+C Two-component system KO
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Two-Component System - Escherichia coli O145:H28 RM13516 (EHEC)
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C ECRM13516_0380 phoR; Phosphate regulon sensor protein PhoR (SphS) K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C ECRM13516_0379 phoB; Phosphate regulon transcriptional regulatory protein PhoB (SphR) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C ECRM13516_1459 phoQ; Sensor protein PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C ECRM13516_1460 phoP; Transcriptional regulatory protein PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C ECRM13516_4145 envZ; Osmolarity sensory histidine kinase EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C ECRM13516_4146 ompR; Two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C ECRM13516_2003 rstB; Sensory histidine kinase in two-component regulatory system with RstA K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C ECRM13516_2002 rstA; Transcriptional regulatory protein RstA K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C ECRM13516_4761 cpxA; Copper sensory histidine kinase CpxA K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C ECRM13516_4762 cpxR; Copper-sensing two-component system response regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C ECRM13516_5439 creC; Two-component response regulator CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C ECRM13516_5438 creB; Two-component response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C ECRM13516_2668 baeS; Sensory histidine kinase BaeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C ECRM13516_2669 baeR; Response regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C ECRM13516_4995 basS; Sensor protein basS/pmrB K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C ECRM13516_4996 basR; Transcriptional regulatory protein basR/pmrA K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C ECRM13516_0531 ybcZ; Osmosensitive K+ channel histidine kinase KdpD K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C ECRM13516_0532 ylcA; Copper-sensing two-component system response regulator CusR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C ECRM13516_3795 qseC; Sensory histidine kinase QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C ECRM13516_3794 qseB; Two-component system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C ECRM13516_0660 kdpD; Osmosensitive K+ channel histidine kinase KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C ECRM13516_0659 kdpE; DNA-binding response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C ECRM13516_1099 torS; Sensor protein torS K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C ECRM13516_1101 torR; TorCAD operon transcriptional regulatory protein TorR K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C ECRM13516_3973 arcB; Aerobic respiration control sensor protein arcB K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C ECRM13516_5441 arcA; Aerobic respiration control protein arcA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C ECRM13516_2450 yedV; Putative two component system histidine kinase YedV K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C ECRM13516_2451 yedW; putative 2-component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C ECRM13516_1550 narX; Nitrate/nitrite sensor protein K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C ECRM13516_1549 narL; Nitrate/nitrite response regulator protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C ECRM13516_3147 narQ; Nitrate/nitrite sensor protein K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C ECRM13516_2897 narP; Nitrate/nitrite response regulator protein K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C ECRM13516_4518 uhpB; Sensor histidine protein kinase UhpB, glucose-6-phosphate specific K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C ECRM13516_4519 uhpA; Transcriptional regulatory protein UhpA K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
C ECRM13516_0342 Sensor histidine protein kinase UhpB, glucose-6-phosphate specific K20263 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3]
C ECRM13516_0343 Transcriptional regulatory protein UhpA K20264 fusR; two-component system, NarL family, response regulator FusR
B RcsC-RcsD-RcsB (capsule synthesis)
C ECRM13516_2924 rscC; Two-component sensor protein RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C ECRM13516_2922 rcsD; Two-component sensor protein RcsD K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C ECRM13516_2923 rcsB; DNA-binding capsular synthesis response regulator RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C ECRM13516_3510 barA; BarA sensory histidine kinase K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C ECRM13516_2399 uvrY; BarA-associated response regulator UvrY (GacA, SirA) K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C ECRM13516_3057 evgS; Hybrid sensory histidine kinase in two-component regulatory system with EvgA K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C ECRM13516_3056 evgA; Positive transcription regulator EvgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C ECRM13516_0524 fimZ; Transcriptional regulator of fimbriae expression FimZ (LuxR/UhpA family) K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C ECRM13516_0588 citA; Sensor kinase CitA, DpiB K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C ECRM13516_0589 citB; Transcriptional regulatory protein CitB, DpiA K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C ECRM13516_5008 dcuS; Fumarate respiration sensor kinase protein DcuS K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C ECRM13516_5007 dcuR; Fumarate respiration transcriptional regulator DcuR K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C ECRM13516_2754 yehU; Autolysin sensor kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C ECRM13516_3067 putative sensor protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C ECRM13516_2753 yehT; putative response regulatory protein yehT K02477 K02477; two-component system, LytTR family, response regulator
C ECRM13516_3068 ypdB; putative response regulatory protein ypdB K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C ECRM13516_4722 glnL; Nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C ECRM13516_4721 glnG; Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C ECRM13516_4861 hydH; Sensor protein of zinc sigma-54-dependent two-component system K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C ECRM13516_4862 hydG; Response regulator of zinc sigma-54-dependent two-component system K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C ECRM13516_3239 yfhK; Putative sensor-like histidine kinase YfhK K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C ECRM13516_3237 yfhA; Putative sensory histidine kinase YfhA K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C ECRM13516_2362 cheA; Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C ECRM13516_2356 cheY; Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C ECRM13516_2357 cheB; Chemotaxis response regulator protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C ECRM13516_1562 hnr; Hnr protein K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023