+F Repair protein KO
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DNA Repair and Recombination Proteins - Monodelphis domestica (gray short-tailed opossum)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 103102306 MGMT; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 103106540 ALKBH2; alkB homolog 2, alpha-ketoglutarate dependent dioxygenase K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 100013323 ALKBH3; alkB homolog 3, alpha-ketoglutaratedependent dioxygenase K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 100020863 ASCC3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 554181 POPC1; DNA photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 100023889 UNG; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100031840 CCNO; cyclin O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100021839 TDG; thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100019248 MPG; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100010844 SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100024801 MUTYH; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100025366 MBD4; methyl-CpG binding domain 4, DNA glycosylase K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100023983 OGG1; 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 100030381 NEIL1; nei like DNA glycosylase 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100032683 NEIL2; nei like DNA glycosylase 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 100017570 NEIL3; nei like DNA glycosylase 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 100012520 NTHL1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 100029539 APEX1; apurinic/apyrimidinic endodeoxyribonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 100012903 APEX2; apurinic/apyrimidinic endodeoxyribonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100030097 POLD2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
F 100618118 POLD3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
F 100014853 POLD4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 100027569 POLE; DNA polymerase epsilon, catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 100028960 POLE2; DNA polymerase epsilon 2, accessory subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 100010006 POLE3; DNA polymerase epsilon 3, accessory subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 100032850 POLE4; DNA polymerase epsilon 4, accessory subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 100029293 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100012289 FEN1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 100030148 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100021775 LIG3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 100015515 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 100020823 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100033298 APLF; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100030171 PNKP; polynucleotide kinase 3'-phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 100020248 HMGB1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 100023482 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100019495 PARP1; poly(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100029480 PARP2; poly(ADP-ribose) polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100031207 PARP3; poly(ADP-ribose) polymerase family member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100619386 PARP4; poly(ADP-ribose) polymerase family member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100026296 XPC; XPC complex subunit, DNA damage recognition and repair factor K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 100022113 RAD23B; RAD23 homolog B, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 100021317 RAD23A; RAD23 homolog A, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 100026359 CETN2; centrin 2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 100013521 RBX1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100016493 CUL4A; cullin 4A K10609 CUL4; cullin 4
F 100020368 CUL4B; cullin 4B K10609 CUL4; cullin 4
F 100027158 DDB1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100016157 DDB2; damage specific DNA binding protein 2 K10140 DDB2; DNA damage-binding protein 2
F 100021792 DNA damage-binding protein 2-like K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100014728 POLR2A; RNA polymerase II subunit A K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100012197 POLR2B; RNA polymerase II subunit B K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 100016249 POLR2C; RNA polymerase II subunit C K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100018533 POLR2D; RNA polymerase II subunit D K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 100015794 POLR2E; RNA polymerase II subunit E K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 100017209 POLR2F; RNA polymerase II subunit F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100010697 POLR2G; RNA polymerase II subunit G K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 100013916 POLR2H; RNA polymerase II subunit H K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 100014201 POLR2I; RNA polymerase II subunit I K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 100017767 POLR2J; RNA polymerase II subunit J K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100023403 POLR2K; RNA polymerase II subunit K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 100013521 RBX1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100016493 CUL4A; cullin 4A K10609 CUL4; cullin 4
F 100020368 CUL4B; cullin 4B K10609 CUL4; cullin 4
F 100027158 DDB1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100032223 ERCC8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 100014770 ERCC6; ERCC excision repair 6, chromatin remodeling factor K10841 ERCC6; DNA excision repair protein ERCC-6
F 100024845 UVSSA; UV stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 100010548 ELOF1; elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100018843 ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 100012006 ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 100019855 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100010571 GTF2H2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100015833 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100024026 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 103093721 GTF2H4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 100027647 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 100019498 CDK7; cyclin dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 100011386 CCNH; cyclin H K06634 CCNH; cyclin H
E 100027126 MNAT1; MNAT1, CDK activating kinase assembly factor K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 100018386 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 100014496 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100014611 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100028831 RPA3; replication protein A3 K10740 RPA3; replication factor A3
D Other NER factors
E 100019963 XPA; XPA, DNA damage recognition and repair factor K10847 XPA; DNA-repair protein complementing XP-A cells
E 100011871 ERCC1; ERCC excision repair 1, endonuclease non-catalytic subunit K10849 ERCC1; DNA excision repair protein ERCC-1
E 100024202 ERCC4; ERCC excision repair 4, endonuclease catalytic subunit K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 100025456 ERCC5; ERCC excision repair 5, endonuclease K10846 ERCC5; DNA excision repair protein ERCC-5
E 100016403 MMS19; MMS19 homolog, cytosolic iron-sulfur assembly component K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 100015239 CUL3; cullin 3 K03869 CUL3; cullin 3
E 100032484 CUL5; cullin 5 K10612 CUL5; cullin 5
E 100028060 ELOC; elongin C K03872 ELOC; elongin-C
E 100018279 ELOB; elongin B K03873 ELOB; elongin-B
E 100010292 ELOA; elongin A K15076 ELOA; elongin-A
E 103102461 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 103094339 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 100015516 UBAP2L; ubiquitin associated protein 2 like K26545 UBAP2; ubiquitin-associated protein 2
E 100011549 UBAP2; ubiquitin associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100033358 MSH2; mutS homolog 2 K08735 MSH2; DNA mismatch repair protein MSH2
E 100015958 MSH3; mutS homolog 3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100033356 MSH6; mutS homolog 6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100028665 PMS1; PMS1 homolog 1, mismatch repair system component K10864 PMS1; DNA mismatch repair protein PMS1
E 100011682 MLH1; mutL homolog 1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100027220 PMS2; PMS1 homolog 2, mismatch repair system component K10858 PMS2; DNA mismatch repair protein PMS2
E 100023484 MLH3; mutL homolog 3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100030097 POLD2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
E 100618118 POLD3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
E 100014853 POLD4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 100018386 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 100014496 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100014611 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100028831 RPA3; replication protein A3 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 100022156 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 100016281 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 100619149 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 100023612 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 100020774 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 100029293 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100020408 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100020248 HMGB1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 100012076 WDR76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100014068 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100015557 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100021870 NBN; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100014337 BARD1; BRCA1 associated RING domain 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100012821 BRCA1-A complex subunit Abraxas-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 100017569 FAM175A; family with sequence similarity 175 member A K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 100617807 UIMC1; ubiquitin interaction motif containing 1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 100016075 BABAM1; BRISC and BRCA1 A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 100026430 BRE; brain and reproductive organ-expressed (TNFRSF1A modulator) K12173 BRE; BRCA1-A complex subunit BRE
E 100014766 BRCC3; BRCA1/BRCA2-containing complex subunit 3 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 100010162 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100010194 BRIP1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100030030 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 100030017 DNA topoisomerase 2-binding protein 1-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100010941 RBBP8; RB binding protein 8, endonuclease K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 100014068 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100015557 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100021870 NBN; nibrin K10867 NBN; nibrin
D BRCA complex
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100049015 BRCA2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 100027303 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 100027424 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 100027424 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 100028433 RAD51B; RAD51 paralog B K10869 RAD51L1; RAD51-like protein 1
E 100011576 RAD51C; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 100021651 RAD51D; RAD51 paralog D K10871 RAD51L3; RAD51-like protein 3
E 100019285 XRCC2; X-ray repair cross complementing 2 K10879 XRCC2; DNA-repair protein XRCC2
E 100020866 XRCC3; X-ray repair cross complementing 3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 100020944 RAD52; RAD52 homolog, DNA repair protein K10873 RAD52; DNA repair and recombination protein RAD52
E 100024572 RDM1; RAD52 motif containing 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 100024068 RAD54L; RAD54-like (S. cerevisiae) K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100021217 RAD54L2; RAD54-like 2 (S. cerevisiae) K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100029785 RAD54B; RAD54 homolog B (S. cerevisiae) K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 100011463 RECQL; RecQ like helicase K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100026575 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100019443 WRN; Werner syndrome RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100014352 BLM; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100019551 RECQL4; RecQ like helicase 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 100027279 RECQL5; RecQ like helicase 5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100014352 BLM; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100015750 TOP3B; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100029388 TOP3A; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100021531 RMI1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100025287 RMI2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 100018386 RPA1; replication protein A1 K07466 RFA1; replication factor A1
E 100014496 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100014611 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 100028831 RPA3; replication protein A3 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 100012739 PPP4C; protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 100016860 PPP4R1; protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100027275 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100012451 PPP4R2; protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100014868 PPP4R3A; protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100032020 PPP4R3B; protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100014809 PPP4R4; protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 100030016 AP5B1; adaptor related protein complex 5 beta 1 subunit K19022 AP5B1; AP-5 complex subunit beta-1
E 100020887 AP5M1; adaptor related protein complex 5 mu 1 subunit K19023 AP5M1; AP-5 complex subunit mu-1
E 100031112 AP5S1; adaptor related protein complex 5 sigma 1 subunit K19024 AP5S1; AP-5 complex subunit sigma-1
E 100013857 AP5Z1; adaptor related protein complex 5 zeta 1 subunit K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 100021488 SMC5; structural maintenance of chromosomes 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100011747 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100618131 SMC6; structural maintenance of chromosomes 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100013252 FAM84A; family with sequence similarity 84 member A K22805 FAM84A; protein FAM84A
E 100016241 NSMCE1; NSE1 homolog, SMC5-SMC6 complex component K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100032252 NSMCE2; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100617402 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 103098792 NSMCE4A; NSE4 homolog A, SMC5-SMC6 complex component K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 100011446 SLF1; SMC5-SMC6 complex localization factor 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 100029881 SLF2; SMC5-SMC6 complex localization factor 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100025292 EME1; essential meiotic structure-specific endonuclease 1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 100011288 EME2; essential meiotic structure-specific endonuclease subunit 2 K10883 EME2; crossover junction endonuclease EME2
E 100028590 EXD2; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 100029893 MUS81; MUS81 structure-specific endonuclease subunit K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 103105146 SWI5; SWI5 homologous recombination repair protein K10991 SWI5; DNA repair protein Swi5/Sae3
E 100618308 SFR1; SWI5 dependent homologous recombination repair protein 1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100616924 SLX1A; SLX1 homolog A, structure-specific endonuclease subunit K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 100016277 SLX4; SLX4 structure-specific endonuclease subunit K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 100012368 SPG11; spastic paraplegia 11 (autosomal recessive) K19026 SPG11; spatacsin
E 100028398 ZFYVE26; zinc finger FYVE-type containing 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100019490 RAD51AP1; RAD51 associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 100013035 MORF4L1; mortality factor 4 like 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100032613 SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100030015 FIGNL1; fidgetin like 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100030809 SPIDR; scaffolding protein involved in DNA repair K22806 SPIDR; DNA repair-scaffolding protein
E 100032318 FAM84B; family with sequence similarity 84 member B K22810 FAM84B; protein FAM84B
E 100010361 BRAT1; BRCA1 associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 100018528 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100021041 ZSWIM7; zinc finger SWIM-type containing 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 100010921 SWSAP1; SWIM-type zinc finger 7 associated protein 1 K25771 SWSAP1; ATPase SWSAP1
E 100018741 EMSY; EMSY, BRCA2 interacting transcriptional repressor K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100619907 HSF2BP; heat shock transcription factor 2 binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 100026969 MMS22L; MMS22 like, DNA repair protein K26125 MMS22L; protein MMS22-like
E 100019049 TONSL; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 100016237 BOD1L1; biorientation of chromosomes in cell division 1 like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 100021233 PARPBP; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 100028863 XRCC6; X-ray repair cross complementing 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100013619 XRCC5; X-ray repair cross complementing 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100030684 PRKDC; protein kinase, DNA-activated, catalytic polypeptide K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100014068 MRE11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100015557 RAD50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 100018117 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100014894 XRCC4; X-ray repair cross complementing 4 K10886 XRCC4; DNA-repair protein XRCC4
E 100010576 NHEJ1; non-homologous end joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100023482 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100025794 POLM; DNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 554183 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 100030148 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 100020823 APTX; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100033298 APLF; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100014840 DCLRE1C; DNA cross-link repair 1C K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 100024191 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100012023 SMCHD1; structural maintenance of chromosomes flexible hinge domain containing 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 103103797 PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 103104510 C1H9orf142; chromosome 1 open reading frame, human C9orf142 K25772 PAXX; protein PAXX
E 103096000 C8H7orf49; chromosome 8 open reading frame, human C7orf49 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 103093951 JMJD8; jumonji domain containing 8 K25792 JMJD8; jumonji domain-containing protein 8
E 100033294 C1H20orf196; chromosome 1 open reading frame, human C20orf196 K26128 SHLD1; shieldin complex subunit 1
E 100020126 FAM35A; family with sequence similarity 35 member A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 100027499 FANCA; Fanconi anemia complementation group A K10888 FANCA; fanconi anemia group A protein
E 100031860 FANCB; Fanconi anemia complementation group B K10889 FANCB; fanconi anemia group B protein
E 100013900 FANCC; Fanconi anemia complementation group C K10890 FANCC; fanconi anemia group C protein
E 100028417 FANCE; Fanconi anemia complementation group E K10892 FANCE; fanconi anemia group E protein
E 103095165 FANCF; Fanconi anemia complementation group F K10893 FANCF; fanconi anemia group F protein
E 100028459 FANCG; Fanconi anemia complementation group G K10894 FANCG; fanconi anemia group G protein
E 100033325 FANCL; Fanconi anemia complementation group L K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100025437 FANCM; Fanconi anemia complementation group M K10896 FANCM; fanconi anemia group M protein
E 100012924 FAAP24; Fanconi anemia core complex associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 100030340 FAAP100; Fanconi anemia core complex associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 100011897 HES1; hes family bHLH transcription factor 1 K06054 HES1; hairy and enhancer of split 1
E 100027474 HES4; hes family bHLH transcription factor 4 K06054 HES1; hairy and enhancer of split 1
E 100029890 CENPX; centromere protein X K15360 STRA13; centromere protein X
E 100014786 UBE2T; ubiquitin conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 100014352 BLM; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100015750 TOP3B; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100029388 TOP3A; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100021531 RMI1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100025287 RMI2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100024226 FANCD2; Fanconi anemia complementation group D2 K10891 FANCD2; fanconi anemia group D2 protein
E 100016421 FANCI; Fanconi anemia complementation group I K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 554178 BRCA1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100049015 BRCA2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 100010194 BRIP1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100027303 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 100021648 FAN1; FANCD2 and FANCI associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 100027424 RAD51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 100011576 RAD51C; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 100618328 TELO2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
E 100031700 USP1; ubiquitin specific peptidase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 100021027 WDR48; WD repeat domain 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 100015864 PPP6C; protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 100011292 PPP6R2; protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 100011710 PPP6R3; protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 100030566 ANKRD28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 100029617 ANKRD44; ankyrin repeat domain 44 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
E 100619045 RNF8; ring finger protein 8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100022084 RNF168; ring finger protein 168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 100012888 RNF169; ring finger protein 169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 100012223 HERC2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 100015288 WRAP53; WD repeat containing antisense to TP53 K23314 WRAP53; telomerase Cajal body protein 1
E 100023406 TPRN; taperin K24164 TPRN; taperin
E 103095276 ZCWPW1; zinc finger CW-type and PWWP domain containing 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 100019680 WDR70; WD repeat domain 70 K24752 WDR70; WD repeat-containing protein 70
E 100012076 WDR76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 100011953 POLH; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 100010072 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 100014509 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100012790 REV1; REV1, DNA directed polymerase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100022401 REV3L; REV3 like, DNA directed polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 100022326 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 100011856 UBE2A; ubiquitin conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 100014677 UBE2B; ubiquitin conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 100023569 RAD18; RAD18, E3 ubiquitin protein ligase K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100617443 HLTF; helicase like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 100030667 UBE2V2; ubiquitin conjugating enzyme E2 V2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100538346 UBE2V1; ubiquitin conjugating enzyme E2 V1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100011853 UBE2N; ubiquitin conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 100011673 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 100029293 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100021233 PARPBP; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
D 100029184 SPRTN; SprT-like N-terminal domain K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 103106127 GCNA; germ cell nuclear acidic peptidase K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100014782 RAD9A; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100020133 RAD9B; RAD9 checkpoint clamp component B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 100019465 HUS1; HUS1 checkpoint clamp component K10903 HUS1; HUS1 checkpoint protein
D 100020845 RAD1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100031333 RAD17; RAD17 checkpoint clamp loader component K06662 HRAD17; cell cycle checkpoint protein
D 100016281 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100619149 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100023612 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 100020774 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 100020845 RAD1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 100617368 TIMELESS; timeless circadian clock K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100024898 TIPIN; TIMELESS interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100031378 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 100618328 TELO2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 100032848 TTI1; TELO2 interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
D 100032879 TTI2; TELO2 interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 100024967 BAG6; BCL2 associated athanogene 6 K23390 BAG6; large proline-rich protein BAG6
D 724043 UBL4A; ubiquitin like 4A K23388 UBL4; ubiquitin-like protein 4
D 724042 UBL4B; ubiquitin like 4B K23388 UBL4; ubiquitin-like protein 4
D 100028113 GET4; golgi to ER traffic protein 4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100019691 ATR; ATR serine/threonine kinase K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100023426 ATRIP; ATR interacting protein K10905 ATRIP; ATR interacting protein
D 100026797 ATM; ATM serine/threonine kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 497248 TP53; tumor protein p53 K04451 TP53; tumor protein p53
D 100016170 CHEK1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 100030584 CHEK2; checkpoint kinase 2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 100018150 CDC25A; cell division cycle 25A K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100025023 CDC25C; cell division cycle 25C K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 100014440 M-phase inducer phosphatase 3-like K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 100030704 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100024059 YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100032061 YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100016805 YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100029105 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100012276 YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 100022068 NAV2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 100021160 WEE1; WEE1 G2 checkpoint kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100024283 WEE2; WEE1 homolog 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100014506 PER1; period circadian clock 1 K21944 PER1; period circadian protein 1
D 100022127 PER2; period circadian clock 2 K02633 PER2; period circadian protein 2
D 100027169 PER3; period circadian clock 3 K21945 PER3; period circadian protein 3
D 103092449 MDC1; mediator of DNA damage checkpoint 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 100010608 PLS3; plastin 3 K17336 PLS3; plastin-3
D 100016897 AEN; apoptosis enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100024987 PLK3; polo like kinase 3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100020530 PLK5; polo like kinase 5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 100021205 NEK1; NIMA related kinase 1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100028128 NEK5; NIMA related kinase 5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100020318 NEK4; NIMA related kinase 4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100031740 NEK10; NIMA related kinase 10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 100030254 NEK11; NIMA related kinase 11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100015751 DONSON; downstream neighbor of SON K22422 DONSON; protein downstream neighbor of Son
D 100011126 KANK2; KN motif and ankyrin repeat domains 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100022205 KANK1; KN motif and ankyrin repeat domains 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100025474 KANK3; KN motif and ankyrin repeat domains 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100031732 KANK4; KN motif and ankyrin repeat domains 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100021476 schlafen family member 11-like K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 100019198 CHMP4C; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 100024840 VPS4B; vacuolar protein sorting 4 homolog B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100020119 VPS4A; vacuolar protein sorting 4 homolog A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100032031 ZFYVE19; zinc finger FYVE-type containing 19 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100025931 SDE2; SDE2 telomere maintenance homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 100017636 POLQ; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 100032103 MYBBP1A; MYB binding protein 1a K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 100015298 PRIMPOL; primase and DNA directed polymerase K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100023478 TREX1; three prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 100013741 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 100027124 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 100027461 DCLRE1A; DNA cross-link repair 1A K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100033168 DCLRE1B; DNA cross-link repair 1B K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 100019738 EXO5; exonuclease 5 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 100030702 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100016078 ZRANB3; zinc finger RANBP2-type containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100016110 ANKLE1; ankyrin repeat and LEM domain containing 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 100017500 HELQ; helicase, POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 100014225 ERCC6L2; ERCC excision repair 6 like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 100027038 PRPF19; pre-mRNA processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 100011979 CDC5L; cell division cycle 5 like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 100030739 BCAS2; BCAS2, pre-mRNA processing factor K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 100024419 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 100029012 NUDT15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100029290 NUDT1; nudix hydrolase 1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100033092 NUDT18; nudix hydrolase 18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 100025751 DUT; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100013713 RRM1; ribonucleotide reductase catalytic subunit M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 100030856 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100031990 RRM2; ribonucleotide reductase regulatory subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 103102306 MGMT; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 554181 POPC1; DNA photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 100023889 UNG; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100010844 SMUG1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100019248 MPG; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100024801 MUTYH; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100012520 NTHL1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100018297 SSBP1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100018297 SSBP1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 100029012 NUDT15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100025751 DUT; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024