+F Repair protein KO
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DNA Repair and Recombination Proteins - Mycobacterium tuberculosis BT2
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D HKBT2_1404 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E HKBT2_3131 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E HKBT2_1786 mpg; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HKBT2_3799 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E HKBT2_3886 nth; ultraviolet N-glycosylase/AP lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E HKBT2_0905 ercC3; DNA helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D HKBT2_1243 mutT2; putative mutator protein MutT2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_0429 mutT3; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_1688 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_2843 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D HKBT2_1404 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E HKBT2_3131 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E HKBT2_1343 hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E HKBT2_1405 alkA; ada regulatory protein AlkA K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E HKBT2_1786 mpg; 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E HKBT2_3799 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E HKBT2_1293 tagA; DNA-3-methyladenine glycosidase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E HKBT2_3075 fpg; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E HKBT2_0993 formamidopyrimidine-DNA-glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E HKBT2_2605 formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E HKBT2_3482 nei; endonuclease VIII K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E HKBT2_3886 nth; ultraviolet N-glycosylase/AP lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E HKBT2_0444 xthA; exodeoxyribonuclease III protein K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E HKBT2_0706 endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E HKBT2_3171 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E HKBT2_1725 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E HKBT2_1734 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E HKBT2_1729 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E HKBT2_1517 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E HKBT2_3376 uvrD2; putative ATP dependent DNA helicase UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_3380 UvrD/Rep family helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_1000 uvrD1; ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_1725 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E HKBT2_3171 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F HKBT2_0701 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F HKBT2_0702 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F HKBT2_3668 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F HKBT2_1487 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F HKBT2_1077 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E HKBT2_1180 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E HKBT2_1179 xseB; exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E HKBT2_1655 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E HKBT2_0004 dnaN; DNA polymerase subunit III beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E HKBT2_2550 hypothetical protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E HKBT2_3854 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E HKBT2_3927 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E HKBT2_2313 hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E HKBT2_3937 dnaZX; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E HKBT2_3171 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E HKBT2_3376 uvrD2; putative ATP dependent DNA helicase UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_3380 UvrD/Rep family helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_1000 uvrD1; ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E HKBT2_2620 hypothetical protein K03111 ssb; single-strand DNA-binding protein
E HKBT2_0059 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E HKBT2_0661 recB; exodeoxyribonuclease V subunit beta K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E HKBT2_0662 recC; exodeoxyribonuclease V subunit gamma K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E HKBT2_0660 recD; exodeoxyribonuclease V subunit alpha K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E HKBT2_2883 recA; DNA recombination protein RecA K03553 recA; recombination protein RecA
E HKBT2_2738 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E HKBT2_2737 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E HKBT2_2739 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E HKBT2_1499 priA; primosome assembly protein PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E HKBT2_2883 recA; DNA recombination protein RecA K03553 recA; recombination protein RecA
E HKBT2_3796 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E HKBT2_0005 recF; DNA replication and repair protein K03629 recF; DNA replication and repair protein RecF
E HKBT2_3128 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E HKBT2_2495 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E HKBT2_3931 recR; recombination protein RecR K06187 recR; recombination protein RecR
E HKBT2_1794 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E HKBT2_2738 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E HKBT2_2737 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E HKBT2_2739 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E HKBT2_2653 hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E HKBT2_0986 Ku protein K10979 ku; DNA end-binding protein Ku
E HKBT2_0987 ATP dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F HKBT2_0008 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F HKBT2_0007 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F HKBT2_3856 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F HKBT2_3141 hupB; DNA-binding protein hupB K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F HKBT2_2495 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F HKBT2_3931 recR; recombination protein RecR K06187 recR; recombination protein RecR
F HKBT2_3171 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F HKBT2_1734 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F HKBT2_1729 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D HKBT2_1645 dinX; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D HKBT2_3216 dinP; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D HKBT2_2883 recA; DNA recombination protein RecA K03553 recA; recombination protein RecA
D HKBT2_2866 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D HKBT2_1794 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D HKBT2_3591 hypothetical protein K14161 imuB; protein ImuB
D HKBT2_3565 dnaE2; error-prone DNA polymerase K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D HKBT2_2620 hypothetical protein K03111 ssb; single-strand DNA-binding protein
D HKBT2_0059 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D HKBT2_2882 recX; recombination regulator RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D HKBT2_1419 dinG; ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D HKBT2_3481 lhr; ATP-dependent helicase Lhr K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D HKBT2_1243 mutT2; putative mutator protein MutT2 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_0429 mutT3; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_1688 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D HKBT2_3140 mutT1; putative hydrolase MutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D HKBT2_1798 MutT/nudix family protein K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D HKBT2_2843 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D HKBT2_3211 nrdE; ribonucleotide-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HKBT2_0594 putative ribonucleoside-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D HKBT2_3208 nrdF2; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D HKBT2_0249 nrdB; ribonucleoside-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D HKBT2_2084 nrdF1; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D HKBT2_2985 hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024