+E Replication protein KO
#
DNA Replication Proteins - Saccharomyces cerevisiae (budding yeast)
%
!
AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D YML065W ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D YBR060C ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D YLL004W ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D YPR162C ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D YNL261W ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D YHR118C ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D YJL194W CDC6; AAA family ATPase CDC6 K02213 CDC6; cell division control protein 6
D YBL023C MCM2; MCM DNA helicase complex subunit MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D YEL032W MCM3; MCM DNA helicase complex subunit MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D YPR019W MCM4; MCM DNA helicase complex subunit MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D YLR274W MCM5; MCM DNA helicase complex subunit MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D YGL201C MCM6; MCM DNA helicase complex subunit MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D YBR202W MCM7; mini-chromosome maintenance complex protein 7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D YDL017W CDC7; serine/threonine protein kinase CDC7 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D YDR052C DBF4; protein serine/threonine kinase activating protein DBF4 K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D YDR013W PSF1; DNA replication protein PSF1 K10732 GINS1; GINS complex subunit 1
D YJL072C PSF2; DNA replication protein PSF2 K10733 GINS2; GINS complex subunit 2
D YOL146W PSF3; DNA replication protein PSF3 K10734 GINS3; GINS complex subunit 3
D YDR489W SLD5; DNA replication protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D YJL090C DPB11; protein kinase activating protein DPB11 K03507 DPB11; DNA replication regulator DPB11
D YKL108W SLD2; Sld2p K10729 SLD2; DNA replication regulator SLD2
D YGL113W SLD3; Sld3p K10731 SLD3; DNA replication regulator SLD3
D YLR103C CDC45; DNA replication initiation factor CDC45 K06628 CDC45; cell division control protein 45
D YIL150C MCM10; Mcm10p K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D YNL102W POL1; DNA-directed DNA polymerase alpha catalytic subunit POL1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D YBL035C POL12; DNA-directed DNA polymerase alpha subunit POL12 K02321 POLA2; DNA polymerase alpha subunit B
D YIR008C PRI1; DNA primase subunit PRI1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D YKL045W PRI2; DNA primase subunit PRI2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D YNL262W POL2; DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D YPR175W DPB2; DNA polymerase epsilon noncatalytic subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D YDR121W DPB4; DNA polymerase epsilon noncatalytic subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D YBR278W DPB3; DNA polymerase epsilon noncatalytic subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
D YJL065C DLS1; Dls1p K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D YDL102W POL3; DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D YJR006W POL31; DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
D YJR043C POL32; DNA polymerase delta subunit POL32 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D YOR330C MIP1; DNA-directed DNA polymerase gamma MIP1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D YAR007C RFA1; replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
D YNL312W RFA2; Rfa2p K10739 RFA2; replication factor A2
C RFC (replication factor C)
D YOR217W RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D YJR068W RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D YOL094C RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D YNL290W RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D YBR087W RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D YMR234W RNH1; RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D YNL072W RNH201; ribonuclease H2 catalytic subunit RNH201 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
C Other elongation factors
D YBR088C POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D YHR164C DNA2; bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D YKL017C HCS1; ATP-dependent 5'-3' DNA helicase HCS1 K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D YKL113C RAD27; multifunctional nuclease RAD27 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D YOR033C EXO1; Rad2 family nuclease EXO1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D YDL164C CDC9; DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
E YDL220C CDC13; telomere-binding protein CDC13 K11115 CDC13; cell division control protein 13
E YDR082W STN1; Stn1p K11117 STN1; protein STN1
E YLR010C TEN1; Ten1p K11116 TEN1; telomere length regulation protein
D RIF proteins
E YBR275C RIF1; DNA-binding protein RIF1 K11118 RIF1; RAP1-interacting factor 1
E YLR453C RIF2; Rif2p K11119 RIF2; RAP1-interacting factor 2
D SIR proteins
E YKR101W SIR1; Sir1p K11120 SIR1; regulatory protein SIR1
E YDL042C SIR2; NAD-dependent histone deacetylase SIR2 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E YOL068C HST1; histone deacetylase HST1 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E YPL015C HST2; histone deacetylase HST2 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E YDR191W HST4; NAD-dependent histone deacetylase HST4 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E YOR025W HST3; NAD-dependent histone deacetylase HST3 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E YLR442C SIR3; chromatin-silencing protein SIR3 K11122 SIR3; regulatory protein SIR3
E YDR227W SIR4; chromatin-silencing protein SIR4 K11123 SIR4; regulatory protein SIR4
D YNL216W RAP1; DNA-binding transcription factor RAP1 K09426 RAP1; Myb-like DNA-binding protein RAP1
C Telomerase complex (animals)
D YLR318W EST2; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E YHR089C GAR1; H/ACA snoRNP pseudouridylase subunit GAR1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E YDL208W NHP2; snoRNA-binding protein NHP2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E YHR072W-A NOP10; snoRNP complex protein NOP10 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E YLR175W CBF5; pseudouridine synthase CBF5 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D YDR206W EBS1; Ebs1p K11132 EST1; telomere elongation protein [EC:2.7.7.-]
D YLR233C EST1; Est1p K11132 EST1; telomere elongation protein [EC:2.7.7.-]
D YLR318W EST2; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D YIL009C-A EST3; telomerase subunit EST3 K11133 EST3; telomere replication protein
D Sm core complex
E YER029C SMB1; mRNA splicing protein SMB1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E YGR074W SMD1; mRNA splicing protein SMD1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E YLR275W SMD2; mRNA splicing protein SMD2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E YLR147C SMD3; mRNA splicing protein SMD3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E YOR159C SME1; mRNA splicing protein SME1 K11097 SNRPE; small nuclear ribonucleoprotein E
E YPR182W SMX3; mRNA splicing protein SMX3 K11098 SNRPF; small nuclear ribonucleoprotein F
E YFL017W-A SMX2; mRNA splicing protein SMX2 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D YOR144C ELG1; Elg1p K11134 ELG1; telomere length regulation protein
D YJR068W RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D YOL094C RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D YNL290W RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D YBR087W RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D YMR224C MRE11; MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
D YNL250W RAD50; MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D YBL088C TEL1; DNA-binding protein kinase TEL1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D YMR190C SGS1; ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D YPL022W RAD1; ssDNA endodeoxyribonuclease RAD1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D YGR280C PXR1; telomerase inhibitor K11135 PINX1; Pin2-interacting protein X1
D YGR099W TEL2; Tel2p K11137 TELO2; telomere length regulation protein
D YHR031C RRM3; DNA helicase K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D YML061C PIF1; DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D YNL187W SWT21; Swt21p K23314 WRAP53; telomerase Cajal body protein 1
D YPL128C TBF1; Tbf1p K22485 TBF1; protein TBF1
B DNA Topoisomerases
C YOL006C TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C YNL088W TOP2; DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C YLR234W TOP3; DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E YMR234W RNH1; RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E YMR234W RNH1; RNA-DNA hybrid ribonuclease K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E YHR164C DNA2; bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E YKL113C RAD27; multifunctional nuclease RAD27 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E YDL164C CDC9; DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022