+E Replication protein KO
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DNA Replication Proteins - Drosophila melanogaster (fruit fly)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D Dmel_CG10667 Orc1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D Dmel_CG3041 Orc2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D Dmel_CG4088 Orc3; origin recognition complex subunit 3, isoform A K02605 ORC3; origin recognition complex subunit 3
D Dmel_CG2917 Orc4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D Dmel_CG7833 Orc5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D Dmel_CG1584 Orc6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D Dmel_CG8171 dup; double parked, isoform B K10727 CDT1; chromatin licensing and DNA replication factor 1
D Dmel_CG5971 Cdc6; cell division cycle 6 K02213 CDC6; cell division control protein 6
D Dmel_CG7538 Mcm2; minichromosome maintenance 2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D Dmel_CG4206 Mcm3; minichromosome maintenance 3, isoform A K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D Dmel_CG1616 dpa; disc proliferation abnormal, isoform B K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D Dmel_CG4082 Mcm5; minichromosome maintenance 5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D Dmel_CG4039 Mcm6; minichromosome maintenance 6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D Dmel_CG4978 Mcm7; minichromosome maintenance 7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D Dmel_CG5940 CycA; cyclin A, isoform A K06627 CCNA; cyclin-A
D Dmel_CG3938 CycE; cyclin E, isoform A K06626 CCNE; G1/S-specific cyclin-E1
D Dmel_CG10498 Cdk2; Cyclin-dependent kinase 2, isoform C K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D Dmel_CG32742 Cdc7; Cdc7 kinase, isoform B K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D Dmel_CG5790 CG5790; uncharacterized protein, isoform B K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D Dmel_CG9187 Psf1; partner of Sld five 1 K10732 GINS1; GINS complex subunit 1
D Dmel_CG18013 Psf2; partner of Sld five 2, isoform C K10733 GINS2; GINS complex subunit 2
D Dmel_CG2222 Psf3; partner of Sld five 3, isoform B K10734 GINS3; GINS complex subunit 3
D Dmel_CG14549 Sld5; Sld5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D Dmel_CG11156 mus101; mutagen-sensitive 101 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D Dmel_CG7487 RecQ4; RecQ4 helicase K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Dmel_CG3658 Cdc45; cell division cycle 45 K06628 CDC45; cell division control protein 45
D Dmel_CG9241 Mcm10; minichromosome maintenance 10 K10736 MCM10; minichromosome maintenance protein 10
D Dmel_CG34174 CG34174; uncharacterized protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D Dmel_CG6349 PolA1; DNA polymerase alpha subunit 1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D Dmel_CG5923 PolA2; DNA polymerase alpha subunit 2 K02321 POLA2; DNA polymerase alpha subunit B
D Dmel_CG7108 Prim1; DNA primase subunit 1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D Dmel_CG5553 Prim2; DNA primase subunit 2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D Dmel_CG6768 PolE1; DNA polymerase epsilon subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D Dmel_CG10489 PolE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D Dmel_CG13399 Chrac-14; chromatin accessibility complex 14kD protein K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D Dmel_CG11301 PolE4; DNA polymerase epsilon subunit 4, isoform B K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D Dmel_CG5949 PolD1; DNA polymerase delta subunit 1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D Dmel_CG12018 PolD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D Dmel_CG3975 PolD3; DNA polymerase delta subunit 3, isoform B K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D Dmel_CG8987 PolG1; DNA polymerase gamma subunit 1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D Dmel_CG33650 PolG2; DNA polymerase gamma subunit 2 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D Dmel_CG9633 RPA1; replication protein A1 K07466 RFA1; replication factor A1
D Dmel_CG9273 RPA2; replication protein A2, isoform B K10739 RFA2; replication factor A2
D Dmel_CG15220 RPA3; replication protein A3, isoform B K10740 RPA3; replication factor A3
C RFC (replication factor C)
D Dmel_CG1119 Gnf1; germ line transcription factor 1, isoform A K10754 RFC1; replication factor C subunit 1
D Dmel_CG8142 CG8142; uncharacterized protein K10755 RFC2_4; replication factor C subunit 2/4
D Dmel_CG14999 RfC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D Dmel_CG5313 RfC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Dmel_CG6258 RfC38; replication factor C 38kD subunit, isoform B K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D Dmel_CG8729 rnh1; ribonuclease H1, isoform A K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Dmel_CG13690 CG13690; uncharacterized protein K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D Dmel_CG11164 CG11164; uncharacterized protein, isoform B K10744 RNASEH2B; ribonuclease H2 subunit B
D Dmel_CG30105 CG30105; uncharacterized protein K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D Dmel_CG9193 PCNA; proliferating cell nuclear antigen, isoform A K04802 PCNA; proliferating cell nuclear antigen
D Dmel_CG10262 PCNA2; proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
D Dmel_CG2990 Dna2; DNA replication helicase/nuclease 2, isoform C K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D Dmel_CG8648 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Dmel_CG10387 tos; tosca K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D Dmel_CG16838 elg1; enhanced level of genomic instability 1, isoform C K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
D Dmel_CG3183 geminin; geminin, isoform B K10749 GMNN; geminin
D Dmel_CG3510 CycB; cyclin B, isoform A K21770 CCNB2; G2/mitotic-specific cyclin-B2
D Dmel_CG5814 CycB3; cyclin B3, isoform B K21771 CCNB3; G2/mitotic-specific cyclin-B3
D Dmel_CG5363 Cdk1; Cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D Dmel_CG6369 Smg6; Smg6 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D Dmel_CG8954 Smg5; Smg5 nonsense mediated mRNA decay factor, isoform C K11125 SMG5; protein SMG5
D Dyskerin complex
E Dmel_CG4038 Gar1; Gar1 ribonucleoprotein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E Dmel_CG5258 NHP2; NHP2, isoform B K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E Dmel_CG7637 Nop10; Nop10 ribonucleoprotein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E Dmel_CG3333 Nop60B; nucleolar protein at 60B, isoform B K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E Dmel_CG5352 SmB; small ribonucleoprotein particle protein SmB K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E Dmel_CG10753 SmD1; small ribonucleoprotein particle protein SmD1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E Dmel_CG1249 SmD2; small ribonucleoprotein particle protein SmD2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E Dmel_CG8427 SmD3; small ribonucleoprotein particle protein SmD3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E Dmel_CG18591 SmE; small ribonucleoprotein particle protein SmE K11097 SNRPE; small nuclear ribonucleoprotein E
E Dmel_CG16792 SmF; small ribonucleoprotein particle protein SmF K11098 SNRPF; small nuclear ribonucleoprotein F
E Dmel_CG9742 SNRPG; small nuclear ribonucleoprotein G, isoform B K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D Dmel_CG8142 CG8142; uncharacterized protein K10755 RFC2_4; replication factor C subunit 2/4
D Dmel_CG14999 RfC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D Dmel_CG5313 RfC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Dmel_CG6258 RfC38; replication factor C 38kD subunit, isoform B K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D Dmel_CG16928 mre11; meiotic recombination 11 K10865 MRE11; double-strand break repair protein MRE11
D Dmel_CG6339 rad50; rad50, isoform D K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D Dmel_CG6754 nbs; nbs, isoform D K10867 NBN; nibrin
C Other termination factors
D Dmel_CG6535 tefu; telomere fusion K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D Dmel_CG6920 Blm; bloom syndrome helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Dmel_CG3697 mei-9; meiotic 9, isoform B K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D Dmel_CG40411 Parp1; Poly-(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D Dmel_CG4719 Tnks; tankyrase, isoform A K10799 TNKS; tankyrase [EC:2.4.2.30]
D Dmel_CG11180 CG11180; uncharacterized protein, isoform B K11135 PINX1; Pin2-interacting protein X1
D Dmel_CG4078 Rtel1; regulator of telomere elongation helicase 1, isoform B K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D Dmel_CG3238 Pif1; Pif1 DNA helicase, isoform B K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D Dmel_CG1507 Pur-alpha; Purine-rich binding protein-alpha, isoform E K21772 PURA; transcriptional activator protein Pur-alpha
D Dmel_CG9226 WDR79; WD repeat domain 79, isoform C K23314 WRAP53; telomerase Cajal body protein 1
D Dmel_CG5986 CG5986; uncharacterized protein, isoform B K25059 SDE2; replication stress response regulator SDE2
D Dmel_CG6443 CG6443; uncharacterized protein K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C Dmel_CG6146 Top1; topoisomerase 1, isoform C K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C Dmel_CG10223 Top2; topoisomerase 2, isoform B K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C Dmel_CG3458 Top3beta; topoisomerase 3beta, isoform B K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C Dmel_CG10123 Top3alpha; topoisomerase 3alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D Dmel_CG4337 mtSSB; mitochondrial single stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E Dmel_CG8729 rnh1; ribonuclease H1, isoform A K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E Dmel_CG8729 rnh1; ribonuclease H1, isoform A K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E Dmel_CG2990 Dna2; DNA replication helicase/nuclease 2, isoform C K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E Dmel_CG8648 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022