+C Two-component system KO
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Two-Component System - Shewanella oneidensis
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C SO_1559 phoR; phosphate-responsive two component signal transduction system histidine kinase with PAS and DUF3329 domains PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C SO_1558 phoB; phosphate-responsive two component signal transduction system response regulator PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C SO_1945 phoQ; two component signal transduction system histidine kinase PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C SO_4648 two component signal transduction system histidine kinase K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C SO_1946 phoP; two component signal transduction system response regulator PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
C SO_4647 two component signal transduction system response regulator OmpR family K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C SO_4634 envZ; osmolarity-responsive two component signal transduction system histidine kinase EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C SO_4633 ompR; osmolarity-responsive two component signal transduction system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
C SO_4478 cpxA; periplasmic stress-responsive two component signal transduction system histidine kinase CpxA K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C SO_4477 cpxR; periplasmic stress-responsive two component signal transduction system response regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
C SO_2105 qseC; AI-3-responsive two component signal transduction system histidine kinase QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C SO_2104 qseB; AI-3-responsive two component signal transduction system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C SO_0059 kdpE; two component signal transduction system controlling the osmosenstive K+ channel response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C SO_1230 torS; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C SO_1228 torR; TMAO-responsive two component signal transduction system response regulator TorR K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C SO_3988 arcA; two component signal transduction system controlling aerobic respiration response regulator ArcA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C SO_3595 rstB; two component signal transduction system histidine kinase RstB K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C SO_2426 two component signal transduction system response regulator K02483 K02483; two-component system, OmpR family, response regulator
C SO_3594 rstA; two component signal transduction system controlling curli production response regulator RstA K02483 K02483; two-component system, OmpR family, response regulator
C SO_4428 two component signal transduction system response regulator OmpR family K02483 K02483; two-component system, OmpR family, response regulator
C SO_2193 two component signal transduction system controlling sortase system response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
C SO_3981 narQ; nitrate/nitrite-responsive two component signal transduction system histidine kinase NarQ K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C SO_3982 narP; nitrate/nitrite-responsive two component signal transduction system response regulator NarP K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C SO_4444 rcsB; two component signal transduction system response regulator of capsule flagella and curli biosynthesis RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C SO_3457 barA; two component signal transduction system hybrid histidine kinase/response regulator with DUF2222 and Hpt domains BarA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C SO_1860 uvrY; two component signal transduction system response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
C SO_0352 two component signal transduction system histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C SO_0351 two component signal transduction system response regulator LuxR family K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C SO_2822 yehU; two component signal transduction system histidine kinase with GAF sensory domain YehU K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C SO_2823 yehT; two component signal transduction system response regulator YehT K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C SO_4471 glnL; nitrogen-responsive two component signal transduction system histidine kinase with PAS sensory domain GlnL K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C SO_4472 glnG; nitrogen-responsive two component signal transduction system Sigma54-dependent response regulator GlnG K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C SO_3138 dctD; C4-dicarboxylate-responsive two component Sigma54-dependent signal transduction system response regulator DctD K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C SO_4717 tungstate-responsive two component signal transduction system histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C SO_2121 cheA; chemotaxis signal transduction system histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C SO_3207 cheA; chemotaxis signal transduction system histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C SO_2120 cheY; chemotaxis signal transduction system response regulator CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SO_2318 cheY; chemotaxis signal transduction system response regulator CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SO_3209 cheY; chemotaxis signal transduction system response regulator CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SO_0549 two component signal transduction system response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C SO_2327 cheB; chemotaxis signal transduction system response regulator with glutamate methylesterase domain CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SO_2126 cheB; chemotaxis signal transduction system response regulator with glutamate methylesterase domain CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SO_3206 cheB; chemotaxis signal transduction system response regulator with glutamate methylesterase domain CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C SO_1989 cheV; chemotaxis signal transduction system response regulator CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C SO_3123 cheV; chemotaxis signal transduction system response regulator CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C SO_3252 cheV; chemotaxis signal transduction system response regulator CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
C SO_4155 ttrS; thiosulfate/tetrathionate-responsive two component signal transduction system histidine kinase TtrS K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
C SO_1417 two component signal transduction system histidine kinase K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
C SO_4157 ttrR; thiosulfate/tetrathionate-responsive two component signal transduction system response regulator TtrR K13041 ttrR; two-component system, LuxR family, response regulator TtrR
C SO_1416 two component signal transduction system response regulator LuxR family K13041 ttrR; two-component system, LuxR family, response regulator TtrR
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C SO_3231 flrB; two component signal transduction system controlling flagellar biosynthesis histidine kinase with PAS sensory domain FlrB K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C SO_3230 flrC; two component signal transduction system controlling flagella biosynthesis Sigma54-dependent response regulator FlrC K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C SO_4173 prrB; oxygen-responsive two component signal transduction system controlling redox affected systems histidine kinase PrrB K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C SO_4172 prrA; oxygen-responsive two component signal transduction system controlling redox affected systems response regulator PrrA K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023