC:2.1.1.264 2.1.1.173]
D HDEF_0749 radical SAM domain protein K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]
D HDEF_2272 yciL; pseudouridine synthase (makes pseudouridine2605 in 23 S RNA) K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]
D HDEF_0442 rluC; 23S rRNA pseudouridylate synthase K06179 rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]
D HDEF_0553 rluD; pseudouridine synthase K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D HDEF_0499 rimI; modification of 30S ribosomal subunit protein S18; acetylation of N-terminal alanine K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]
D HDEF_2325 rimM; 16S rRNA processing protein K02860 rimM; 16S rRNA processing protein RimM
D HDEF_0817 prmA; methylation of 50S ribosomal subunit protein L11 K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]
D HDEF_1600 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase K07320 prmB; ribosomal protein L3 glutamine methyltransferase [EC:2.1.1.298]
D HDEF_p0006 conserved hypothetical protein K18850 ycfD; 50S ribosomal protein L16 3-hydroxylase [EC:1.14.11.47]
D HDEF_0169 hypothetical protein K18850 ycfD; 50S ribosomal protein L16 3-hydroxylase [EC:1.14.11.47]
D HDEF_1123 hypothetical protein K18850 ycfD; 50S ribosomal protein L16 3-hydroxylase [EC:1.14.11.47]
D HDEF_0352 rne; RNase E: endoribonuclease for rRNA processing and mRNA degradation K08300 rne; ribonuclease E [EC:3.1.26.12]
D HDEF_1729 rng; RNase G (ribonuclease G) K08301 rng; ribonuclease G [EC:3.1.26.-]
D HDEF_0601 Holliday junction resolvase-like protein K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]
D HDEF_0325 deaD; cold-shock DeaD box ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D HDEF_0456 srmB; ATP-dependent RNA helicase K05590 srmB; ATP-dependent RNA helicase SrmB [EC:5.6.2.7]
D HDEF_0477 putative GTP-binding protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D HDEF_0756 engA; putative GTP-binding protein K03977 engA; GTPase
D HDEF_1718 rimN; putative ribosome maturation factor K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D HDEF_0626 spoT; bifunctional: (p)ppGpp synthetase II; guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D HDEF_0330 rbfA; 30S ribosome-binding factor K02834 rbfA; ribosome-binding factor A
D HDEF_0333 hypothetical protein K09748 rimP; ribosome maturation factor RimP
D HDEF_0047 putative metal-dependent hydrolase K07042 ybeY; probable rRNA maturation factor
D HDEF_2113 hypothetical protein K09889 yjgA; ribosome-associated protein
D HDEF_0555 raiA; ribosome associated factor, stabilizes ribosomes against dissociation K05809 raiA; ribosome-associated inhibitor A
D HDEF_0338 translation-associated GTPase K06942 ychF; ribosome-binding ATPase
D HDEF_0443 hypothetical protein K07040 yceD; DUF177 domain-containing protein
C 03016 Transfer RNA biogenesis [BR:hde03016]
D HDEF_1538 cca; fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D HDEF_0366 gltX; glutamate tRNA synthetase, catalytic subunit K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D HDEF_0391 proS; proline tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D HDEF_0831 ileS; isoleucine tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D HDEF_2038 leuS; leucine tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D HDEF_1807 metG; methionine tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D HDEF_0764 glnS; glutamine tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D HDEF_0639 argS; arginine tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D HDEF_0009 lysU; lysine tRNA synthetase, inducible K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D HDEF_0868 aspS; aspartate tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D HDEF_0012 alaS; alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D HDEF_0877 asnS; asparagine tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D HDEF_1824 thrS; threonine tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D HDEF_1279 serS; serine tRNA synthetase; also charges selenocystein tRNA with serine K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D HDEF_1542 cysS; cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D HDEF_0219 valS; valine tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D HDEF_0753 hisS; histidine tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D HDEF_1828 pheS; phenylalanine tRNA synthetase, alpha-subunit K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D HDEF_1830 pheT; phenylalanine tRNA synthetase, beta-subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D HDEF_0671 tyrS; tyrosine tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D HDEF_1634 trpS; tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D HDEF_0101 hinT; putative inhibitor of protein kinase C, contains a transferase domain K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D HDEF_0359 trmI; tRNA (m7G46) methyltransferase, SAM-dependent K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D HDEF_0782 truA; pseudouridylate synthase I K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D HDEF_0329 truB; tRNA pseudouridine 5S synthase K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D HDEF_0542 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D HDEF_1718 rimN; putative ribosome maturation factor K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D HDEF_0493 miaA; delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D HDEF_2008 mnmE; GTPase involved in tRNA modification and in thiophene and furan oxidation K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D HDEF_2343 gidA; glucose-inhibited cell-division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D HDEF_2011 rnpA; RNase P, protein C5 component, processes tRNA, 4.5S RNA K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D HDEF_1893 catalytic subunit of RNAse P K01978 rnpB; M1 RNA
D HDEF_1492 dnaQ_2; DNA polymerase III epsilon subunit K03683 rnt; ribonuclease T [EC:3.1.13.-]
D HDEF_0509 rph; RNase PH K00989 rph; ribonuclease PH [EC:2.7.7.56]
D HDEF_0029 rnb; ribonuclease II K01147 rnb; exoribonuclease II [EC:3.1.13.1]
D HDEF_0515 rnd; RNase D, processes tRNA precursor K03684 rnd; ribonuclease D [EC:3.1.13.5]
D HDEF_0611 glyQ; glycine tRNA synthetase, alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D HDEF_0612 glyS; glycine tRNA synthetase, beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D HDEF_0396 CMP/dCMP deaminase; zinc-binding K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
D HDEF_2018 dusA; tRNA-dihydrouridine synthase A K05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]
D HDEF_1305 putative methyltransferase, Methyltransf_12 domain protein K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]
D HDEF_1306 methyltransferase K15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]
D HDEF_2324 trmD; tRNA (guanine-1-)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D HDEF_1743 rRNA methylase, SpoU family K15396 trmJ; tRNA (cytidine32/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]
D HDEF_1804 yibK; putative tRNA/rRNA methyltransferase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
D HDEF_0556 mnmA; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D HDEF_0517 sirA; conserved protein required for cell growth K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D HDEF_0076 tusB; tRNA 2-thiouridine synthesizing protein B K07237 tusB; tRNA 2-thiouridine synthesizing protein B
D HDEF_0077 tusC; tRNA 2-thiouridine synthesizing protein C K07236 tusC; tRNA 2-thiouridine synthesizing protein C
D HDEF_0078 tusD; tRNA 2-thiouridine synthesizing sulfurtransferase D K07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D HDEF_1918 tusE; tRNA 2-thiouridine synthesizing sulfurtransferase E K11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]
D HDEF_2079 putative aminomethyltransferase K06980 ygfZ; tRNA-modifying protein YgfZ
D HDEF_0086 queA; S-adenosylmethionine:tRNA (m6t6A37) ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D HDEF_0767 queC; queuosine biosynthesis protein, ExsB domain protein K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D HDEF_1717 sscR; 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D HDEF_0210 conserved hypothetical protein, Radical_SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D HDEF_1045 queF_1; GTP cyclohydrolase I, copy 1 K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D HDEF_1522 queF_2; GTP cyclohydrolase I, -2 K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D HDEF_0085 tgt; tRNA-guanine transglycosylase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D HDEF_0213 putative ATPase of the PP-loop superfamily K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D HDEF_0513 putative peptidase, M22 family K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D HDEF_0458 O-sialoglycoprotein endopeptidase, Peptidase_M22 domain protein K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D HDEF_0489 putative P-loop hydrolase K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D HDEF_0301 rnr; RNase R, 3'-5' exoribonuclease K12573 rnr; ribonuclease R [EC:3.1.13.1]
D HDEF_0327 pnp; polynucleotide phosphorylase/polyadenylase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D HDEF_2149 addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_0960 addiction module,PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_0430 vagD; addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_p0008 putative addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
C 03012 Translation factors [BR:hde03012]
D HDEF_0113 yciH; translation initiation factor K03113 EIF1; translation initiation factor 1
D HDEF_0331 infB; protein chain initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D HDEF_1825 infC; protein chain initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D HDEF_1311 tsf; protein chain elongation factor EF-Ts K02357 tsf; elongation factor Ts
D HDEF_0718 tufB; protein chain elongation factor EF-Tu; possible GTP-binding factor (duplicate of tufA) K02358 tuf; elongation factor Tu
D HDEF_0719 fusA; protein chain elongation factor EF-G, GTP-binding K02355 fusA; elongation factor G
D HDEF_2117 prfA; peptide chain release factor RF-1 K02835 prfA; peptide chain release factor 1
D HDEF_1309 frr; ribosome recycling factor K02838 frr; ribosome recycling factor
D HDEF_2116 prmC; N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2 K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]
D HDEF_2084 pth; peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]
D HDEF_0463 infA; protein chain initiation factor IF-1 K02518 infA; translation initiation factor IF-1
D HDEF_1895 efp; elongation factor P (EF-P) K02356 efp; elongation factor P
D HDEF_0480 lysS; putative lysyl-tRNA synthetase with Class II aaRS and biotin synthetase domains K04568 epmA; elongation factor P--(R)-beta-lysine ligase [EC:6.3.1.-]
D HDEF_1896 yjeK; putative aminomutase K19810 epmB; L-lysine 2,3-aminomutase [EC:5.4.3.-]
D HDEF_0010 prfB; peptide chain release factor RF-2 K02836 prfB; peptide chain release factor 2
D HDEF_2273 prfC; peptide chain release factor RF-3; possible GTP-binding factor K02837 prfC; peptide chain release factor 3
C 03110 Chaperones and folding catalysts [BR:hde03110]
D HDEF_0462 clpA; ATP-dependent specificity subunit of clpA-clpP serine protease K03694 clpA; ATP-dependent Clp protease ATP-binding subunit ClpA
D HDEF_0488 clpB; ATP-dependent protease, Hsp 100 K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB
D HDEF_0808 clpX; ATPase, chaperone subunit of serine protease K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
D HDEF_1270 hslU; ATPase component of the HslUV protease, also functions as molecular chaperone K03667 hslU; ATP-dependent HslUV protease ATP-binding subunit HslU
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
D HDEF_0372 dnaK; chaperone Hsp70 in DNA biosynthesis/cell division K04043 dnaK; molecular chaperone DnaK
D HDEF_0629 groEL; chaperone Hsp60 (GroEL) K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D HDEF_0371 dnaJ; heat shock protein (Hsp40), co-chaperone with DnaK K03686 dnaJ; molecular chaperone DnaJ
D HDEF_1967 djlA; co-chaperone of DnaK (DnaJ-like), implicated in regulation of colanic acid capsule K05801 djlA; DnaJ like chaperone protein
D HDEF_1754 grpE; Hsp 24 nucleotide exchange factor K03687 GRPE; molecular chaperone GrpE
D HDEF_1226 ibpB; small heat shock protein K04080 ibpA; molecular chaperone IbpA
D HDEF_1351 ibp; heat shock chaperone K04080 ibpA; molecular chaperone IbpA
D HDEF_0628 groES; chaperone Hsp10 (GroES) K04078 groES; chaperonin GroES
D HDEF_1488 degP_2; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1479 degP_1; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
D HDEF_1964 hflB; ATP-dependent zinc-metallo protease K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D HDEF_2341 atpB; membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D HDEF_0791 secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) K03071 secB; preprotein translocase subunit SecB
D HDEF_0806 PPIC-type peptidyl-prolyl cis-trans isomerase K03770 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]
D HDEF_0079 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8]
D HDEF_0833 fkbP; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) K03774 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8]
D HDEF_0777 surA; peptidyl-prolyl cis-trans isomerase (PPIase) K03771 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]
D HDEF_0091 trxA; thioredoxin 1, redox factor K03671 TXN; thioredoxin
D HDEF_0093 grxA; glutaredoxin 1 redox coenzyme K03674 grxA; glutaredoxin 1
D HDEF_1491 putative glutaredoxin K07390 grxD; monothiol glutaredoxin
D HDEF_1545 dsbA; periplasmic protein disulfide isomerase I K03673 dsbA; protein dithiol oxidoreductase (disulfide-forming) [EC:1.8.4.15]
D HDEF_1520 dsbB; oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I K03611 dsbB; protein dithiol:quinone oxidoreductase [EC:1.8.5.9]
C 04131 Membrane trafficking [BR:hde04131]
D HDEF_0747 ndk; multifunctional: nucleoside diphosphate kinase; apyrimidinic endonuclease; 3'-phosphodiesterase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D HDEF_0023 gapA; glyceraldehyde-3-phosphate dehydrogenase A K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D HDEF_0267 gpmA; phosphoglyceromutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D HDEF_0803 pykF; pyruvate kinase I (formerly F), fructose-stimulated K00873 PK; pyruvate kinase [EC:2.7.1.40]
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
C 04121 Ubiquitin system [BR:hde04121]
C 03051 Proteasome [BR:hde03051]
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
C 03032 DNA replication proteins [BR:hde03032]
D HDEF_0682 rnhA; RNase HI, degrades RNA of DNA-RNA hybrids K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D HDEF_0909 dcm_1; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D HDEF_p0014 hu; DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1521 hupA_3; HU, DNA-binding transcriptional regulator, alpha subunit -3 K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1162 hupB; DNA-binding protein HU-beta, NS1 (HU-1), plays a role in DNA replication and in rpo translation K03530 hupB; DNA-binding protein HU-beta
D HDEF_1831 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
D HDEF_0697 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
D HDEF_1739 dnaA; DNA replication initiator protein K02313 dnaA; chromosomal replication initiator protein
D HDEF_0678 dnaB; replicative DNA helicase; chromosome replication; chain elongation K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D HDEF_0984 dnaC; DNA biosynthesis protein K02315 dnaC; DNA replication protein DnaC
D HDEF_0644 dnaG; DNA biosynthesis; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
D HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D HDEF_0586 rnhB; RNAse HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D HDEF_1639 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D HDEF_0270 seqA; negative modulator of replication initiation K03645 seqA; negative modulator of initiation of replication
D HDEF_1910 hda; regulatory factor involved in inactivation of DnaA K10763 hda; DnaA-homolog protein
D HDEF_1516 gyrA; DNA gyrase (type II topoisomerase), subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D HDEF_1742 gyrB; DNA gyrase, subunit B (type II topoisomerase) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D HDEF_0801 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D HDEF_0799 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D HDEF_1767 topA; DNA topoisomerase type I, omega protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
C 03036 Chromosome and associated proteins [BR:hde03036]
D HDEF_0909 dcm_1; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D HDEF_0532 rnc; RNase III, ds RNA K03685 rnc; ribonuclease III [EC:3.1.26.3]
D HDEF_2063 hns; transcriptional regulator, DNA-binding protein HLP-II (HU, BH2, HD, NS), increases DNA thermal stability K03746 hns; DNA-binding protein H-NS
D HDEF_p0014 hu; DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1521 hupA_3; HU, DNA-binding transcriptional regulator, alpha subunit -3 K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1162 hupB; DNA-binding protein HU-beta, NS1 (HU-1), plays a role in DNA replication and in rpo translation K03530 hupB; DNA-binding protein HU-beta
D HDEF_1831 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
D HDEF_0697 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
D HDEF_1739 dnaA; DNA replication initiator protein K02313 dnaA; chromosomal replication initiator protein
D HDEF_1758 diaA; DnaA initiator-associating factor for replication initiation K12961 diaA; DnaA initiator-associating protein
D HDEF_0367 fis; DNA-binding protein for site-specific recombination and inversion, transcription of rRNA and tRNA operons, and DNA replication K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
D HDEF_0494 hfq; host factor I for bacteriophage Q beta replication K03666 hfq; host factor-I protein
D HDEF_1834 mukB; kinesin-like cell division protein involved in sister chromosome partitioning K03632 mukB; chromosome partition protein MukB
D HDEF_1833 mukE; putative killing protein suppressor K03804 mukE; chromosome partition protein MukE
D HDEF_1832 mukF; mukF protein (killing factor KICB) K03633 mukF; chromosome partition protein MukF
D HDEF_1779 ftsA; cell division protein with ATPase domain, involved in recruitment of FtsK to Z ring K03590 ftsA; cell division protein FtsA
D HDEF_1716 ftsB; cell division protein K05589 ftsB; cell division protein FtsB
D HDEF_2307 ftsE; cell division protein for septal ring assimbly and stability K09812 ftsE; cell division transport system ATP-binding protein
D HDEF_1789 ftsI; division-specific transpeptidase, penicillin-binding protein 3 K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]
D HDEF_1790 ftsL; cell division protein; ingrowth of wall at septum K03586 ftsL; cell division protein FtsL
D HDEF_1272 ftsN; essential cell division protein, epimerase-or mutase-like protein K03591 ftsN; cell division protein FtsN
D HDEF_1780 ftsQ; cell division protein; ingrowth of wall at septum K03589 ftsQ; cell division protein FtsQ
D HDEF_1784 ftsW; essential cell division protein, stablilzes FtsZ ring, required for PBP2 expression K03588 ftsW; cell division protein FtsW
D HDEF_2306 ftsX; cell division protein for septal ring assimbly and stability K09811 ftsX; cell division transport system permease protein
D HDEF_1778 ftsZ; tubulin-like GTP-binding protein and GTPase, forms circumferential ring in cell division K03531 ftsZ; cell division protein FtsZ
D HDEF_0768 zipA; cell division protein involved in FtsK recruitment to Z ring K03528 zipA; cell division protein ZipA
D HDEF_2076 zapA; Z-ring-associated protein K09888 zapA; cell division protein ZapA
D HDEF_0561 hypothetical protein K09892 zapB; cell division protein ZapB
D HDEF_0725 hypothetical protein K18778 zapD; cell division protein ZapD
D HDEF_1816 yhcM; putative ATPase, with nucleoside triP hydrolase domain protein K06916 zapE; cell division protein ZapE
D HDEF_0491 amiB; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D HDEF_1623 multidrug efflux pump, membrane fusion (MFP/HlyD) family K03585 acrA; membrane fusion protein, multidrug efflux system
D HDEF_0020 minC; cell division inhibitor minC K03610 minC; septum site-determining protein MinC
D HDEF_0021 minD; cell division inhibitor minD K03609 minD; septum site-determining protein MinD
D HDEF_0022 minE; cell division topological specificity factor K03608 minE; cell division topological specificity factor
D HDEF_0270 seqA; negative modulator of replication initiation K03645 seqA; negative modulator of initiation of replication
D HDEF_1726 mreB; mecillinam resistance-associated protein K03569 mreB; rod shape-determining protein MreB and related proteins
D HDEF_1727 mreC; rod shape-determining protein K03570 mreC; rod shape-determining protein MreC
D HDEF_1728 mreD; rod shape-determining protein K03571 mreD; rod shape-determining protein MreD
D HDEF_0673 mrdB; rod shape-determining membrane protein; cell elongation K05837 rodA; rod shape determining protein RodA
D HDEF_2176 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_0737 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_2145 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_p0010 conserved hypothetical protein HDEF_p0010 K03496 parA; chromosome partitioning protein
D HDEF_1038 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_1398 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_1148 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_0801 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D HDEF_0799 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D HDEF_2343 gidA; glucose-inhibited cell-division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D HDEF_2342 gidB; methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D HDEF_1808 putative ATPase K03593 mrp; ATP-binding protein involved in chromosome partitioning
D HDEF_0097 engB; putative GTP-binding protein K03978 engB; GTP-binding protein
C 03400 DNA repair and recombination proteins [BR:hde03400]
D HDEF_1277 phrB; deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D HDEF_0455 ung; uracil-DNA-glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D HDEF_1122 mpg_1; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D HDEF_1323 mpg_2; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D HDEF_0358 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D HDEF_1596 nth; DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D HDEF_0543 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HDEF_2318 dut; deoxyuridinetriphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D HDEF_0641 xthA; exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D HDEF_0155 recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D HDEF_0769 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D HDEF_0863 polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) K02335 polA; DNA polymerase I [EC:2.7.7.7]
D HDEF_1815 uvrA; DNA excision repair enzyme subunit, with UvrBC K03701 uvrA; excinuclease ABC subunit A
D HDEF_1619 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
D HDEF_1529 uvrC; excinuclease UvrABC, endonuclease subunit K03703 uvrC; excinuclease ABC subunit C
D HDEF_0700 uvrD; DNA-dependent ATPase I and helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D HDEF_0711 rpoB; RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D HDEF_0710 rpoC; RNA polymerase, beta prime subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D HDEF_1841 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D HDEF_0625 rpoZ; RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D HDEF_0121 mfd; transcription-repair ATP-dependent coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D HDEF_1628 mutS; methyl-directed mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D HDEF_0492 mutL_1; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_p0005 mutL; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_1386 mutL_2; enzyme in methyl-directed mismatch repair K03572 mutL; DNA mismatch repair protein MutL
D HDEF_1904 mutH_1; putative methyl-directed mismatch repair protein with restriction endonuclease-like domain K03573 mutH; DNA mismatch repair protein MutH
D HDEF_1920 sbcB; exonuclease I, 3' --> 5'-specific; deoxyribophosphodiesterase K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
D HDEF_1282 xseA; exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D HDEF_1606 xseB; exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D HDEF_0209 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D HDEF_1740 dnaN; DNA polymerase III, beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D HDEF_0220 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
D HDEF_2040 holA; DNA polymerase III, delta subunit, probably ATP hydrolase K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D HDEF_0452 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D HDEF_0683 dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D HDEF_2087 dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D HDEF_0500 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_1639 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D HDEF_1167 vsr; DNA mismatch endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
D HDEF_0033 recB; exonuclease V, beta chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
D HDEF_0034 recC; exonuclease V, gamma chain with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
D HDEF_0032 recD; exonuclease V (RecBCD complex), alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D HDEF_0025 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
D HDEF_1940 ruvA; Holliday junction helicase, subunit A K03550 ruvA; holliday junction DNA helicase RuvA
D HDEF_1939 ruvB; Holliday junction helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D HDEF_0870 ruvC; Holliday junction nuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D HDEF_0885 rus; endonuclease RUS K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
D HDEF_0504 priA; primosomal protein N' (factor Y) directs replication fork assembly at D-loops, ATP-dependent K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D HDEF_0584 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
D HDEF_1301 radA; DNA repair/recombination protein K04485 radA; DNA repair protein RadA/Sms
D HDEF_0627 recG; DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D HDEF_0534 recO; gap repair protein, part of RecFOR complex K03584 recO; DNA repair protein RecO (recombination protein O)
D HDEF_2089 recR; gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction K06187 recR; recombination protein RecR
D HDEF_0828 recN; protein used in recombination and DNA repair with nucleoside triphosphate hydrolase domain K03631 recN; DNA repair protein RecN (Recombination protein N)
D HDEF_0058 rgdC; putative ribonuclease K03554 rdgC; recombination associated protein RdgC
D HDEF_1516 gyrA; DNA gyrase (type II topoisomerase), subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D HDEF_1742 gyrB; DNA gyrase, subunit B (type II topoisomerase) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D HDEF_1767 topA; DNA topoisomerase type I, omega protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D HDEF_p0014 hu; DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1521 hupA_3; HU, DNA-binding transcriptional regulator, alpha subunit -3 K05787 hupA; DNA-binding protein HU-alpha
D HDEF_1162 hupB; DNA-binding protein HU-beta, NS1 (HU-1), plays a role in DNA replication and in rpo translation K03530 hupB; DNA-binding protein HU-beta
D HDEF_0367 fis; DNA-binding protein for site-specific recombination and inversion, transcription of rRNA and tRNA operons, and DNA replication K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
D HDEF_1831 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit K04764 ihfA; integration host factor subunit alpha
D HDEF_0697 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit K05788 ihfB; integration host factor subunit beta
D HDEF_2063 hns; transcriptional regulator, DNA-binding protein HLP-II (HU, BH2, HD, NS), increases DNA thermal stability K03746 hns; DNA-binding protein H-NS
D HDEF_2303 rep; Rep helicase, a single-stranded DNA-dependent ATPase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D HDEF_0307 nrdA; ribonucleoside diphosphate reductase 1, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HDEF_0306 nrdB; ribonucleoside-diphosphate reductase 1, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C 03029 Mitochondrial biogenesis [BR:hde03029]
D HDEF_0331 infB; protein chain initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D HDEF_1825 infC; protein chain initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D HDEF_1311 tsf; protein chain elongation factor EF-Ts K02357 tsf; elongation factor Ts
D HDEF_0718 tufB; protein chain elongation factor EF-Tu; possible GTP-binding factor (duplicate of tufA) K02358 tuf; elongation factor Tu
D HDEF_0719 fusA; protein chain elongation factor EF-G, GTP-binding K02355 fusA; elongation factor G
D HDEF_0533 era; GTPase believed to be involved in coordination of cell cycle, energy metabolism, cell division K03595 era; GTPase
D HDEF_0671 tyrS; tyrosine tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D HDEF_2038 leuS; leucine tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D HDEF_0868 aspS; aspartate tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D HDEF_0639 argS; arginine tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D HDEF_1536 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0575 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0919 putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D HDEF_0592 surface antigen/outer membrane protein, OMP85 family K07277 SAM50; outer membrane protein insertion porin family
D HDEF_0372 dnaK; chaperone Hsp70 in DNA biosynthesis/cell division K04043 dnaK; molecular chaperone DnaK
D HDEF_1754 grpE; Hsp 24 nucleotide exchange factor K03687 GRPE; molecular chaperone GrpE
D HDEF_0629 groEL; chaperone Hsp60 (GroEL) K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D HDEF_0628 groES; chaperone Hsp10 (GroES) K04078 groES; chaperonin GroES
D HDEF_0371 dnaJ; heat shock protein (Hsp40), co-chaperone with DnaK K03686 dnaJ; molecular chaperone DnaJ
D HDEF_0542 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D HDEF_1491 putative glutaredoxin K07390 grxD; monothiol glutaredoxin
D HDEF_1808 putative ATPase K03593 mrp; ATP-binding protein involved in chromosome partitioning
D HDEF_0066 cyoE; protoheme IX farnesyltransferase (heme O biosynthesis) K02257 COX10; heme o synthase [EC:2.5.1.141]
D HDEF_2009 yidC; protein involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY K03217 yidC; YidC/Oxa1 family membrane protein insertase
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
B
B 09183 Protein families: signaling and cellular processes
C 02000 Transporters [BR:hde02000]
D HDEF_1204 msbA; lipid transport protein, flippase (ABC superfamily, membrane (N-terminal), atp_bind (C-terminal)) K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6]
D HDEF_0278 rtxB_2; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12530 rtxB; ATP-binding cassette, subfamily B, bacterial RtxB
D HDEF_0276 rtxB_1; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12531 rtxE; ATP-binding cassette, subfamily B, bacterial RtxE
D HDEF_0268 putative ABC-type secretion protein K12541 lapB; ATP-binding cassette, subfamily C, bacterial LapB
D HDEF_0539 ABC-type antimicrobial peptide transport system, permease K05685 macB; macrolide transport system ATP-binding/permease protein [EC:7.6.2.-]
D HDEF_0658 uup; putative transport protein (ABC superfamily, atp_bind) K15738 uup; ABC transport system ATP-binding/permease protein
D HDEF_0607 tbpA; thiamin transporter subunit K02064 thiB; thiamine transport system substrate-binding protein
D HDEF_0606 thiP; thiamin transport protein (ABC superfamily, membrane) K02063 thiP; thiamine transport system permease protein
D HDEF_0605 thiQ; thiamin transport protein (ABC superfamily, atp_bind) K02062 thiQ; thiamine transport system ATP-binding protein [EC:7.6.2.15]
D HDEF_1952 yrbD; putative organic solvent ABC transporter, cytoplasmic membrane protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein
D HDEF_1951 yrbE; putative ABC transporter, permease protein K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein
D HDEF_1950 yrbF; putative ABC-type transport system, resistance to organic solvents, ATP-binding protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein
D HDEF_1953 putative ABC-type transport system protein K07323 mlaC; phospholipid transport system substrate-binding protein
D HDEF_2256 pstS; high-affinity phosphate transport protein (ABC superfamily, peri_bind) K02040 pstS; phosphate transport system substrate-binding protein
D HDEF_2255 pstC; high-affinity phosphate transport protein (ABC superfamily, membrane) K02037 pstC; phosphate transport system permease protein
D HDEF_2254 pstA; high-affinity phosphate transport protein (ABC superfamily, membrane) K02038 pstA; phosphate transport system permease protein
D HDEF_2253 ptsB; phosphate transport ATP-binding K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D HDEF_0376 glnH; high-affinity glutamine transport protein (ABC superfamily, peri_bind) K10036 glnH; glutamine transport system substrate-binding protein
D HDEF_0377 glnP; high-affinity glutamine transport protein (ABC superfamily, membrane) K10037 glnP; glutamine transport system permease protein
D HDEF_0378 glnQ; high-affinity glutamine transport protein (ABC superfamily, atp_bind) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_1771 artI; arginine transport protein (ABC superfamily, peri_bind) K09997 artI; arginine transport system substrate-binding protein
D HDEF_1773 artQ; arginine transport protein (ABC superfamily, membrane) K09998 artM; arginine transport system permease protein
D HDEF_1772 artM; arginine transport protein (ABC superfamily, membrane) K09999 artQ; arginine transport system permease protein
D HDEF_1770 artP; arginine transport protein (ABC superfamily, atp_bind) K10000 artP; arginine transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_1618 gltL; glutamate-aspartate ABC transporter ATP-binding component K10004 gltL; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1]
D HDEF_0389 metQ; D-methionine transport protein (ABC superfamily, peri_bind) K02073 metQ; D-methionine transport system substrate-binding protein
D HDEF_0388 metI; D- and L-methionine transport protein (ABC superfamily, membrane) K02072 metI; D-methionine transport system permease protein
D HDEF_0387 metN; D- and L-methionine transport protein (ABC superfamily, atp_bind) K02071 metN; D-methionine transport system ATP-binding protein
D HDEF_0002 polar amino acid ABC transporter periplasmic amino acid-binding subunit K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D HDEF_0003 polar amino acid ABC transporter inner membrane subunit K02029 ABC.PA.P; polar amino acid transport system permease protein
D HDEF_0004 polar amino acid ABC transporter permease K02029 ABC.PA.P; polar amino acid transport system permease protein
D HDEF_2104 sapB; peptide transport protein (ABC superfamily, membrane) K19227 sapB; cationic peptide transport system permease protein
D HDEF_2103 sapC; peptide transport protein (ABC superfamily, membrane) K19228 sapC; cationic peptide transport system permease protein
D HDEF_2102 sapD; peptide transport protein (ABC superfamily, atp_bind) K19229 sapD; cationic peptide transport system ATP-binding protein
D HDEF_2101 sapF; peptide transport protein (ABC superfamily, atp_bind) K19230 sapF; cationic peptide transport system ATP-binding protein
D HDEF_2133 hmuT; hemin ABC transporter, periplasmic hemin-binding K25132 hmuT; heme transport system substrate-binding protein
D HDEF_2134 hmuU; hemin ABC transporter, permease K25133 hmuU; heme transport system permease protein
D HDEF_2135 hmuV; hemin ABC transporter, ATP-binding K10834 hmuV; heme transport system ATP-binding protein [EC:7.6.2.5]
D HDEF_1869 fecD; citrate-dependent iron (III) transport protein (ABC superfamily, membrane) K02015 ABC.FEV.P; iron complex transport system permease protein
D HDEF_0651 znuA; high-affinity Zn transport protein (ABC superfamily, peri_bind) K09815 znuA; zinc transport system substrate-binding protein
D HDEF_0649 znuB; high-affinity Zn transport protein (ABC superfamily, membrane) K09816 znuB; zinc transport system permease protein
D HDEF_0650 znuC; high-affinity Zn transport protein (ABC superfamily, atp_bind) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D HDEF_2126 yfeA; chelated iron ABC transporter, periplasmic iron binding protein K11604 sitA; manganese/iron transport system substrate-binding protein
D HDEF_2124 yfeC; chelated iron transport system membrane protein K11605 sitC; manganese/iron transport system permease protein
D HDEF_2123 yfeD; chelated iron ABC transporter, permease protein K11606 sitD; manganese/iron transport system permease protein
D HDEF_2125 yfeB; chelated iron ABC transporter, ATP-binding protein K11607 sitB; manganese/iron transport system ATP-binding protein
D HDEF_0222 putative permease K07091 lptF; lipopolysaccharide export system permease protein
D HDEF_0223 putative permease K11720 lptG; lipopolysaccharide export system permease protein
D HDEF_1944 yhbG; putative transport protein (ABC superfamily, atp_bind) K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5]
D HDEF_0122 lolC; transport protein of outer membrane lipoproteins (ABC superfamily, membrane) K09808 lolC_E; lipoprotein-releasing system permease protein
D HDEF_0124 lolE; transport protein of outer membrane lipoproteins (ABC superfamily, membrane) K09808 lolC_E; lipoprotein-releasing system permease protein
D HDEF_0123 lolD; transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind) K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-]
D HDEF_2306 ftsX; cell division protein for septal ring assimbly and stability K09811 ftsX; cell division transport system permease protein
D HDEF_2307 ftsE; cell division protein for septal ring assimbly and stability K09812 ftsE; cell division transport system ATP-binding protein
D HDEF_1775 yadH; putative transport protein (ABC superfamily, membrane) K01992 ABC-2.P; ABC-2 type transport system permease protein
D HDEF_1776 yadG; putative transport protein (ABC superfamily, atp_bind) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D HDEF_0061 sufC; putative transport protein associated with Fe-S cluster assembly (ABC superfamily, atp_bind) K09013 sufC; Fe-S cluster assembly ATP-binding protein
D HDEF_0050 cmrA; multidrug/chloramphenicol efflux transport protein (MFS family) K08160 mdfA; MFS transporter, DHA1 family, multidrug/chloramphenicol efflux transport protein
D HDEF_0051 cmrB; multidrug/chloramphenicol efflux transport protein (MFS family) K08160 mdfA; MFS transporter, DHA1 family, multidrug/chloramphenicol efflux transport protein
D HDEF_1871 putative transporter, major facilitator superfamily K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein
D HDEF_2220 putative sugar transporter, major facilitator superfamily K08369 ydjE; MFS transporter, putative metabolite:H+ symporter
D HDEF_0323 ptsI; PTS family enzyme I and Hpr components, PEP-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D HDEF_0324 ptsH; PTS family Hpr protein, phosphohistidinoprotein-hexose phosphotransferase K02784 ptsH; phosphocarrier protein HPr
D HDEF_1820 fruB; PTS family enzyme IIA (N-terminal); FPr (C-terminal), fructose-specific K11183 fruB; multiphosphoryl transfer protein [EC:2.7.1.202]
D HDEF_0322 crr; PTS family enzyme IIA component K02777 crr; sugar PTS system EIIA component [EC:2.7.1.-]
D HDEF_0454 ptsG; PTS family enzyme IIC (N-terminal); enzyme IIB (C-terminal), glucose-specific K02779 ptsG; glucose PTS system EIICB or EIICBA component [EC:2.7.1.199]
D HDEF_1822 fruA; PTS family enzyme IIB'BC, fructose-specific K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D HDEF_0159 manX; PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D HDEF_0158 manY; PTS family enzyme IIC, mannose-specific K02795 manY; mannose PTS system EIIC component
D HDEF_0157 manZ; PTS family enzyme IID, mannose-specific K02796 manZ; mannose PTS system EIID component
D HDEF_1943 ptsN; PTS family enzyme IIA, sugar-specific, regulates N metabolism K02806 ptsN; nitrogen PTS system EIIA component [EC:2.7.1.-]
D HDEF_1261 sspA; stringent starvation protein A K03599 sspA; stringent starvation protein A
D HDEF_0505 mscL; mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel
D HDEF_0479 mechanosensitive ion channel K22051 mscM; miniconductance mechanosensitive channel
D HDEF_0535 mscS; mechanosensitive channel protein (MscS family) K03442 mscS; small conductance mechanosensitive channel
D HDEF_0162 tolQ; inner membrane protein K03562 tolQ; biopolymer transport protein TolQ
D HDEF_0164 tolR; tol protein R K03560 tolR; biopolymer transport protein TolR
D HDEF_0230 CorC/HlyC transporter containing CBS domain K03699 tlyC; magnesium and cobalt exporter, CNNM family
D HDEF_2329 corB; putative Mg2+ and Co2+ transporter K03699 tlyC; magnesium and cobalt exporter, CNNM family
D HDEF_2275 ompN; outer membrane pore protein N, non-specific K09476 ompF; outer membrane pore protein F
D HDEF_0224 ompA; outer membrane protein 3a (II*;G;d) K03286 TC.OOP; OmpA-OmpF porin, OOP family
D HDEF_2065 ompX; outer membrane protease, receptor for phage OX2 K16078 ail; attachment invasion locus protein
D HDEF_0280 type V secretory pathway, adhesin K12678 aidA-I; autotransporter family porin
D HDEF_0709 putative outer membrane autotransporter, pertactin domain protein K12678 aidA-I; autotransporter family porin
D HDEF_2131 hmuR; TonB-dependent hemin receptor K16087 TC.FEV.OM3; hemoglobin/transferrin/lactoferrin receptor protein
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_1960 siiC; putative type I transport system, outer membrane efflux protein K12543 lapE; outer membrane protein, adhesin transport system
D HDEF_0592 surface antigen/outer membrane protein, OMP85 family K07277 SAM50; outer membrane protein insertion porin family
D HDEF_0755 yfgL; outer membrane protein assembly complex subunit, 7 PQQ enzyme repeats K17713 bamB; outer membrane protein assembly factor BamB
D HDEF_1838 nlpB; lipoprotein-34 K07287 bamC; outer membrane protein assembly factor BamC
D HDEF_0554 yfiO; outer membrane protein assembly complex subunit, DNA uptake lipoprotein K05807 bamD; outer membrane protein assembly factor BamD
D HDEF_0829 smpA; small membrane protein A K06186 bamE; outer membrane protein assembly factor BamE
D HDEF_0773 putative outer membrane protein K07278 tamA; translocation and assembly module TamA
D HDEF_0772 hypothetical protein K09800 tamB; translocation and assembly module TamB
D HDEF_1945 hypothetical protein K09774 lptA; lipopolysaccharide export system protein LptA
D HDEF_1946 hypothetical protein K11719 lptC; lipopolysaccharide export system protein LptC
D HDEF_0778 imp; organic solvent tolerance K04744 lptD; LPS-assembly protein
D HDEF_2039 rlpB; minor lipoprotein K03643 lptE; LPS-assembly lipoprotein
D HDEF_1511 sipB; type III translocation machinery component K13285 sipB; invasin B
D HDEF_0142 sseC; type III secretion translocon protein K15345 sseC; secreted effector protein SseC
D HDEF_0046 corC; putative Mg2+ and Co2+ transporter K06189 corC; hemolysin (HlyC) family protein
D HDEF_0680 lysP; lysine-specific permease (APC family) K11733 lysP; lysine-specific permease
D HDEF_1273 aroP; aromatic amino acid transport protein (APC family) K11734 aroP; aromatic amino acid transport protein AroP
D HDEF_0401 proY; proline transport protein (APC family) K11736 proY; proline-specific permease ProY
D HDEF_1624 multidrug efflux pump K18138 acrB; multidrug efflux pump
D HDEF_1908 rhtA; threonine and homoserine efflux protein (DMT family) K11939 rhtA; inner membrane transporter RhtA
D HDEF_0860 arnE; subunit of ArnE/ArnF undecaprenyl-phosphate-alpha-L-Ara4N flippase K12962 arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE
D HDEF_0818 panF; sodium:pantothenate symporter (SSS family) K14392 panF; sodium/pantothenate symporter
D HDEF_1210 putP; major sodium:proline symporter (SSS family) K11928 putP; sodium/proline symporter
D HDEF_0370 nhaA; sodium:proton antiporter (NhaA family) K03313 nhaA; Na+:H+ antiporter, NhaA family
D HDEF_0016 cvrA; putative Na:H transport protein (CPA1 family) K11105 cvrA; potassium/hydrogen antiporter
D HDEF_2037 trkH; potassium transport protein, requires TrkE (Trk family) K03498 trkH; trk/ktr system potassium uptake protein
D HDEF_1723 trkA; potassium transport protein, NAD(P)-binding (Trk family) K03499 trkA; trk/ktr system potassium uptake protein
D HDEF_1464 codB_2; cytosine transport protein (NCS1 family) K10974 codB; cytosine permease
D HDEF_0170 codB_1; cytosine transport protein (NCS1 family) K10974 codB; cytosine permease
D HDEF_0305 tyrP; tyrosine-specific transport protein (HAAAP family) K03834 tyrP; tyrosine-specific transport protein
D HDEF_1819 mtr; tryptophan-specific transport protein (HAAAP family) K03835 mtr; tryptophan-specific transport protein
D HDEF_1595 sdaC; putative serine transport protein (HAAAP family) K03837 sdaC; serine transporter
D HDEF_0640 mviN; putative virulence factor K03980 murJ; putative peptidoglycan lipid II flippase
D HDEF_0205 virulence factor mviN-like protein K03980 murJ; putative peptidoglycan lipid II flippase
D HDEF_1244 kup; low-affinity potassium transport system (KUP family) K03549 kup; KUP system potassium uptake protein
D HDEF_0024 putative permease K03548 perM; putative permease
D HDEF_1044 hypothetical protein K09125 yhhQ; queuosine precursor transporter
D HDEF_1784 ftsW; essential cell division protein, stablilzes FtsZ ring, required for PBP2 expression K03588 ftsW; cell division protein FtsW
D HDEF_2066 tonB; energy transducer; uptake of iron, cyanocobalimin K03832 tonB; periplasmic protein TonB
D HDEF_0167 pal; pal protein K03640 pal; peptidoglycan-associated lipoprotein
D HDEF_0165 tolA; tol protein A K03646 tolA; colicin import membrane protein
D HDEF_0166 tolB; tol protein B K03641 tolB; TolB protein
D HDEF_0277 rtxD; putative ABC associated RTX toxin transporter, HlyD/MFP family K12532 rtxD; membrane fusion protein, RTX toxin transport system
D HDEF_1961 siiD; putative type I transport system, membrane permease HylD family K12542 lapC; membrane fusion protein, adhesin transport system
D HDEF_1623 multidrug efflux pump, membrane fusion (MFP/HlyD) family K03585 acrA; membrane fusion protein, multidrug efflux system
D HDEF_1257 hypothetical protein K25859 acrZ; accessory protein, multidrug efflux pump
D HDEF_0541 ABC-type antimicrobial peptide transport system, membrane fusion K13888 macA; membrane fusion protein, macrolide-specific efflux system
D HDEF_1876 feoA; ferrous iron transport protein A K04758 feoA; ferrous iron transport protein A
D HDEF_1877 feoB; ferrous iron transport protein B (FeoB family) K04759 feoB; ferrous iron transport protein B
D HDEF_1878 hypothetical protein K07490 feoC; ferrous iron transport protein C
C 02044 Secretion system [BR:hde02044]
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_0278 rtxB_2; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12530 rtxB; ATP-binding cassette, subfamily B, bacterial RtxB
D HDEF_0276 rtxB_1; putative ABC RTX toxin transporter, fused ATP binding/permease domains K12531 rtxE; ATP-binding cassette, subfamily B, bacterial RtxE
D HDEF_0277 rtxD; putative ABC associated RTX toxin transporter, HlyD/MFP family K12532 rtxD; membrane fusion protein, RTX toxin transport system
D HDEF_0268 putative ABC-type secretion protein K12541 lapB; ATP-binding cassette, subfamily C, bacterial LapB
D HDEF_1961 siiD; putative type I transport system, membrane permease HylD family K12542 lapC; membrane fusion protein, adhesin transport system
D HDEF_1960 siiC; putative type I transport system, outer membrane efflux protein K12543 lapE; outer membrane protein, adhesin transport system
D HDEF_0243 hypothetical protein K02452 gspC; general secretion pathway protein C
D HDEF_0241 gspD; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02453 gspD; general secretion pathway protein D
D HDEF_0239 gspE; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02454 gspE; general secretion pathway protein E [EC:7.4.2.8]
D HDEF_0349 gspG; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02456 gspG; general secretion pathway protein G
D HDEF_0348 gspH; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02457 gspH; general secretion pathway protein H
D HDEF_0347 gspI; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02458 gspI; general secretion pathway protein I
D HDEF_0346 gspJ; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02459 gspJ; general secretion pathway protein J
D HDEF_0344 gspK; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02460 gspK; general secretion pathway protein K
D HDEF_0343 gspL; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02461 gspL; general secretion pathway protein L
D HDEF_0342 gspM; putative protein exporter, transport across outer membrane (General Secretory Pathway) K02462 gspM; general secretion pathway protein M
D HDEF_0340 pilD; PilD type IV pilus leader peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D HDEF_0750 pilF; PilF type IV pilus biogenesis/stability protein K02656 pilF; type IV pilus assembly protein PilF
D HDEF_0481 pilT_1; PilT-like ATPase type IV pilus biogenesis protein K02669 pilT; twitching motility protein PilT
D HDEF_0318 hypothetical protein K02279 cpaB; pilus assembly protein CpaB
D HDEF_0317 rcpA; putative tight adherance operon protein K02280 cpaC; pilus assembly protein CpaC
D HDEF_0315 hypothetical protein K02282 cpaE; pilus assembly protein CpaE
D HDEF_0313 tadB; putative tight adherance operon protein B K12510 tadB; tight adherence protein B
D HDEF_0312 tadC; putative tight adherance operon protein C K12511 tadC; tight adherence protein C
D HDEF_0311 tadD; putative tight adherance operon protein D K12512 tadD; tight adherence protein D
D HDEF_0310 tadE; putative tight adherance operon protein E K12513 tadE; tight adherence protein E
D HDEF_0309 hypothetical protein K12514 tadF; tight adherence protein F
D HDEF_0308 tadG; putative tight adherance operon protein G K12515 tadG; tight adherence protein G
D HDEF_0038 hypothetical protein K02679 ppdA; prepilin peptidase dependent protein A
D HDEF_0037 pulJ; putative prepilin peptidase-dependent protein B K02680 ppdB; prepilin peptidase dependent protein B
D HDEF_0035 hypothetical protein K02681 ppdC; prepilin peptidase dependent protein C
D HDEF_0610 pilA; PilA type IV pilus major pilin subunit K02682 ppdD; prepilin peptidase dependent protein D
D HDEF_0609 hofB; putative integral membrane protein involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake with P-loop containing nucleoside triphosphate hydrolysis domain K02504 hofB; protein transport protein HofB
D HDEF_0608 hofC; component in type IV pilin biogenesis, transmembrane protein K02505 hofC; protein transport protein HofC
D HDEF_2260 pilM_4; PilM-like ATPase type IV pilus biogenesis protein K12288 hofM; pilus assembly protein HofM
D HDEF_2261 pilN_5; fimbrial assembly protein K12289 hofN; pilus assembly protein HofN
D HDEF_2262 hypothetical protein K12290 hofO; pilus assembly protein HofO
D HDEF_2264 hofQ; putative transport protein, possibly in biosynthesis of type IV pilin K02507 hofQ; protein transport protein HofQ
D HDEF_1924 putative integral membrane protein, YGGT domains K02221 yggT; YggT family protein
D HDEF_0805 hypothetical protein K02237 comEA; competence protein ComEA
D HDEF_1205 DNA internalization-related competence protein with metallo-beta-lactamase domain K02238 comEC; competence protein ComEC
D HDEF_0147 ssaC; type III outer membrane secretin precursor K03219 yscC; type III secretion protein C
D HDEF_0146 ssaD; type III secretion apparatus protein K03220 yscD; type III secretion protein D
D HDEF_0137 ssaG; type III secretion system apparatus protein K03221 yscF; type III secretion protein F
D HDEF_1218 putative type III secretion needle protein K03221 yscF; type III secretion protein F
D HDEF_0134 ssaJ; needle complex inner membrane lipoprotein K03222 yscJ; type III secretion protein J
D HDEF_0128 ssaN; type III secretion system ATPase K03224 yscN; ATP synthase in type III secretion protein N [EC:7.4.2.8]
D HDEF_1505 spaO; type III surface presentation of antigens protein K03225 yscQ; type III secretion protein Q
D HDEF_0125 ssaQ; type III secretion system protein K03225 yscQ; type III secretion protein Q
D HDEF_2251 ssaR; type III secretion system protein K03226 yscR; type III secretion protein R
D HDEF_2250 ssaS; type III secretion system apparatus protein K03227 yscS; type III secretion protein S
D HDEF_2249 ssaT; type III secretion system apparatus protein K03228 yscT; type III secretion protein T
D HDEF_2248 ssaU; type III secretion system apparatus protein K03229 yscU; type III secretion protein U
D HDEF_1499 invA; type III needle complex export protein K03230 yscV; type III secretion protein V
D HDEF_0129 ssaV; type III secretion system apparatus protein K03230 yscV; type III secretion protein V
D HDEF_1497 invG; type III outer membrane secretin precursor K22504 invG; type III secretion system outer membrane ring protein
D HDEF_1216 prgK; type III needle complex inner membrane lipoprotein K22505 prgK; type III secretion system inner membrane ring protein
D HDEF_1501 invC; type III ATP synthase K22506 spaL; type III secretion system ATPase [EC:7.4.2.8]
D HDEF_1506 spaP; type III surface presentation of antigens protein K22507 spaP; type III secretion system export apparatus protein
D HDEF_1507 spaQ; type III needle complex export protein K22508 spaQ; type III secretion system export apparatus protein
D HDEF_1508 spaR; type III needle complex export protein K22509 spaR; type III secretion system export apparatus protein
D HDEF_1509 spaS; type III surface presentation of antigens protein K22510 spaS; type III secretion system export apparatus switch protein
D HDEF_1498 invE; type III invasion protein K22511 invE; type III secretion system protein
D HDEF_1500 invB; type III secretion chaperone K22512 spaK; type III secretion system chaperone
D HDEF_1502 spaM; type III needle complex assembly protein K22513 spaM; type III secretion system protein
D HDEF_1219 prgH; type III needle complex inner membrane protein K22488 prgH; type III secretion system protein
D HDEF_1217 prgJ; type III needle inner rod protein K22487 prgJ; type III secretion system protein
D HDEF_1331 triB; TriB conjugal transfer protein K03197 virB2; type IV secretion system protein VirB2
D HDEF_0432 virB5; VirB5 conjugal transfer protein K03200 virB5; type IV secretion system protein VirB5
D HDEF_1333 triD; TriD conjugal transfer protein K03200 virB5; type IV secretion system protein VirB5
D HDEF_0428 virB6; VirB6 conjugal transfer protein K03201 virB6; type IV secretion system protein VirB6
D HDEF_1335 triE; TriE conjugal transfer protein K03201 virB6; type IV secretion system protein VirB6
D HDEF_1338 triG; TriG conjugal transfer protein K03203 virB8; type IV secretion system protein VirB8
D HDEF_0419 virB9; VirB9 conjugative transfer protein K03204 virB9; type IV secretion system protein VirB9
D HDEF_1339 triH; TriH conjugal transfer protein K03204 virB9; type IV secretion system protein VirB9
D HDEF_1340 triI; TriI conjugal transfer protein K03195 virB10; type IV secretion system protein VirB10
D HDEF_0417 virB10; VirB10 conjugal transfer protein K03195 virB10; type IV secretion system protein VirB10
D HDEF_1341 triJ; TriJ conjugal transfer protein K03196 virB11; type IV secretion system protein VirB11 [EC:7.4.2.8]
D HDEF_0416 virB11; VirB11 conjugative transfer protein K03196 virB11; type IV secretion system protein VirB11 [EC:7.4.2.8]
D HDEF_1342 taxB; TaxB conjugal transfer protein K03205 virD4; type IV secretion system protein VirD4 [EC:7.4.2.8]
D HDEF_0959 traJ_1; TraJ conjugal transfer protein K12203 dotB; defect in organelle trafficking protein DotB [EC:7.2.4.8]
D HDEF_p0039 traJ; TraJ conjugal transfer protein K12203 dotB; defect in organelle trafficking protein DotB [EC:7.2.4.8]
D HDEF_1418 traJ_2; TraJ conjugal transfer protein K12203 dotB; defect in organelle trafficking protein DotB [EC:7.2.4.8]
D HDEF_1419 traI_2; TraI conjugal transfer protein K12204 dotC; defect in organelle trafficking protein DotC
D HDEF_0958 traI_1; TraI conjugal transfer protein K12204 dotC; defect in organelle trafficking protein DotC
D HDEF_p0041 traI; TraI conjugal transfer protein K12204 dotC; defect in organelle trafficking protein DotC
D HDEF_p0040 traH; TraH conjugal transfer protein K12205 dotD; defect in organelle trafficking protein DotD
D HDEF_1420 traH_2; TraH conjugal transfer protein K12205 dotD; defect in organelle trafficking protein DotD
D HDEF_0957 traH_1; TraH conjugal transfer protein K12205 dotD; defect in organelle trafficking protein DotD
D HDEF_p0027 traU; TraU conjugal transfer protein K12206 icmB; intracellular multiplication protein IcmB [EC:7.2.4.8]
D HDEF_0970 traU; TraU conjugal transfer protein K12206 icmB; intracellular multiplication protein IcmB [EC:7.2.4.8]
D HDEF_0968 traO; TraO conjugal transfer protein K12209 icmE; intracellular multiplication protein IcmE
D HDEF_p0033 traO; TraO conjugal transfer protein K12209 icmE; intracellular multiplication protein IcmE
D HDEF_p0032 traP; TraP conjugal transfer protein K12211 icmG; intracellular multiplication protein IcmG
D HDEF_0967 traN; TraN conjugal transfer protein K12213 icmK; intracellular multiplication protein IcmK
D HDEF_p0034 traN; TraN conjugal transfer protein K12213 icmK; intracellular multiplication protein IcmK
D HDEF_0966 traM_1; TraM conjugal transfer protein K12214 icmL; intracellular multiplication protein IcmL
D HDEF_p0035 traM; TraM conjugal transfer protein K12214 icmL; intracellular multiplication protein IcmL
D HDEF_p0016 trbC; TrbC conjugal transfer protein K12217 icmO; intracellular multiplication protein IcmO [EC:7.2.4.8]
D HDEF_0980 trbC_2; TrbC conjugal transfer protein K12217 icmO; intracellular multiplication protein IcmO [EC:7.2.4.8]
D HDEF_p0019 trbA; TrbA conjugal transfer protein K12218 icmP; intracellular multiplication protein IcmP
D HDEF_0978 trbA; TrbA conjugal transfer protein K12218 icmP; intracellular multiplication protein IcmP
D HDEF_1417 traK_2; TraK conjugal transfer protein K12222 icmT; intracellular multiplication protein IcmT
D HDEF_p0038 traK; TraK conjugal transfer protein K12222 icmT; intracellular multiplication protein IcmT
D HDEF_0962 traK_1; TraK conjugal transfer protein K12222 icmT; intracellular multiplication protein IcmT
D HDEF_0965 traL; TraL conjugal transfer protein K12227 K12227; TraL protein
D HDEF_p0018 trbB; TrbB conjugal transfer protein K12228 trbB; TrbB protein
D HDEF_0979 trbB; TrbB conjugal transfer protein K12228 trbB; TrbB protein
D HDEF_0280 type V secretory pathway, adhesin K12678 aidA-I; autotransporter family porin
D HDEF_0709 putative outer membrane autotransporter, pertactin domain protein K12678 aidA-I; autotransporter family porin
D HDEF_0288 hypothetical protein K21965 ecpB; Mat/Ecp fimbriae periplasmic chaperone
D HDEF_2096 secA; preprotein translocase, ATPase secretion component (General Secretory Pathway) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D HDEF_0791 secB; molecular chaperone in protein export, enhances activity of SecA (General Secretory Pathway) K03071 secB; preprotein translocase subunit SecB
D HDEF_0083 secD; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03072 secD; preprotein translocase subunit SecD
D HDEF_0717 secE; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03073 secE; preprotein translocase subunit SecE
D HDEF_0082 secF; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03074 secF; preprotein translocase subunit SecF
D HDEF_0337 secG; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03075 secG; preprotein translocase subunit SecG
D HDEF_1846 secY; preprotein translocase, membrane component, transport across inner membrane (General Secretory Pathway) K03076 secY; preprotein translocase subunit SecY
D HDEF_2327 ffh; 4.5S-RNP protein, GTP-binding export factor, part of signal recognition particle with 4.5 RNA K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D HDEF_2308 ftsY; cell division protein: membrane binding (N-terminal); GTPase domain (C-terminal) K03110 ftsY; fused signal recognition particle receptor
D HDEF_0084 yajC; preprotein translocase, auxillary membrane component (General Secretory Pathway) K03210 yajC; preprotein translocase subunit YajC
D HDEF_2009 yidC; protein involved in protein translocation and folding, substrates includes ATP synthase, SecYEG, LacY K03217 yidC; YidC/Oxa1 family membrane protein insertase
D HDEF_1735 tatA; TatABCE protein translocation system subunit K03116 tatA; sec-independent protein translocase protein TatA
D HDEF_1737 tatC; twin-arginine translocase subunit, sec-independent protein export K03118 tatC; sec-independent protein translocase protein TatC
C 02042 Bacterial toxins [BR:hde02042]
D HDEF_0230 CorC/HlyC transporter containing CBS domain K03699 tlyC; magnesium and cobalt exporter, CNNM family
D HDEF_2329 corB; putative Mg2+ and Co2+ transporter K03699 tlyC; magnesium and cobalt exporter, CNNM family
C 02022 Two-component system [BR:hde02022]
D HDEF_1803 cpxR; response regulator in two-component regulatory system with CpxA K07662 cpxR; two-component system, OmpR family, response regulator CpxR
D HDEF_1519 arcB; hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
D HDEF_1901 arcA; response regulator in two-component regulatory system with ArcB (or CpxA), regulates respiratory and fermentative metabolism (OmpR family) K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
D HDEF_1801 rcsB; response regulator (positive) in two-component regulatory system with RcsC and YojN K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
D HDEF_1629 barA; hybrid sensory histidine kinase in two-component regulatory system with UvrY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
D HDEF_1528 uvrY; UvrY transcriptional regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
D HDEF_0080 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA, regulates multidrug resistance K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
D HDEF_2060 putative transcriptional regulator, response regulator receiver and GerE domains K07690 evgA; two-component system, NarL family, response regulator EvgA
D HDEF_0149 putative two-component sensor/regulator K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA
D HDEF_0150 putative regulator in two-component regulatory system with BarA (LuxR/UhpA familiy) K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB
C 02035 Bacterial motility proteins [BR:hde02035]
D HDEF_0481 pilT_1; PilT-like ATPase type IV pilus biogenesis protein K02669 pilT; twitching motility protein PilT
D HDEF_0340 pilD; PilD type IV pilus leader peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D HDEF_0750 pilF; PilF type IV pilus biogenesis/stability protein K02656 pilF; type IV pilus assembly protein PilF
D HDEF_0318 hypothetical protein K02279 cpaB; pilus assembly protein CpaB
D HDEF_0317 rcpA; putative tight adherance operon protein K02280 cpaC; pilus assembly protein CpaC
D HDEF_0315 hypothetical protein K02282 cpaE; pilus assembly protein CpaE
C 03037 Cilium and associated proteins
C 04812 Cytoskeleton proteins [BR:hde04812]
D HDEF_1726 mreB; mecillinam resistance-associated protein K03569 mreB; rod shape-determining protein MreB and related proteins
D HDEF_1778 ftsZ; tubulin-like GTP-binding protein and GTPase, forms circumferential ring in cell division K03531 ftsZ; cell division protein FtsZ
D HDEF_1779 ftsA; cell division protein with ATPase domain, involved in recruitment of FtsK to Z ring K03590 ftsA; cell division protein FtsA
D HDEF_0020 minC; cell division inhibitor minC K03610 minC; septum site-determining protein MinC
D HDEF_0021 minD; cell division inhibitor minD K03609 minD; septum site-determining protein MinD
D HDEF_0022 minE; cell division topological specificity factor K03608 minE; cell division topological specificity factor
D HDEF_2176 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_0737 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_2145 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_p0010 conserved hypothetical protein HDEF_p0010 K03496 parA; chromosome partitioning protein
D HDEF_1038 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_1398 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
D HDEF_1148 plasmid partition protein ParA-like protein K03496 parA; chromosome partitioning protein
C 04147 Exosome [BR:hde04147]
D HDEF_2093 htpG; chaperone Hsp90, heat shock protein C 62.5 K04079 HSP90A; molecular chaperone HtpG
D HDEF_0766 eno; enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D HDEF_0023 gapA; glyceraldehyde-3-phosphate dehydrogenase A K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D HDEF_1540 pgk; phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D HDEF_0803 pykF; pyruvate kinase I (formerly F), fructose-stimulated K00873 PK; pyruvate kinase [EC:2.7.1.40]
D HDEF_0087 ahpC; alkyl hydroperoxide reductase, C22 subunit, thioredoxin-like protein K03386 PRDX2_4; peroxiredoxin 2/4 [EC:1.11.1.24]
D HDEF_0629 groEL; chaperone Hsp60 (GroEL) K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D HDEF_0372 dnaK; chaperone Hsp70 in DNA biosynthesis/cell division K04043 dnaK; molecular chaperone DnaK
D HDEF_0049 pgi; glucosephosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D HDEF_1925 guaB; IMP dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D HDEF_0718 tufB; protein chain elongation factor EF-Tu; possible GTP-binding factor (duplicate of tufA) K02358 tuf; elongation factor Tu
D HDEF_0101 hinT; putative inhibitor of protein kinase C, contains a transferase domain K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D HDEF_2095 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D HDEF_2086 apt; adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D HDEF_2111 hemB; 5-aminolevulinate dehydratase (porphobilinogen synthase) K01698 hemB; porphobilinogen synthase [EC:4.2.1.24]
D HDEF_2074 serA; D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D HDEF_2035 purH; bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D HDEF_2042 lpd_2; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D HDEF_0646 zwf; glucose-6-phosphate dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
D HDEF_0053 tpiA; triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D HDEF_0267 gpmA; phosphoglyceromutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
C 02048 Prokaryotic defense system [BR:hde02048]
D HDEF_1592 putative restriction endonuclease, N6_Mtase domain protein K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D HDEF_1639 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D HDEF_1005 DNA methylase, N6_N4_Mtase domain protein K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D HDEF_0909 dcm_1; DNA cytosine methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D HDEF_2022 group II intron encoded reverse transcriptase K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_2002 group II intron encoded reverse transcriptase K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_1451 conserved hypothetical phage protein K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_1112 phage HNH endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_1011 phage HNH endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_0981 group II intron encoded reverse transcriptase K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D HDEF_0745 restriction endonuclease, Mrr_cat domain protein K07448 mrr; restriction system protein
D HDEF_0256 addiction module toxin K07171 mazF; mRNA interferase MazF [EC:3.1.-.-]
D HDEF_1393 chpB; addiction module, toxin ChpB K18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]
D HDEF_1394 chpS; addiction module, antitoxin ChpS K18842 chpS; antitoxin ChpS
D HDEF_1077 addiction module antitoxin K06218 relE; mRNA interferase RelE/StbE
D HDEF_1076 addiction module antitoxin K18918 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB
D HDEF_1448 addiction module toxin K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D HDEF_1232 addiction module toxin K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D HDEF_1125 addiction module antitoxin K07473 dinJ; DNA-damage-inducible protein J
D HDEF_1447 addiction module antitoxin K07473 dinJ; DNA-damage-inducible protein J
D HDEF_1233 addiction module antitoxin K07473 dinJ; DNA-damage-inducible protein J
D HDEF_1085 addiction module toxin K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D HDEF_0110 addiction module toxin K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D HDEF_1086 addiction module antitoxin K19159 yefM; antitoxin YefM
D HDEF_1625 hha; hemolysin expression modulator K05839 hha; haemolysin expression modulating protein
D HDEF_p0021 conserved hypothetical protein HDEF_p0021 K19092 parE1_3_4; toxin ParE1/3/4
D HDEF_1121 addiction module K19092 parE1_3_4; toxin ParE1/3/4
D HDEF_1037 hypothetical protein K19166 higB; mRNA interferase HigB [EC:3.1.-.-]
D HDEF_p0026 addiction module, toxin K07334 higB-1; toxin HigB-1
D HDEF_1036 putative transcriptional regulator, HTH_3 domain protein K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D HDEF_p0028 addiction module, antitoxin K21498 higA-1; antitoxin HigA-1
D HDEF_2149 addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_0960 addiction module,PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_0430 vagD; addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_p0008 putative addiction module, PIN domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D HDEF_0961 addiction module, SpoVT/AbrB domain protein K18829 mvpT; antitoxin VapB
D HDEF_0431 vagC; addiction module K18829 mvpT; antitoxin VapB
D HDEF_2150 addiction module, SpoVT/AbrB domain protein K18829 mvpT; antitoxin VapB
D HDEF_0261 addiction module, PIN domain protein K07062 fitB; toxin FitB [EC:3.1.-.-]
D HDEF_0976 addiction module, PIN domain protein K07062 fitB; toxin FitB [EC:3.1.-.-]
D HDEF_0427 addiction module, PIN domain protein K07062 fitB; toxin FitB [EC:3.1.-.-]
D HDEF_0260 addiction module K21495 fitA; antitoxin FitA
D HDEF_2169 stbC_2; addiction module K21495 fitA; antitoxin FitA
D HDEF_1778 ftsZ; tubulin-like GTP-binding protein and GTPase, forms circumferential ring in cell division K03531 ftsZ; cell division protein FtsZ
D HDEF_1726 mreB; mecillinam resistance-associated protein K03569 mreB; rod shape-determining protein MreB and related proteins
D HDEF_0801 parC; DNA topoisomerase IV, subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D HDEF_0799 parE; DNA topoisomerase IV, subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D HDEF_0366 gltX; glutamate tRNA synthetase, catalytic subunit K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D HDEF_0559 hypothetical protein K19168 cptA; toxin CptA
D HDEF_0560 hypothetical protein K09159 cptB; antitoxin CptB
D HDEF_0542 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C 04030 G protein-coupled receptors
C 04050 Cytokine receptors
C 04054 Pattern recognition receptors
C 03310 Nuclear receptors
C 04040 Ion channels
C 04031 GTP-binding proteins
C 04052 Cytokines and neuropeptides
C 04515 Cell adhesion molecules
C 04090 CD molecules
C 01504 Antimicrobial resistance genes [BR:hde01504]
D HDEF_0050 cmrA; multidrug/chloramphenicol efflux transport protein (MFS family) K08160 mdfA; MFS transporter, DHA1 family, multidrug/chloramphenicol efflux transport protein
D HDEF_0051 cmrB; multidrug/chloramphenicol efflux transport protein (MFS family) K08160 mdfA; MFS transporter, DHA1 family, multidrug/chloramphenicol efflux transport protein
D HDEF_1020 beta-lactamase K17836 penP; beta-lactamase class A [EC:3.5.2.6]
D HDEF_1623 multidrug efflux pump, membrane fusion (MFP/HlyD) family K03585 acrA; membrane fusion protein, multidrug efflux system
D HDEF_1624 multidrug efflux pump K18138 acrB; multidrug efflux pump
D HDEF_0321 tolC; outer membrane channel K12340 tolC; outer membrane protein
D HDEF_2060 putative transcriptional regulator, response regulator receiver and GerE domains K07690 evgA; two-component system, NarL family, response regulator EvgA
D HDEF_2275 ompN; outer membrane pore protein N, non-specific K09476 ompF; outer membrane pore protein F
C 00535 Proteoglycans
C 00536 Glycosaminoglycan binding proteins
C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
C 04091 Lectins
C 04990 Domain-containing proteins not elsewhere classified
B
B 09185 Viral protein families
C 03200 Viral proteins [BR:hde03200]
D HDEF_1455 phage lysis protein, endopeptidase K14744 rzpD; prophage endopeptidase [EC:3.4.-.-]
D HDEF_1010 phage lysis protein K14744 rzpD; prophage endopeptidase [EC:3.4.-.-]
D HDEF_0892 hypothetical protein K14744 rzpD; prophage endopeptidase [EC:3.4.-.-]
C 03210 Viral fusion proteins
B
B 09184 RNA family
C 03100 Non-coding RNAs [BR:hde03100]
D HDEF_1304 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D HDEF_1318 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D HDEF_1646 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0548 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_1919 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0015 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D HDEF_0360 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D HDEF_0684 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D HDEF_1532 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D HDEF_0812 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D HDEF_0813 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D HDEF_1752 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D HDEF_2033 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D HDEF_0686 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D HDEF_1531 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D HDEF_0549 tRNA-His K14226 tRNA-His; tRNA His
D HDEF_1319 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D HDEF_0336 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_1594 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0814 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0550 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_1533 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D HDEF_0572 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_1527 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_1658 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D HDEF_2246 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0815 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0335 tRNA-Met K14230 tRNA-Met; tRNA Met
D HDEF_0871 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D HDEF_0551 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D HDEF_2112 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D HDEF_0014 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_2069 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_2291 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D HDEF_0685 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D HDEF_0688 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D HDEF_1315 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_1749 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_2030 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D HDEF_0687 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D HDEF_0571 tRNA-Val K14237 tRNA-Val; tRNA Val
D HDEF_1515 tRNA-Val K14237 tRNA-Val; tRNA Val
D HDEF_1753 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1320 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_2034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D HDEF_1317 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_2032 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_1751 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D HDEF_1316 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_2031 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_1750 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D HDEF_1893 catalytic subunit of RNAse P K01978 rnpB; M1 RNA
#
A09190 Not Included in Pathway or Brite
B
B 09191 Unclassified: metabolism
C 99980 Enzymes with EC numbers
D HDEF_2232 msrB_2; methionine sulfoxide reductase K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]
D HDEF_1400 msrB_1; methionine sulfoxide reductase K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]
D HDEF_0120 tpx; thiol peroxidase K11065 tpx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24]
D HDEF_0484 ftn; cytoplasmic ferritin (iron storage protein) K02217 ftnA; ferritin [EC:1.16.3.2]
D HDEF_0054 fpr; ferredoxin-NADP reductase K00528 fpr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]
D HDEF_0044 lnt; apolipoprotein N-acyltransferase, copper homeostasis protein, inner membrane K03820 lnt; apolipoprotein N-acyltransferase [EC:2.3.1.269]
D HDEF_0026 aat; leucyl/phenylalanyl-tRNA-protein transferase K00684 aat; leucyl/phenylalanyl-tRNA---protein transferase [EC:2.3.2.6]
D HDEF_1916 lgt; phosphatidylglycerol-prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]
D HDEF_1655 P45; APSE-2 prophage; DNA polymerase K02334 dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]
D HDEF_2024 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_2000 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0297 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0723 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_p0017 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1223 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0441 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1937 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0351 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0540 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0619 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0796 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0847 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0982 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1156 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1375 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1415 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_2001 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_2023 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0582 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0726 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0992 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_1251 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_2321 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_0983 group II intron encoded reverse transcriptase K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]
D HDEF_2270 conserved hypothetical protein, PHP domain protein K07053 E3.1.3.97; 3',5'-nucleoside bisphosphate phosphatase [EC:3.1.3.97]
D HDEF_1541 sixA; phosphohistidine phosphatase K08296 sixA; phosphohistidine phosphatase [EC:3.1.3.-]
D HDEF_0411 putative phosphoesterase K01128 SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]
D HDEF_0453 putative metallodependent hydrolase, TatD domain protein K03424 tatD; TatD DNase family protein [EC:3.1.21.-]
D HDEF_0269 putative alpha/beta hydrolase fold protein K01175 ybfF; esterase [EC:3.1.-.-]
D HDEF_1675 F; APSE-2 prophage; lysozyme K01185 E3.2.1.17; lysozyme [EC:3.2.1.17]
D HDEF_0409 phage lysozyme K01185 E3.2.1.17; lysozyme [EC:3.2.1.17]
D HDEF_1459 phage lysozyme K01185 E3.2.1.17; lysozyme [EC:3.2.1.17]
D HDEF_1007 phage lysozyme K01185 E3.2.1.17; lysozyme [EC:3.2.1.17]
D HDEF_1720 def; peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D HDEF_1287 mgtA; P-type ATPase, Mg2+ ATPase transport protein K01531 mgtA; P-type Mg2+ transporter [EC:7.2.2.14]
C 99981 Carbohydrate metabolism
C 99982 Energy metabolism
D HDEF_0001 mioC; FMN-binding protein K06205 mioC; MioC protein
D HDEF_2288 fldA; flavodoxin 1 K03839 fldA; flavodoxin I
C 99983 Lipid metabolism
C 99984 Nucleotide metabolism
C 99985 Amino acid metabolism
D HDEF_0482 putative alanine racemase K06997 yggS; PLP dependent protein
C 99986 Glycan metabolism
D HDEF_0116 hypothetical protein K08992 lapA; lipopolysaccharide assembly protein A
D HDEF_0115 putative N-acetylglucosaminyl transferase K19804 lapB; lipopolysaccharide assembly protein B
C 99987 Cofactor metabolism
D HDEF_0706 hemY; protein in late step of protoheme IX synthesis with tetratricopeptide repeats (TPR) domain K02498 hemY; HemY protein
D HDEF_1734 ubiB; 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway K03688 ubiB; ubiquinone biosynthesis protein
D HDEF_1733 conserved hypothetical protein, SCP2 domain protein K03690 ubiJ; ubiquinone biosynthesis accessory factor UbiJ
D HDEF_0793 hypothetical protein K09806 ubiK; ubiquinone biosynthesis accessory factor UbiK
C 99988 Secondary metabolism
C 99999 Others
B
B 09192 Unclassified: genetic information processing
C 99973 Transcription
D HDEF_0233 cspE_1; RNA chaperone, transcription antiterminator K03704 cspA; cold shock protein
D HDEF_1288 cspE_2; RNA chaperone, transcription antiterminator, affects expression of rpoS and uspA K03704 cspA; cold shock protein
D HDEF_0826 cspC; cold shock protein, transcription antiterminator, affects expression of rpoS and uspA K03704 cspA; cold shock protein
D HDEF_1584 phage anti-repressor protein K07741 antB; anti-repressor protein
D HDEF_2052 phage anti-repressor protein K07741 antB; anti-repressor protein
D HDEF_1724 transcriptional accessory protein, RNA binding S1 domain protein K06959 tex; protein Tex
C 99974 Translation
C 99975 Protein processing
D HDEF_0461 clpS; regulatory protein for ClpA substrate specificity K06891 clpS; ATP-dependent Clp protease adaptor protein ClpS
D HDEF_0810 tig; peptidyl-prolyl cis/trans isomerase (trigger factor), molecular chaperone involved in cell division K03545 tig; trigger factor
D HDEF_0702 smpB; trans-translation protein K03664 smpB; SsrA-binding protein
D HDEF_0236 yifB; putative enzyme (N-terminal); putative transcriptional regulator with P-loop containing nucleoside triphosphate hydrolase domain (C-terminal) K07391 comM; magnesium chelatase family protein
D HDEF_0545 nfuA; Fe/S biogenesis protein K07400 nfuA; Fe/S biogenesis protein NfuA
D HDEF_0145 ssaE; putative type III secretion system effector K18984 ssaE; secretion system chaperone SsaE
C 99976 Replication and repair
D HDEF_1913 radC; associated with replication fork, possible DNA repair protein K03630 radC; DNA repair protein RadC
D HDEF_1759 hypothetical protein K07460 yraN; putative endonuclease
D HDEF_1679 P18; APSE-2 prophage; terminase K06909 xtmB; phage terminase large subunit
D HDEF_1144 putative resolvase K14060 pinR; putative DNA-invertase from lambdoid prophage Rac
D HDEF_0963 traC_1; DNA primase TraC K06919 K06919; putative DNA primase/helicase
D HDEF_p0037 traC; DNA primase TraC K06919 K06919; putative DNA primase/helicase
D HDEF_2175 putative transposase K18320 IS15; transposase, IS6 family
D HDEF_1151 ISHde3, transposase orfA K07483 K07483; transposase
D HDEF_1570 ISHde3, transposase orfA K07483 K07483; transposase
D HDEF_2280 ISHde3, transposase orfA K07483 K07483; transposase
D HDEF_1235 ISHde4 transposase, orfA K07483 K07483; transposase
D HDEF_0926 ISHde4 transposase, orfA K07483 K07483; transposase
D HDEF_2153 ISHde7, transposase orfA K07486 K07486; transposase
D HDEF_1053 ISHde7 transposase orfA K07486 K07486; transposase
D HDEF_2282 ISHde3, transposase orfB K07497 K07497; putative transposase
D HDEF_0925 ISHde4 transposase, orfB K07497 K07497; putative transposase
D HDEF_1152 ISHde3, transposase orfB K07497 K07497; putative transposase
D HDEF_1107 ISHde4 transposase, orfB K07497 K07497; putative transposase
D HDEF_1114 ISHde4 transposase, orfB K07497 K07497; putative transposase
D HDEF_1236 ISHde4 transposase, orfB K07497 K07497; putative transposase
C 99979 Viral proteins
C 99998 Others
D HDEF_2088 hypothetical protein K09747 ebfC; nucleoid-associated protein EbfC
B
B 09193 Unclassified: signaling and cellular processes
C 99977 Transport
D HDEF_0638 brnQ; branched-chain amino acid transport system II (LIV-II) (LIVCS family) K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family
C 99978 Cell growth
D HDEF_2067 ispZ; putative membrane protein, intracellular septation protein K06190 ispZ; intracellular septation protein
D HDEF_0363 peptidase, M23 family domain protein K22719 envC; murein hydrolase activator
C 99993 Cell motility
D HDEF_0102 putative lipoprotein K07337 K07337; penicillin-binding protein activator
D HDEF_2085 sxy; hypothetical protein K07343 tfoX; DNA transformation protein and related proteins
C 99995 Signaling proteins
D HDEF_1480 proQ_1; putative structural transport element K03607 proQ; ProP effector
D HDEF_1487 proQ_2; putative structural transport element K03607 proQ; ProP effector
D HDEF_0473 uspA; universal stress protein A K06149 uspA; universal stress protein A
D HDEF_0056 typA; protein possibly involved in LPS biosynthesis and host colonization K06207 typA; GTP-binding protein
D HDEF_0303 hypothetical protein K07184 ygiM; SH3 domain protein
D HDEF_1968 hypothetical protein K09767 yajQ; cyclic-di-GMP-binding protein
C 99992 Structural proteins
D HDEF_0798 lolA; periplasmic chaperone effects translocation of lipoproteins from inner membrane to outer membrane K03634 lolA; outer membrane lipoprotein carrier protein
D HDEF_2119 lolB; outer membrane component involved in lipoprotein localization K02494 lolB; outer membrane lipoprotein LolB
D HDEF_0088 vacJ; lipoprotein precursor K04754 mlaA; phospholipid-binding lipoprotein MlaA
D HDEF_0669 slyB; putative outer membrane lipoprotein K06077 slyB; outer membrane lipoprotein SlyB
D HDEF_0591 hlpA; periplasmic chaperone K06142 hlpA; outer membrane protein
D HDEF_1713 nlpD; lipoprotein K06194 nlpD; lipoprotein NlpD
D HDEF_0214 hypothetical protein K07283 ydiY; putative salt-induced outer membrane protein
D HDEF_0042 asmA; suppressor of ompF assembly mutants K07289 asmA; AsmA protein
C 99994 Others
D HDEF_2252 phoU; transcriptional repressor for high-affinity phosphate uptake K02039 phoU; phosphate transport system protein
D HDEF_0119 integral membrane protein, tellurite resistance TerC family K05794 terC; tellurite resistance protein TerC
D HDEF_2132 hmuS; hemin transport K07225 hmuS; putative hemin transport protein
B
B 09194 Poorly characterized
C 99996 General function prediction only
D HDEF_0787 colicin V production protein K03558 cvpA; membrane protein required for colicin V production
D HDEF_1290 pqiB; paraquat-inducible protein B K06192 pqiB; paraquat-inducible protein B
D HDEF_0354 erpA; hypothetical protein K15724 erpA; iron-sulfur cluster insertion protein
D HDEF_0059 sufA; Fe-S cluster assembly protein K05997 sufA; Fe-S cluster assembly protein SufA
D HDEF_0060 sufB; putative transport protein associated with Fe-S cluster assembly K09014 sufB; Fe-S cluster assembly protein SufB
D HDEF_0062 sufD; required for stability of Fe-S component of FhuF K09015 sufD; Fe-S cluster assembly protein SufD
D HDEF_2122 ydjM; LexA regulated protein, possible SOS response K07038 K07038; inner membrane protein
D HDEF_0064 sufE; stimulator of SufS activity K02426 sufE; cysteine desulfuration protein SufE
D HDEF_0081 putative sulfurtransferase, rhodanese-like domain protein K07146 K07146; UPF0176 protein
D HDEF_0055 hypothetical protein K03745 slyX; SlyX protein
D HDEF_0786 hypothetical protein K03749 dedD; DedD protein
D HDEF_1805 sanA; vancomycin sensitivity, putative oxidoreductase K03748 sanA; SanA protein
D HDEF_0783 dedA; putative integral membrane protein K03975 dedA; membrane-associated protein
D HDEF_1291 pqiA; paraquat-inducible protein A, membrane K03808 pqiA; paraquat-inducible protein A
C 99997 Function unknown
D HDEF_0457 putative membrane protein K06890 K06890; uncharacterized protein
D HDEF_2206 phage T4-like baseplate assembly protein with lysozyme activity K06903 W; Bacteriophage baseplate protein W
D HDEF_2121 ydjN; putative transport protein K06956 K06956; uncharacterized protein
D HDEF_2099 putative sulfatase K07014 K07014; uncharacterized protein
D HDEF_2286 yfcH; putative cell division inhibitor, NAD(P)-binding K07071 K07071; uncharacterized protein
D HDEF_2010 conserved hypothetical phage protein K08998 K08998; uncharacterized protein
D HDEF_2231 hypothetical protein K09131 K09131; uncharacterized protein
D HDEF_0675 hypothetical protein K09158 K09158; uncharacterized protein
D HDEF_0171 hypothetical protein K09703 K09703; uncharacterized protein
D HDEF_1991 hypothetical protein K09779 K09779; uncharacterized protein
D HDEF_0234 hypothetical protein K09791 K09791; uncharacterized protein
D HDEF_0945 hypothetical protein K09803 K09803; uncharacterized protein
D HDEF_p0051 conserved hypothetical protein HDEF_p0051 K09803 K09803; uncharacterized protein
D HDEF_1289 hypothetical protein K09857 K09857; uncharacterized protein
D HDEF_1275 hypothetical protein K09861 K09861; uncharacterized protein
D HDEF_1817 yhcB; cytochrome d ubiquinol oxidase subunit III K09908 K09908; uncharacterized protein
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#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: June 10, 2024