+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Brachybacterium faecium</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
B  SenX3-RegX3 (phosphate starvation response)
C    Bfae_09300 histidine kinase	K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3] 
C    Bfae_09290 response regulator with CheY-like receiver domain and winged-helix DNA-binding domain	K07776 regX3; two-component system, OmpR family, response regulator RegX3 
B  PhoQ-PhoP (magnesium transport)
B  EnvZ-OmpR (osmotic stress response)
B  RstB-RstA
B  CpxA-CpxR (envelope stress response)
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
B  BaeS-BaeR (envelope stress response)
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
B  KdpD-KdpE (potassium transport)
B  TorS-TorR (TMAO respiration)
B  ArcB-ArcA (anoxic redox control)
B  TctE-TctD (tricarboxylic acid transport)
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
C    Bfae_20640 signal transduction histidine kinase	K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3] 
C    Bfae_20650 response regulator with CheY-like receiver domain and winged-helix DNA-binding domain	K07670 mtrA; two-component system, OmpR family, response regulator MtrA 
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    Bfae_07900 signal transduction histidine kinase	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    Bfae_02950 signal transduction histidine kinase	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    Bfae_07910 response regulator with CheY-like receiver domain and winged-helix DNA-binding domain	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
B  NarQ-NarP (nitrate respiration)
B  UhpB-UhpA (hexose phosphates uptake)
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
B  BarA-UvrY (central carbon metabolism)
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
C    Bfae_06330 signal transduction histidine kinase	K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3] 
C    Bfae_03390 signal transduction histidine kinase	K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3] 
C    Bfae_06340 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	K07693 desR; two-component system, NarL family, response regulator DesR 
C    Bfae_03380 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	K07693 desR; two-component system, NarL family, response regulator DesR 
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
C    Bfae_18330 histidine kinase	K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3] 
C    Bfae_18340 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	K07695 devR; two-component system, NarL family, response regulator DevR 
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
B  GlrK-GlrR (amino sugar metabolism)
B  PgtB-PgtA (phosphoglycerate transport)
B  DctB-DctD (C4-dicarboxylate transport)
B  KinB-AlgB (alginate production)
C    Bfae_27560 signal transduction histidine kinase	K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] 
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
B  AauS-AauR (acidic amino acids utilization)
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
B  PdtaS-PdtaR
C    Bfae_20510 signal transduction histidine kinase	K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3] 
C    Bfae_14950 response regulator with putative antiterminator output domain	K22010 pdtaR; two-component system, response regulator PdtaR 
B  NasS-NasT
B  Unclassified
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#Last updated: December 14, 2023