+F Repair protein KO
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DNA Repair and Recombination Proteins - Sphingobacterium thalpophilum
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NCTC11429_04864 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E NCTC11429_01776 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E NCTC11429_01136 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NCTC11429_00980 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D NCTC11429_04076 S1/P1 Nuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D NCTC11429_03585 nucleoside triphosphatase YtkD K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_03655 NUDIX domain K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_03708 nudG; CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_04069 mutator mutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_04796 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_00561 RNA pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_02076 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NCTC11429_04282 ada_2; Regulatory protein of adaptative response K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D NCTC11429_00518 ada_1; Regulatory protein of adaptative response K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D NCTC11429_04864 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E NCTC11429_01776 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E NCTC11429_01136 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NCTC11429_01953 tag; DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E NCTC11429_04395 mutM_2; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E NCTC11429_04232 mutM_1; Formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E NCTC11429_00980 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E NCTC11429_04560 xthA; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E NCTC11429_00182 exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E NCTC11429_01949 exoA; Exodeoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E NCTC11429_02241 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E NCTC11429_00577 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E NCTC11429_01671 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E NCTC11429_01454 uvrA_1; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E NCTC11429_02027 uvrA_2; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E NCTC11429_00928 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E NCTC11429_02190 uvrC; Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E NCTC11429_00535 pcrA; ATP-dependent DNA helicase pcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC11429_01671 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E NCTC11429_00577 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F NCTC11429_00658 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F NCTC11429_00657 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F NCTC11429_01013 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F NCTC11429_01842 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E NCTC11429_03912 mutS_3; DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
E NCTC11429_03913 mutS_4; DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
E NCTC11429_00820 mutS_1; DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
E NCTC11429_04465 mutS2; MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E NCTC11429_02026 mutL; DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E NCTC11429_01508 xseA; Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E NCTC11429_01509 exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E NCTC11429_03750 dnaE_2; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NCTC11429_00583 dnaE_1; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NCTC11429_01566 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E NCTC11429_04920 DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E NCTC11429_01567 dnaX_1; DNA polymerase III subunit tau K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E NCTC11429_04173 dinG; Probable ATP-dependent helicase dinG homolog K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NCTC11429_04591 polC_2; DNA polymerase III polC-type K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NCTC11429_01430 polC_1; DNA polymerase III polC-type K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NCTC11429_02084 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NCTC11429_03060 dnaX_2; DNA polymerase III subunit tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E NCTC11429_00577 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E NCTC11429_00535 pcrA; ATP-dependent DNA helicase pcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NCTC11429_03300 ssb_3; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
E NCTC11429_01083 ssb_1; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
E NCTC11429_01135 ssb_2; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
E NCTC11429_03612 vsr; Very short patch repair protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E NCTC11429_00981 recA; Recombinase A K03553 recA; recombination protein RecA
E NCTC11429_00878 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E NCTC11429_04485 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E NCTC11429_01004 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E NCTC11429_02324 priA; Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E NCTC11429_04064 sbcC; Nuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E NCTC11429_04065 sbcD; Nuclease sbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E NCTC11429_00981 recA; Recombinase A K03553 recA; recombination protein RecA
E NCTC11429_01504 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E NCTC11429_00787 recF; DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF
E NCTC11429_01886 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E NCTC11429_02241 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E NCTC11429_01535 recO; Recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
E NCTC11429_04175 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E NCTC11429_03110 recN; Recombination protein N K03631 recN; DNA repair protein RecN (Recombination protein N)
E NCTC11429_00878 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E NCTC11429_04485 ruvB; Holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E NCTC11429_01004 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E NCTC11429_01958 addA; ATP-dependent helicase/nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E NCTC11429_04064 sbcC; Nuclease sbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E NCTC11429_04065 sbcD; Nuclease sbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
E NCTC11429_01969 Ornithine/acetylornithine aminotransferase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E NCTC11429_04151 Ku protein K10979 ku; DNA end-binding protein Ku
E NCTC11429_05207 Putative DNA ligase-like protein Rv0938/MT0965 K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E NCTC11429_00159 Putative DNA ligase-like protein Rv0938/MT0965 K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F NCTC11429_04085 gyrA_2; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F NCTC11429_02691 gyrB_2; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F NCTC11429_04153 Eukaryotic DNA topoisomerase I, catalytic core K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F NCTC11429_04724 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F NCTC11429_01635 TL29 K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F NCTC11429_02241 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F NCTC11429_01535 recO; Recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
F NCTC11429_04175 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F NCTC11429_00577 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F NCTC11429_04717 recQ_2; ATP-dependent DNA helicase recQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NCTC11429_02694 recQ_1; ATP-dependent DNA helicase recQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NCTC11429_01454 uvrA_1; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F NCTC11429_02027 uvrA_2; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F NCTC11429_00928 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D NCTC11429_03751 dinB_1; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D NCTC11429_04938 dinB_2; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D NCTC11429_00981 recA; Recombinase A K03553 recA; recombination protein RecA
D NCTC11429_03110 recN; Recombination protein N K03631 recN; DNA repair protein RecN (Recombination protein N)
D NCTC11429_04124 Uncharacterized conserved protein K14160 imuA; protein ImuA
D NCTC11429_04125 DNA polymerase IV K14161 imuB; protein ImuB
D NCTC11429_04126 dnaE_3; DNA polymerase III subunit alpha K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D NCTC11429_03300 ssb_3; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
D NCTC11429_01083 ssb_1; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
D NCTC11429_01135 ssb_2; Helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
D NCTC11429_00589 recombination regulator RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D NCTC11429_03235 polX; DNA polymerase/3'-5' exonuclease PolX K02347 polX; DNA polymerase (family X)
C DNA helicases
D NCTC11429_04631 ATP-dependent helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D NCTC11429_03585 nucleoside triphosphatase YtkD K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_03655 NUDIX domain K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_03708 nudG; CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_04069 mutator mutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_04796 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_00561 RNA pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_02076 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NCTC11429_02053 nrdE2; Ribonucleoside-diphosphate reductase subunit alpha 2 K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D NCTC11429_02052 nrdF1; Ribonucleoside-diphosphate reductase subunit beta nrdF1 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D NCTC11429_02320 nrnA; Bifunctional oligoribonuclease and PAP phosphatase nrnA K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024