+E Replication protein KO
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DNA Replication Proteins - Klebsiella variicola 342
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
C GINS complex
C Other initiation factors
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
C DNA polymerase epsilon complex
C DNA polymerase delta complex
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
C RFC (replication factor C)
C RNase H
D KPK_4506 rnhA; ribonuclease H K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
C Other elongation factors
B DNA Replication Termination Factors
C DNA methylation enzymes
D KPK_1851 dcm; DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D KPK_3378 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D KPK_2860 putative DNA modification methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D KPK_4188 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D Dyskerin complex
C Telomerase complex (fungi)
D Sm core complex
C ELG1-RFC complex
C MRN complex
C Other termination factors
B DNA Topoisomerases
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D KPK_5292 hupA; DNA-binding protein HU, alpha subunit K05787 hupA; DNA-binding protein HU-alpha
D KPK_4280 hupB; DNA-binding protein HU, beta subunit K03530 hupB; DNA-binding protein HU-beta
D KPK_2144 ihfA; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
D KPK_3620 ihfB; integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
D KPK_0001 dnaA; chromosomal replication initiator protein DnaA K02313 dnaA; chromosomal replication initiator protein
D KPK_5236 dnaB; replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D KPK_4803 dnaC; DNA replication protein DnaC K02315 dnaC; DNA replication protein DnaC
D KPK_4170 ATP binding protein, IstB family K02315 dnaC; DNA replication protein DnaC
D KPK_0645 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D KPK_5229 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
E KPK_4536 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E KPK_0002 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E KPK_5004 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E KPK_3901 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E KPK_3459 holB; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E KPK_4504 dnaQ; DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E KPK_4228 dnaX; DNA polymerase III, tau subunit K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E KPK_4785 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E KPK_1930 holE_1; DNA polymerase III, theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
E KPK_4159 holE_2; DNA polymerase III theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D RNase H
E KPK_4506 rnhA; ribonuclease H K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E KPK_4537 rnhB; ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D Other elongation factors
E KPK_5510 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E KPK_1381 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E KPK_0101 ligB; NAD(+)-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E KPK_4506 rnhA; ribonuclease H K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E KPK_4537 rnhB; ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
B DNA Replication Termination Factors
C Terminus site-binding protein
D KPK_2942 tus; DNA replication terminus site-binding protein K10748 tus; DNA replication terminus site-binding protein
D KPK_A0008 putative DNA replication terminus site-binding protein K10748 tus; DNA replication terminus site-binding protein
C DNA methylation enzymes
D KPK_0358 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
C Prevention of re-replication factors
D KPK_3860 seqA; protein SeqA K03645 seqA; negative modulator of initiation of replication
D KPK_1317 hda; DnaA regulatory inactivator Hda K10763 hda; DnaA-homolog protein
B DNA Topoisomerases
C KPK_1511 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C KPK_0004 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C KPK_0685 parC; DNA topoisomerase IV, A subunit K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
C KPK_0678 parE; DNA topoisomerase IV, B subunit K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
C KPK_3166 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
C KPK_3236 topB; DNA topoisomerase 3 K03169 topB; DNA topoisomerase III [EC:5.6.2.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022