+D #

  Transporters - Methylobacillus flagellatus

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AABC transporters, eukaryotic type B ABCA (ABC1) subfamily C ABCA1, 2, 3, 4, 7, 12, 13 subgroups C ABCA5, 6, 8, 9, 10 subgroups B ABCB (MDR/TAP) subfamily C ABCB2, 3, 8, 9, 10 subgroups C ABCB1, 4, 5 subgroups C ABCB6, 7 subgroups C ABCB11 subgroup C ABCB-BAC subgroup D Mfla_2090 Lipid A export ATP-binding/permease protein MsbA K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6] D Mfla_1192 ABC transporter related protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Mfla_0332 ABC transporter, ATP-binding/permease protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Mfla_1549 ABC transporter related protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Mfla_1554 ABC transporter related protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Mfla_1555 ABC transporter related protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Mfla_1548 ABC transporter related protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial B ABCC (CFTR/MRP) subfamily C ABCC1, 2, 3, 4, 5, 6, 10, 11, 12, 13 subgroups C ABCC7 subgroup C ABCC8, 9 subgroups C ABCC-BAC subgroup D Mfla_2440 ABC transporter related protein K12541 lapB; ATP-binding cassette, subfamily C, bacterial LapB D Mfla_1348 Type I secretion system ATPase, PrtD K12536 hasD; ATP-binding cassette, subfamily C, type I secretion system permease/ATPase D Mfla_1347 Type I secretion system ATPase, PrtD K12536 hasD; ATP-binding cassette, subfamily C, type I secretion system permease/ATPase B ABCD (ALD) subfamily C ABCD1 subgroup C ABCD2 subgroup C ABCD3 subgroup C ABCD4 subgroup C Others B ABCG (White) subfamily C ABCG1, 4 subgroups C ABCG2, 3 subgroups C ABCG5, 8 subgroups B Other subfamilies C Macrolide exporter C Other ABC transporters D Mfla_1199 ABC transporter related protein K15738 uup; ABC transport system ATP-binding/permease protein # AABC transporters, prokaryotic type B Mineral and organic ion transporters C Sulfate/thiosulfate transporter D Mfla_0614 Thiosulphate-binding protein K02048 cysP; sulfate/thiosulfate transport system substrate-binding protein D Mfla_0620 Thiosulphate-binding protein K23163 sbp; sulfate/thiosulfate transport system substrate-binding protein D Mfla_0611 Sulfate ABC transporter, permease protein CysT K02046 cysU; sulfate/thiosulfate transport system permease protein D Mfla_0610 Sulfate ABC transporter, permease protein CysW K02047 cysW; sulfate/thiosulfate transport system permease protein D Mfla_0609 Sulphate transport system permease protein 1 K02045 cysA; sulfate/thiosulfate transport system ATP-binding protein [EC:7.3.2.3] C Molybdate transporter D Mfla_1391 molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 modA; molybdate transport system substrate-binding protein D Mfla_1392 Molybdate ABC transporter, permease protein K02018 modB; molybdate transport system permease protein D Mfla_1393 ABC transporter related protein K02017 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5] C Molybdate/tungstate transporter C Tungstate transporter C Nitrate/nitrite transporter D Mfla_2172 putative nitrate transporter component, nrtA K15576 nrtA; nitrate/nitrite transport system substrate-binding protein D Mfla_0327 nitrate transporter periplasmic component K15576 nrtA; nitrate/nitrite transport system substrate-binding protein D Mfla_2171 nitrate transport permease K15577 nrtB; nitrate/nitrite transport system permease protein D Mfla_0326 nitrate transport permease K15577 nrtB; nitrate/nitrite transport system permease protein D Mfla_0325 nitrate transport ATP-binding subunits C and D K15578 nrtC; nitrate/nitrite transport system ATP-binding protein [EC:7.3.2.4] D Mfla_2170 nitrate transport ATP-binding subunits C and D K15578 nrtC; nitrate/nitrite transport system ATP-binding protein [EC:7.3.2.4] C Bicarbonate transporter C Taurine transporter C Sulfonate transporter D Mfla_1564 sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA K15553 ssuA; sulfonate transport system substrate-binding protein D Mfla_1563 sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA K15553 ssuA; sulfonate transport system substrate-binding protein D Mfla_1557 binding-protein-dependent transport systems inner membrane component K15554 ssuC; sulfonate transport system permease protein D Mfla_1556 binding-protein-dependent transport systems inner membrane component K15554 ssuC; sulfonate transport system permease protein D Mfla_1561 ABC transporter related protein K15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14] C Phthalate transporter C Iron(III) transporter C Thiamine transporter C Spermidine/putrescine transporter C Putrescine transporter C Putative spermidine/putrescine transporter C Mannopine transporter C 2-Aminoethylphosphonate transporter C Glycine betaine/proline transporter C Osmoprotectant transporter C Riboflavin transporter C Putative hydroxymethylpyrimidine transporter C Putative thiamine transporter C Putative thiamine transporter C NitT/TauT family transporter D Mfla_1859 ABC transport system substrate-binding protein K02051 ABC.SN.S; NitT/TauT family transport system substrate-binding protein D Mfla_1858 binding-protein-dependent transport systems inner membrane component K02050 ABC.SN.P; NitT/TauT family transport system permease protein D Mfla_2559 binding-protein-dependent transport systems inner membrane component K02050 ABC.SN.P; NitT/TauT family transport system permease protein D Mfla_1857 ABC transporter related protein K02049 ABC.SN.A; NitT/TauT family transport system ATP-binding protein D Mfla_2560 ABC transporter related protein K02049 ABC.SN.A; NitT/TauT family transport system ATP-binding protein B Saccharide, polyol, and lipid transporters C Maltose/maltodextrin transporter D Mfla_2347 carbohydrate ABC transporter ATP-binding protein, CUT1 family K10111 malK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] C Maltose transporter C Arabinogalactan oligomer/maltooligosaccharide transport system D Mfla_2347 carbohydrate ABC transporter ATP-binding protein, CUT1 family K10111 malK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] C Raffinose/stachyose/melibiose transporter C Alpha-glucoside transporter C Glucose/arabinose transporter C Glucose/mannose transporter C Trehalose/maltose transporter D Mfla_2348 carbohydrate ABC transporter substrate-binding protein, CUT1 family K10236 thuE; trehalose/maltose transport system substrate-binding protein D Mfla_2349 carbohydrate ABC transporter membrane protein 1, CUT1 family K10237 thuF; trehalose/maltose transport system permease protein D Mfla_2350 carbohydrate ABC transporter membrane protein 2, CUT1 family K10238 thuG; trehalose/maltose transport system permease protein D Mfla_2347 carbohydrate ABC transporter ATP-binding protein, CUT1 family K10111 malK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] C Trehalose transporter C N-Acetylglucosamine transporter C Cellobiose transporter C N,N'-Diacetylchitobiose transporter C Putative chitobiose transporter C L-Arabinose transporter C Lactose/L-arabinose transporter C L-Arabinose/D-xylose transporter C Oligogalacturonide transporter C Alpha-1,4-digalacturonate transporter C Putative aldouronate transporter C Alpha-galactoside transporter C Methyl-galactoside transporter C D-Galactose transporter C D-Xylose transporter C Xylobiose transporter C Fucose transporter C Sugar transporter C Multiple sugar transporter C D-Allose transporter C Fructose transporter C Rhamnose transporter C Ribose transporter C Galactofuranose transporter C Erythritol transporter C Putative xylitol transporter C Inositol transporter C Inositol transporter C Inositol-phosphate transporter C Fructooligosaccharide transporter C Fructooligosaccharide transporter C Glycerol transporter C Putative sn-Glycerol 3-phosphate transporter C Putative sorbitol/mannitol transporter D Mfla_2347 carbohydrate ABC transporter ATP-binding protein, CUT1 family K10111 malK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] C Arabinooligosaccharide transporter C Arabinooligosaccharide transporter C Polygalacturonan/rhamnogalacturonan transporter C Pectin-derived oligosaccharide transporter C General nucleoside transporter C Riboflavin transporter C UDP-glucose/iron transporter C AI-2 transporter C gamma-Hexachlorocyclohexane transporter D Mfla_2368 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_0239 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_2365 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_0238 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_2366 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Mfla_0237 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Mfla_2369 putative lipoprotein K18480 linN; cholesterol transport system auxiliary component C Phospholipid transporter D Mfla_0240 toluene tolerance K07323 mlaC; phospholipid transport system substrate-binding protein D Mfla_2368 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_0239 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_2365 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_0238 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_2366 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Mfla_0237 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Mfla_0241 STAS domain K07122 mlaB; phospholipid transport system transporter-binding protein C Mce system transporter D Mfla_2368 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_0239 Mammalian cell entry related protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Mfla_2365 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_0238 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Mfla_2366 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Mfla_0237 ABC transporter related protein K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein C Putative multiple sugar transporter D Mfla_2347 carbohydrate ABC transporter ATP-binding protein, CUT1 family K10111 malK; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] C Putative simple sugar transporter B Phosphate and amino acid transporters C Phosphate transporter D Mfla_0795 phosphate ABC transporter substrate-binding protein, PhoT family K02040 pstS; phosphate transport system substrate-binding protein D Mfla_0794 phosphate ABC transporter membrane protein 1, PhoT family K02037 pstC; phosphate transport system permease protein D Mfla_0793 phosphate ABC transporter membrane protein 2, PhoT family K02038 pstA; phosphate transport system permease protein D Mfla_0792 phosphate ABC transporter ATP-binding protein, PhoT family K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] C Phosphonate transporter C Lysine/arginine/ornithine transporter C Histidine transporter C Glutamine transporter C Arginine transporter C Glutamate/aspartate transporter C Aspartate/glutamate/glutamine transporter C Octopine/nopaline transporter C General L-amino acid transporter C Glutamate transporter C Cystine transporter C L-Cystine transporter C Arginine/ornithine transporter C Arginine/lysine/histidine/glutamine transporter C Arginine/lysine/histidine transporter C Hydroxyproline transporter C Branched-chain amino acid transporter D Mfla_0462 amino acid/amide ABC transporter substrate-binding protein, HAAT family K01999 livK; branched-chain amino acid transport system substrate-binding protein D Mfla_0152 amino acid/amide ABC transporter substrate-binding protein, HAAT family K01999 livK; branched-chain amino acid transport system substrate-binding protein D Mfla_0155 amino acid/amide ABC transporter membrane protein 1, HAAT family K01997 livH; branched-chain amino acid transport system permease protein D Mfla_0156 amino acid/amide ABC transporter membrane protein 2, HAAT family K01998 livM; branched-chain amino acid transport system permease protein D Mfla_0153 amino acid/amide ABC transporter ATP-binding protein 1, HAAT family K01995 livG; branched-chain amino acid transport system ATP-binding protein D Mfla_0154 amino acid/amide ABC transporter ATP-binding protein 2, HAAT family K01996 livF; branched-chain amino acid transport system ATP-binding protein C Neutral amino acid transporter C D-Methionine transporter C Urea transporter D Mfla_1775 amino acid/amide ABC transporter substrate-binding protein, HAAT family K11959 urtA; urea transport system substrate-binding protein D Mfla_1774 amino acid/amide ABC transporter membrane protein 1, HAAT family K11960 urtB; urea transport system permease protein D Mfla_1773 amino acid/amide ABC transporter membrane protein 2, HAAT family K11961 urtC; urea transport system permease protein D Mfla_1772 ABC transporter related protein K11962 urtD; urea transport system ATP-binding protein D Mfla_1771 amino acid/amide ABC transporter ATP-binding protein 2, HAAT family K11963 urtE; urea transport system ATP-binding protein C Putative tryptophan/tyrosine transporter C Putative lysine transporter C Putative lysine/arginine/ornithine/histidine/octopine transporter C Putative S-methylcysteine transporter C Putative polar amino acid transporter B Peptide and nickel transporters C Oligopeptide transporter C Dipeptide transporter C Dipeptide transporter C Cationic peptide transporter C Nickel transporter C Nickel transporter C Glutathione transporter C Peptides/nickel transporter D Mfla_1483 extracellular solute-binding protein, family 5 K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D Mfla_1850 extracellular solute-binding protein, family 5 K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D Mfla_2388 extracellular solute-binding protein, family 5 K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D Mfla_1484 binding-protein-dependent transport systems inner membrane component K02033 ABC.PE.P; peptide/nickel transport system permease protein D Mfla_1485 binding-protein-dependent transport systems inner membrane component K02034 ABC.PE.P1; peptide/nickel transport system permease protein D Mfla_1847 binding-protein-dependent transport systems inner membrane component K02034 ABC.PE.P1; peptide/nickel transport system permease protein D Mfla_2390 binding-protein-dependent transport systems inner membrane component K02034 ABC.PE.P1; peptide/nickel transport system permease protein D Mfla_2391 ABC transporter related protein K02031 ddpD; peptide/nickel transport system ATP-binding protein D Mfla_1617 ABC transporter related protein K02032 ddpF; peptide/nickel transport system ATP-binding protein C Microcin C transporter D Mfla_1539 extracellular solute-binding protein, family 5 K13893 yejA; microcin C transport system substrate-binding protein D Mfla_1542 binding-protein-dependent transport systems inner membrane component K13894 yejB; microcin C transport system permease protein D Mfla_1541 binding-protein-dependent transport systems inner membrane component K13895 yejE; microcin C transport system permease protein D Mfla_1540 ABC transporter related protein K13896 yejF; microcin C transport system ATP-binding protein B Metallic cation, iron-siderophore and vitamin B12 transporters C Ferric citrate transporter C Ferric hydroxamate transporter C Ferric hydroxamate/heme transporter C Heme transporter D Mfla_1605 periplasmic binding protein K25132 hmuT; heme transport system substrate-binding protein D Mfla_1606 transport system permease protein K25133 hmuU; heme transport system permease protein D Mfla_1607 ABC transporter related protein K10834 hmuV; heme transport system ATP-binding protein [EC:7.6.2.5] C Heme transporter C Iron-siderophore transporter C Iron-siderophore transporter C Iron-siderophore transporter C Iron complex transporter D Mfla_0114 periplasmic binding protein K02016 ABC.FEV.S; iron complex transport system substrate-binding protein C Vitamin B12 transporter C Cobalamin transporter C Manganese transporter C Manganese transporter C Zinc transporter C Iron/zinc/manganese/copper transporter C Manganese/iron transporter C Manganese/zinc transporter C Manganese/zinc/iron transporter C Manganese/iron transporter C Cobalt transporter C Nickel transporter C Biotin transporter C Energy-coupling factor transporter C Putative zinc/manganese transporter B ABC-2 type and other transporters C Multidrug/hemolysin transporter C Capsular polysaccharide transporter C Vi polysaccharide transporter C Homopolymeric O-antigen D Mfla_1269 ABC-2 K09690 wzm; homopolymeric O-antigen transport system permease protein C Lipopolysaccharide transporter D Mfla_0221 permease YjgP/YjgQ K07091 lptF; lipopolysaccharide export system permease protein D Mfla_0220 permease YjgP/YjgQ K11720 lptG; lipopolysaccharide export system permease protein D Mfla_0141 ABC transporter related protein K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] C Teichoic acid transporter C Lipooligosaccharide transporter C Sodium transporter C Lantibiotic transporter C Lantibiotic transporter C Copper-processing transporter C Gliding motility-associated transporter D Mfla_0683 ABC transporter, permease protein, putative K25151 gldF; gliding motility-associated transport system permease protein D Mfla_0682 ABC transporter related protein K25152 gldA; gliding motility-associated transport system ATP-binding protein D Mfla_0684 conserved hypothetical protein K25153 gldG; gliding motility-associatede transport system auxiliary component C Putative peptide transporter C Hemin transporter C Daunorubicin/doxorubicin transporter C Oleandomycin transporter C Pyoluteorin transporter C Drug efflux transporter C Linearmycin/streptolysin S transporer C Bacitracin transporter C Bacitracin transporter C Bacitracin transporter C Beta-exotoxin I transporter C Polyether ionophore transporter C Uncharacterized ABC transporter C Cationic antimicrobial peptide transporter C Fluoroquinolones transporter C Lipoprotein-releasing transporter D Mfla_2095 Lipoprotein releasing system, transmembrane protein, LolC/E family K09808 lolC_E; lipoprotein-releasing system permease protein D Mfla_2094 Lipoprotein releasing system, ATP-binding protein K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-] C Acetoin utilization transporter C Antimicrobial peptide resistance transporter C Heterocyst specific transporter C Heme transporter C Cell division transporter D Mfla_0731 cell division protein FtsX K09811 ftsX; cell division transport system permease protein D Mfla_0732 cell division ATP-binding protein FtsE K09812 ftsE; cell division transport system ATP-binding protein C Viologen exporter family transporter C Antilisterial bacteriocin subtilosin biosynthesis transporter C ABC-2 type transporter C ABC-2 type transporter D Mfla_0243 ABC-2 K01992 ABC-2.P; ABC-2 type transport system permease protein D Mfla_2239 ABC-2 K01992 ABC-2.P; ABC-2 type transport system permease protein D Mfla_0166 ABC-2 K01992 ABC-2.P; ABC-2 type transport system permease protein D Mfla_2238 ABC transporter related protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D Mfla_0242 ABC transporter related protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein C Putative ABC transporter D Mfla_1252 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Mfla_0704 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Mfla_1251 ABC transporter related protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Mfla_0705 ABC transporter related protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein C Orphan ABC ATPase # ASolute carrier family (SLC) B SLC1: High-affinity glutamate and neutral amino acid transporter B SLC2: Facilitative GLUT transporter B SLC3: Heavy subunits of the heteromeric amino acid transporters B SLC4: Bicarbonate transporter B SLC5: Sodium glucose cotransporter B SLC6: Sodium- and chloride-dependent neurotransmitter transporter B SLC7: Cationic amino acid transporter/glycoprotein-associated B SLC8: Na+/Ca2+ exchanger B SLC9: Na+/H+ exchanger B SLC10: Sodium bile salt cotransporter B SLC11: Proton-coupled metal ion transporter B SLC12: Electroneutral cation-coupled Cl cotransporter B SLC13: Human Na+-sulfate/carboxylate cotransporter B SLC14: Urea transporter B SLC15: Proton oligopeptide cotransporter B SLC16: Monocarboxylate transporter B SLC17: Vesicular glutamate transporter B SLC18: Vesicular amine transporter B SLC19: Folate/thiamine transporter B SLC20: Type III Na+-phosphate cotransporter B SLC21/ASLCO: Organic anion transporter B SLC22: Organic cation/anion/zwitterion transporter B SLC23: Na+-dependent ascorbic acid transporter B SLC24: Na+/(Ca2+-K+) exchanger B SLC25: Mitochondrial carrier B SLC26: Multifunctional anion exchanger B SLC27: Fatty acid transporter B SLC28: Na+-coupled nucleoside transporter B SLC29: Facilitative nucleoside transporter B SLC30: Zinc efflux transporter B SLC31: Copper transporter B SLC32: Vesicular inhibitory amino acid transporter B SLC33: Acetyl-CoA transporter B SLC34: Type II Na+-phosphate cotransporter B SLC35: Nucleoside-sugar transporter B SLC36: Proton-coupled amino acid transporter B SLC37: Sugar-phosphate/phosphate exchanger B SLC38: System A and System N sodium-coupled neutral amino acid transporter B SLC39: Metal ion transporter B SLC40: Basolateral iron transporter B SLC41: MgtE-like magnesium transporter B SLC42: Rh ammonium transporter B SLC43: Na+-independent, system-L-like amino acid transporter B SLC44: Choline-like transporter B SLC45: H+/sugar cotransporter B SLC46: Folate transporter B SLC47: Multidrug and Toxin Extrusion (MATE) family B SLC48: Heme transporter B SLC49: FLVCR-related transporter B SLC50: Sugar efflux transporter B SLC51: Transporter of steroid-derived molecules B SLC52: Riboflavin transporter B SLC54: Mitochondrial pyruvate carrier B SLC56: Sideroflexin B SLC57: NiPA-like magnesium transporter B SLC58: MagT-like magnesium transporter B SLC62: Pyrophosphate transporter B SLC65: NPC-type cholesterol transporter B SLC66: Lysosomal lysine-arginine transporter # AMajor facilitator superfamily (MFS) B Sugar transporters C Sugar porter (SP) family [TC:2.A.1.1] C Oligosaccharide:H+ symporter (OHS) family [TC:2.A.1.5] C Fucose:H+ symporter (FHS) family [TC:2.A.1.7] C Sugar efflux transporter (SET) [TC:2.A.1.20] C Nucleoside:H+ symporter (NHS) family [TC:2.A.1.10] C N-Acetylglucosamine transporter (NAG-T) family [TC:2.A.1.58] B Organic acid transporters C Metabolite:H+ symporter (MHS) family [TC:2.A.1.6] C Oxalate:formate antiporter (OFA) family [TC:2.A.1.11] C Sialate:H+ symporter (SHS) family [TC:2.A.1.12] C Monocarboxylate transporter (MCT) family [TC:2.A.1.13] C Anion:cation symporter (ACS) family [TC:2.A.1.14] C Aromatic acid:H+ symporter (AAHS) family [TC:2.A.1.15] C Cyanate porter (CP) family [TC:2.A.1.17] D Mfla_1289 major facilitator superfamily MFS_1 K03449 MFS.CP; MFS transporter, CP family, cyanate transporter D Mfla_0891 Twin-arginine translocation pathway signal K03449 MFS.CP; MFS transporter, CP family, cyanate transporter D Mfla_1035 Twin-arginine translocation pathway signal K03449 MFS.CP; MFS transporter, CP family, cyanate transporter C Organic cation transporter (OCT) family [TC:2.A.1.19] C Phenylproprionate permease (PPP) [TC:2.A.1.27] D Mfla_2136 major facilitator superfamily MFS_1 K05820 hcaT; MFS transporter, PPP family, 3-phenylpropionic acid transporter C L-Amino acid transporter-3 (LAT3) family (SLC43 family) [TC:2.A.1.44] C Proton coupled folate transporter/heme carrier protein (PCFT/HCP) family [TC:2.A.1.50] B Phosphate and organophosphate transporters C Phosphate:H+ symporter (PHS) family [TC:2.A.1.9] C Organophosphate:Pi antiporter (OPA) family [TC:2.A.1.4] C 1-Arseno-3-phosphoglycerate exporter (APGE) family [TC:2.A.1.83] B Nitrate/nitrite transporters C Nitrate/nitrite porter (NNP) family [TC:2.A.1.8] D Mfla_0321 Nitrate transporter K02575 NRT2; MFS transporter, NNP family, nitrate/nitrite transporter C Proton-dependent oligopeptide transporter (POT/PTR) family [TC:2.A.17] B Lipid transporters C Lysophospholipid transporter (LplT) family [TC:2.A.1.42] D Mfla_2630 major facilitator superfamily MFS_1 K08227 lplT; MFS transporter, LPLT family, lysophospholipid transporter D Mfla_2310 major facilitator superfamily MFS_1 K08227 lplT; MFS transporter, LPLT family, lysophospholipid transporter C Sphingosine-1-phosphate transporter (Spinster) family [TC:2.A.1.49] B Metal transporters C Siderophore-iron transporter (SIT) family [TC:2.A.1.16] C Enterobactin (siderophore) exporter (EntS) family [TC:2.A.1.38] C Nickel resistance (Nre) family [TC:2.A.1.31] C MFS domain-containing protein family [TC:2.A.1.40] C Putative bacteriochlorophyll delivery (BCD) family [TC:2.A.1.41] B Protein transporters C Vesicular neurotransmitter transporter (VNT) [TC:2.A.1.22] C Peptide-acetyl-CoA transporter (PAT) [TC:2.A.1.25] C Feline leukemia virus subgroup C receptor (FLVCR) [TC:2.A.1.28] B Drug transporters C Drug:H+ antiporter-1 (12 spanner) (DHA1) family [TC:2.A.1.2] D Mfla_1677 Drug resistance transporter Bcr/CflA subfamily K07552 bcr; MFS transporter, DHA1 family, multidrug resistance protein D Mfla_0749 Drug resistance transporter Bcr/CflA subfamily K07552 bcr; MFS transporter, DHA1 family, multidrug resistance protein D Mfla_1201 major facilitator superfamily MFS_1 K19577 ydhP; MFS transporter, DHA1 family, inner membrane transport protein C Drug:H+ antiporter-2 (14 spanner) (DHA2) family [TC:2.A.1.3] C Drug:H+ antiporter-3 (12 spanner) (DHA3) [TC:2.A.1.21] C Putative aromatic compound/drug exporter (ACDE) family [TC:2.A.1.32] C Fosmidomycin resistance (Fsr) family [TC:2.A.1.35] C Acriflavin-sensitivity (YnfM) family [TC:2.A.1.36] C Glycerophosphodiester uptake (GlpU) family [TC:2.A.1.52] B Unknown transporters C Unknown major facilitator-1 (UMF1) [TC:2.A.1.24] C Unknown major facilitator-2 (UMF2) [TC:2.A.1.26] C Putative YqgE transporter (YqgE) family [TC:2.A.1.33] C Others # APhosphotransferase system (PTS) B Enzyme I and HPr C Enzyme I [TC:8.A.7] D Mfla_0148 phosphoenolpyruvate--protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] C Phosphocarrier protein HPr [TC:8.A.8] D Mfla_0147 HPrNtr K02784 ptsH; phosphocarrier protein HPr C Multiphosphoryl transfer protein B Enzyme II [TC:4.A] C Glucose-specific II component C Glucose-specific II component C N-Acetylglucosamine-specific II component C Maltose/glucose-specific II component C Maltose-specific II component C D-Glucosamine-specific II component C Sucrose-specific II component C Beta-glucoside-specific II component C Beta-glucoside (arbutin/salicin/cellobiose)-specific II component C Trehalose-specific II component C N-Acetylmuramic acid-specific II component C Alpha-glucoside-specific II component C Fructose-specific II component C Fructose-specific II-like component C Mannitol-specific II component C 2-O-A-Mannosyl-D-glycerate-specific II component C Lactose-specific II component C Cellobiose-specific II component C Glucitol/sorbitol-specific II component C Galactitol-specific II component C Galactose-specific II component C Mannose-specific II component C Mannose-specific II component D Mfla_0146 PTS system fructose subfamily IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] C Fructoselysine/glucoselysine-specific II component C Fructose-specific II component C Sorbose-specific II component C N-Acetylgalactosamine-specific II component C Galactosamine-specific II component C D-Glucosaminate-specific II component C Ascorbate-specific II component C Nitrogen regulatory II component C EI/HPr/EIIA hybrid protein # AOther transporters B Aquaporins and small neutral solute transporters [TC:1.A.8] C Aquaporins D Mfla_0179 MIP family channel protein K06188 aqpZ; aquaporin Z C Aquaglyceroporins or glycerol-uptake facilitators B Pores ion channels [TC:1] C Mfla_2071 TrkA-N K10716 kch; voltage-gated potassium channel C Mfla_2514 ammonium transporter K03320 amt; ammonium transporter, Amt family C Mfla_0434 ammonium transporter K03320 amt; ammonium transporter, Amt family C Mfla_1757 ammonium transporter K03320 amt; ammonium transporter, Amt family C Mfla_2116 glutathione S-transferase-like protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] C Mfla_0507 glutathione S-transferase-like protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] C Mfla_0263 glutathione S-transferase-like protein K03599 sspA; stringent starvation protein A C Mfla_1843 protein of unknown function UPF0005 K19416 yccA; modulator of FtsH protease C Mfla_0331 formate/nitrite transporter K21993 fdhC; formate transporter C Mfla_0647 large conductance mechanosensitive channel protein K03282 mscL; large conductance mechanosensitive channel C Mfla_2612 MscS Mechanosensitive ion channel K22044 ybiO; moderate conductance mechanosensitive channel C Mfla_0018 MscS Mechanosensitive ion channel K16053 ybdG; miniconductance mechanosensitive channel C Mfla_0306 magnesium transporter K06213 mgtE; magnesium transporter C Mfla_1940 putative chemotaxis transmembrane protein MotA K02556 motA; chemotaxis protein MotA C Mfla_1949 MotA/TolQ/ExbB proton channel K02556 motA; chemotaxis protein MotA C Mfla_1939 OmpA/MotB K02557 motB; chemotaxis protein MotB C Mfla_1950 OmpA/MotB K02557 motB; chemotaxis protein MotB C Mfla_0877 outer membrane transport energization protein ExbB K03561 exbB; biopolymer transport protein ExbB C Mfla_2092 MotA/TolQ/ExbB proton channel K03561 exbB; biopolymer transport protein ExbB C Mfla_1559 outer membrane transport energization protein ExbB K03561 exbB; biopolymer transport protein ExbB C Mfla_2404 outer membrane transport energization protein ExbB K03561 exbB; biopolymer transport protein ExbB C Mfla_1021 outer membrane transport energization protein ExbB K03561 exbB; biopolymer transport protein ExbB C Mfla_1022 outer membrane transport energization protein ExbD K03559 exbD; biopolymer transport protein ExbD C Mfla_1558 outer membrane transport energization protein ExbD K03559 exbD; biopolymer transport protein ExbD C Mfla_0878 outer membrane transport energization protein ExbD K03559 exbD; biopolymer transport protein ExbD C Mfla_2091 Biopolymer transport protein ExbD/TolR K03559 exbD; biopolymer transport protein ExbD C Mfla_2402 outer membrane transport energization protein ExbD K03559 exbD; biopolymer transport protein ExbD C Mfla_2403 outer membrane transport energization protein ExbD K03559 exbD; biopolymer transport protein ExbD C Mfla_2342 Cell division and transport-associated protein TolQ K03562 tolQ; biopolymer transport protein TolQ C Mfla_2341 Cell division and transport-associated protein TolR K03560 tolR; biopolymer transport protein TolR C Mfla_1221 camphor resistance protein CrcB K06199 crcB; fluoride exporter C Mfla_0092 protein of unknown function UPF0187 K08994 yneE; ion channel-forming bestrophin family protein C Mfla_0510 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family C Mfla_2502 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family C Mfla_1578 OmpA/MotB K03286 TC.OOP; OmpA-OmpF porin, OOP family C Mfla_2658 membrane protein involved in aromatic hydrocarbon degradation K06076 fadL; long-chain fatty acid transport protein C Mfla_2318 TonB-dependent siderophore receptor K16090 fiu; catecholate siderophore receptor C Mfla_0095 TonB-dependent siderophore receptor K16090 fiu; catecholate siderophore receptor C Mfla_1351 TonB-dependent receptor K16091 fecA; Fe(3+) dicitrate transport protein C Mfla_0977 TonB-dependent receptor K16091 fecA; Fe(3+) dicitrate transport protein C Mfla_0818 TonB-dependent receptor, plug K16091 fecA; Fe(3+) dicitrate transport protein C Mfla_0833 TonB-dependent receptor K16091 fecA; Fe(3+) dicitrate transport protein C Mfla_0122 TonB-dependent receptor K16092 btuB; vitamin B12 transporter C Mfla_1905 TonB-dependent receptor K16089 TC.FEV.OM2; outer membrane receptor for ferrienterochelin and colicins C Mfla_2679 TonB-dependent receptor K16087 TC.FEV.OM3; hemoglobin/transferrin/lactoferrin receptor protein C Mfla_1599 TonB-dependent receptor, plug K16087 TC.FEV.OM3; hemoglobin/transferrin/lactoferrin receptor protein C Mfla_1603 TonB-dependent receptor, plug K16087 TC.FEV.OM3; hemoglobin/transferrin/lactoferrin receptor protein C Mfla_2193 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_2301 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_1989 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_1993 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_2653 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_0537 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_2387 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_0109 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_0134 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_1016 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_1547 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_2351 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_0872 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_0708 TonB-dependent receptor, plug K02014 TC.FEV.OM; iron complex outermembrane recepter protein C Mfla_1345 Type I secretion outer membrane protein, TolC K12538 hasF; outer membrane protein, type I secretion system C Mfla_2553 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system C Mfla_2568 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system C Mfla_0502 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system C Mfla_1304 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system C Mfla_1630 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system C Mfla_2534 Type I secretion outer membrane protein, TolC K12340 tolC; outer membrane protein C Mfla_2221 outer membrane efflux protein K12340 tolC; outer membrane protein C Mfla_2435 outer membrane efflux protein K12543 lapE; outer membrane protein, adhesin transport system C Mfla_1794 RND efflux system, outer membrane lipoprotein, NodT K18903 oprC; outer membrane protein, multidrug efflux system C Mfla_1359 RND efflux system, outer membrane lipoprotein, NodT K18139 oprM; outer membrane protein, multidrug efflux system C Mfla_2544 RND efflux system, outer membrane lipoprotein, NodT K18139 oprM; outer membrane protein, multidrug efflux system C Mfla_1591 RND efflux system, outer membrane lipoprotein, NodT K18139 oprM; outer membrane protein, multidrug efflux system C Mfla_0169 RND efflux system, outer membrane lipoprotein, NodT K18139 oprM; outer membrane protein, multidrug efflux system C Mfla_0372 RND efflux system, outer membrane lipoprotein, NodT K18139 oprM; outer membrane protein, multidrug efflux system C Mfla_2026 polysaccharide export protein K01991 wza; polysaccharide biosynthesis/export protein C Mfla_1522 surface antigen (D15) K07277 SAM50; outer membrane protein insertion porin family C Mfla_1615 Pyrrolo-quinoline quinone K17713 bamB; outer membrane protein assembly factor BamB C Mfla_0842 uncharacterized lipoprotein K07287 bamC; outer membrane protein assembly factor BamC C Mfla_0986 uncharacterized lipoprotein K07287 bamC; outer membrane protein assembly factor BamC C Mfla_1613 putative competence lipoprotein precursor K05807 bamD; outer membrane protein assembly factor BamD C Mfla_0776 SmpA/OmlA K06186 bamE; outer membrane protein assembly factor BamE C Mfla_1820 surface antigen (D15) K07278 tamA; translocation and assembly module TamA C Mfla_1821 protein of unknown function DUF490 K09800 tamB; translocation and assembly module TamB C Mfla_0140 OstA-like protein K09774 lptA; lipopolysaccharide export system protein LptA C Mfla_0141 ABC transporter related protein K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] C Mfla_0139 protein of unknown function DUF1239 K11719 lptC; lipopolysaccharide export system protein LptC C Mfla_2149 Organic solvent tolerance protein K04744 lptD; LPS-assembly protein C Mfla_2156 Rare lipoprotein B K03643 lptE; LPS-assembly lipoprotein C Mfla_0648 CBS K06189 corC; hemolysin (HlyC) family protein B Electrochemical potential-driven transporters [TC:2] C Mfla_1806 cation diffusion facilitator family transporter K16264 czcD; cobalt-zinc-cadmium efflux system protein C Mfla_0707 zinc/iron permease K16267 zipB; zinc and cadmium transporter C Mfla_1597 zinc/iron permease K16267 zipB; zinc and cadmium transporter C Mfla_0387 zinc/iron permease K07238 TC.ZIP; zinc transporter, ZIP family C Mfla_2551 Heavy metal efflux pump CzcA K15726 czcA; heavy metal efflux system protein C Mfla_0504 Heavy metal efflux pump CzcA K15726 czcA; heavy metal efflux system protein C Mfla_1306 Heavy metal efflux pump CzcA K15726 czcA; heavy metal efflux system protein C Mfla_2566 Heavy metal efflux pump CzcA K15726 czcA; heavy metal efflux system protein C Mfla_1793 Hydrophobe/amphiphile efflux-1 HAE1 K18902 bpeF; multidrug efflux pump C Mfla_2533 acriflavin resistance protein K18303 mexK; multidrug efflux pump C Mfla_1360 Hydrophobe/amphiphile efflux-1 HAE1 K18095 mexY; multidrug efflux pump C Mfla_1592 Hydrophobe/amphiphile efflux-1 HAE1 K18138 acrB; multidrug efflux pump C Mfla_2545 RND multidrug efflux transporter MexB K18138 acrB; multidrug efflux pump C Mfla_2556 RND multidrug efflux transporter MexB K18138 acrB; multidrug efflux pump C Mfla_0743 acriflavin resistance protein K07788 mdtB; multidrug efflux pump C Mfla_0744 acriflavin resistance protein K07789 mdtC; multidrug efflux pump C Mfla_0883 small multidrug resistance protein K03297 emrE; small multidrug resistance pump C Mfla_1027 small multidrug resistance protein K03297 emrE; small multidrug resistance pump C Mfla_1634 small multidrug resistance protein K11741 sugE; quaternary ammonium compound-resistance protein SugE C Mfla_2554 protein of unknown function UPF0060 K09771 TC.SMR3; small multidrug resistance family-3 protein C Mfla_0485 protein of unknown function UPF0060 K09771 TC.SMR3; small multidrug resistance family-3 protein C Mfla_2361 Kef-type potassium/proton antiporter, CPA2 family K11747 kefB; glutathione-regulated potassium-efflux system protein KefB C Mfla_2362 Kef-type potassium/proton antiporter accessory protein, CPA2 family K11748 kefG; glutathione-regulated potassium-efflux system ancillary protein KefG C Mfla_1130 transporter, CPA2 family K26735 KEA4_5_6; K+:H+ antiporter C Mfla_0658 Kef-type potassium/proton antiporter, CPA2 family K26735 KEA4_5_6; K+:H+ antiporter C Mfla_2441 Chromate transporter K07240 chrA; chromate transporter C Mfla_1992 sulphate transporter K03321 TC.SULP; sulfate permease, SulP family C Mfla_0005 sulphate transporter K03321 TC.SULP; sulfate permease, SulP family C Mfla_1721 Na+/Pi-cotransporter K03324 yjbB; phosphate:Na+ symporter C Mfla_1491 arsenite efflux ATP-binding protein ArsA K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-] C Mfla_1489 arsenite efflux membrane protein ArsB (TC 3.A.4.1.1; TC 2.A.45.1.1) K03893 arsB; arsenical pump membrane protein C Mfla_0582 multisubunit potassium/proton antiporter, PhaB subunit / multisubunit potassium/proton antiporter, PhaA subunit K05559 phaA; multicomponent K+:H+ antiporter subunit A C Mfla_0581 multisubunit potassium/proton antiporter, PhaC subunit K05560 phaC; multicomponent K+:H+ antiporter subunit C C Mfla_0580 multisubunit potassium/proton antiporter, PhaD subunit K05561 phaD; multicomponent K+:H+ antiporter subunit D C Mfla_0579 multisubunit potassium/proton antiporter, PhaE subunit K05562 phaE; multicomponent K+:H+ antiporter subunit E C Mfla_0578 multisubunit potassium/proton antiporter, PhaF subunit K05563 phaF; multicomponent K+:H+ antiporter subunit F C Mfla_0577 multisubunit potassium/proton antiporter, PhaG subunit K05564 phaG; multicomponent K+:H+ antiporter subunit G C Mfla_2210 integral membrane protein MviN K03980 murJ; putative peptidoglycan lipid II flippase C Mfla_1846 protein of unknown function DUF165 K09125 yhhQ; queuosine precursor transporter C Mfla_0450 multiple antibiotic resistance (MarC)-related protein K05595 marC; multiple antibiotic resistance protein C Mfla_2270 cell division-specific peptidoglycan biosynthesis regulator FtsW K03588 ftsW; cell division protein FtsW C Mfla_1363 protein of unknown function DUF204 K23242 mntP; manganese efflux pump family protein C Mfla_1883 iron permease FTR1 K07243 FTR; high-affinity iron transporter C Mfla_2306 outer membrane transport energization protein TonB K03832 tonB; periplasmic protein TonB C Mfla_0876 outer membrane transport energization protein TonB K03832 tonB; periplasmic protein TonB C Mfla_1560 outer membrane transport energization protein TonB K03832 tonB; periplasmic protein TonB C Mfla_2507 TonB-like protein K03832 tonB; periplasmic protein TonB C Mfla_1020 outer membrane transport energization protein TonB K03832 tonB; periplasmic protein TonB C Mfla_2401 outer membrane transport energization protein TonB K03832 tonB; periplasmic protein TonB C Mfla_2338 OmpA/MotB K03640 pal; peptidoglycan-associated lipoprotein C Mfla_2340 Cell division and transport-associated protein TolA K03646 tolA; colicin import membrane protein C Mfla_2339 TolB-like protein K03641 tolB; TolB protein B Primary active transporters [TC:3] B Transmembrane electron carriers [TC:5] B Accessory factors involved in transport [TC:8] C Mfla_1346 Type I secretion membrane fusion protein, HlyD K12537 hasE; membrane fusion protein, type I secretion system C Mfla_2567 secretion protein HlyD K15727 czcB; membrane fusion protein, heavy metal efflux system C Mfla_0503 secretion protein HlyD K15727 czcB; membrane fusion protein, heavy metal efflux system C Mfla_2552 secretion protein HlyD K15727 czcB; membrane fusion protein, heavy metal efflux system C Mfla_1305 Secretion protein HlyD K07798 cusB; membrane fusion protein, copper/silver efflux system C Mfla_2437 Type I secretion membrane fusion protein, HlyD K12542 lapC; membrane fusion protein, adhesin transport system C Mfla_1792 secretion protein HlyD K18901 bpeE; membrane fusion protein, multidrug efflux system C Mfla_2532 secretion protein HlyD K18302 mexJ; membrane fusion protein, multidrug efflux system C Mfla_1361 secretion protein HlyD K18094 mexX; membrane fusion protein, multidrug efflux system C Mfla_1593 secretion protein HlyD K03585 acrA; membrane fusion protein, multidrug efflux system C Mfla_2557 secretion protein HlyD K03585 acrA; membrane fusion protein, multidrug efflux system C Mfla_0374 secretion protein HlyD K03585 acrA; membrane fusion protein, multidrug efflux system C Mfla_0212 secretion protein HlyD K03585 acrA; membrane fusion protein, multidrug efflux system C Mfla_0742 secretion protein HlyD K07799 mdtA; membrane fusion protein, multidrug efflux system C Mfla_2024 Protein-tyrosine kinase K00903 epsB; protein-tyrosine kinase [EC:2.7.10.3] C Mfla_2025 lipopolysaccharide biosynthesis K25590 epsF; protein tyrosine kinase modulator B Others C Mfla_0175 MgtC/SapB transporter K07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein C Mfla_1430 copper resistance D K07245 pcoD; copper resistance protein D C Mfla_1429 copper resistance protein CopC K07156 copC; copper resistance protein C C Mfla_1315 MltA-interacting MipA K07274 mipA; MipA family protein ! #
#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2024 #
ABC classifications based on Igarashi et al. (2004) and Tomii & Kanehisa (1998) #
MFS classification taken from TCDB