+F Repair protein KO
#
DNA Repair and Recombination Proteins - Escherichia coli O139:H28 E24377A (ETEC)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EcE24377A_0733 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E EcE24377A_2867 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EcE24377A_3307 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EcE24377A_1842 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D EcE24377A_0101 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EcE24377A_4141 dut; dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EcE24377A_2512 ada; regulatory protein Ada K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D EcE24377A_0733 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D EcE24377A_2511 alkB; alkylated DNA repair protein AlkB K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E EcE24377A_2867 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EcE24377A_3533 mug; G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E EcE24377A_2361 alkA; DNA-3-methyladenine glycosylase 2 K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E EcE24377A_3307 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EcE24377A_4044 tag; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E EcE24377A_4136 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E EcE24377A_0740 nei; endonuclease VIII K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E EcE24377A_1842 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E EcE24377A_1972 xth; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E EcE24377A_2456 nfo; endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E EcE24377A_4541 nfi; endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E EcE24377A_3218 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E EcE24377A_4148 ligB; NAD(+)-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcE24377A_2698 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E EcE24377A_4382 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E EcE24377A_4610 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E EcE24377A_0842 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E EcE24377A_2146 uvrC; excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E EcE24377A_1963 cho; excinuclease cho K05984 cho; excinuclease Cho [EC:3.1.25.-]
E EcE24377A_4332 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcE24377A_3362 helicase, UvrD family K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcE24377A_4382 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E EcE24377A_4148 ligB; NAD(+)-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcE24377A_2698 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F EcE24377A_4528 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F EcE24377A_4529 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F EcE24377A_3778 rpoA; DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F EcE24377A_4152 rpoZ; DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F EcE24377A_1236 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E EcE24377A_3030 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E EcE24377A_4728 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E EcE24377A_3151 mutH; DNA mismatch repair endonuclease MutH K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E EcE24377A_2302 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EcE24377A_0453 xseB; exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E EcE24377A_2074 exoX; exodeoxyribonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E EcE24377A_0188 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E EcE24377A_4211 dnaN; DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E EcE24377A_4830 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E EcE24377A_0666 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E EcE24377A_1220 holB; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E EcE24377A_0221 dnaQ; DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E EcE24377A_0507 dnaX; DNA polymerase III, tau and gamma subunits K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E EcE24377A_4967 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E EcE24377A_2071 holE; DNA polymerase III, theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E EcE24377A_4148 ligB; NAD(+)-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcE24377A_2698 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E EcE24377A_4332 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcE24377A_3362 helicase, UvrD family K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcE24377A_4611 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E EcE24377A_D0002 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E EcE24377A_3857 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EcE24377A_2191 vsr; very short patch repair protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E EcE24377A_3140 recB; exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E EcE24377A_3142 recC; exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E EcE24377A_3139 recD; exodeoxyribonuclease V, alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E EcE24377A_2983 recA; protein RecA K03553 recA; recombination protein RecA
E EcE24377A_2091 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EcE24377A_2090 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EcE24377A_2093 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E EcE24377A_0821 rusA; crossover junction endodeoxyribonuclease RusA K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EcE24377A_1435 crossover junction endodeoxyribonuclease RusA homolog K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EcE24377A_1267 crossover junction endodeoxyribonuclease RusA homolog K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EcE24377A_4471 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E EcE24377A_4762 priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E EcE24377A_0503 priC; primosomal replication protein N'' K04067 priC; primosomal replication protein N''
E EcE24377A_4955 dnaT; primosomal protein 1 K02317 dnaT; DNA replication protein DnaT
E EcE24377A_2302 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EcE24377A_0424 sbcC; nuclease SbcCD, C subunit K03546 sbcC; DNA repair protein SbcC/Rad50
E EcE24377A_0425 sbcD; nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E EcE24377A_2983 recA; protein RecA K03553 recA; recombination protein RecA
E EcE24377A_4988 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E EcE24377A_4210 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E EcE24377A_4156 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E EcE24377A_3218 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E EcE24377A_2851 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E EcE24377A_0510 recR; recombination protein RecR K06187 recR; recombination protein RecR
E EcE24377A_2900 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E EcE24377A_0420 putative recombination-associated exonuclease RdgC K03554 rdgC; recombination associated protein RdgC
E EcE24377A_2091 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EcE24377A_2090 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EcE24377A_2093 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E EcE24377A_3057 cas1; CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E EcE24377A_2482 putative helicase K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E EcE24377A_0424 sbcC; nuclease SbcCD, C subunit K03546 sbcC; DNA repair protein SbcC/Rad50
E EcE24377A_0425 sbcD; nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
E EcE24377A_4836 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F EcE24377A_2526 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F EcE24377A_4209 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F EcE24377A_1474 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F EcE24377A_4543 hupA; DNA-binding protein HU-alpha K05787 hupA; DNA-binding protein HU-alpha
F EcE24377A_0476 hupB; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F EcE24377A_3218 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F EcE24377A_2851 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F EcE24377A_0510 recR; recombination protein RecR K06187 recR; recombination protein RecR
F EcE24377A_4148 ligB; NAD(+)-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F EcE24377A_2698 ligA; DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F EcE24377A_3746 fis; DNA-binding protein Fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F EcE24377A_1931 ihfA; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F EcE24377A_1009 ihfB; integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F EcE24377A_2302 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F EcE24377A_4343 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F EcE24377A_4610 uvrA; excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F EcE24377A_0842 uvrB; excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
F EcE24377A_1386 hns; DNA-binding protein H-NS K03746 hns; DNA-binding protein H-NS
F EcE24377A_3387 DNA-binding protein H-NS homolog K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D EcE24377A_0265 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D EcE24377A_1329 umuC; protein UmuC K03502 umuC; DNA polymerase V
D EcE24377A_1328 umuD; protein UmuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D EcE24377A_2983 recA; protein RecA K03553 recA; recombination protein RecA
D EcE24377A_4596 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D EcE24377A_2900 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D EcE24377A_0062 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D EcE24377A_4611 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D EcE24377A_D0002 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D EcE24377A_4147 DNA-damage-inducible protein D K14623 dinD; DNA-damage-inducible protein D
D EcE24377A_1184 dinI; DNA-damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D EcE24377A_2982 recX; regulatory protein RecX K03565 recX; regulatory protein
D EcE24377A_3886 putative transposase, YhgA K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D EcE24377A_2599 conserved hypothetical protein K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D EcE24377A_0135 conserved hypothetical protein K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D EcE24377A_2542 conserved hypothetical protein K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D EcE24377A_4288 rep; ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D EcE24377A_1077 helD; helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D EcE24377A_0290 helicase, UvrD family K03658 helD; DNA helicase IV [EC:5.6.2.4]
D EcE24377A_0866 putative ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EcE24377A_2034 conserved hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EcE24377A_1865 lhr; DEAD/DEAH box helicase family protein Lhr K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D EcE24377A_0101 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EcE24377A_4141 dut; dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D EcE24377A_2531 nrdA; ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EcE24377A_2956 nrdE; ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EcE24377A_2532 nrdB; ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D EcE24377A_2957 nrdF; ribonucleoside-diphosphate reductase, beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024