+E	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Messenger RNA Biogenesis - Drosophila ananassae</h2>
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A<b>Eukaryotic type</b>
B  mRNA processing factors
C    5' end processing
D      Capping factors
E        6498788 mRNA-capping enzyme	K13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74] 
E        6503642 cyclin-dependent kinase 7	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        6504176 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	K14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57] 
D      Cap binding complex
E        6504102 nuclear cap-binding protein subunit 1	K12882 NCBP1; nuclear cap-binding protein subunit 1 
E        6499553 nuclear cap-binding protein subunit 2	K12883 NCBP2; nuclear cap-binding protein subunit 2 
C    3' end processing
D      Pre-mRNA cleavage factor Im (CFIm)
E        6506202 cleavage and polyadenylation specificity factor subunit CG7185 isoform X1	K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7 
D      Pre-mRNA cleavage factor IIm (CFIIm)
E        6494046 protein CLP1 homolog	K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] 
E        6494940 uncharacterized protein LOC6494940 isoform X5	K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11 
D      Cleavage and polyadenylation specificity factor (CPSF) complex
E        6494213 cleavage and polyadenylation specificity factor subunit 1	K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1 
E        6500879 cleavage and polyadenylation specificity factor 73	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
E        26514018 cleavage and polyadenylation specificity factor subunit 4	K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4 
E        6499454 pre-mRNA 3'-end-processing factor FIP1	K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1 
E        6499136 pre-mRNA 3' end processing protein WDR33	K15542 PFS2; polyadenylation factor subunit 2 
E        6498036 WD repeat-containing protein 82	K14962 WDR82; COMPASS component SWD2 
E        6502328 serine/threonine-protein phosphatase alpha-1 isoform	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        6499833 serine/threonine-protein phosphatase alpha-2 isoform	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        6503731 serine/threonine-protein phosphatase alpha-3 isoform	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        6496057 serine/threonine-protein phosphatase PP-Y	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        6503127 RNA polymerase II subunit A C-terminal domain phosphatase SSU72	K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] 
D      Cleavage stimulation factor (CSTF) complex
E        6505899 cleavage stimulation factor subunit 1	K14406 CSTF1; cleavage stimulation factor subunit 1 
E        6499704 cleavage stimulation factor subunit 2	K14407 CSTF2; cleavage stimulation factor subunit 2 
E        6501421 symplekin	K06100 SYMPK; symplekin 
D      U7-dependent histone pre-mRNA processing factors
E        6496926 small nuclear ribonucleoprotein-associated protein B	K11086 SNRPB; small nuclear ribonucleoprotein B and B' 
E        6495148 small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        26513924 probable small nuclear ribonucleoprotein E	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        6494939 small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        6503938 probable small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
E        6493949 uncharacterized protein LOC6493949	K25591 LSM10; U7 snRNA-associated Sm-like protein LSm10 
E        6493943 U7 snRNA-associated Sm-like protein LSm11	K25592 LSM11; U7 snRNA-associated Sm-like protein LSm11 
E        6500879 cleavage and polyadenylation specificity factor 73	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
E        6499704 cleavage stimulation factor subunit 2	K14407 CSTF2; cleavage stimulation factor subunit 2 
E        6501421 symplekin	K06100 SYMPK; symplekin 
E        6501185 histone RNA hairpin-binding protein	K18710 SLBP; histone RNA hairpin-binding protein 
E        6494805 uncharacterized protein LOC6494805 isoform X1	K25593 CASP8AP2; CASP8-associated protein 2 
D      DRB sensitivity inducing factor (DSIF) complex
E        6496241 transcription elongation factor SPT4	K15171 SUPT4H1; transcription elongation factor SPT4 
E        6495192 transcription elongation factor SPT5	K15172 SUPT5H; transcription elongation factor SPT5 
D      N6-methyltransferase complex
E        6499822 N6-adenosine-methyltransferase MT-A70-like protein	K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348] 
E        6497454 N6-adenosine-methyltransferase non-catalytic subunit	K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit 
E        26514457 N(6)-adenine-specific DNA methyltransferase METTL4	K24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72] 
E        6495163 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase	K11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346] 
E        6494633 protein virilizer	K22910 VIRMA; protein virilizer 
D      Poly(A) addition factors
D      Negative regulators of mRNA 3' end processing
E        6497069 zinc finger protein swm	K13192 RBM26; RNA-binding protein 26 
E        6495302 TAR DNA-binding protein 43	K23600 TARDBP; TAR DNA-binding protein 43 
C    Other processing factors
D      6493203 DNA/RNA-binding protein KIN17	K13102 KIN; DNA/RNA-binding protein KIN17 
D      6494558 uncharacterized protein LOC6494558 isoform X1	K23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19] 
D      6496655 serrate RNA effector molecule homolog isoform X1	K27103 SRRT; serrate RNA effector molecule 
B  mRNA surveillance and transport factors
C    Transport factors
D      EJC complex
E        6494814 RNA-binding protein 8A	K12876 RBM8A; RNA-binding protein 8A 
E        6494794 protein mago nashi	K12877 MAGOH; protein mago nashi 
E        6500111 THO complex subunit 4	K12881 THOC4; THO complex subunit 4 
E        6497567 ATP-dependent RNA helicase WM6 isoform X1	K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7] 
E        6501117 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        6499297 coiled-coil domain-containing protein 174	K25178 CCDC174; coiled-coil domain-containing protein 174 
E        6501616 histone deacetylase complex subunit SAP18	K14324 SAP18; histone deacetylase complex subunit SAP18 
E        6497514 apoptotic chromatin condensation inducer in the nucleus	K12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus 
E        6501249 RNA-binding protein with serine-rich domain 1-A	K14325 RNPS1; RNA-binding protein with serine-rich domain 1 
E        6506697 serine/arginine repetitive matrix protein 1	K13171 SRRM1; serine/arginine repetitive matrix protein 1 
D      TREX complex
E        6501415 THO complex subunit 1	K12878 THOC1; THO complex subunit 1 
E        6498120 THO complex subunit 2 isoform X1	K12879 THOC2; THO complex subunit 2 
E        6499466 THO complex subunit 3	K12880 THOC3; THO complex subunit 3 
E        6500111 THO complex subunit 4	K12881 THOC4; THO complex subunit 4 
E        6495726 THO complex subunit 5	K13174 THOC5; THO complex subunit 5 
E        6493437 THO complex protein 7	K13176 THOC7; THO complex subunit 7 
D      TREX-2 complex
E        6507901 PCI domain-containing protein 2 homolog	K23801 PCID2; nuclear mRNA export protein PCID2/THP1 
E        6503461 probable 26S proteasome complex subunit sem1	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        6503072 enhancer of yellow 2 transcription factor isoform X1	K11368 ENY2; enhancer of yellow 2 transcription factor 
D      Nuclear pore complex
E        6495943 nucleoprotein TPR	K09291 TPR; nucleoprotein TPR 
E        6494496 mRNA export factor	K14298 RAE1; mRNA export factor 
E        6499782 protein SEC13 homolog	K14004 SEC13; protein transport protein SEC13 
E        6495129 nuclear pore complex protein Nup75	K14304 NUP85; nuclear pore complex protein Nup85 
E        6494920 probable nucleoporin Nup54	K14308 NUP54; nuclear pore complex protein Nup54 
E        6501506 nuclear pore complex protein Nup98-Nup96	K14297 NUP98; nuclear pore complex protein Nup98-Nup96 
E        6499792 nuclear pore complex protein Nup133	K14300 NUP133; nuclear pore complex protein Nup133 
E        6498646 nuclear pore complex protein Nup154	K14312 NUP155; nuclear pore complex protein Nup155 
E        6498449 nuclear pore complex protein Nup160 homolog	K14303 NUP160; nuclear pore complex protein Nup160 
E        6500394 nuclear pore complex protein Nup58	K14307 NUPL1; nucleoporin p58/p45 
E        6496491 nucleoporin seh1	K14299 SEH1; nucleoporin SEH1 
E        6495309 NTF2-related export protein	K14285 NXT1_2; NTF2-related export protein 1/2 
D      Ran-mediated transport factors
E        6503097 GTP-binding nuclear protein Ran	K07936 RAN; GTP-binding nuclear protein Ran 
E        6506723 GTP-binding nuclear protein Ran	K07936 RAN; GTP-binding nuclear protein Ran 
E        6497807 LOW QUALITY PROTEIN: ELAV-like protein 2	K13208 ELAVL2_3_4; ELAV like protein 2/3/4 
E        6504076 ELAV-like protein 2 isoform X2	K13208 ELAVL2_3_4; ELAV like protein 2/3/4 
E        6504888 protein elav isoform X2	K13208 ELAVL2_3_4; ELAV like protein 2/3/4 
E        6494000 transitional endoplasmic reticulum ATPase TER94 isoform X3	K13525 VCP; transitional endoplasmic reticulum ATPase 
E        6498044 exportin-1	K14290 XPO1; exportin-1 
E        6495015 ran-binding protein 16 isoform X1	K18460 XPO7; exportin-7 
D      eIF4F and regulatory proteins
E        6502727 eukaryotic translation initiation factor 4E type 2 isoform X2	K03259 EIF4E; translation initiation factor 4E 
E        6506375 eukaryotic translation initiation factor 4E1 isoform X1	K03259 EIF4E; translation initiation factor 4E 
E        6504700 eukaryotic translation initiation factor 4E1 isoform X2	K03259 EIF4E; translation initiation factor 4E 
E        6507732 eukaryotic translation initiation factor 4E1	K03259 EIF4E; translation initiation factor 4E 
E        6498401 eukaryotic initiation factor 4A isoform X1	K03257 EIF4A; translation initiation factor 4A 
E        6502274 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4H	K24086 EIF4H; translation initiation factor 4H 
E        6498052 eukaryotic translation initiation factor 4E-binding protein 3	K18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2 
E        6499922 synaptic functional regulator FMR1 isoform X1	K15516 FMR; fragile X mental retardation protein 
E        6505642 cytoplasmic FMR1-interacting protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        6499125 ATP-dependent RNA helicase bel isoform X2	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        6495501 polyadenylate-binding protein	K13126 PABPC; polyadenylate-binding protein 
E        6499716 polyadenylate-binding protein-interacting protein 2	K27470 PAIP2; polyadenylate-binding protein-interacting protein 2 
E        6501508 helicase SKI2W	K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6] 
E        6506236 deformed epidermal autoregulatory factor 1 isoform X2	K23041 DEAF1; deformed epidermal autoregulatory factor 1 
E        6504758 malignant T-cell-amplified sequence 1 homolog	K07575 MCTS; malignant T-cell-amplified sequence 
E        6504425 density-regulated protein homolog	K24272 DENR; density-regulated protein 
D      APOBEC1-ACF complex
D      Other transport factors
E        6500152 heterogeneous nuclear ribonucleoprotein 87F isoform X1	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        6501354 heterogeneous nuclear ribonucleoprotein A1 isoform X2	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        6500480 CUGBP Elav-like family member 2 isoform X1	K14411 MSI; RNA-binding protein Musashi 
E        6507034 RNA-binding protein Musashi homolog Rbp6 isoform X3	K14411 MSI; RNA-binding protein Musashi 
E        6501335 ribonucleoprotein RB97D	K14411 MSI; RNA-binding protein Musashi 
E        6507580 HBS1-like protein	K14416 HBS1; elongation factor 1 alpha-like protein 
E        6505446 protein pelota	K06965 PELO; protein pelota 
E        6496503 polyadenylate-binding protein 2	K14396 PABPN1; polyadenylate-binding protein 2 
E        6503257 DEAD-box helicase Dbp80 isoform X2	K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7] 
E        6496542 pre-mRNA-splicing factor syf1 homolog	K12867 SYF1; pre-mRNA-splicing factor SYF1 
E        6505482 transcriptional activator protein Pur-beta	K21772 PURA; transcriptional activator protein Pur-alpha 
E        6496892 leukocyte receptor cluster member 8 homolog	K23802 LENG8; SAC3 family protein LENG8/THP3 
C    Surveillance factors
D      Surveillance complex
E        6493201 eukaryotic peptide chain release factor subunit 1	K03265 ETF1; peptide chain release factor subunit 1 
E        6497026 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1	K03267 ERF3; peptide chain release factor subunit 3 
D      Protein phosphatase 2A
E        6504501 serine/threonine-protein phosphatase PP2A	K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] 
E        6498034 serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit isoform X1	K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A 
E        6500913 protein phosphatase PP2A 55 kDa regulatory subunit isoform X1	K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B 
E        6500410 uncharacterized protein LOC6500410	K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' 
E        6499555 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4	K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B' 
E        6501476 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B' 
D      Other surveillance factors
E        6498418 protein SMG5	K11125 SMG5; protein SMG5 
E        6501444 telomerase-binding protein EST1A	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
E        6493741 selenocysteine insertion sequence-binding protein 2	K19539 SECISBP2; selenocysteine insertion sequence-binding protein 2 
E        6502904 probable ATP-dependent RNA helicase DHX34	K20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6] 
E        6495625 GTP-binding protein 1	K24887 GTPBP1; GTP-binding protein 1 
C    Factors involved in mRNA localization
D      Cargo complex
E        6505055 protein penguin	K14844 PUF6; pumilio homology domain family member 6 
E        6494065 unconventional myosin-Va isoform X1	K10357 MYO5; myosin V 
E        6497915 protein bicaudal D	K18739 BICD; protein bicaudal D 
E        6494685 uncharacterized protein LOC6494685	K18740 EXD1; exonuclease 3'-5' domain-containing protein 1 
D      Factors that have mRNA localization signals
E        6504746 actin-5C	K05692 ACTB_G1; actin beta/gamma 1 
E        6496662 actin-42A	K05692 ACTB_G1; actin beta/gamma 1 
E        6500576 homeotic protein bicoid isoform X3	K18659 BCD; homeotic protein bicoid 
E        6493005 T-box-containing protein TBX6L	K10180 TBX6; T-box protein 6 
E        6499595 enhancer of split m7 protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6501000 enhancer of split m5 protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6501003 enhancer of split mbeta protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6506978 protein hairy	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6495451 protein deadpan	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6499589 enhancer of split mdelta protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6499590 enhancer of split mgamma protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6499593 enhancer of split m3 protein	K09090 HESN; hairy and enhancer of split, invertebrate 
E        6499596 enhancer of split m8 protein	K09090 HESN; hairy and enhancer of split, invertebrate 
D      Trans-acting binding proteins
E        6496285 far upstream element-binding protein 3	K13210 FUBP; far upstream element-binding protein 
E        6505630 elongation factor 1-alpha 2	K03231 EEF1A; elongation factor 1-alpha 
E        6501180 elongation factor 1-gamma	K03233 EEF1G; elongation factor 1-gamma 
E        6500154 RNA-binding protein squid isoform X1	K03102 SQD; squid 
D      Other mRNA localization factors
E        6499922 synaptic functional regulator FMR1 isoform X1	K15516 FMR; fragile X mental retardation protein 
E        6505642 cytoplasmic FMR1-interacting protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        6497020 CUGBP Elav-like family member 2 isoform X1	K02177 BRU; bruno 
E        6493719 Y-box factor homolog	K09276 YBX1; Y-box-binding protein 1 
C    mRNA cycle factors
D      Common to processing body (P body) and stress granule
E        6503195 5'-3' exoribonuclease 1 isoform X1	K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] 
E        6494017 protein argonaute-2 isoform X1	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        6502727 eukaryotic translation initiation factor 4E type 2 isoform X2	K03259 EIF4E; translation initiation factor 4E 
E        6506375 eukaryotic translation initiation factor 4E1 isoform X1	K03259 EIF4E; translation initiation factor 4E 
E        6504700 eukaryotic translation initiation factor 4E1 isoform X2	K03259 EIF4E; translation initiation factor 4E 
E        6507732 eukaryotic translation initiation factor 4E1	K03259 EIF4E; translation initiation factor 4E 
E        6499125 ATP-dependent RNA helicase bel isoform X2	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        6498559 ATP-dependent RNA helicase me31b	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
E        6493301 protein LSM14 homolog B isoform X4	K18749 LSM14; protein LSM14 
E        6493719 Y-box factor homolog	K09276 YBX1; Y-box-binding protein 1 
E        6501852 LIM domain-containing protein jub isoform X2	K16682 AJUBA; LIM domain-containing protein 
E        6494300 putative helicase mov-10-B.2	K18422 MOV10; helicase MOV-10 [EC:5.6.2.5] 
E        6506174 transportin-2	K18752 TNPO1; transportin-1 
E        6498418 protein SMG5	K11125 SMG5; protein SMG5 
E        6501444 telomerase-binding protein EST1A	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
E        26515054 protein lin-28 homolog	K18754 LIN28; protein lin-28 
E        6497750 protein bicaudal C	K18756 BICC1; protein bicaudal C 
E        6500152 heterogeneous nuclear ribonucleoprotein 87F isoform X1	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        6501354 heterogeneous nuclear ribonucleoprotein A1 isoform X2	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        6504562 cAMP-dependent protein kinase catalytic subunit 1	K04345 PKA; protein kinase A [EC:2.7.11.11] 
E        6505956 cAMP-dependent protein kinase catalytic subunit 2 isoform X2	K04345 PKA; protein kinase A [EC:2.7.11.11] 
E        6499549 hormone receptor 4 isoform X1	K18757 LARP1; la-related protein 1 
E        6498926 la-related protein 1 isoform X1	K18757 LARP1; la-related protein 1 
E        6501074 ataxin-2 homolog	K23625 ATXN2_2L; ataxin 2/2L 
D      P-body specific factors
E        6495815 U6 snRNA-associated Sm-like protein LSm1	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        26514390 U6 snRNA-associated Sm-like protein LSm3	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        6496929 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        6506153 U6 snRNA-associated Sm-like protein LSm5	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        6495066 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        6497369 U6 snRNA-associated Sm-like protein LSm7	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
E        6493737 kinesin light chain isoform X1	K10407 KLC; kinesin light chain 
E        6494065 unconventional myosin-Va isoform X1	K10357 MYO5; myosin V 
E        6494393 tubulin alpha-2 chain	K07374 TUBA; tubulin alpha 
E        6499546 tubulin alpha-3 chain	K07374 TUBA; tubulin alpha 
E        6500432 tubulin alpha-1 chain	K07374 TUBA; tubulin alpha 
E        6507779 tubulin alpha-4 chain	K07374 TUBA; tubulin alpha 
E        6495348 CCR4-NOT transcription complex subunit 1 isoform X2	K12604 CNOT1; CCR4-NOT transcription complex subunit 1 
E        6501431 regulator of gene activity isoform X1	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        26514865 CCR4-NOT transcription complex subunit 6 isoform X2	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        6493268 CCR4-NOT transcription complex subunit 7 isoform X1	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        6495072 PAN2-PAN3 deadenylation complex catalytic subunit PAN2	K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
E        6506900 PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1	K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 
E        6506543 enhancer of mRNA-decapping protein 3	K12615 EDC3; enhancer of mRNA-decapping protein 3 
E        6497059 enhancer of mRNA-decapping protein 4 homolog	K12616 EDC4; enhancer of mRNA-decapping protein 4 
E        6493995 RING finger protein nhl-1 isoform X2	K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27] 
E        6496515 protein wech	K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27] 
E        6494686 DNA-directed RNA polymerase II subunit RPB7	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
E        6501364 YTH domain-containing family protein isoform X1	K20102 YTHDF; YTH domain-containing family protein 
D      Stress granule specific factors
E        6500748 nucleolysin TIAR	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        6501640 oligouridylate-binding protein 1B isoform X4	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        6495501 polyadenylate-binding protein	K13126 PABPC; polyadenylate-binding protein 
E        6499922 synaptic functional regulator FMR1 isoform X1	K15516 FMR; fragile X mental retardation protein 
E        6500391 ras GTPase-activating protein-binding protein 1	K24983 G3BP2; Ras GTPase-activating protein-binding protein 2 
E        6493798 eukaryotic translation initiation factor 2A	K15026 EIF2A; translation initiation factor 2A 
E        6494206 eukaryotic translation initiation factor 3 subunit B	K03253 EIF3B; translation initiation factor 3 subunit B 
E        6498401 eukaryotic initiation factor 4A isoform X1	K03257 EIF4A; translation initiation factor 4A 
E        6501117 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        26514261 ribosomal protein S6 kinase 2 beta	K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1] 
E        6505489 guanine nucleotide-binding protein subunit beta-like protein	K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein 
E        6503733 histone deacetylase 6 isoform X1	K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98] 
B  mRNA degradation factors
C    5'-3' decay
D      Decapping complex
E        6498559 ATP-dependent RNA helicase me31b	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
E        6506543 enhancer of mRNA-decapping protein 3	K12615 EDC3; enhancer of mRNA-decapping protein 3 
E        6497059 enhancer of mRNA-decapping protein 4 homolog	K12616 EDC4; enhancer of mRNA-decapping protein 4 
D      Lsm complex
E        6495815 U6 snRNA-associated Sm-like protein LSm1	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        26514390 U6 snRNA-associated Sm-like protein LSm3	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        6496929 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        6506153 U6 snRNA-associated Sm-like protein LSm5	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        6495066 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        6497369 U6 snRNA-associated Sm-like protein LSm7	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
D      5' exonucleases
E        6503195 5'-3' exoribonuclease 1 isoform X1	K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] 
E        6498242 5'-3' exoribonuclease 2 homolog	K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-] 
D      Other 5'-3' decay factors
E        6501420 m7GpppX diphosphatase	K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59] 
E        6507250 probable helicase with zinc finger domain	K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-] 
C    3'-5' decay
D      Core exosome factors
E        6497054 exosome complex component CSL4	K07573 CSL4; exosome complex component CSL4 
E        6494698 exosome complex component RRP4	K03679 RRP4; exosome complex component RRP4 
E        6496834 exosome complex component RRP40	K03681 RRP40; exosome complex component RRP40 
E        6498427 exosome complex component RRP41	K11600 RRP41; exosome complex component RRP41 
E        6500251 exosome complex component RRP46	K12590 RRP46; exosome complex component RRP46 
E        6493707 exosome complex component MTR3	K12587 MTR3; exosome complex component MTR3 
E        6494148 exosome complex exonuclease RRP42	K12589 RRP42; exosome complex component RRP42 
D      Exosome cofactors
E        6503433 exosome complex exonuclease RRP44	K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-] 
D      TRAMP complex
E        6497735 exosome RNA helicase MTR4	K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6] 
D      Ski complex
E        6501508 helicase SKI2W	K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6] 
E        6495083 tetratricopeptide repeat protein 37 isoform X1	K12600 SKI3; superkiller protein 3 
E        6500634 WD repeat-containing protein 61	K12602 WDR61; WD repeat-containing protein 61 
D      Ccr4-NOT complex
E        26514865 CCR4-NOT transcription complex subunit 6 isoform X2	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        6495348 CCR4-NOT transcription complex subunit 1 isoform X2	K12604 CNOT1; CCR4-NOT transcription complex subunit 1 
E        6501431 regulator of gene activity isoform X1	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        6493268 CCR4-NOT transcription complex subunit 7 isoform X1	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        6502986 CCR4-NOT transcription complex subunit 9	K12606 RCD1; CCR4-NOT transcription complex subunit 9 
E        6499898 CCR4-NOT transcription complex subunit 10	K12607 CNOT10; CCR4-NOT transcription complex subunit 10 
D      Pan complex
E        6495072 PAN2-PAN3 deadenylation complex catalytic subunit PAN2	K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
E        6506900 PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1	K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 
D      Other 3'-5' decay factors
E        6499531 nocturnin isoform X1	K18764 NOCT; nocturnin [EC:3.1.3.108] 
E        6501420 m7GpppX diphosphatase	K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59] 
E        6507250 probable helicase with zinc finger domain	K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-] 
E        6493007 protein Smaug isoform X2	K27396 SMG; protein Smaug 
E        6494714 focadhesin	K27498 FOCAD; focadhesin 
C    Other degradation factors
D      RNases
E        6500123 endoribonuclease ZC3H12A	K18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-] 
#
A<b>Prokaryotic type</b>
B  Bacterial mRNA degradation factors
C    RNA degradosome components
D      Ribonucreases
E        6496482 ribonuclease 3	K03685 rnc; ribonuclease III [EC:3.1.26.3] 
D      Helicases
D      Other RNA degradosome components
E        6498680 enolase	K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] 
E        6499983 polyribonucleotide nucleotidyltransferase 1, mitochondrial	K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] 
E        6494878 ATP-dependent 6-phosphofructokinase isoform X5	K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] 
C    Other RNA degradation factors
D      Chaperones
E        6494224 heat shock 70 kDa protein cognate 5	K04043 dnaK; molecular chaperone DnaK 
E        6503005 heat shock protein 60A	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
E        6503339 60 kDa heat shock protein homolog 1, mitochondrial	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
E        6498382 60 kDa heat shock protein homolog 2, mitochondrial	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
D      Others
D      Bacterial Small RNA Regulators
B  Archeal mRNA degradation factors
C    Exosome components
D      Core exosome
E        6494698 exosome complex component RRP4	K03679 RRP4; exosome complex component RRP4 
E        6497054 exosome complex component CSL4	K07573 CSL4; exosome complex component CSL4 
D      Cofactors
E        6498427 exosome complex component RRP41	K11600 RRP41; exosome complex component RRP41 
E        6494148 exosome complex exonuclease RRP42	K12589 RRP42; exosome complex component RRP42 
D      Others
!
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#Last updated: April 25, 2024