+F Repair protein KO
#
DNA Repair and Recombination Proteins - Anas platyrhynchos (mallard)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101797041 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 119718593 ALKBH2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 101803990 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 101802733 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 101799833 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 119718511 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 113840356 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101802890 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 101800009 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 101805011 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 113845027 OGG1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 101797968 NEIL1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 101796576 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 101796632 NEIL3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 101805159 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
F 119715226 POLD2; LOW QUALITY PROTEIN: DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 101797382 POLD3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 101790280 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 113845344 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 101805197 POLE2; DNA polymerase epsilon subunit 2 isoform X2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 101797381 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 113845596 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 119713445 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 101804902 FEN1; LOW QUALITY PROTEIN: flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101796914 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 101792343 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 101797881 LIG3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 101791881 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 101792244 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101790043 APLF; aprataxin and PNK-like factor isoform X2 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101797353 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 101796177 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101792302 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 101795446 PARP4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 113845099 PARP3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 101796054 XPC; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 101794851 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 101794531 centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 101796040 RBX1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101795785 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 101797069 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 101793052 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 101791096 DDB2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 119715428 POLR2A; LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 101792149 POLR2B; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 101795720 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 101793499 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 113845648 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 101804077 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 119717722 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 101794932 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 101795435 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 101791485 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 101796040 RBX1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 101795785 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 101797069 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 101793052 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 101795558 ERCC8; DNA excision repair protein ERCC-8 isoform X5 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 101791363 ERCC6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 101790279 UVSSA; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
D TFIIH complex
E 101799920 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 101798703 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 101792131 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 101799969 GTF2H3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 101801404 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 101801428 CDK7; cyclin-dependent kinase 7 isoform X3 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 101791436 CCNH; cyclin-H K06634 CCNH; cyclin H
E 101791525 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X2 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 101799316 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 101794627 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 101797991 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 101791272 XPA; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 101794451 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 101799732 DNA repair protein complementing XP-G cells isoform X3 K10846 ERCC5; DNA excision repair protein ERCC-5
E 101796914 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 119717293 MMS19; LOW QUALITY PROTEIN: MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 101793545 CUL3; cullin-3 K03869 CUL3; cullin 3
E 101790105 CUL5; cullin-5 K10612 CUL5; cullin 5
E 101790533 ELOC; elongin-C K03872 ELOC; elongin-C
E 101799581 elongin-A isoform X1 K15076 ELOA; elongin-A
E 119713645 ELOA; LOW QUALITY PROTEIN: elongin-A K15076 ELOA; elongin-A
E 101796405 UBAP2L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 101805008 UBAP2; ubiquitin-associated protein 2 isoform X4 K26545 UBAP2; ubiquitin-associated protein 2
E 101790407 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 101802532 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 101797839 MSH3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 101799348 MSH6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 101799905 PMS1; PMS1 protein homolog 1 isoform X2 K10864 PMS1; DNA mismatch repair protein PMS1
E 101789748 MLH1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 101803003 PMS2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 101792234 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 119715226 POLD2; LOW QUALITY PROTEIN: DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 101797382 POLD3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 101799316 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 101794627 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 101797991 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 101791622 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 101790369 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 101798395 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 101794103 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 101798240 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 119713445 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 101793164 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 101797353 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 101796914 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 101790260 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 101802731 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 101800129 RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 101802208 NBN; LOW QUALITY PROTEIN: nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101800768 BARD1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101798365 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X3 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 101804226 UIMC1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 113845646 BABAM1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 101793627 BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 101800040 BRCC3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101791710 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101804079 TOPBP1; LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101798964 RBBP8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 101802731 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 101800129 RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 101802208 NBN; LOW QUALITY PROTEIN: nibrin K10867 NBN; nibrin
D BRCA complex
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101799101 BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 101799925 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 101800716 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 101800716 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 101793904 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 101795896 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 101790122 RAD51D; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 101796468 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 101799145 XRCC3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 101791025 RAD52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 113840018 RDM1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 101797498 RAD54L; DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 101803849 RAD54L2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 101793436 RAD54B; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 101799196 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 101803062 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 101790058 BLM; LOW QUALITY PROTEIN: Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101804253 RECQL5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 101790058 BLM; LOW QUALITY PROTEIN: Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101790026 TOP3A; LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101800122 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 119714368 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113845236 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 101799316 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 101794627 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 101797991 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 101790264 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101805171 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 101793672 PPP4R2; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 101795592 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101798998 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101803179 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 101794872 AP5M1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 101789663 AP5Z1; LOW QUALITY PROTEIN: AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 101798439 SMC5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 101800359 SMC6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 101794654 LRATD1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 101796032 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 101801975 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 101795597 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 101797587 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 101789384 SLF2; LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 101801007 EME1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 101795979 EXD2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 101792721 SWI5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 101796472 SFR1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 101802092 SLX4; LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 101800161 GEN1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 101791024 SPG11; LOW QUALITY PROTEIN: spatacsin K19026 SPG11; spatacsin
E 101796378 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 101803682 RAD51AP1; RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 101803020 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 101800495 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 101796315 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 101804608 SPIDR; LOW QUALITY PROTEIN: DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 101801776 LRATD2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 101805396 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 101799885 CFAP410; cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 101799703 HDGFL2; hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 101800775 ZSWIM7; zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 101797437 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X10 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 101791355 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 101803774 MMS22L; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 101804555 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 101794139 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
E 119717126 PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 101794332 XRCC6; LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 101797870 XRCC5; X-ray repair cross-complementing protein 5 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 101804792 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 101802731 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 101800129 RAD50; LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 101804830 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 101796738 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 101791223 NHEJ1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 101796177 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 101802023 DNTT; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 101792343 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 101792244 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101790043 APLF; aprataxin and PNK-like factor isoform X2 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101795806 DCLRE1C; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 101805471 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 101800540 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 101804755 PWWP3A; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 101802290 PAXX; protein PAXX isoform X6 K25772 PAXX; protein PAXX
E 113845295 JMJD8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 101795336 SHLD1; shieldin complex subunit 1 isoform X1 K26128 SHLD1; shieldin complex subunit 1
E 101795863 SHLD2; shieldin complex subunit 2 isoform X2 K26129 SHLD2; shieldin complex subunit 2
E 106017265 SHLD3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 101798613 FANCA; LOW QUALITY PROTEIN: Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 101792108 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 101802801 FANCC; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 101790431 FANCE; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 101801598 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 101802479 FANCG; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 101801202 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 101804655 FANCM; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 101802863 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 113845540 FAAP100; LOW QUALITY PROTEIN: Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 101792654 HES4; LOW QUALITY PROTEIN: transcription factor HES-4 K06054 HES1; hairy and enhancer of split 1
E 113844479 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 101801085 CENPS; LOW QUALITY PROTEIN: centromere protein S K11511 APITD1; centromere protein S
E 106014564 CENPX; centromere protein X K15360 STRA13; centromere protein X
E 101801407 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 101790058 BLM; LOW QUALITY PROTEIN: Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 101790026 TOP3A; LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 101800122 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 119714368 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113845236 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 101799377 FANCD2; LOW QUALITY PROTEIN: Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 101792078 FANCI; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 101789679 BRCA1; breast cancer type 1 susceptibility protein isoform X3 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101799101 BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 101791710 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 101799925 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 101790167 FAN1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 101800716 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 101795896 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 101802123 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 101791738 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 101799605 WDR48; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 101789972 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 101799955 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 101798021 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 101798140 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 101798999 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 119714630 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 101804196 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 101793852 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 101798950 RNF169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 101796116 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 101792008 TPRN; taperin isoform X1 K24164 TPRN; taperin
E 101803320 WDR70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 101790260 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 101793822 POLH; LOW QUALITY PROTEIN: DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 101791971 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 101805175 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 101791707 REV1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 101796249 REV3L; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 101805384 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 101799305 UBE2A; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 101803032 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X2 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 101795815 RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 101803740 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 101789636 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 119713445 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101794139 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 119717126 PCNA-interacting partner-like isoform X1 K27412 PARPBP; PCNA-interacting partner
D 101793115 SPRTN; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 101796872 GCNA; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 119717224 RAD9A; LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 119718480 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 101797233 HUS1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 101801319 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 101790901 RAD17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 101790369 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101798395 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 101794103 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101798240 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 101801319 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 119714616 TIMELESS; LOW QUALITY PROTEIN: protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 101790855 TIPIN; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 101802961 CLSPN; LOW QUALITY PROTEIN: claspin K25773 CLSPN; claspin
C Triple T complex
D 101802123 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 101800958 TTI1; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 101789418 TTI2; TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 101791412 GET4; Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 101799646 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 101795925 ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 101803327 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 101790669 CHEK1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 119718547 CHEK2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 101800901 CDC25A; LOW QUALITY PROTEIN: M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 101794264 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101795960 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101804502 YWHAQ; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 101804428 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 110353990 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 101794386 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 101799595 NAV2; neuron navigator 2 isoform X3 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 101801524 WEE2; wee1-like protein kinase 2 isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101801701 WEE1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 101801476 PER2; period circadian protein homolog 2 isoform X2 K02633 PER2; period circadian protein 2
D 101795351 PER3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 101791530 PLS3; plastin-3 K17336 PLS3; plastin-3
D 119718061 AEN; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 101797863 PLK3; serine/threonine-protein kinase PLK3 isoform X1 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 101797316 NEK4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101804085 NEK1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101795060 NEK5; serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101804905 NEK10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 101801421 NEK11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 101802090 DONSON; LOW QUALITY PROTEIN: protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 101791933 KANK4; KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101796394 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101795756 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101793010 CHMP4C; charged multivesicular body protein 4c isoform X1 K24782 CHMP4C; charged multivesicular body protein 4C
D 119715931 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 119718130 VPS4A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101804907 ZFYVE19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 101791713 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 101800811 POLQ; LOW QUALITY PROTEIN: DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 101789790 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 101789508 PRIMPOL; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 101799355 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 106014610 DCLRE1B; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 101799113 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
C Helicases
D 101797996 HELQ; helicase POLQ-like isoform X4 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 101797239 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 101797655 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 101790788 CDC5L; cell division cycle 5-like protein isoform X1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 101804917 BCAS2; pre-mRNA-splicing factor SPF27 isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 101793296 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 106018266 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101796502 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 101798193 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101796445 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 119716811 LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 101794665 RRM2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 101798489 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 101797041 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 101799833 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 119718511 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 101800009 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 101805011 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 101805159 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 101801333 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 101801333 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 106018266 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101798193 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024