+D Chaperone KO
#
Chaperones and Folding Catalysts - Caenorhabditis elegans (nematode)
%
!
AHeat shock proteins
B HSP110
C CELE_C30C11.4 hsp-110; Heat shock protein 110 K09485 HSP110; heat shock protein 110kDa
C CELE_T24H7.2 T24H7.2; Hypoxia up-regulated protein 1 K09486 HYOU1; hypoxia up-regulated 1
C CELE_T14G8.3 T14G8.3; Hypoxia up-regulated protein 1 K09486 HYOU1; hypoxia up-regulated 1
B HSP100
C CELE_D2030.2 D2030.2; ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
C CELE_K07A3.3 K07A3.3; ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
B HSP90
C CELE_C47E8.5 hsp-90; Heat shock protein 90 K04079 HSP90A; molecular chaperone HtpG
C CELE_T05E11.3 enpl-1; Endoplasmin homolog K09487 HSP90B; heat shock protein 90kDa beta
C CELE_R151.7 hsp-75; Histidine kinase/HSP90-like ATPase domain-containing protein K09488 TRAP1; TNF receptor-associated protein 1
B HSP70 / DNAK
C CELE_F26D10.3 hsp-1; Heat shock protein hsp-1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C CELE_F44E5.4 F44E5.4; Heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C CELE_C12C8.1 hsp-70; Heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C CELE_F44E5.5 F44E5.5; Heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C CELE_F11F1.1 F11F1.1; DUF148 domain-containing protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C CELE_C15H9.6 hsp-3; Heat shock 70 kDa protein C K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C CELE_F43E2.8 hsp-4; Endoplasmic reticulum chaperone BiP homolog K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C CELE_F54C9.2 stc-1; Heat shock 70 kDa protein 13 K09491 STCH; stress 70 protein chaperone microsome-associated 60kDa protein
C CELE_C37H5.8 hsp-6; Heat shock protein hsp-6 K04043 dnaK; molecular chaperone DnaK
B HSP60 / Chaperonin
C CELE_T05C12.7 cct-1; T-complex protein 1 subunit alpha K09493 CCT1; T-complex protein 1 subunit alpha
C CELE_T21B10.7 cct-2; T-complex protein 1 subunit beta K09494 CCT2; T-complex protein 1 subunit beta
C CELE_F54A3.3 cct-3; T-complex protein 1 subunit gamma K09495 CCT3; T-complex protein 1 subunit gamma
C CELE_K01C8.10 cct-4; T-complex protein 1 subunit delta K09496 CCT4; T-complex protein 1 subunit delta
C CELE_C07G2.3 cct-5; T-complex protein 1 subunit epsilon K09497 CCT5; T-complex protein 1 subunit epsilon
C CELE_F01F1.8 cct-6; T-complex protein 1 subunit zeta K09498 CCT6; T-complex protein 1 subunit zeta
C CELE_T10B5.5 cct-7; T-complex protein 1 subunit eta K09499 CCT7; T-complex protein 1 subunit eta
C CELE_Y55F3AR.3 cct-8; T-complex protein 1 subunit theta K09500 CCT8; T-complex protein 1 subunit theta
C CELE_Y22D7AL.5 hsp-60; Chaperonin homolog Hsp-60, mitochondrial K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B HSP47
B HSP40 / DNAJ
C CELE_F39B2.10 dnj-12; DNaJ domain (prokaryotic heat shock protein) K09502 DNAJA1; DnaJ homolog subfamily A member 1
C CELE_T05C3.5 dnj-19; DNaJ domain (prokaryotic heat shock protein) K09503 DNAJA2; DnaJ homolog subfamily A member 2
C CELE_F22B7.5 dnj-10; DnaJ homolog dnj-10 K09504 DNAJA3; DnaJ homolog subfamily A member 3
C CELE_T03F6.2 dnj-17; J domain-containing protein K09506 DNAJA5; DnaJ homolog subfamily A member 5
C CELE_F54D5.8 dnj-13; J domain-containing protein K09511 DNAJB5; DnaJ homolog subfamily B member 5
C CELE_W03A5.7 dnj-24; J domain-containing protein K09512 DNAJB6; DnaJ homolog subfamily B member 6
C CELE_T15H9.7 dnj-20; DnaJ homolog dnj-20 K09517 DNAJB11; DnaJ homolog subfamily B member 11
C CELE_B0035.14 dnj-1; DnaJ homolog subfamily B member 1 K09518 DNAJB12; DnaJ homolog subfamily B member 12
C CELE_F54F2.9 F54F2.9; Uncharacterized protein K09521 DNAJC1; DnaJ homolog subfamily C member 1
C CELE_F38A5.13 dnj-11; DnaJ homolog subfamily C member 2 K09522 DNAJC2; DnaJ homolog subfamily C member 2
C CELE_C55B6.2 dnj-7; J domain-containing protein K09523 DNAJC3; DnaJ homolog subfamily C member 3
C CELE_Y54E10BL.4 dnj-28; J domain-containing protein K09523 DNAJC3; DnaJ homolog subfamily C member 3
C CELE_C01G8.4 dnj-4; J domain-containing protein K09524 DNAJC4; DnaJ homolog subfamily C member 4
C CELE_K02G10.8 dnj-14; J domain-containing protein K09525 DNAJC5; DnaJ homolog subfamily C member 5
C CELE_Y71F9B.16 dnj-30; J domain-containing protein K09528 DNAJC8; DnaJ homolog subfamily C member 8
C CELE_T24H10.3 dnj-23; J domain-containing protein K09529 DNAJC9; DnaJ homolog subfamily C member 9
C CELE_Y47H9C.5 dnj-27; DnaJ homolog subfamily C member 10 K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
C CELE_F11G11.7 dnj-9; J domain-containing protein K09531 DNAJC11; DnaJ homolog subfamily C member 11
C CELE_K07F5.16 K07F5.16; J domain-containing protein K09532 DNAJC12; DnaJ homolog subfamily C member 12
C CELE_F18C12.2 rme-8; J domain-containing protein K09533 DNAJC13; DnaJ homolog subfamily C member 13
C CELE_C04A2.7 dnj-5; DnaJ homolog dnj-5 K09534 DNAJC14; DnaJ homolog subfamily C member 14
C CELE_C56C10.13 dnj-8; DnaJ homolog subfamily C member 16 K09536 DNAJC16; DnaJ homolog subfamily C member 16
C CELE_T23B12.7 dnj-22; J domain-containing protein K09537 DNAJC17; DnaJ homolog subfamily C member 17
C CELE_T19B4.4 dnj-21; Mitochondrial import inner membrane translocase subunit TIM14 K09539 DNAJC19; DnaJ homolog subfamily C member 19
C CELE_Y63D3A.6 dnj-29; J domain-containing protein K09540 SEC63; translocation protein SEC63
C CELE_B0035.2 dnj-2; DnaJ homolog dnj-2 K19371 DNAJC25; DnaJ homolog subfamily C member 25
C CELE_K08D10.2 dnj-15; J domain-containing protein K04082 hscB; molecular chaperone HscB
B HSP33
B HSP24
C CELE_C34C12.8 C34C12.8; GrpE protein homolog, mitochondrial K03687 GRPE; molecular chaperone GrpE
B HSP20
B HSP15
B HSP10
C CELE_Y22D7AL.10 Y22D7AL.10; 10 kDa heat shock protein, mitochondrial K04078 groES; chaperonin GroES
B GimC
C CELE_C08F8.1 pfd-1; putative prefoldin subunit 1 K09548 PFDN1; prefoldin subunit 1
C CELE_H20J04.5 pfd-2; Prefoldin subunit 2 K09549 PFDN2; prefoldin subunit 2
C CELE_B0035.4 pfd-4; putative prefoldin subunit 4 K09550 PFDN4; prefoldin subunit 4
C CELE_R151.9 pfd-5; putative prefoldin subunit 5 K04797 pfdA; prefoldin alpha subunit
C CELE_F21C3.5 pfd-6; putative prefoldin subunit 6 K04798 pfdB; prefoldin beta subunit
#
AOther chaperones and cochaperones
B Calnexin / calreticulin
C CELE_ZK632.6 cnx-1; Calnexin K08054 CANX; calnexin
C CELE_Y38A10A.5 crt-1; Calreticulin K08057 CALR; calreticulin
B DegP / HtrA
B AAA proteases
C CELE_Y38F2AR.7 ppgn-1; AAA+ ATPase domain-containing protein K09552 SPG7; spastic paraplegia 7 [EC:3.4.24.-]
C CELE_Y47G6A.10 spg-7; AFG3-like protein spg-7 K08956 AFG3; AFG3 family protein [EC:3.4.24.-]
B PapD
B SecB
B Sti1 / p60
C CELE_R09E12.3 sti-1; Stress-induced-phosphoprotein 1 K09553 STIP1; stress-induced-phosphoprotein 1
B Cdc37 / p50
C CELE_W08F4.8 cdc-37; Hsp90 chaperone protein kinase-targeting subunit K09554 CDC37; cell division cycle protein 37
B BAG
C CELE_F57B10.11 bag-1; BAG family molecular chaperone regulator 1 K09555 BAG1; BCL2-associated athanogene 1
C CELE_H14N18.1 unc-23; BAG domain-containing protein K09556 BAG2; BCL2-associated athanogene 2
B Others
C CELE_T12D8.8 hip-1; STI1 domain-containing protein K09560 ST13; suppressor of tumorigenicity protein 13
C CELE_T09B4.10 chn-1; U-box domain-containing protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C CELE_F42A6.6 F42A6.6; Hikeshi-like domain-containing protein K23327 HIKESHI; protein Hikeshi
C CELE_Y110A7A.13 chp-1; Cysteine and histidine-rich domain-containing protein 1 K16729 CHORDC1; cysteine and histidine-rich domain-containing protein
C CELE_Y73F8A.26 Y73F8A.26; Uncharacterized protein K19606 CRTAP; cartilage-associated protein
C CELE_F30H5.1 unc-45; UNC-45/Cro1/She4 central domain-containing protein K21991 UNC45; protein unc-45
C CELE_C11H1.7 C11H1.7; DUF3456 domain-containing protein K22816 CNPY3_4; protein canopy 3/4
C CELE_C18E9.11 ooc-5; Torsin-like protein K22990 TOR1; torsin-1
C CELE_C44B12.2 ost-1; SPARC K24262 SPARC; secreted protein acidic and rich in cysteine
C CELE_R05F9.10 sgt-1; SGTA homodimerization domain-containing protein K16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha
C CELE_C34B2.5 ttc-1; TPR_REGION domain-containing protein K24926 TTC1; tetratricopeptide repeat protein 1
C CELE_C17G10.2 ttc-4; Cns1/TTC4 wheel domain-containing protein K24927 TTC4; tetratricopeptide repeat protein 4
C CELE_ZK1058.4 ccdc-47; PAT complex subunit CCDC47 K24962 CCDC47; PAT complex subunit CCDC47
C CELE_K10B2.4 K10B2.4; Protein Asterix K24963 WDR83OS; PAT complex subunit Asterix
C CELE_F09E5.17 bmy-1; Boca/MESD chaperone for YWTD beta-propeller-EGF K25366 MESD; LRP chaperone MESD
C CELE_T14A8.1 ric-3; Resistance to inhibitors of cholinesterase protein 3 K26164 RIC3; protein RIC-3
C CELE_C01G10.8 ahsa-1; Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein K26216 AHSA1; activator of Hsp90 ATPase protein 1
#
AIntramolecular chaperones
B Subtilisin family
C CELE_F11A6.1 kpc-1; Furin-like protease kpc-1 K01349 FURIN; furin [EC:3.4.21.75]
C CELE_C51E3.7 egl-3; Neuroendocrine convertase 2 K01360 PCSK2; proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
C CELE_F21H12.6 tpp-2; Tripeptidyl-peptidase 2 K01280 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10]
B Papain family
C CELE_C52E4.1 cpr-1; Gut-specific cysteine proteinase K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_T10H4.12 cpr-3; Cathepsin B-like cysteine proteinase 3 K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_F44C4.3 cpr-4; Cathepsin B-like cysteine proteinase 4 K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_F32H5.1 F32H5.1; Peptidase C1A papain C-terminal domain-containing protein K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_W07B8.1 cpr-8; Peptidase C1A papain C-terminal domain-containing protein K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_W07B8.4 W07B8.4; Peptidase C1A papain C-terminal domain-containing protein K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_W07B8.5 cpr-5; Cathepsin B-like cysteine proteinase 5 K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_F36D3.9 cpr-2; Peptidase C1A papain C-terminal domain-containing protein K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_F57F5.1 cpr-9; Peptidase C1A papain C-terminal domain-containing protein K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_C25B8.3 cpr-6; Cathepsin B-like cysteine proteinase 6 K01363 CTSB; cathepsin B [EC:3.4.22.1]
C CELE_T03E6.7 cpl-1; Cathepsin L-like K01365 CTSL; cathepsin L [EC:3.4.22.15]
B Other peptidases
C CELE_F13D12.6 ctsa-1.2; Serine carboxypeptidase ctsa-1.2 K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
C CELE_Y40D12A.2 ctsa-4.2; Carboxypeptidase K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
C CELE_F41C3.5 ctsa-1.1; Serine carboxypeptidase ctsa-1.1 K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
C CELE_Y16B4A.2 Y16B4A.2; Carboxypeptidase K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Others
C CELE_T14F9.3 hex-1; Beta-hexosaminidase A K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
#
AProtein folding catalysts
B Peptidyl prolyl isomerase
C Cyclophilin
D CELE_Y49A3A.5 cyn-1; Peptidyl-prolyl cis-trans isomerase 1 K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D CELE_F31C3.1 cyn-5; Peptidyl-prolyl cis-trans isomerase 5 K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D CELE_F42G9.2 cyn-6; Peptidyl-prolyl cis-trans isomerase 6 K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D CELE_Y116A8C.34 cyn-13; Peptidyl-prolyl cis-trans isomerase E K09564 PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]
D CELE_T22F3.12 T22F3.12; Peptidyl-prolyl cis-trans isomerase K09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
D CELE_D1009.2 cyn-8; Peptidyl-prolyl cis-trans isomerase 8 K09566 PPIG; peptidyl-prolyl isomerase G (cyclophilin G) [EC:5.2.1.8]
D CELE_T01B7.4 cyn-11; Peptidyl-prolyl cis-trans isomerase 11 K09567 PPIH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]
D CELE_C34D4.12 cyn-12; Peptidyl-prolyl cis-trans isomerase K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
D CELE_F59E10.2 cyn-4; Peptidyl-prolyl cis-trans isomerase 4 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
D CELE_B0252.4 cyn-10; Peptidyl-prolyl cis-trans isomerase 10 K12734 PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 [EC:5.2.1.8]
D CELE_F39H2.2 sig-7; Peptidyl-prolyl cis-trans isomerase sig-7 K12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]
D CELE_Y87G2A.6 cyn-15; PPIase cyclophilin-type domain-containing protein K12736 PPWD1; peptidylprolyl isomerase domain and WD repeat-containing protein 1 [EC:5.2.1.8]
D CELE_Y17G7B.9 cyn-16; PPIase cyclophilin-type domain-containing protein K12737 SDCCAG10; peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]
D CELE_F59A2.1 npp-9; Nuclear Pore complex Protein K12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
C FKBP
D CELE_Y18D10A.19 fkb-2; peptidylprolyl isomerase K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]
D CELE_F36H1.1 fkb-1; peptidylprolyl isomerase K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
D CELE_F31D4.3 fkb-6; peptidylprolyl isomerase K09571 FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]
D CELE_C05C8.3 fkb-3; peptidylprolyl isomerase K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
D CELE_C50F2.6 fkb-5; peptidylprolyl isomerase K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
C Parvulin
D CELE_Y110A2AL.13 pinn-1; Peptidyl-prolyl cis-trans isomerase K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
D CELE_Y48C3A.16 pinn-4; Peptidyl-prolyl cis-trans isomerase K09579 PIN4; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 [EC:5.2.1.8]
B Protein disulfide isomerase
C CELE_B0024.9 trx-2; putative thioredoxin-2 K03671 TXN; thioredoxin
C CELE_B0228.5 trx-1; Thioredoxin-1 K03671 TXN; thioredoxin
C CELE_Y44E3A.3 trx-4; Thioredoxin K03671 TXN; thioredoxin
C CELE_Y34D9A.6 glrx-10; Glutaredoxin-1 K03676 grxC; glutaredoxin 3
C CELE_ZK121.1 glrx-21; Glutaredoxin domain-containing protein K03676 grxC; glutaredoxin 3
C CELE_C07G1.8 glrx-22; Glutaredoxin domain-containing protein K03676 grxC; glutaredoxin 3
C CELE_F10D7.3 F10D7.3; putative monothiol glutaredoxin F10D7.3 K03676 grxC; glutaredoxin 3
C CELE_Y49E10.2 glrx-5; Glutaredoxin domain-containing protein K07390 grxD; monothiol glutaredoxin
C CELE_Y46E12A.3 Y46E12A.3; Glutaredoxin domain-containing protein K17479 GRXCR1; glutaredoxin domain-containing cysteine-rich protein 1
C CELE_C07A12.4 pdi-2; Protein disulfide-isomerase 2 K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
C CELE_C14B1.1 pdi-1; Protein disulfide-isomerase 1 K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
C CELE_H06O01.1 pdi-3; Protein disulfide-isomerase K08056 PDIA3; protein disulfide-isomerase A3 [EC:5.3.4.1]
C CELE_C14B9.2 C14B9.2; putative protein disulfide-isomerase A4 K09582 PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]
C CELE_B0403.4 pdi-6; Protein disulfide-isomerase A6 homolog K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C CELE_Y49E10.4 Y49E10.4; protein disulfide-isomerase K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C CELE_ZK973.11 ZK973.11; Thioredoxin domain-containing protein K09585 TMX3; protein disulfide-isomerase [EC:5.3.4.1]
C CELE_F09E8.2 crld-1; Protein disulfide isomerase crld-1 K24335 CRELD; protein disulfide-isomerase [EC:5.3.4.1]
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: January 25, 2024