+E Replication protein KO
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DNA Replication Proteins - Xenopus laevis (African clawed frog)
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 398063 orc1.L; origin recognition complex subunit 1 L homeolog K02603 ORC1; origin recognition complex subunit 1
D 394365 orc2.S; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 379084 orc3.S; origin recognition complex subunit 3 S homeolog K02605 ORC3; origin recognition complex subunit 3
D 397923 orc4.L; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 734494 orc5.L; origin recognition complex subunit 5 L homeolog K02607 ORC5; origin recognition complex subunit 5
D 446747 orc6.L; origin recognition complex subunit 6 L homeolog K02608 ORC6; origin recognition complex subunit 6
D 398024 cdt1.L; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 108715404 cdt1.S; DNA replication factor Cdt1-like isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 398082 cdc6.S; cell division cycle 6 S homeolog K02213 CDC6; cell division control protein 6
D 403388 cdc6.L; cell division cycle 6 L homeolog K02213 CDC6; cell division control protein 6
D 380451 mcm2.L; DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 108715875 mcm2.S; DNA replication licensing factor mcm2-like isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 379850 zmcm3.L; zygotic DNA replication licensing factor mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 397821 mcm3.L; maternal DNA replication licensing factor mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 397843 mcm4.L; DNA replication licensing factor mcm4-B K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 373601 mcm4.S; DNA replication licensing factor mcm4-A K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 380587 mcm5.L; DNA replication licensing factor mcm5-A K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 379699 mcm5.S; DNA replication licensing factor mcm5-B K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 380282 mcm6.2.S; zygotic DNA replication licensing factor mcm6-B K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 398071 mcm6.L; maternal DNA replication licensing factor mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 394426 mcm6.2.L; zygotic DNA replication licensing factor mcm6-A K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 108705347 maternal DNA replication licensing factor mcm6-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 397852 mcm7.S; DNA replication licensing factor mcm7-A K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
D 380414 mcm7.L; DNA replication licensing factor mcm7-B K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 397933 ccna2.S; cyclin-A2 K06627 CCNA; cyclin-A
D 447494 ccna1.L; cyclin A1 L homeolog K06627 CCNA; cyclin-A
D 734775 ccna2.L; cyclin A2 L homeolog K06627 CCNA; cyclin-A
D 397885 ccna1.S; cyclin-A1 K06627 CCNA; cyclin-A
D 380219 ccne2.L; cyclin E2 L homeolog K06626 CCNE; G1/S-specific cyclin-E1
D 397840 ccne1.L; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 495419 ccne2.S; uncharacterized protein LOC495419 K06626 CCNE; G1/S-specific cyclin-E1
D 397841 ccne1.S; G1/S-specific cyclin-E3 K06626 CCNE; G1/S-specific cyclin-E1
D 432036 cdk2.L; uncharacterized protein LOC432036 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 399314 cdk2.S; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 398099 cdc7.L; cell division cycle 7 L homeolog K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 398599 dbf4.L; protein DBF4 homolog A K06629 DBF4; protein DBF4
D 398696 dbf4b.L; protein DBF4 homolog B K06629 DBF4; protein DBF4
C GINS complex
D 443928 gins1.S; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 444053 gins2.L; GINS complex subunit 2 (Psf2 homolog) L homeolog K10733 GINS2; GINS complex subunit 2
D 380310 gins3.L; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 414663 gins4.L; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 398573 topbp1.L; DNA topoisomerase II binding protein 1 L homeolog K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 733317 rts; RECQL4-helicase-like protein K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 446991 cdc45.S; cell division cycle 45 S homeolog K06628 CDC45; cell division control protein 45
D 398081 cdc45.L; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 734487 mcm8.L; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 431809 mcm9.L; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 398196 mcm10.L; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 108711083 helb.L; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 444599 cinp.S; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 108698784 cinp.L; cyclin-dependent kinase 2-interacting protein-like K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 431919 mtbp.S; mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 443616 ticrr.L; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 398200 pola1.S; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 446807 pola2.L; polymerase (DNA directed), alpha 2, accessory subunit L homeolog K02321 POLA2; DNA polymerase alpha subunit B
D 380513 prim1.S; DNA primase subunit 1 S homeolog K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 496363 prim2.S; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 394427 pole.L; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 399116 pole2.L; DNA-directed DNA polymerase epsilon 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 407748 pole3.L; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 779084 pole4.L; DNA-directed DNA polymerase epsilon 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 447518 pold1.L; DNA-directed DNA polymerase delta 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 379793 pold2.L; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 398707 pold3.L; DNA-directed DNA polymerase delta 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 397851 polg.L; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 398112 polg2.L; DNA polymerase subunit gamma-2, mitochondrial precursor K02333 POLG2; DNA polymerase gamma 2
D 108702233 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 108708846 rpa1.S; replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 397937 rpa1.L; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 443819 rpa2.L; replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
D 100036853 rpa2.S; replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
D 495401 rpa3.L; replication protein A3 L homeolog K10740 RPA3; replication factor A3
D 446650 rpa3.S; replication protein A3 S homeolog K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 100380972 rfc1.L; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 431883 rfc2.L; replication factor C subunit 2 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 398706 rfc4.L; replication factor C subunit 4 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 108709658 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 380369 rfc5.L; replication factor C subunit 5 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 734626 rfc3.L; replication factor C subunit 3 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 443952 rfc5.S; replication factor C subunit 5 S homeolog K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 414644 rnaseh1.S; ribonuclease H1 S homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 734386 MGC146443.L; uncharacterized protein LOC734386 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 735129 rnaseh1.L; ribonuclease H1 L homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 108717167 MGC146443.S; ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 443655 rnaseh2a.L; ribonuclease H2 subunit A L homeolog K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 496343 rnaseh2b.L; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 108713944 rnaseh2c.L; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 398425 pcna.L; proliferating cell nuclear antigen L homeolog K04802 PCNA; proliferating cell nuclear antigen
D 394328 pcna.S; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 378492 dna2.S; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 394303 fen1.L; flap endonuclease 1-A K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 394311 fen1.S; flap endonuclease 1-B K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 108696916 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 399140 exo1.S; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 108701282 zranb3.L; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 397978 lig1.L; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 108701222 atad5.L; ATPase family AAA domain-containing protein 5 isoform X2 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 399257 dnmt1.L; DNA methyltransferase 1 L homeolog K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100036795 dnmt1.S; DNA methyltransferase 1 S homeolog K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 108718324 DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 108701970 DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 108716062 DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 399373 gmnn.S; geminin, DNA replication inhibitor S homeolog K10749 GMNN; geminin
D 398096 gmnn.L; geminin, DNA replication inhibitor L homeolog K10749 GMNN; geminin
D 108718385 mcidas.L; multicilin-like isoform X1 K26119 MCIDAS; multicilin
D 100158359 mcidas.S; multicilin K26119 MCIDAS; multicilin
D 397742 ccnb1.2.S; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 379888 ccnb1.2.L; cyclin B1 L homeolog K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 398163 ccnb1.S; cyclin B1 S homeolog K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 108718066 ccnb1.L; G2/mitotic-specific cyclin-B1-like K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 397743 ccnb2.S; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 398888 ccnb2.L; uncharacterized protein LOC398888 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 398162 cyclin B5 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 379048 ccnb3.S; cyclin B3 S homeolog K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 779404 ccnb3.L; cyclin B3 L homeolog K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 380246 cdk1.S; cyclin-dependent kinase 1-A K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 379785 cdk1.L; cyclin-dependent kinase 1-B K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 403374 pot1.L; protection of telomeres 1 L homeolog K11109 POT1; protection of telomeres protein 1
E 403376 terf1.L; telomeric repeat binding factor (NIMA-interacting) 1 L homeolog K11110 TERF1; telomeric repeat-binding factor 1
E 734203 terf2.L; telomeric repeat binding factor 2 L homeolog K11111 TERF2; telomeric repeat-binding factor 2
E 108715427 terf2.S; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 779358 tinf2.L; TERF1 (TRF1)-interacting nuclear factor 2 L homeolog K11112 TINF2; TERF1-interacting nuclear factor 2
E 403377 terf2ip.L; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 733156 XB5835883.L; telomere end-binding protein PTOP K11114 ACD; adrenocortical dysplasia protein
E 108720072 uncharacterized protein XB5835883.S isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 108704824 telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 108712475 telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 108715173 membrane-anchored junction protein-like isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 100653506 ctc1.S; CTS telomere maintenance complex component 1 S homeolog K23311 CTC1; CST complex subunit CTC1
E 734784 stn1.S; STN1, CST complex subunit S homeolog K23312 STN1; CST complex subunit STN1
E 100653507 ten1.L; TEN1 CST complex subunit L homeolog K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 108707965 smg6.L; telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 108700391 protein SMG5-like K11125 SMG5; protein SMG5
D 100137701 smg5.L; protein SMG5 K11125 SMG5; protein SMG5
D 373635 tert.L; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 108715203 tep1.L; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 108710196 gar1.L; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 108706707 gar1.S; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 108710993 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 108713221 nhp2.S; H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100049738 nop10.S; NOP10 ribonucleoprotein S homeolog K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 108715140 H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 733436 dkc1.L; H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 373635 tert.L; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 379853 snrpb.S; small nuclear ribonucleoprotein polypeptides B and B1 S homeolog K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 734887 snrpb.L; small nuclear ribonucleoprotein polypeptides B and B1 L homeolog K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 108708738 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 443747 snrpd1.L; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 108720016 snrpd1.S; small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100381103 snrpd2.L; small nuclear ribonucleoprotein D2 polypeptide L homeolog K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 431993 snrpd3.L; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 379046 snrpd3.S; uncharacterized protein LOC379046 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 443996 snrpe.L; small nuclear ribonucleoprotein polypeptide E L homeolog K11097 SNRPE; small nuclear ribonucleoprotein E
E 443926 snrpe.S; small nuclear ribonucleoprotein polypeptide E S homeolog K11097 SNRPE; small nuclear ribonucleoprotein E
E 121393259 small nuclear ribonucleoprotein E-like isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 121393263 small nuclear ribonucleoprotein E-like isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 380595 snrpf.S; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 108711072 snrpf.L; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 779307 snrpg.S; small nuclear ribonucleoprotein polypeptide G S homeolog K11099 SNRPG; small nuclear ribonucleoprotein G
E 108711541 snrpg.L; small nuclear ribonucleoprotein G isoform X1 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 431883 rfc2.L; replication factor C subunit 2 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 398706 rfc4.L; replication factor C subunit 4 L homeolog K10755 RFC2_4; replication factor C subunit 2/4
D 108709658 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 380369 rfc5.L; replication factor C subunit 5 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 734626 rfc3.L; replication factor C subunit 3 L homeolog K10756 RFC3_5; replication factor C subunit 3/5
D 443952 rfc5.S; replication factor C subunit 5 S homeolog K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 394308 mre11.L; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 495064 rad50.L; RAD50 homolog, double strand break repair protein L homeolog K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 108713276 rad50.S; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 403373 nbn.L; nibrin L homeolog K10867 NBN; nibrin
C Other termination factors
D 398148 atm.L; ATM serine/threonine kinase L homeolog K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 398079 wrn.L; Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 373628 blm.S; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 108711520 blm.L; Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 373602 prkdc.L; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 446411 ercc4.L; excision repair cross-complementation group 4 L homeolog K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 397928 parp1.L; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 446370 parp2.S; poly(ADP-ribose) polymerase 2 S homeolog K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 496154 parp3.L; poly(ADP-ribose) polymerase family member 3 L homeolog K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108715186 parp2.L; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108708726 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108708727 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108708728 parp4.1.L; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108709018 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 495279 tnks.S; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100036993 tnks2.S; poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 733328 poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 444795 pinx1.L; PIN2 (TERF1) interacting telomerase inhibitor 1 L homeolog K11135 PINX1; Pin2-interacting protein X1
D 108700952 rtel1.L; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 443621 telo2.L; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 108703490 trir.S; telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 734591 trir.L; uncharacterized protein LOC734591 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 101027299 rif1.S; replication timing regulatory factor 1 S homeolog K11138 RIF1; telomere-associated protein RIF1
D 734585 pif1.L; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108705305 transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 446744 pura.L; purine-rich element binding protein A L homeolog K21772 PURA; transcriptional activator protein Pur-alpha
D 108712237 purg.L; purine-rich element-binding protein gamma isoform X1 K21800 PURG; purine-rich element-binding protein gamma
D 108704646 purg.S; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 108711780 wrap53.L; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 431906 sde2.S; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 108716487 sde2.L; replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
D 398667 rtf2.S; replication termination factor 2 S homeolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 399263 top1.1.L; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108719456 DNA topoisomerase 1 isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 734592 top1.2.S; DNA topoisomerase I, gene 2 S homeolog K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108719958 top2b.S; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100381038 top2b.L; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 398512 top2a.L; DNA topoisomerase II alpha L homeolog K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 398564 top3b.L; DNA topoisomerase III beta L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 444125 top3a.L; DNA topoisomerase III alpha L homeolog K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100037159 ssbp1.S; single-stranded DNA-binding protein 1-B, mitochondrial K03111 ssb; single-strand DNA-binding protein
D 397915 ssbp1.L; single-stranded DNA-binding protein 1-A, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 414644 rnaseh1.S; ribonuclease H1 S homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 734386 MGC146443.L; uncharacterized protein LOC734386 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 735129 rnaseh1.L; ribonuclease H1 L homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 108717167 MGC146443.S; ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 414644 rnaseh1.S; ribonuclease H1 S homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 734386 MGC146443.L; uncharacterized protein LOC734386 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 735129 rnaseh1.L; ribonuclease H1 L homeolog K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 108717167 MGC146443.S; ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 378492 dna2.S; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 394303 fen1.L; flap endonuclease 1-A K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 394311 fen1.S; flap endonuclease 1-B K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108696916 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 397978 lig1.L; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022