+F Repair protein KO
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DNA Repair and Recombination Proteins - Escherichia coli K-12 MG1655
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D b1335 ogt; methylated-DNA--[protein]-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D b0708 phr; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E b2580 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E b2961 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E b1633 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D b0099 mutT; 8-oxo-dGTP diphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D b3640 dut; dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D b1335 ogt; methylated-DNA--[protein]-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D b2213 ada; DNA-binding transcriptional dual regulator/DNA repair protein Ada K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D b0708 phr; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D b2212 alkB; DNA oxidative demethylase K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E b2580 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E b3068 mug; stationary phase mismatch/uracil DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E b2068 alkA; DNA-3-methyladenine glycosylase 2 K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E b2961 mutY; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E b3549 tag; 3-methyl-adenine DNA glycosylase I, constitutive K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E b3635 mutM; DNA-formamidopyrimidine glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E b0714 nei; endonuclease VIII K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E b1633 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E b1749 xthA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E b2159 nfo; endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E b3998 nfi; endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E b2892 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E b2411 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E b3647 ligB; DNA ligase B K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E b3863 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E b4058 uvrA; excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
E b0779 uvrB; excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
E b1913 uvrC; excision nuclease subunit C K03703 uvrC; excinuclease ABC subunit C
E b1741 cho; excinuclease Cho K05984 cho; excinuclease Cho [EC:3.1.25.-]
E b3813 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E b3863 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E b2411 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E b3647 ligB; DNA ligase B K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F b3987 rpoB; RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F b3988 rpoC; RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F b3295 rpoA; RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F b3649 rpoZ; RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F b1114 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E b2733 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E b4170 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E b2831 mutH; DNA mismatch repair protein MutH K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E b2011 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E b2509 xseA; exodeoxyribonuclease VII subunit XseA K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E b0422 xseB; exodeoxyribonuclease VII subunit XseB K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E b1844 exoX; exonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E b0184 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E b3701 dnaN; beta sliding clamp K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E b4259 holC; DNA polymerase III subunit chi K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E b0640 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E b1099 holB; DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E b0215 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E b0470 dnaX; DNA polymerase III subunit tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E b4372 holD; DNA polymerase III subunit psi K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E b1842 holE; DNA polymerase III subunit theta K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E b2411 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E b3647 ligB; DNA ligase B K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E b3813 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E b4059 ssb; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
E b3387 dam; DNA adenine methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E b1960 vsr; DNA mismatch endonuclease Vsr K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E b2820 recB; exodeoxyribonuclease V subunit RecB K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E b2822 recC; exodeoxyribonuclease V subunit RecC K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E b2819 recD; exodeoxyribonuclease V subunit RecD K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E b2699 recA; DNA recombination/repair protein RecA K03553 recA; recombination protein RecA
E b1861 ruvA; Holliday junction branch migration complex subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E b1860 ruvB; Holliday junction branch migration complex subunit RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E b1863 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E b0550 rusA; DLP12 prophage; crossover junction endodeoxyribonuclease RusA K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E b3935 priA; primosome factor N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E b4201 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E b0467 priC; primosomal replication protein N'' K04067 priC; primosomal replication protein N''
E b4362 dnaT; primosomal protein DnaT K02317 dnaT; DNA replication protein DnaT
E b2011 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E b0397 sbcC; ATP dependent, structure specific DNA nuclease - SbcC subunit K03546 sbcC; DNA repair protein SbcC/Rad50
E b0398 sbcD; ATP dependent, structure specific DNA nuclease - SbcD subunit K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E b2699 recA; DNA recombination/repair protein RecA K03553 recA; recombination protein RecA
E b4389 radA; DNA recombination protein K04485 radA; DNA repair protein RadA/Sms
E b3700 recF; DNA repair protein RecF K03629 recF; DNA replication and repair protein RecF
E b3652 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E b2892 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E b2565 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E b0472 recR; DNA repair protein RecR K06187 recR; recombination protein RecR
E b2616 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E b0393 rdgC; nucleoid-associated protein RdgC K03554 rdgC; recombination associated protein RdgC
E b1861 ruvA; Holliday junction branch migration complex subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E b1860 ruvB; Holliday junction branch migration complex subunit RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E b1863 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E b2755 cas1; multifunctional nuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
E b2184 radD; putative DNA repair helicase RadD K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E b0397 sbcC; ATP dependent, structure specific DNA nuclease - SbcC subunit K03546 sbcC; DNA repair protein SbcC/Rad50
E b0398 sbcD; ATP dependent, structure specific DNA nuclease - SbcD subunit K03547 sbcD; DNA repair protein SbcD/Mre11
E b4263 yjgR; DUF853 domain-containing protein YjgR K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F b2231 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F b3699 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F b1274 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F b4000 hupA; DNA-binding protein HU-alpha K05787 hupA; DNA-binding protein HU-alpha
F b0440 hupB; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F b1350 recE; Rac prophage; exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F b1349 recT; Rac prophage; recombinase RecT K07455 recT; recombination protein RecT
F b2892 recJ; ssDNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F b2565 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F b0472 recR; DNA repair protein RecR K06187 recR; recombination protein RecR
F b2411 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F b3647 ligB; DNA ligase B K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F b3261 fis; DNA-binding transcriptional dual regulator Fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F b1712 ihfA; integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F b0912 ihfB; integration host factor subunit beta K05788 ihfB; integration host factor subunit beta
E Supressor
F b2011 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F b3822 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F b4058 uvrA; excision nuclease subunit A K03701 uvrA; excinuclease ABC subunit A
F b0779 uvrB; excision nuclease subunit B K03702 uvrB; excinuclease ABC subunit B
F b1237 hns; DNA-binding transcriptional dual regulator H-NS K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D b0231 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D b1184 umuC; DNA polymerase V catalytic protein K03502 umuC; DNA polymerase V
D b1183 umuD; DNA polymerase V protein UmuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D b2699 recA; DNA recombination/repair protein RecA K03553 recA; recombination protein RecA
D b4043 lexA; DNA-binding transcriptional repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D b2616 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D b0060 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D b4059 ssb; ssDNA-binding protein K03111 ssb; single-strand DNA-binding protein
D b3645 dinD; DNA damage-inducible protein D K14623 dinD; DNA-damage-inducible protein D
D b1061 dinI; DNA damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D b2698 recX; RecA inhibitor RecX K03565 recX; regulatory protein
D b3411 rpnA; recombination-promoting nuclease RpnA K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D b2305 rpnB; recombination-promoting nuclease RpnB K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D b0132 rpnC; recombination-promoting nuclease RpnC K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D b2244 rpnE; inactive recombination-promoting nuclease-like protein RpnE K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D b3778 rep; ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D b0962 helD; DNA helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D b0799 dinG; ATP-dependent DNA helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D b1808 yoaA; putative ATP-dependent 5' to 3' DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D b1653 lhr; putative ATP-dependent helicase Lhr K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D b0099 mutT; 8-oxo-dGTP diphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D b3640 dut; dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D b2675 nrdE; ribonucleoside-diphosphate reductase 2 subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D b2234 nrdA; ribonucleoside-diphosphate reductase 1 subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D b2676 nrdF; ribonucleoside-diphosphate reductase 2 subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D b2235 nrdB; ribonucleoside-diphosphate reductase 1 subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024