+F Repair protein KO
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DNA Repair and Recombination Proteins - Shigella flexneri 2003036
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SFy_2631 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SFy_0791 PhrB K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E SFy_3752 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SFy_4210 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SFy_2371 Nth K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D SFy_0123 MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SFy_5245 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D SFy_2631 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D SFy_3264 regulatory protein ada K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D SFy_0791 PhrB K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D SFy_3262 AlkB K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E SFy_3752 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E SFy_4435 G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E SFy_4210 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E SFy_5105 Tag K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E SFy_5239 formamidopyrimidine/5-formyluracil/5-hydroxymethyluracil DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E SFy_0780 Endonuclease 8 K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E SFy_2371 Nth K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E SFy_2114 exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E SFy_3187 putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E SFy_5830 Endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E SFy_4099 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E SFy_3502 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SFy_5253 NAD-dependent DNA ligase adenylation domain protein K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E SFy_5617 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E SFy_5959 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E SFy_0988 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E SFy_2798 excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E SFy_2130 Excinuclease cho K05984 cho; excinuclease Cho [EC:3.1.25.-]
E SFy_5550 DNA-dependent helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SFy_5617 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E SFy_3502 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SFy_5253 NAD-dependent DNA ligase adenylation domain protein K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F SFy_5813 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F SFy_5816 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F SFy_4742 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F SFy_5256 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F SFy_1609 Mfd K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E SFy_3915 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E SFy_6206 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E SFy_4048 DNA mismatch repair protein mutH K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E SFy_2955 SbcB K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E SFy_3635 exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E SFy_0447 Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E SFy_2657 exodeoxyribonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E SFy_0236 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E SFy_5360 DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E SFy_6072 HolC K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E SFy_0873 HolA K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E SFy_1589 HolB K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E SFy_0274 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E SFy_0524 DnaX K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E SFy_6320 DNA polymerase III subunit psi K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E SFy_2655 DNA polymerase III subunit theta K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E SFy_3502 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E SFy_5253 NAD-dependent DNA ligase adenylation domain protein K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E SFy_5550 DNA-dependent helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E SFy_5958 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E SFy_4838 Dam methyltransferase with SUUR K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E SFy_2868 Vsr K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E SFy_4035 exonuclease V subunit beta K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E SFy_4038 RecC K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E SFy_4034 RecD K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E SFy_3869 RecA K03553 recA; recombination protein RecA
E SFy_2680 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SFy_2679 Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SFy_2683 Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E SFy_2718 crossover junction endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E SFy_2914 crossover junction endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E SFy_2218 endodeoxyribonuclease RusA family protein K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E SFy_5738 PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E SFy_0521 PriC K04067 priC; primosomal replication protein N''
E SFy_6307 primosomal protein I K02317 dnaT; DNA replication protein DnaT
E SFy_2955 SbcB K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E SFy_0416 SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SFy_0417 SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E SFy_3869 RecA K03553 recA; recombination protein RecA
E SFy_6349 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E SFy_5361 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E SFy_5260 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E SFy_4099 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E SFy_3732 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E SFy_0527 hypothetical protein K06187 recR; recombination protein RecR
E SFy_3795 RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E SFy_0412 RdgC K03554 rdgC; recombination associated protein RdgC
E SFy_2680 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E SFy_2679 Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E SFy_2683 Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E SFy_3222 type III restriction enzyme, res subunit K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E SFy_0416 SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E SFy_0417 SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E SFy_6066 YjgR K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F SFy_3285 GyrA K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F SFy_5363 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F SFy_1833 TopA K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F SFy_5833 DNA-binding protein HU-alpha K05787 hupA; DNA-binding protein HU-alpha
F SFy_0483 DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F SFy_1973 exodeoxyribonuclease VIII K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F SFy_4099 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F SFy_3732 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F SFy_0527 hypothetical protein K06187 recR; recombination protein RecR
F SFy_3502 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F SFy_5253 NAD-dependent DNA ligase adenylation domain protein K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F SFy_4706 DNA-binding protein fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F SFy_2175 Integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F SFy_1240 Integration host factor subunit beta K05788 ihfB; integration host factor subunit beta
E Supressor
F SFy_2955 SbcB K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F SFy_5565 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F SFy_5959 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F SFy_0988 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
F SFy_1782 global DNA-binding transcriptional dual regulator H-NS K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D SFy_0377 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D SFy_1700 UmUC K03502 umuC; DNA polymerase V
D SFy_1699 Protein umuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D SFy_3869 RecA K03553 recA; recombination protein RecA
D SFy_5979 hypothetical protein K01356 lexA; repressor LexA [EC:3.4.21.88]
D SFy_3795 RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D SFy_0070 PolB K02336 polB; DNA polymerase II [EC:2.7.7.7]
D SFy_5958 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D SFy_5251 DinD K14623 dinD; DNA-damage-inducible protein D
D SFy_1539 DNA damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D SFy_2693 bacteriophage protein K12149 dinI; DNA-damage-inducible protein I
D SFy_3111 DNA-damage-inducible protein K12149 dinI; DNA-damage-inducible protein I
D SFy_3867 hypothetical protein K03565 recX; regulatory protein
D SFy_4877 YhgA K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D SFy_3386 YfcI K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D SFy_0169 uncharacterized protein yadD K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D SFy_3310 YfaD K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D SFy_5504 ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D SFy_1318 HelD K03658 helD; DNA helicase IV [EC:5.6.2.4]
D SFy_2034 hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SFy_1017 DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D SFy_2406 ATP-dependent helicase, putative K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D SFy_0123 MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D SFy_5245 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D SFy_3837 ribonucleotide-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SFy_3294 NrdA K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D SFy_3295 ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D SFy_3838 NrdF K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024