+F Repair protein KO
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DNA Repair and Recombination Proteins - Acanthamoeba castellanii
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D ACA1_071250 DEAD box RNA helicase, putative K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D ACA1_236160 type II CPD DNA photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E ACA1_238440 UracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_182000 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_056950 hypothetical protein K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_157770 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_227080 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_287990 singlestrand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E ACA1_252850 A/Gspecific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E ACA1_288780 base excision DNA repair protein, HhHGPD subfamily protein K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E ACA1_112920 base excision DNA repair protein, HhHGPD subfamily protein K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E ACA1_041990 endonuclease VIII protein, putative K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E ACA1_142260 exodeoxyribonuclease III, putative K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E ACA1_280690 apurinic endonuclease (APN1) subfamily protein K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F ACA1_289040 polymerase (DNA directed), delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F ACA1_289820 DNA polymerase epsilon subunit B protein K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F ACA1_369010 polymerase (DNA directed), epsilon, putative K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F ACA1_097020 DNA polymerase epsilon subunit B protein K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F ACA1_325190 CCAATbox binding transcription factor subunit HAP3-related, putative K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E ACA1_056970 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_369120 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_206010 proliferating cell nuclear antigen, cterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_089310 hypothetical protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E ACA1_155260 XPG Iregion domain containing protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E ACA1_324730 XPG Iregion domain containing protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E ACA1_171710 ligase I, DNA, ATPdependent, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E ACA1_244870 DNA polymerase beta, putative K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E ACA1_374140 BRCA1 C Terminus (BRCT) domain containing protein K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E ACA1_325460 tyrosylDNA phosphodiesterase-related, putative K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E ACA1_270320 histidine triad domain containing protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E ACA1_159200 DNA 3'phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E ACA1_333840 DNA 3'phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E ACA1_170240 DNA 3'phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E ACA1_192970 basic helixloop-helix (bHLH) family protein K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E ACA1_173240 Poly(ADPribose) polymerase catalytic domain containing protein K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E ACA1_181230 Poly(ADPribose) polymerase catalytic domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E ACA1_262210 ubiquitin domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E ACA1_256450 Poly(ADPribose) polymerase catalytic domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E ACA1_272710 Poly(ADPribose) polymerase catalytic domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E ACA1_149970 Poly(ADPribose) polymerase catalytic domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E ACA1_200050 Poly(ADPribose) polymerase catalytic domain containing protein K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F ACA1_061920 Rad23, putative K10839 RAD23; UV excision repair protein RAD23
F ACA1_374320 UBA/TSN domain containing protein K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F ACA1_368020 RINGbox protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F ACA1_069430 cullin 4B, putative K10609 CUL4; cullin 4
F ACA1_323330 cullin family protein K10609 CUL4; cullin 4
E NER4 complex
F ACA1_389620 SNF2 family Nterminal domain containing protein K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F ACA1_158460 DNAdirected RNA polymerase, beta subunit K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F ACA1_291620 DNAdirected RNA polymerase II subunit rpb4, putative K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F ACA1_169330 RNA polymerase Rpb5, Cterminal domain containing protein K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F ACA1_093730 RNA polymerase subunit K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F ACA1_190750 DNAdirected RNA polymerase II subunit RPB7, putative K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F ACA1_365330 hypothetical protein K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F ACA1_116890 DNA-directed RNA polymerase II family protein K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F ACA1_092940 hypothetical protein K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F ACA1_218440 RNA polymerase Rpb3/Rpb11 dimerization domain containing protein K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F ACA1_368020 RINGbox protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F ACA1_069430 cullin 4B, putative K10609 CUL4; cullin 4
F ACA1_323330 cullin family protein K10609 CUL4; cullin 4
F ACA1_300850 CSA protein K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F ACA1_366120 SNF2 family Nterminal domain containing protein K10841 ERCC6; DNA excision repair protein ERCC-6
F ACA1_288640 elongation factor 1, putative K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E ACA1_171520 DNA repair helicase rad25 subfamily protein K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E ACA1_058750 Nucleotide excision repair protein, putative K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E ACA1_391550 Ssl1like protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E ACA1_050620 TFIIH basal transcription factor complex subunit 2, putative K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E ACA1_225900 transcription factor tfb2 subfamily protein K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E ACA1_068690 RNA polymerase II transcription factor B subunit 5, putative K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E ACA1_364240 cyclin, Nterminal domain containing protein K06634 CCNH; cyclin H
E ACA1_278190 CDK-activating kinase assembly factor MAT1 protein K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E ACA1_178740 replication factora protein 1 (rpa1) subfamily protein K07466 RFA1; replication factor A1
E ACA1_011160 replication protein A2 family protein, putative K10739 RFA2; replication factor A2
E ACA1_063630 singlestranded DNA binding protein, putative K10740 RPA3; replication factor A3
D Other NER factors
E ACA1_377430 DNA repair protein rad10 subfamily protein K10849 ERCC1; DNA excision repair protein ERCC-1
E ACA1_171710 ligase I, DNA, ATPdependent, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E ACA1_065940 HEAT repeat domain containing protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
E ACA1_064500 elongation factor SIII p15 subunit, putative K03872 ELOC; elongin-C
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E ACA1_031570 DNA mismatch repair protein msh2, putative K08735 MSH2; DNA mismatch repair protein MSH2
E ACA1_172850 DNA mismatch repair protein msh2, putative K08735 MSH2; DNA mismatch repair protein MSH2
E ACA1_128040 MutS domain V domain containing protein K08736 MSH3; DNA mismatch repair protein MSH3
E ACA1_089000 MutS domain containing protein K08737 MSH6; DNA mismatch repair protein MSH6
E ACA1_340910 MutS domain V domain containing protein K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E ACA1_115690 DNA mismatch repair protein, C-terminal domain containing protein K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E ACA1_289040 polymerase (DNA directed), delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E ACA1_289820 DNA polymerase epsilon subunit B protein K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E ACA1_178740 replication factora protein 1 (rpa1) subfamily protein K07466 RFA1; replication factor A1
E ACA1_011160 replication protein A2 family protein, putative K10739 RFA2; replication factor A2
E ACA1_063630 singlestranded DNA binding protein, putative K10740 RPA3; replication factor A3
D RFC (replication factor C)
E ACA1_109730 replication factor rfc1 c terminal domain containing protein K10754 RFC1; replication factor C subunit 1
E ACA1_040860 DNA replication factor C complex subunit 2, putative K10755 RFC2_4; replication factor C subunit 2/4
E ACA1_252580 Replication factor C protein K10755 RFC2_4; replication factor C subunit 2/4
E ACA1_039460 replication factor C (activator 1) 3, putative K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E ACA1_056970 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_369120 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_206010 proliferating cell nuclear antigen, cterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
E ACA1_173950 XPG Iregion domain containing protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E ACA1_171710 ligase I, DNA, ATPdependent, putative K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E ACA1_064360 DNA repair protein (mre11), putative K10865 MRE11; double-strand break repair protein MRE11
E ACA1_063900 rad50 subfamily protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E ACA1_289970 FHA domain containing protein K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
E ACA1_288660 hypothetical protein K20776 BABAM; BRISC and BRCA1-A complex member 1
E ACA1_197600 BRCA1/BRCA2containing complex subunit 3, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E ACA1_018990 Subunit of DNA polymerase II K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E ACA1_167100 hypothetical protein K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E ACA1_064360 DNA repair protein (mre11), putative K10865 MRE11; double-strand break repair protein MRE11
E ACA1_063900 rad50 subfamily protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E ACA1_289970 FHA domain containing protein K10867 NBN; nibrin
D BRCA complex
E ACA1_110350 BRCA2 repeat-containing protein K08775 BRCA2; breast cancer 2 susceptibility protein
E ACA1_201650 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E ACA1_201650 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
E ACA1_374060 Rad51l1 protein K10869 RAD51L1; RAD51-like protein 1
E ACA1_166930 RAD51, putative K10870 RAD51L2; RAD51-like protein 2
E ACA1_198280 hypothetical protein K10871 RAD51L3; RAD51-like protein 3
E ACA1_368210 DNA repair protein XRCC3, putative K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E ACA1_188580 DNA repair and recombination protein RAD52, putative K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E ACA1_184930 DNA repair and recombination protein RAD54, putative K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E ACA1_051660 DNA repair and recombination protein RAD54B, putative K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E ACA1_331590 ATPdependent DNA helicase, RecQ subfamily protein K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E ACA1_282350 ATPdependent DNA helicase, RecQ subfamily protein K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E ACA1_174470 hypothetical protein K10990 RMI1; RecQ-mediated genome instability protein 1
E ACA1_205950 hypothetical protein K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E ACA1_178740 replication factora protein 1 (rpa1) subfamily protein K07466 RFA1; replication factor A1
E ACA1_011160 replication protein A2 family protein, putative K10739 RFA2; replication factor A2
E ACA1_063630 singlestranded DNA binding protein, putative K10740 RPA3; replication factor A3
D Protein phosphatase 4
E ACA1_251050 Ser/Thr phosphatase family protein K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E ACA1_296330 Serine/threonine protein phosphatase, putative K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E ACA1_177730 protein phosphatase 4 regulatory subunit 1, putative K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E ACA1_264020 hypothetical protein K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E ACA1_071280 adaptor complexes medium subunit family protein K19023 AP5M1; AP-5 complex subunit mu-1
E ACA1_116400 hypothetical protein K19024 AP5S1; AP-5 complex subunit sigma-1
E ACA1_382400 hypothetical protein K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E ACA1_201620 structural maintenance of chromosomes 5 smc5, putative K22803 SMC5; structural maintenance of chromosomes protein 5
E ACA1_198540 RecF/RecN/SMC domain containing protein K22804 SMC6; structural maintenance of chromosomes protein 6
E ACA1_116820 Nse1, component of SMC56 complex, putative K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E ACA1_074900 E3 SUMOprotein ligase NSE2, putative K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E ACA1_263870 MAGE family protein K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E ACA1_370150 Nse4 protein K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E ACA1_246830 ERCC4 domain containing protein K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E ACA1_019640 DSS1/SEM1 family protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E ACA1_208210 GIYYIG catalytic domain containing protein K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E ACA1_022360 hypothetical protein K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E ACA1_089270 chromatin modificationrelated protein eaf3, putative K11339 MORF4L1; mortality factor 4-like protein 1
E ACA1_324740 HD domain containing protein K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E ACA1_113490 hypothetical protein K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E ACA1_131040 ATPase, AAA domain containing protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E ACA1_155470 ATPase, AAA domain containing protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E ACA1_400330 HEAT repeat domain containing protein K23112 BRAT1; BRCA1-associated ATM activator 1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E ACA1_396690 ATPdependent DNA helicase ii, 70 kDa subunit (ku70) superfamily protein K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E ACA1_182790 ATPdependent DNA helicase K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E ACA1_064360 DNA repair protein (mre11), putative K10865 MRE11; double-strand break repair protein MRE11
E ACA1_063900 rad50 subfamily protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E ACA1_296020 DNA repair protein K10886 XRCC4; DNA-repair protein XRCC4
E ACA1_290740 hypothetical protein K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E ACA1_244870 DNA polymerase beta, putative K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E ACA1_270320 histidine triad domain containing protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E ACA1_068120 Endonuclease/Exonuclease/phosphatase family protein K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E ACA1_060660 Endonuclease/Exonuclease/phosphatase family protein K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E ACA1_175470 endonuclease/exonuclease/phosphatase family protein K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E ACA1_024170 jumonji domain containing 8, putative K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E ACA1_070390 Fanconi anemia, complementation group L family protein K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E ACA1_376610 DEAD/DEAH box helicase domain containing protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E ACA1_035580 hypothetical protein K15360 STRA13; centromere protein X
E ACA1_296850 Ubiquitinconjugating enzyme E2 T, putative K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E ACA1_174470 hypothetical protein K10990 RMI1; RecQ-mediated genome instability protein 1
E ACA1_205950 hypothetical protein K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E ACA1_282530 Fanconi anemia, complementation group I, putative K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E ACA1_110350 BRCA2 repeat-containing protein K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E ACA1_276330 VRRNUC domain containing protein K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E ACA1_201650 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
E ACA1_166930 RAD51, putative K10870 RAD51L2; RAD51-like protein 2
E ACA1_030730 Telomere length regulation protein TEL2, putative K11137 TELO2; telomere length regulation protein
C Other DSBR factors
D Protein phosphatase 6
E ACA1_028670 protein phosphatase 6, catalytic subunit isoform a, putative K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E ACA1_232520 SIT4 phosphataseassociated protein K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E ACA1_061740 Sec7 and ankyrin domain containing protein K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E ACA1_071890 FHA domain containing protein K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
D Others
E ACA1_073090 WD domain, G-beta repeat-containing protein K23314 WRAP53; telomerase Cajal body protein 1
E ACA1_288540 WD repeat domain 70, putative K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D ACA1_202440 ImpB/MucB/SamB family protein K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D ACA1_054730 DNA polymerase kappa, putative K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D ACA1_128500 ubiquitinconjugating enzyme E2-17 kDa, putative K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D ACA1_065120 ubiquitinconjugating enzyme, putative K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D ACA1_108810 SNF2 family protein K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D ACA1_067390 SNF2 domain containing protein K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D ACA1_152950 ubiquitin-conjugating enzyme family protein K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D ACA1_321320 ubiquitin-conjugating enzyme, putative K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D ACA1_056970 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
D ACA1_369120 proliferating cell nuclear antigen, Nterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
D ACA1_206010 proliferating cell nuclear antigen, cterminal domain containing protein K04802 PCNA; proliferating cell nuclear antigen
D ACA1_387880 hypothetical protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D ACA1_088870 checkpoint protein hus1, putative K10903 HUS1; HUS1 checkpoint protein
C HRAD17(Rad24)-RFC complex
D ACA1_175040 Rad17 cell cycle checkpoint protein K06662 HRAD17; cell cycle checkpoint protein
D ACA1_040860 DNA replication factor C complex subunit 2, putative K10755 RFC2_4; replication factor C subunit 2/4
D ACA1_252580 Replication factor C protein K10755 RFC2_4; replication factor C subunit 2/4
D ACA1_039460 replication factor C (activator 1) 3, putative K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
D ACA1_030730 Telomere length regulation protein TEL2, putative K11137 TELO2; telomere length regulation protein
D ACA1_061840 hypothetical protein K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D ACA1_010180 DUF410 family protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D ACA1_004200 serine-protein kinase ATR family protein K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D ACA1_061390 FATC domain containing protein K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D ACA1_130960 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_297750 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_073260 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_198710 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_258330 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_121510 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, putative K06630 YWHAE; 14-3-3 protein epsilon
D ACA1_200020 protein kinase domain containing protein K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D ACA1_191880 calponin domain containing protein K17336 PLS3; plastin-3
D ACA1_192000 protein kinase domain containing protein K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D ACA1_071690 vacuolar protein sorting factor 4, putative K12196 VPS4; vacuolar protein-sorting-associated protein 4
D ACA1_392150 ATPase, AAA domain containing protein K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D ACA1_236150 DNA-directed DNA polymerase K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D ACA1_092680 herpesviridae ul52/ul70 dna primase K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D ACA1_199550 DNA cross-link repair protein, putative K15340 DCLRE1A; DNA cross-link repair 1A protein
D ACA1_276360 endonuclease V protein K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D ACA1_169220 SAM domain (Sterile alpha motif) domain containing protein K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D ACA1_138450 S1/P1 Nuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1]
D ACA1_364760 endonuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
C PSO4 complex
D ACA1_289060 hypothetical protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D ACA1_314230 Myblike DNA binding protein, putative K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D ACA1_376220 breast carcinoma amplified sequence 2 (bcas2) protein K12861 BCAS2; pre-mRNA-splicing factor SPF27
D ACA1_400170 WD domain, Gbeta repeat-containing protein K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D ACA1_231550 hydrolase, NUDIX domain containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D ACA1_074590 NUDIX hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D ACA1_131530 hydrolase, NUDIX domain containing protein K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D ACA1_371250 hypothetical protein K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_386510 dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_359770 deoxyuridine 5'triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_105900 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_119180 ribonucleosidediphosphate reductase, alpha subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D ACA1_236160 type II CPD DNA photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E ACA1_238440 UracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_182000 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_056950 hypothetical protein K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_157770 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_227080 uracilDNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ACA1_287990 singlestrand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E ACA1_252850 A/Gspecific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
E ACA1_184680 5'3' exonuclease, SAM domain containing protein K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E ACA1_184680 5'3' exonuclease, SAM domain containing protein K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D ACA1_231550 hydrolase, NUDIX domain containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D ACA1_371250 hypothetical protein K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_386510 dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_359770 deoxyuridine 5'triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ACA1_105900 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024