+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Methanobacterium congolense</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
D      MCBB_2239 rpa; Replication factor A	K07466 RFA1; replication factor A1 
C    RFC (replication factor C)
C    RNase H
C    Other elongation factors
D      MCBB_2200 pcn; DNA polymerase sliding clamp {ECO:0000255|HAMAP-Rule:MF_00317}	K04802 PCNA; proliferating cell nuclear antigen 
D      MCBB_0569 fen; Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_00614}	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      MCBB_0172 lig; DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407}	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      MCBB_0347 dnaG; DNA primase DnaG {ECO:0000255|HAMAP-Rule:MF_00007}	K02316 dnaG; DNA primase [EC:2.7.7.101] 
C    Initiation factors (archaeal)
D      MCBB_2324 cdc6-1; ORC1-type DNA replication protein 1 {ECO:0000255|HAMAP-Rule:MF_01407}	K10725 cdc6A; archaeal cell division control protein 6 
D      MCBB_1704 cdc6-2; ORC1-type DNA replication protein 2 {ECO:0000255|HAMAP-Rule:MF_01407}	K10725 cdc6A; archaeal cell division control protein 6 
D      MCBB_1738 MCM7; DNA replication licensing factor MCM7	K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] 
D      MCBB_0961 priS; DNA primase small subunit PriS {ECO:0000255|HAMAP-Rule:MF_00700}	K02683 priS; DNA primase small subunit [EC:2.7.7.102] 
D      MCBB_0971 priL; DNA primase large subunit PriL {ECO:0000255|HAMAP-Rule:MF_00701}	K18882 priL; DNA primase large subunit 
D      MCBB_2199 putative protein {ECO:0000313|EMBL:AIS33062,1}	K09723 ginS; DNA replication factor GINS 
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        MCBB_0220 rnhB; Ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
C    Elongation factors (archaeal)
D      B-family DNA polymerases
E        MCBB_2165 polB1; DNA polymerase PolB subunit 1	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
E        MCBB_0486 polB2; DNA polymerase PolB subunit 2	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
D      D-family DNA polymerases
E        MCBB_0105 polC; DNA polymerase II large subunit {ECO:0000255|HAMAP-Rule:MF_00324}	K02322 polC; DNA polymerase II large subunit [EC:2.7.7.7] 
E        MCBB_2329 polB; DNA polymerase II small subunit	K02323 polB; DNA polymerase II small subunit [EC:2.7.7.7] 
D      RNase H
E        MCBB_0220 rnhB; Ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
E        MCBB_1583 rfcL; Replication factor C large subunit	K04800 rfcL; replication factor C large subunit 
E        MCBB_1582 rfcS; Replication factor C small subunit	K04801 rfcS; replication factor C small subunit 
D      Other elongation factors
E        MCBB_0569 fen; Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_00614}	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        MCBB_0172 lig; DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407}	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
D      MCBB_1498 mjaIIIM; Modification methylase MjaIII	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    MCBB_0300 top6A; Type 2 DNA topoisomerase 6 subunit A {ECO:0000255|HAMAP-Rule:MF_00132}	K03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2] 
C    MCBB_0301 top6B; Type 2 DNA topoisomerase 6 subunit B {ECO:0000255|HAMAP-Rule:MF_00322}	K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2] 
C    MCBB_1734 topA; DNA topoisomerase 1 {ECO:0000255|HAMAP-Rule:MF_00952}	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: November 2, 2022