+F Repair protein KO
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DNA Repair and Recombination Proteins - Ehrlichia chaffeensis Liberty
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E ECHLIB_0831 DNA-3-methyladenine glycosylase family protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E ECHLIB_0287 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D ECHLIB_0622 dut; dUTP diphosphatase family protein K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E ECHLIB_1008 uracil-DNA glycosylase, 4 family protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E ECHLIB_0831 DNA-3-methyladenine glycosylase family protein K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E ECHLIB_0532 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E ECHLIB_0287 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E ECHLIB_0459 xth; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E ECHLIB_0068 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E ECHLIB_0810 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E ECHLIB_0354 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E ECHLIB_0284 uvrD/REP helicase N-terminal domain protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E ECHLIB_0810 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F ECHLIB_0205 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F ECHLIB_0206 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F ECHLIB_0690 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F ECHLIB_0342 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F ECHLIB_0852 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E ECHLIB_0317 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E ECHLIB_0263 mutL; DNA mismatch repair MutL family protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E ECHLIB_1024 xseA; exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E ECHLIB_0882 exonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E ECHLIB_0225 dnaE1; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E ECHLIB_0151 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E ECHLIB_0968 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E ECHLIB_0336 ATPase associated with various cellular activities family protein K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E ECHLIB_0598 dnaQ; DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E ECHLIB_0018 dnaX; DNA polymerase III, subunit gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E ECHLIB_0810 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E ECHLIB_0284 uvrD/REP helicase N-terminal domain protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E ECHLIB_0324 ssb; single-stranded DNA-binding family protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E ECHLIB_0072 recA; protein RecA K03553 recA; recombination protein RecA
E ECHLIB_0792 ruvA, C-terminal domain protein K03550 ruvA; holliday junction DNA helicase RuvA
E ECHLIB_0793 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E ECHLIB_0003 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E ECHLIB_0642 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E ECHLIB_0072 recA; protein RecA K03553 recA; recombination protein RecA
E ECHLIB_0806 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E ECHLIB_1006 recF/RecN/SMC N terminal domain protein K03629 recF; DNA replication and repair protein RecF
E ECHLIB_1018 helicase conserved C-terminal domain protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E ECHLIB_0068 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E ECHLIB_0590 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E ECHLIB_0300 recR; recombination protein RecR K06187 recR; recombination protein RecR
E ECHLIB_0792 ruvA, C-terminal domain protein K03550 ruvA; holliday junction DNA helicase RuvA
E ECHLIB_0793 ruvB; holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E ECHLIB_0003 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E ECHLIB_0733 uvrD/REP helicase N-terminal domain protein K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E ECHLIB_0321 PD-(D/E)XK nuclease superfamily protein K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F ECHLIB_0286 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F ECHLIB_0514 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F ECHLIB_0386 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F ECHLIB_0335 bacterial DNA-binding family protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F ECHLIB_0068 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F ECHLIB_0590 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F ECHLIB_0300 recR; recombination protein RecR K06187 recR; recombination protein RecR
F ECHLIB_0810 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F ECHLIB_0931 ihfA; integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F ECHLIB_0722 bacterial DNA-binding family protein K05788 ihfB; integration host factor subunit beta
E Supressor
F ECHLIB_0354 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D ECHLIB_0072 recA; protein RecA K03553 recA; recombination protein RecA
D ECHLIB_0324 ssb; single-stranded DNA-binding family protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D ECHLIB_0622 dut; dUTP diphosphatase family protein K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ECHLIB_0667 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D ECHLIB_0372 ribonucleotide reductase, small chain family protein K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024