+C Two-component system KO
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Two-Component System - Sinorhizobium meliloti 1021
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C SMc02147 phoR; Probable phosphate regulon sensor histidine kinase transmembrane protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C SMc02140 phoB; Phosphate regulon transcriptional regulatory protein K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C SMc01595 Putative sensor histidine kinase transmembrane protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C SMc01593 Two-component response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C SMa2327 KdpD histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C SMa2325 Response regulator K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C SM_b20721 putative two-component sensor histidine kinase protein K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C SM_b20722 putative two-component response regulator protein K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
C SMc04446 chvG; Signal transduction histidine kinase, regulator of succinoglycan synthesis K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]
C SMc02560 chvI; Transcriptional regulatory protein K14981 chvI; two-component system, OmpR family, response regulator ChvI
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C SMc03046 rem; Response regulator of exponential growth motility K21603 ftcR; two-component system, OmpR family, flagellar system response regulator FtcR
C SMc02366 ragA; Probable response regulator K02483 K02483; two-component system, OmpR family, response regulator
C SMc00458 feuP; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 K02483; two-component system, OmpR family, response regulator
C SM_b20219 putative response regulator protein K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C SM_b21520 putative two-component response regulator protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C SM_b20078 probable response regulator K02479 K02479; two-component system, NarL family, response regulator
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C SM_b21545 putative two-component response regulator protein K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C SMc01042 ntrB; Nitrogen assimilation regulatory protein K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C SMc01043 ntrC; Nitrogen assimilation regulatory protein K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C SMc01044 ntrY; Probable nitrogen regulation transmembrane protein K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C SMc01045 ntrX; Probable nitrogen regulation protein K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C SM_b20612 dctB; C4-dicarboxylate transport sensor protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C SM_b21201 putative two-component sensor histidine kinase protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C SM_b20613 dctD; C4-dicarboxylate transport transcriptional regulatory protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C SM_b21200 putative two-component response regulator protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C SMa1558 Sensor histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C SMc03007 cheA; Chemotaxis protein (sensory transduction histidine kinase) K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C SMc03006 cheY1; Chemotaxis regulator protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SMc03011 cheY2; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SMc00653 Putative 2-component receiver domain protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SMa1561 cheB2; CheB2 chemotaxis methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SM_b20514 protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SMc03010 cheB; Protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SM_b20515 putative methyltransferase K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
C SMc04212 Putative sensor histidine kinase transmembrane protein K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]
C SMc02369 Putative sensor histidine kinase transmembrane protein K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]
C SMc00059 Putative sensor histidine kinase K11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3]
C SMc01370 pleD; Response regulator containing a CheY-like receiver domain and a GGDEF domain K02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65]
C SMc01371 divK; DivK cell division response regulator, essential cell cycle regulator K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
C SMc00471 Putative sensor histidine kinase transmembrane protein K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
C SMc00654 ctrA; Cell cycle transcriptional regulator CtrA, autoregulated, response regulator K13584 ctrA; two-component system, cell cycle response regulator CtrA
C SMc04044 Single domain response regulator K13589 cpdR; two-component system, cell cycle response regulator CpdR
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C SMa1229 fixL; FixL oxygen-regulated histidine kinase K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3]
C SMa1227 fixJ; FixJ response regulator K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C SMc02585 actS; Two component sensor histidine kinase, essential for acid-tolerance K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C SMc02584 actR; Two component response regulator, essential for acid-tolerance K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
C SM_b21114 nrtA; NrtA nitrate transport protein K22067 nasS; two-component system, oxyanion-binding sensor
C SM_b21115 putative response regulator protein K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023