+F Repair protein KO
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DNA Repair and Recombination Proteins - Staphylococcus carnosus subsp. carnosus
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SCA_2000 adaB; putative methylated DNA-protein cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E SCA_0233 ung; putative uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCA_1843 putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SCA_1441 putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SCA_1086 nth; putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SCA_2148 putative mutator protein mutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_0053 mutT; mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_1392 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_0486 dut; putative dUTP pyrophosphatase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SCA_2000 adaB; putative methylated DNA-protein cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E SCA_0233 ung; putative uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SCA_2193 hypothetical protein K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E SCA_1843 putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E SCA_1441 putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SCA_1270 tag; putative DNA-3-methyladenine glycosidase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SCA_1296 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SCA_1086 nth; putative endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SCA_1178 putative AP endonuclease family 2 protein K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E SCA_1247 putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E SCA_1477 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SCA_1297 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SCA_0408 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E SCA_0407 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E SCA_0764 uvrC; putative excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E SCA_1478 pcrA; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCA_2307 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCA_1297 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SCA_1477 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SCA_0199 rpoB; RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SCA_0200 rpoC; RNA polymerase beta-prime chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SCA_1709 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SCA_1631 hypothetical protein K03048 rpoE; DNA-directed RNA polymerase subunit delta
F SCA_0827 putative DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SCA_0153 mfd; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E SCA_0945 mutS; putative DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E SCA_0762 mutS2; MutS2-like protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E SCA_0946 mutL; putative DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E SCA_1147 putative exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SCA_1146 putative exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E SCA_1308 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SCA_0899 polC; homolog of DNA polymerase III, alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E SCA_2473 dnaN; DNA polymerase III beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SCA_1208 putative DNA-binding protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SCA_0125 holB; putative DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SCA_1466 conserved hypothetical protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SCA_0119 dnaX; DNA polymerase III gamma and tau subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E SCA_1477 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SCA_1478 pcrA; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCA_2307 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SCA_0027 ssb; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SCA_1600 ssb; single strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SCA_0475 ssb; putative single strand DNA binding protein,phage associated K03111 ssb; single-strand DNA-binding protein
E SCA_2230 hypothetical protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SCA_1231 conserved hypothetical protein K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SCA_0926 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
E SCA_1253 ruvA; holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E SCA_1252 ruvB; holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SCA_0830 priA; putative primosomal replication factor Y (primosomal protein N') K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E SCA_0988 putative ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E SCA_0987 putative exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E SCA_0926 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
E SCA_0182 radA; DNA repair protein radA K04485 radA; DNA repair protein RadA/Sms
E SCA_2471 recF; DNA repair and genetic recombination protein K03629 recF; DNA replication and repair protein RecF
E SCA_0850 recG; putative ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SCA_1247 putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E SCA_1188 recO; putative recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
E SCA_0121 recR; putative recombination protein K06187 recR; recombination protein RecR
E SCA_1143 recN; similar to DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E SCA_1083 recU; putative recombination protein U K03700 recU; recombination protein U
E SCA_1253 ruvA; holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E SCA_1252 ruvB; holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D AddAB pathway proteins
E SCA_0575 addA; putative ATP-dependent nuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E SCA_0574 addB; putative ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E SCA_0988 putative ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E SCA_0987 putative exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SCA_2469 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SCA_2470 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SCA_0884 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SCA_1105 hup; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SCA_1247 putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F SCA_1188 recO; putative recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
F SCA_0121 recR; putative recombination protein K06187 recR; recombination protein RecR
F SCA_1477 lig; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F SCA_0368 recQ; DNA helicase recQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SCA_1113 putative ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SCA_0408 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F SCA_0407 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SCA_1467 dinP; similar to DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SCA_1008 truncated ImpB/MucB/SamB family protein (fragment 1) K03502 umuC; DNA polymerase V
D SCA_1009 truncated ImpB/MucB/SamB family protein (fragment 2) K03502 umuC; DNA polymerase V
C Other SOS response factors
D SCA_0926 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
D SCA_0980 lexA; DNA damage-inducible repressor LexA (DinR) K01356 lexA; repressor LexA [EC:3.4.21.88]
D SCA_1143 recN; similar to DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D SCA_0027 ssb; putative single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SCA_1600 ssb; single strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SCA_0475 ssb; putative single strand DNA binding protein,phage associated K03111 ssb; single-strand DNA-binding protein
D SCA_1446 putative regulatory protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D SCA_0761 DNA polymerase family X protein K02347 polX; DNA polymerase (family X)
C DNA helicases
D SCA_1089 conserved hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D SCA_2148 putative mutator protein mutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_0053 mutT; mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_1392 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SCA_0486 dut; putative dUTP pyrophosphatase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SCA_0379 nrdE; ribonuceloside diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SCA_0380 nrdF; ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D SCA_1309 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024