+E Replication protein KO
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DNA Replication Proteins - Bos indicus (zebu cattle)
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 109556298 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 109569368 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 109563917 ORC3; origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 109575340 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 109557363 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 109572565 ORC6; origin recognition complex subunit 6 isoform X1 K02608 ORC6; origin recognition complex subunit 6
D 109571636 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 109574553 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 109575919 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 109577345 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 109568210 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 109559494 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 109568195 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 109578367 MCM7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 109560207 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 109566776 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 109568476 CCNE2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 109572914 CCNE1; G1/S-specific cyclin-E1 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 109559386 CDK2; cyclin-dependent kinase 2 isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 109556066 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 109557310 DBF4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 109574092 DBF4B; protein DBF4 homolog B K06629 DBF4; protein DBF4
C GINS complex
D 109567225 GINS1; DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 109572205 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 109572966 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 109553571 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 109568350 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 109571082 CDC45; cell division control protein 45 homolog isoform X1 K06628 CDC45; cell division control protein 45
D 109568129 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 109563779 MCM9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 109567955 MCM10; protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 109559256 HELB; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 109575326 CINP; cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 109568535 MTBP; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 109575738 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 109555246 POLA1; DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 109554618 POLA2; DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 109559346 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
C DNA polymerase epsilon complex
D 109571514 POLE; LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 109565008 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 109563372 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 109571789 POLD1; LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 109557546 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 109569833 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 109554415 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 109575478 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 109573511 POLG2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 109574055 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 109579062 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 109572997 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
D 109558244 RPA3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
D 109555161 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 109560017 RFC1; LOW QUALITY PROTEIN: replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 109557043 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 109578744 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 109566786 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 109571119 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 109563421 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 109561536 RNASEH2A; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 109566738 RNASEH2B; ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 109554536 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 109568119 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 109553883 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 109554620 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 109570086 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 109575391 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 109572798 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 109574265 ATAD5; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 109561577 DNMT1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 109566324 DNMT3A; DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 109567360 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 109577381 GMNN; geminin K10749 GMNN; geminin
D 109575025 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 109565083 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 109553919 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 109557589 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 109571986 TERF2; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 109564770 TINF2; TERF1-interacting nuclear factor 2 isoform X1 K11112 TINF2; TERF1-interacting nuclear factor 2
E 109572145 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 109572616 ACD; adrenocortical dysplasia protein homolog isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 109573019 TERB1; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 109564438 TERB2; LOW QUALITY PROTEIN: telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 109554216 MAJIN; membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 109574208 CTC1; CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 109573641 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 109573618 SMG6; telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 109553279 SMG5; protein SMG5 K11125 SMG5; protein SMG5
D 109575079 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 109564880 TEP1; telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 109560252 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 109561920 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 109564893 NOP10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
C Telomerase complex (fungi)
D 109575079 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 109567218 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 109571929 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 109577851 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 109572962 SNRPD2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 109570700 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 109566092 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 109559404 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 109574461 small nuclear ribonucleoprotein F-like K11098 SNRPF; small nuclear ribonucleoprotein F
E 109573745 small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 109566251 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 109557043 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 109578744 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 109566786 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 109571119 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 109569697 MRE11; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
D 109568506 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 109569718 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 109553502 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 109575643 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 109568449 PRKDC; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 109578663 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 109570525 PARP1; poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 109564883 PARP2; LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 109575871 PARP3; LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 109567055 PARP4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 109553434 TNKS; tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 109578977 TNKS2; tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 109562788 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 109567242 RTEL1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 109578452 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 109561542 C7H19orf43; uncharacterized protein C19orf43 homolog isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 109567799 RIF1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 109564349 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 109564350 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 109562089 PURA; LOW QUALITY PROTEIN: transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 109553536 PURG; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 109574318 WRAP53; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 109570635 SDE2; protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 109567310 RTFDC1; protein RTF2 homolog isoform X1 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 109567452 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 109553359 DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 109553408 DNA topoisomerase 2-beta-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 109574397 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 109571394 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 109573577 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 109557704 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 109563421 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 109563421 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 109553883 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 109554620 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 109572798 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022