+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Esox lucius (northern pike)</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
D      105011894 orc1; origin recognition complex subunit 1 isoform X2	K02603 ORC1; origin recognition complex subunit 1 
D      105007835 orc2; origin recognition complex subunit 2 isoform X1	K02604 ORC2; origin recognition complex subunit 2 
D      105016034 orc3; origin recognition complex subunit 3	K02605 ORC3; origin recognition complex subunit 3 
D      105022548 orc4; origin recognition complex subunit 4 isoform X2	K02606 ORC4; origin recognition complex subunit 4 
D      105023409 orc5; origin recognition complex subunit 5	K02607 ORC5; origin recognition complex subunit 5 
D      105026353 orc6; origin recognition complex subunit 6	K02608 ORC6; origin recognition complex subunit 6 
D      105017041 cdt1; DNA replication factor Cdt1	K10727 CDT1; chromatin licensing and DNA replication factor 1 
D      105021478 cdc6; cell division control protein 6 homolog	K02213 CDC6; cell division control protein 6 
D      105006273 mcm2; DNA replication licensing factor MCM2	K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3] 
D      105018032 mcm3; DNA replication licensing factor MCM3	K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3] 
D      105026399 maternal DNA replication licensing factor mcm3	K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3] 
D      105019516 mcm4; DNA replication licensing factor MCM4 isoform X1	K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3] 
D      105013171 mcm5; DNA replication licensing factor MCM5	K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3] 
D      105021311 mcm6; DNA replication licensing factor MCM6	K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3] 
D      105024246 maternal DNA replication licensing factor mcm6	K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3] 
D      105007427 mcm7; DNA replication licensing factor MCM7	K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3] 
C    CDK (cyclin dependent kinase)
D      105026040 cyclin-A2	K06627 CCNA; cyclin-A 
D      105029983 ccna1; cyclin-A1 isoform X1	K06627 CCNA; cyclin-A 
D      105019239 ccne2; G1/S-specific cyclin-E2 isoform X1	K06626 CCNE; G1/S-specific cyclin-E1 
D      105022734 ccne1; G1/S-specific cyclin-E1	K06626 CCNE; G1/S-specific cyclin-E1 
D      105016957 cdk2; cyclin-dependent kinase 2	K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22] 
C    DDK (Dbf-4 dependent kinase)
D      105023972 cdc7; cell division cycle 7-related protein kinase isoform X1	K02214 CDC7; cell division control protein 7 [EC:2.7.11.1] 
D      105029244 dbf4; protein DBF4 homolog A	K06629 DBF4; protein DBF4 
D      105030982 histone-lysine N-methyltransferase 2D	K06629 DBF4; protein DBF4 
C    GINS complex
D      105025525 gins1; DNA replication complex GINS protein PSF1	K10732 GINS1; GINS complex subunit 1 
D      105027280 gins2; DNA replication complex GINS protein PSF2	K10733 GINS2; GINS complex subunit 2 
D      105018534 gins3; DNA replication complex GINS protein PSF3 isoform X1	K10734 GINS3; GINS complex subunit 3 
D      105014245 gins4; DNA replication complex GINS protein SLD5	K10735 GINS4; GINS complex subunit 4 
C    Other initiation factors
D      105027605 topbp1; DNA topoisomerase 2-binding protein 1	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      105022835 recql4; ATP-dependent DNA helicase Q4 isoform X1	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
D      105014309 cdc45; cell division control protein 45 homolog	K06628 CDC45; cell division control protein 45 
D      105031662 mcm8; DNA helicase MCM8	K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4] 
D      105017951 mcm9; DNA helicase MCM9 isoform X1	K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4] 
D      105028516 protein MCM10 homolog	K10736 MCM10; minichromosome maintenance protein 10 
D      105028960 helb; DNA helicase B	K15254 HELB; DNA helicase B [EC:5.6.2.3] 
D      105031235 protein FAM111A	K24274 FAM111A; protein FAM111A 
D      105023589 cinp; cyclin-dependent kinase 2-interacting protein isoform X1	K26052 CINP; cyclin-dependent kinase 2-interacting protein 
D      105016532 mtbp; mdm2-binding protein isoform X1	K26116 MTBP; Mdm2-binding protein 
D      105028551 ticrr; treslin isoform X1	K26117 TICRR; Treslin 
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
D      105019626 pola1; DNA polymerase alpha catalytic subunit	K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7] 
D      105024425 pola2; DNA polymerase alpha subunit B	K02321 POLA2; DNA polymerase alpha subunit B 
D      105014010 prim1; DNA primase small subunit	K02684 PRI1; DNA primase small subunit [EC:2.7.7.102] 
D      105021372 prim2; DNA primase large subunit isoform X1	K02685 PRI2; DNA primase large subunit 
C    DNA polymerase epsilon complex
D      105014433 pole; DNA polymerase epsilon catalytic subunit A isoform X1	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
D      105015984 pole2; DNA polymerase epsilon subunit 2	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
D      105021784 pole3; DNA polymerase epsilon subunit 3	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
D      105011481 pole4; DNA polymerase epsilon subunit 4	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
C    DNA polymerase delta complex
D      105029055 pold1; DNA polymerase delta catalytic subunit	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
D      105014404 pold2; DNA polymerase delta subunit 2	K02328 POLD2; DNA polymerase delta subunit 2 
D      105010836 pold3; DNA polymerase delta subunit 3	K03504 POLD3; DNA polymerase delta subunit 3 
D      105022875 pold4; DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
C    DNA polymerase gamma complex (mitochondrial)
D      105018416 polg; DNA polymerase subunit gamma-1	K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7] 
D      105021633 polg2; DNA polymerase subunit gamma-2, mitochondrial	K02333 POLG2; DNA polymerase gamma 2 
C    RPA (replication protein A)
D      105028498 replication protein A 70 kDa DNA-binding subunit isoform X1	K07466 RFA1; replication factor A1 
D      105022935 rpa1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
D      105006565 rpa2; replication protein A 32 kDa subunit	K10739 RFA2; replication factor A2 
D      105012379 rpa3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
C    RFC (replication factor C)
D      105009159 rfc1; replication factor C subunit 1 isoform X1	K10754 RFC1; replication factor C subunit 1 
D      105011707 rfc4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
D      105023969 rfc2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      105005894 rfc5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      105011175 rfc3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
C    RNase H
D      105024819 rnaseh1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      105012129 rnaseh2a; ribonuclease H2 subunit A	K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4] 
D      105016629 rnaseh2b; ribonuclease H2 subunit B isoform X1	K10744 RNASEH2B; ribonuclease H2 subunit B 
D      105026701 rnaseh2c; ribonuclease H2 subunit C	K10745 RNASEH2C; ribonuclease H2 subunit C 
C    Other elongation factors
D      105014323 pcna; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      105021325 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
D      105019536 fen1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      105023232 exo1; exonuclease 1 isoform X3	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
D      105022554 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      105024554 lig1; DNA ligase 1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      105012262 atad5; ATPase family AAA domain-containing protein 5 isoform X2	K26118 ATAD5; ATPase family AAA domain-containing protein 5 
D      105013139 ATPase family AAA domain-containing protein 5	K26118 ATAD5; ATPase family AAA domain-containing protein 5 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
D      105027800 dnmt1; DNA (cytosine-5)-methyltransferase 1	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
D      105015448 DNA (cytosine-5)-methyltransferase 3A isoform X1	K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37] 
D      105018056 DNA (cytosine-5)-methyltransferase 3A isoform X1	K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37] 
D      105013882 DNA (cytosine-5)-methyltransferase 3B isoform X1	K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37] 
D      105013881 uncharacterized protein LOC105013881	K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37] 
D      105022397 DNA (cytosine-5)-methyltransferase 3A isoform X1	K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37] 
C    Prevention of re-replication factors
D      105012505 gmnn; geminin	K10749 GMNN; geminin 
D      105029178 mcidas; multicilin	K26119 MCIDAS; multicilin 
D      105015046 ccnb1; G2/mitotic-specific cyclin-B1	K05868 CCNB1; G2/mitotic-specific cyclin-B1 
D      105016586 ccnb2; G2/mitotic-specific cyclin-B2	K21770 CCNB2; G2/mitotic-specific cyclin-B2 
D      105023569 cntd2; cyclin N-terminal domain-containing protein 2	K21770 CCNB2; G2/mitotic-specific cyclin-B2 
D      105029411 ccnb3; G2/mitotic-specific cyclin-B3	K21771 CCNB3; G2/mitotic-specific cyclin-B3 
D      105010542 cdk1; cyclin-dependent kinase 1	K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] 
C    Telomere proteins
D      Shelterin complex
E        105006085 pot1; protection of telomeres protein 1 isoform X1	K11109 POT1; protection of telomeres protein 1 
E        105019641 terf1; telomeric repeat-binding factor 1	K11110 TERF1; telomeric repeat-binding factor 1 
E        105028852 terf2; telomeric repeat-binding factor 2	K11111 TERF2; telomeric repeat-binding factor 2 
E        105020558 tinf2; TERF1-interacting nuclear factor 2 isoform X1	K11112 TINF2; TERF1-interacting nuclear factor 2 
E        105027631 uncharacterized protein LOC105027631 isoform X2	K11112 TINF2; TERF1-interacting nuclear factor 2 
E        105025486 terf2ip; telomeric repeat-binding factor 2-interacting protein 1 isoform X2	K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 
E        105016238 uncharacterized protein LOC105016238 isoform X1	K11114 ACD; adrenocortical dysplasia protein 
D      TERB1-TERB2-MAJIN complex
E        105028712 terb1; telomere repeats-binding bouquet formation protein 1 isoform X1	K25749 TERB1; telomere repeats-binding bouquet formation protein 1 
E        105030777 terb2; telomere repeats-binding bouquet formation protein 2	K25750 TERB2; telomere repeats-binding bouquet formation protein 2 
E        105006356 uncharacterized protein LOC105006356	K25751 MAJIN; membrane-anchored junction protein 
D      CST complex (animals)
E        105012303 stn1; CST complex subunit STN1	K23312 STN1; CST complex subunit STN1 
E        105021630 ten1; CST complex subunit TEN1	K23313 TEN1; CST complex subunit TEN1 
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      105031156 smg6; telomerase-binding protein EST1A isoform X1	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
D      105019277 smg5; protein SMG5 isoform X1	K11125 SMG5; protein SMG5 
D      105027725 tert; telomerase reverse transcriptase	K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49] 
D      105021883 tep1; telomerase protein component 1	K11127 TEP1; telomerase protein component 1 
D      Dyskerin complex
E        105027512 gar1; H/ACA ribonucleoprotein complex subunit 1	K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1 
E        105011279 nhp2; H/ACA ribonucleoprotein complex subunit 2	K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2 
E        105030103 nop10; H/ACA ribonucleoprotein complex subunit 3	K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3 
E        105024589 dkc1; H/ACA ribonucleoprotein complex subunit DKC1	K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] 
C    Telomerase complex (fungi)
D      105027725 tert; telomerase reverse transcriptase	K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49] 
D      Sm core complex
E        105016713 snrpb; small nuclear ribonucleoprotein-associated proteins B and B'	K11086 SNRPB; small nuclear ribonucleoprotein B and B' 
E        105012453 snrpd1; small nuclear ribonucleoprotein Sm D1	K11087 SNRPD1; small nuclear ribonucleoprotein D1 
E        105011020 snrpd2; small nuclear ribonucleoprotein Sm D2	K11096 SNRPD2; small nuclear ribonucleoprotein D2 
E        105014179 snrpd3; small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        105014836 small nuclear ribonucleoprotein Sm D3 isoform X1	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        105025457 snrpe; small nuclear ribonucleoprotein E	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        105021811 small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        105020274 snrpf; small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        105023769 snrpg; small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
C    ELG1-RFC complex
D      105011707 rfc4; replication factor C subunit 4	K10755 RFC2_4; replication factor C subunit 2/4 
D      105023969 rfc2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      105005894 rfc5; replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      105011175 rfc3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
C    MRN complex
D      105024987 mre11; double-strand break repair protein MRE11	K10865 MRE11; double-strand break repair protein MRE11 
D      105011230 LOW QUALITY PROTEIN: DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      105029237 nbn; nibrin isoform X1	K10867 NBN; nibrin 
C    Other termination factors
D      105021770 atm; serine-protein kinase ATM isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      105021732 wrn; Werner syndrome ATP-dependent helicase isoform X1	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
D      105025675 blm; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
D      105019560 prkdc; DNA-dependent protein kinase catalytic subunit	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      105031067 ercc4; DNA repair endonuclease XPF isoform X1	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
D      105006604 parp1; poly [ADP-ribose] polymerase 1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
D      105008840 parp3; protein mono-ADP-ribosyltransferase PARP3 isoform X1	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      105021741 parp2; poly [ADP-ribose] polymerase 2	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      105016442 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X2	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
D      105014743 poly [ADP-ribose] polymerase tankyrase-1 isoform X1	K10799 TNKS; tankyrase [EC:2.4.2.30] 
D      105029443 poly [ADP-ribose] polymerase tankyrase-1 isoform X1	K10799 TNKS; tankyrase [EC:2.4.2.30] 
D      105025135 tnks2; poly [ADP-ribose] polymerase tankyrase-2 isoform X3	K10799 TNKS; tankyrase [EC:2.4.2.30] 
D      105018023 pinx1; PIN2/TERF1-interacting telomerase inhibitor 1	K11135 PINX1; Pin2-interacting protein X1 
D      105013912 rtel1; regulator of telomere elongation helicase 1 isoform X2	K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3] 
D      105021267 telo2; telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
D      105028346 trir; telomerase RNA component interacting RNase	K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-] 
D      105016115 rif1; telomere-associated protein RIF1	K11138 RIF1; telomere-associated protein RIF1 
D      105024112 pif1; LOW QUALITY PROTEIN: ATP-dependent DNA helicase PIF1	K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3] 
D      105010902 pura; transcriptional activator protein Pur-alpha	K21772 PURA; transcriptional activator protein Pur-alpha 
D      105026742 transcriptional activator protein Pur-alpha-like	K21772 PURA; transcriptional activator protein Pur-alpha 
D      105021733 purg; purine-rich element-binding protein gamma	K21800 PURG; purine-rich element-binding protein gamma 
D      105029892 wrap53; telomerase Cajal body protein 1	K23314 WRAP53; telomerase Cajal body protein 1 
D      105027156 sde2; replication stress response regulator SDE2 isoform X2	K25059 SDE2; replication stress response regulator SDE2 
D      105030552 rtf2; replication termination factor 2	K25186 RTF2; replication termination factor 2 
B  DNA Topoisomerases
C    105013965 DNA topoisomerase 1-like	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    105018596 DNA topoisomerase I, mitochondrial isoform X3	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    105025728 DNA topoisomerase I, mitochondrial-like isoform X1	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    105017359 DNA topoisomerase 1 isoform X1	K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1] 
C    105012550 top2b; DNA topoisomerase 2-beta	K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2] 
C    105024531 top2a; DNA topoisomerase 2-alpha	K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2] 
C    105030479 top3a; DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
C    105014540 top3b; DNA topoisomerase 3-beta-1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      105025665 ssbp1; single-stranded DNA-binding protein, mitochondrial	K03111 ssb; single-strand DNA-binding protein 
C    Initiation factors (archaeal)
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        105024819 rnaseh1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      Other elongation factors
C    Elongation factors (archaeal)
D      B-family DNA polymerases
D      D-family DNA polymerases
D      RNase H
E        105024819 rnaseh1; ribonuclease H1	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      RFC (replication factor C)
D      Other elongation factors
E        105021325 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
E        105019536 fen1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        105024554 lig1; DNA ligase 1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
C    Prevention of re-replication factors
B  DNA Topoisomerases
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#Last updated: November 2, 2022