+C Two-component system KO
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Two-Component System - Ketobacter alkanivorans
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C Kalk_12590 hypothetical protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C Kalk_12595 phoB; phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C Kalk_19255 hypothetical protein K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C Kalk_19250 DNA-binding response regulator K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C Kalk_08905 hypothetical protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C Kalk_08915 two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C Kalk_19330 hypothetical protein K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C Kalk_19325 DNA-binding response regulator K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
C Kalk_06875 hypothetical protein K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C Kalk_06880 two-component system response regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C Kalk_01075 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C Kalk_01070 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C Kalk_18585 hypothetical protein K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C Kalk_18580 DNA-binding response regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
C Kalk_13680 hypothetical protein K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C Kalk_13685 pdsR; proteobacterial dedicated sortase system response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C Kalk_09640 hypothetical protein K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C Kalk_09645 two-component system response regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C Kalk_04815 hypothetical protein K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C Kalk_00070 two-component system response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C Kalk_09160 hypothetical protein K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C Kalk_09155 DNA-binding response regulator K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C Kalk_08315 two-component system sensor histidine kinase NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C Kalk_08320 nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
C Kalk_12225 hypothetical protein K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C Kalk_05720 hypothetical protein K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C Kalk_05725 sigma-54-dependent Fis family transcriptional regulator K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C Kalk_10190 hypothetical protein K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C Kalk_18975 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Kalk_03950 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Kalk_18965 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Kalk_03955 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Kalk_19670 hypothetical protein K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Kalk_18980 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Kalk_03930 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Kalk_03150 chemotaxis protein CheW K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C Kalk_04125 chemotaxis protein CheW K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C Kalk_12990 hypothetical protein K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C Kalk_12965 pilus assembly protein PilG K02657 pilG; twitching motility two-component system response regulator PilG
C Kalk_12970 two-component system response regulator K02658 pilH; twitching motility two-component system response regulator PilH
C Kalk_12995 hypothetical protein K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
C Kalk_10395 response regulator K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C Kalk_04000 hypothetical protein K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C Kalk_03995 sigma-54-dependent Fis family transcriptional regulator K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C Kalk_09740 hypothetical protein K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C Kalk_09735 two-component system response regulator K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C Kalk_08540 hypothetical protein K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C Kalk_18450 hypothetical protein K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C Kalk_03910 hypothetical protein K20976 hptB; histidine phosphotransfer protein HptB
C Kalk_03570 hypothetical protein K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
C Kalk_03915 fused response regulator/phosphatase K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C Kalk_00065 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_09185 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_18490 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_05265 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_16620 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_19260 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_03645 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_08040 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_00735 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_05170 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_05685 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS
C Kalk_15380 hypothetical protein K20972 retS; two-component system, sensor histidine kinase RetS
C Kalk_16010 hypothetical protein K20972 retS; two-component system, sensor histidine kinase RetS
C Kalk_09385 hypothetical protein K20972 retS; two-component system, sensor histidine kinase RetS
C Kalk_20915 hypothetical protein K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C Kalk_14960 hypothetical protein K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023