+E Ubiquitin system KO
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Ubiquitin System - Uncinocarpus reesii
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C UREG_07465 ubiquitin K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C UREG_04480 hypothetical protein K02983 RP-S30e; small subunit ribosomal protein S30e
C UREG_03209 gamma-aminobutyric acid receptor associated protein K08341 GABARAP; GABA(A) receptor-associated protein
C UREG_01132 hypothetical protein K08336 ATG12; ubiquitin-like protein ATG12
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C UREG_00365 ubiquitin-activating enzyme E1 1 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C UREG_04385 hypothetical protein K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C UREG_04639 hypothetical protein K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C UREG_01834 similar to NEDD8 activating enzyme K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C UREG_04624 similar to spindle assembly checkpoint protein SLDB K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C UREG_06025 dinucleotide-utilizing enzyme K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C UREG_05678 E1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C UREG_05389 ubiquitin-conjugating enzyme E2-20 kDa K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C UREG_00536 ubiquitin-conjugating enzyme E2-16 kDa K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C UREG_02985 ubiquitin-conjugating enzyme E2 15 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C UREG_03793 ubiquitin-conjugating enzyme E2-18 kDa K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C UREG_01130 ubiquitin-conjugating enzyme E2-23 kDa K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C UREG_04823 hypothetical protein K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C UREG_02599 ubiquitin-conjugating enzyme E2 6 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C UREG_04261 hypothetical protein K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C UREG_04482 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C UREG_03756 hypothetical protein K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C UREG_05889 similar to ubiquitin conjugating enzyme E2 K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C UREG_01831 hypothetical protein K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
C UREG_01389 hypothetical protein K10585 UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]
B UBL-conjugating enzymes
C UREG_05560 ubiquitin-conjugating enzyme E2-18 kDa K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C UREG_06104 NEDD8-conjugating enzyme Ubc12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C UREG_04393 similar to autophagocytosis protein AUT1 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
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AUbiquitin ligases (E3)
B HECT type E3
C UREG_06558 hypothetical protein K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C UREG_01270 hypothetical protein K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C UREG_05780 E3 ubiquitin--protein ligase pub1 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C UREG_05115 HECT protein K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C UREG_06604 hypothetical protein K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C UREG_01907 hypothetical protein K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C UREG_02233 hypothetical protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C UREG_04946 hypothetical protein K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C UREG_04957 hypothetical protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D UREG_03078 hypothetical protein K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D UREG_00791 hypothetical protein K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D UREG_04536 hypothetical protein K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D UREG_07757 hypothetical protein K13346 PEX10; peroxin-10
D UREG_04864 hypothetical protein K13345 PEX12; peroxin-12
D UREG_01801 peroxisomal biogenesis factor 2 K06664 PEX2; peroxin-2
C RBR proteins
D UREG_05445 hypothetical protein K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D UREG_03543 hypothetical protein K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D UREG_00377 hypothetical protein K11976 RNF216; E3 ubiquitin-protein ligase RNF216 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D UREG_00174 hypothetical protein K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D UREG_00591 hypothetical protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D UREG_04617 hypothetical protein K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
D UREG_01281 hypothetical protein K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D UREG_07204 hypothetical protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D UREG_07199 hypothetical protein K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
D UREG_04859 DNA repair protein rad18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D UREG_03242 hypothetical protein K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
D UREG_05145 hypothetical protein K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D UREG_07851 hypothetical protein K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D UREG_01540 hypothetical protein K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D UREG_06040 hypothetical protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D UREG_03363 hypothetical protein K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
B Atypical E3
C UREG_02542 hypothetical protein K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C UREG_03161 hypothetical protein K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
C UREG_01204 hypothetical protein K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C UREG_04898 hypothetical protein K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E UREG_04186 S-phase kinase-associated protein 1A K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E UREG_05266 hypothetical protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E UREG_07532 hypothetical protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E UREG_06359 sulfur metabolite repression control protein K10259 MET30; F-box and WD-40 domain protein MET30
E UREG_01453 hypothetical protein K10259 MET30; F-box and WD-40 domain protein MET30
E UREG_05403 cell division control protein 4 K03361 CDC4; F-box and WD-40 domain protein CDC4
E UREG_06316 hypothetical protein K03361 CDC4; F-box and WD-40 domain protein CDC4
E UREG_02000 hypothetical protein K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E UREG_01757 hypothetical protein K10273 FBXL7; F-box and leucine-rich repeat protein 7
E UREG_00939 hypothetical protein K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E UREG_02046 hypothetical protein K03360 GRR1; F-box and leucine-rich repeat protein GRR1
E UREG_00992 hypothetical protein K10295 FBXO9; F-box protein 9
E UREG_06990 hypothetical protein K10301 FBXO21; F-box protein 21
E UREG_06037 hypothetical protein K15071 RCY1; recyclin-1
C Cul2 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E UREG_04641 hypothetical protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E UREG_01074 hypothetical protein K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E UREG_06523 hypothetical protein K10523 SPOP; speckle-type POZ protein
C Cul4 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E UREG_05000 hypothetical protein K10609 CUL4; cullin 4
D Adoptor protein
E UREG_00164 hypothetical protein K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E UREG_02229 hypothetical protein K10570 ERCC8; DNA excision repair protein ERCC-8
E UREG_06736 hypothetical protein K11795 DCAF6; DDB1- and CUL4-associated factor 6
E UREG_02780 hypothetical protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E UREG_00441 hypothetical protein K11801 DCAF11; DDB1- and CUL4-associated factor 11
E UREG_07310 protein SOF1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E UREG_03968 hypothetical protein K22382 WDR26; WD repeat-containing protein 26
E UREG_05464 hypothetical protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E UREG_04641 hypothetical protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E UREG_04186 S-phase kinase-associated protein 1A K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E UREG_04145 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
D Cullin
E UREG_00991 hypothetical protein K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E UREG_07105 WD-repeat containing protein slp1 K03363 CDC20; cell division cycle 20, cofactor of APC complex
E UREG_07672 hypothetical protein K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E UREG_00544 hypothetical protein K03348 APC1; anaphase-promoting complex subunit 1
E UREG_00794 protein bimA K03350 APC3; anaphase-promoting complex subunit 3
E UREG_02843 hypothetical protein K03351 APC4; anaphase-promoting complex subunit 4
E UREG_00460 hypothetical protein K03352 APC5; anaphase-promoting complex subunit 5
E UREG_03951 hypothetical protein K03353 APC6; anaphase-promoting complex subunit 6
E UREG_03964 hypothetical protein K03355 APC8; anaphase-promoting complex subunit 8
E UREG_02850 hypothetical protein K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D UREG_03415 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D UREG_06626 hypothetical protein K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D UREG_02132 hypothetical protein K23334 RANBP9_10; Ran-binding protein 9/10
D UREG_03253 hypothetical protein K23336 ARMC8; armadillo repeat-containing protein 8
D UREG_04025 hypothetical protein K18624 MAEA; macrophage erythroblast attacher
D UREG_05916 hypothetical protein K23335 GID4; glucose-induced degradation protein 4
D UREG_00724 hypothetical protein K23338 GID8; glucose-induced degradation protein 8
D UREG_03968 hypothetical protein K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
D UREG_05318 hypothetical protein K25216 UBAC2; ubiquitin-associated domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D UREG_04931 hypothetical protein K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D UREG_07763 hypothetical protein K24350 UBXN7; UBX domain-containing protein 7
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D UREG_03682 hypothetical protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D UREG_02874 similar to ubiquitin thiolesterase K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
D UREG_06988 hypothetical protein K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D UREG_06239 similar to ubiquitin specific protease 11 K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D UREG_05674 hypothetical protein K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D UREG_03899 hypothetical protein K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D UREG_01158 hypothetical protein K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D UREG_03243 hypothetical protein K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D UREG_04485 similar to ubiquitin carboxyl-terminal hydrolase K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D UREG_05419 hypothetical protein K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D UREG_05483 hypothetical protein K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D UREG_00811 hypothetical protein K11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]
D UREG_05065 hypothetical protein K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D UREG_00623 CREB protein K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
D UREG_07416 hypothetical protein K11874 UBP16; ubiquitin carboxyl-terminal hydrolase 16 [EC:3.4.19.12]
C OTU
D UREG_00516 hypothetical protein K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D UREG_06915 hypothetical protein K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
C MINDY
D UREG_04015 hypothetical protein K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
C JAMM
D UREG_01736 26S proteasome regulatory subunit rpn11 K03030 PSMD14; 26S proteasome regulatory subunit N11
D UREG_07638 hypothetical protein K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
C PPPDE
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C UREG_03895 hypothetical protein K08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]
C UREG_03682 hypothetical protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C COP9 signalosome (CSN) complex
D UREG_01553 similar to COP9 singlesome subunit 1 K12175 GPS1; COP9 signalosome complex subunit 1
D UREG_00517 COP9 signalosome complex subunit 2 K12176 COPS2; COP9 signalosome complex subunit 2
D UREG_05670 hypothetical protein K12177 COPS3; COP9 signalosome complex subunit 3
D UREG_02691 similar to COP9 signalosome subunit 4 K12178 COPS4; COP9 signalosome complex subunit 4
D UREG_04805 COP9 signalosome complex subunit 5 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D UREG_04302 hypothetical protein K12179 COPS6; COP9 signalosome complex subunit 6
D UREG_00603 hypothetical protein K12180 COPS7; COP9 signalosome complex subunit 7
D UREG_01513 hypothetical protein K12181 COPS8; COP9 signalosome complex subunit 8
D UREG_06621 COP9 signalosome complex subunit 12 K24364 CSN12; COP9 signalosome complex subunit 12
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 3, 2024