+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Aquitalea magnusonii</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    DLM_3747 phosphate regulon sensor protein PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    DLM_3748 phosphate regulon transcriptional regulatory protein PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    DLM_1326 two-component system response regulator QseB	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    DLM_3872 osmolarity sensory histidine kinase EnvZ	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    DLM_3871 two-component system response regulator OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    DLM_0022 sensory histidine kinase	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
C    DLM_0023 transcriptional regulatory protein RstA	K07661 rstA; two-component system, OmpR family, response regulator RstA 
B  CpxA-CpxR (envelope stress response)
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
B  BaeS-BaeR (envelope stress response)
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
C    DLM_3449 sensory histidine kinase QseC	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    DLM_3450 two-component system response regulator QseB	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    DLM_1030 osmosensitive K+ channel histidine kinase KdpD	K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 
C    DLM_1029 sensor histidine kinase	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
B  ArcB-ArcA (anoxic redox control)
B  TctE-TctD (tricarboxylic acid transport)
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
C    DLM_3613 sensory histidine kinase	K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3] 
B  AdeS-AdeR
C    DLM_1702 signal transduction histidine kinase	K18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3] 
C    DLM_1701 two-component response regulator	K18144 adeR; two-component system, OmpR family, response regulator AdeR 
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    DLM_2272 copper sensory histidine kinase CpxA	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    DLM_4143 DNA-binding response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    DLM_3612 transcriptional regulatory protein RstA	K02483 K02483; two-component system, OmpR family, response regulator 
C    DLM_2967 response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    DLM_2273 copper-sensing two-component system response regulator CpxR	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
C    DLM_2736 nitrate/nitrite sensor protein	K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] 
C    DLM_2737 nitrate/nitrite response regulator protein	K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL 
C    DLM_1948 proline sensor-regulator PrlR	K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL 
B  NarQ-NarP (nitrate respiration)
B  UhpB-UhpA (hexose phosphates uptake)
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
B  BarA-UvrY (central carbon metabolism)
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    DLM_3422 hybrid sensory histidine kinase	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    DLM_4051 sensory box histidine kinase	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    DLM_2783 DNA-binding response regulator, LuxR family	K07690 evgA; two-component system, NarL family, response regulator EvgA 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
C    DLM_4127 two-component system sensor protein	K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3] 
C    DLM_4268 autolysis response regulator LytR	K08083 algR; two-component system, LytTR family, response regulator AlgR 
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    DLM_3083 nitrogen regulation protein NtrB	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    DLM_3084 nitrogen regulation protein NR(I)	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
C    DLM_4316 nitrogen regulation protein NtrY	K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3] 
C    DLM_4317 nitrogen regulation protein NtrX	K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX 
B  HydH-HydG (metal tolerance)
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
C    DLM_4042 signal transduction histidine kinase	K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] 
C    DLM_4043 type IV fimbriae expression regulatory protein PilR	K02667 pilR; two-component system, NtrC family, response regulator PilR 
B  GlrK-GlrR (amino sugar metabolism)
C    DLM_0594 putative sensor-like histidine kinase YfhK	K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] 
C    DLM_0596 putative sensory histidine kinase YfhA	K07715 glrR; two-component system, NtrC family, response regulator GlrR 
B  PgtB-PgtA (phosphoglycerate transport)
B  DctB-DctD (C4-dicarboxylate transport)
C    DLM_1933 signal transduction histidine kinase regulating C4-dicarboxylate transport system	K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] 
B  KinB-AlgB (alginate production)
B  HupT-HupR (hydrogenase synthesis regulation)
C    DLM_2355 signal transduction histidine kinase HoxJ	K19661 hupT; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3] 
C    DLM_2346 hydrogenase transcriptional regulatory protein HoxA	K19641 hupR; two-component system, NtrC family, response regulator HupR/HoxA 
B  Unclassified
C    DLM_0247 two-component sensor histidine kinase protein	K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] 
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    DLM_0211 signal transduction histidine kinase CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    DLM_1238 signal transduction histidine kinase CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    DLM_2890 signal transduction histidine kinase CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    DLM_2899 signal transduction histidine kinase CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    DLM_0938 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_2024 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_0213 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_1237 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_1240 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_2891 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_2897 chemotaxis regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    DLM_0966 chemotaxis response regulator protein-glutamate methylesterase CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    DLM_0206 chemotaxis response regulator protein-glutamate methylesterase CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    DLM_1234 chemotaxis response regulator protein-glutamate methylesterase CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    DLM_2886 chemotaxis response regulator protein-glutamate methylesterase CheB	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    DLM_2181 chemotaxis protein methyltransferase CheR	K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] 
C    DLM_0939 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    DLM_0940 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    DLM_2895 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    DLM_2896 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
C    DLM_2711 sensory box histidine kinase	K11443 divK; two-component system, cell cycle response regulator DivK 
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
C    DLM_3628 C4-dicarboxylate transport sensor protein dctS	K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3] 
B  TtrS-TtrR (tetrathionate respiration)
C    DLM_3627 response regulator	K13041 ttrR; two-component system, LuxR family, response regulator TtrR 
B  FixL-FixJ (nitrogen fixation)
C    DLM_0855 probable two-component transmembrane sensor histidine kinase transcription regulator protein	K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] 
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
C    DLM_2894 flagellar sensor histidine kinase FleS	K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] 
C    DLM_0967 flagellar regulatory protein FleQ	K10943 flrC; two-component system, response regulator FlrC 
B  AauS-AauR (acidic amino acids utilization)
C    DLM_0140 signal transduction histidine kinase regulating C4-dicarboxylate transport system	K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] 
C    DLM_0139 two component central transcriptional regulator of acidic amino acid uptake	K17061 aauR; two-component system, response regulator AauR 
C    DLM_1932 C4-dicarboxylate transport transcriptional regulatory protein	K17061 aauR; two-component system, response regulator AauR 
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
C    DLM_2713 response regulator	K13815 rpfG; two-component system, response regulator RpfG 
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
C    DLM_3447 sensor histidine kinase PrrB	K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] 
C    DLM_3446 DNA binding response regulator PrrA	K15012 regA; two-component system, response regulator RegA 
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
C    DLM_3864 sensory box histidine kinase	K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] 
C    DLM_2380 sensory box histidine kinase	K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3] 
C    DLM_1947 two-component hybrid sensor and regulator	K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3] 
C    DLM_2926 probable two-component response regulator	K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator 
B  PdtaS-PdtaR
B  NasS-NasT
C    DLM_1926 nitrate ABC transporter, nitrate-binding protein	K22067 nasS; two-component system, oxyanion-binding sensor 
C    DLM_1927 response regulator NasT	K07183 nasT; two-component system, response regulator / RNA-binding antiterminator 
B  Unclassified
C    DLM_1325 phosphate regulon sensor protein PhoR	K20971 ladS; two-component system, sensor histidine kinase LadS 
C    DLM_1836 sensory box histidine kinase/response regulator	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    DLM_2210 multi-sensor hybrid histidine kinase	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
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#Last updated: December 14, 2023