+E Replication protein KO
#
DNA Replication Proteins - Tribolium castaneum (red flour beetle)
%
!
AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 663974 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 655255 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 664121 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 659529 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 663060 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 661980 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 657477 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 100141992 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 659225 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 657061 DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 662486 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 663668 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 658099 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 655767 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 661369 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 662133 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 657290 uncharacterized LOC657290 K06626 CCNE; G1/S-specific cyclin-E1
D 103314472 cdc2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 103313355 cyclin-dependent kinase 1-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
C GINS complex
D 656137 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 656790 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 656950 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 662335 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100141743 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 655929 RecQ4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 661217 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 662910 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 659967 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 103314886 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 663387 uncharacterized LOC663387 K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 655855 DNApol-alpha180; DNA polymerase alpha 180kD K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 100142430 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 659675 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 660563 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 103314154 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 657660 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 656613 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 656342 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 660566 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 655638 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 661566 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 656813 nucleolin K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 657330 DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100142503 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 658625 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 658683 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
D 657575 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 656876 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 656183 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 656317 RfC40; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 663583 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 655220 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 103314078 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 659221 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 655176 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 656434 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 656673 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 664086 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 661398 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 660612 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 655818 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 658633 DNA ligase K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 662098 ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100141742 DNA (cytosine-5)-methyltransferase PliMCI-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 658957 geminin K10749 GMNN; geminin
D 103313179 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 660418 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 656189 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 663281 uncharacterized LOC663281 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 100142092 protein SMG5 K11125 SMG5; protein SMG5
D 658162 Tert; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 100142234 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 661229 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 662792 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 655639 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 658162 Tert; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 663178 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 658240 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 657212 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 661326 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 103312296 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 658284 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 656057 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 656317 RfC40; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 663583 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 655220 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 103314078 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 658136 mre11; meiotic recombination 11 K10865 MRE11; double-strand break repair protein MRE11
D 658288 rad50; rad50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 100142128 nbs; nbs K10867 NBN; nibrin
C Other termination factors
D 660142 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 658153 Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 659348 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100142060 mei-9; meiotic 9 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 655924 Parp; poly-(ADP-ribose) polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 655990 tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 663916 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 663928 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 659476 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 662482 transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 657678 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 661421 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 656877 protein RTF2 homolog K25186 RTF2; replication termination factor 2
D 655552 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 659830 DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 656003 Top2; DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 664404 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 662387 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 663906 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 659221 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 659221 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 661398 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 660612 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 658633 DNA ligase K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022